Manfred Liebsch

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Current Validation Studies on Alternatives to Animal Experiments in Europe

Horst Spielmann, Manfred Liebsch, 2001 .

An Evaluation of the Proposed OECD Testing Strategy for Skin Corrosion

Andrew P. Worth, Michael Balls, Manfred Liebsch, 1998, Alternatives to laboratory animals : ATLA.

ZEBET's activities to promote alternative methods for the ID50 potency test in botulinum neurotoxin product testing

Barbara Grune, Manfred Liebsch, Andreas Luch, 2010 .

Mission and accomplishments of ZEBET, the national centre for alternatives in Germany at the BfR (Federal Institute for Risk Assessment)

Horst Spielmann, Barbara Grune, Manfred Liebsch, 2008 .

Optimisation of the EpiDerm test protocol for the upcoming ECVAM validation study on in vitro skin irritation tests.

Horst Spielmann, Manfred Liebsch, Helena Kandárová, 2004, ALTEX.

The Three-fold Strategy of ZEBET at the BfR to improve Dissemination of Information on Alternative Methods to Animal Experiments

Barbara Grune, Manfred Liebsch, Andreas Luch, 2010, CRIS.

Modern Approaches to Assessment of the Photo-toxicity (Photoirritation) Potential of Substances and Formulations by Using Tiered Testing Strategy Combining Analytical and In Vitro Test Systems

Manfred Liebsch, Helena Kandarova, D. Jirova, 2012 .

A knowledge-based search engine to navigate the information thicket of nanotoxicology.

Carsten Kneuer, Barbara Grune, Thomas Wächter, 2011, Regulatory toxicology and pharmacology : RTP.

Report of the ZEBET/BfR expert workshop: implementation and enforcement of the 3Rs principle regarding transgenic animals used for scientific purposes

Barbara Grune, Manfred Liebsch, D. Butzke, 2009 .

Skin Corrosion In Vitro: Assessment of the SkinEthic® Reconstituted Human Epidermal (RHE) model for in vitro skin corrosion testing according to OECD TG 431

Horst Spielmann, Manfred Liebsch, Robert Guest, 2005 .

ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin

Horst Spielmann, Manfred Liebsch, Barbara Grune‐Wolff, 2008 .

Use of In Vitro Data and (Q)SARs to Classify Eye Irritating Chemicals in the EU - Experience at the BfR

Horst Spielmann, Manfred Liebsch, Ingrid Gerner, 2005 .

Points of Reference in the Validation Process

Thomas Hartung, Ian Gardner, Christoph Klein, 2008, Alternatives to laboratory animals : ATLA.

The role of alternative test methods in nanotoxicology

Manfred Liebsch, Andreas Luch, Goetz Me, 2010 .

International Validation of In Vitro Test Protocol (EpiDerm- SIT) to Replace the In Vivo Rabbit Test for Hazard Identification of Chemicals

Rodger Curren, Manfred Liebsch, Jürgen Frank, 2009 .

A prevalidation of in-vitro photo genotoxicity tests and the effort to find a useful statistical prediction model.

Manfred Liebsch, Peter Kasper, Roland Frötschl, 2005 .

Alternatives to animal testing: current status and future perspectives

Andreas Luch, Barbara Grune, Manfred Liebsch, 2011, Archives of Toxicology.

Determination of the Starting dose for Acute Oral Toxicity (LD50) Testing in the up and down Procedure (UDP) from Cytotoxicity Data

Horst Spielmann, Manfred Liebsch, Elke Genschow, 1999, Alternatives to laboratory animals : ATLA.

A Prevalidation Study on In Vitro Skin Corrosivity Testing

Michael Balls, Manfred Liebsch, Philip A. Botham, 1995 .

Validation Successes: Chemicals

Horst Spielmann, Manfred Liebsch, H. Spielmann, 2002, Alternatives to laboratory animals : ATLA.

[Reduction of the numbers of animals used for the classification of the acute oral toxicity of chemicals by taking into account cytotoxicity data from the Registry of Cytotoxicity]

Horst Spielmann, Manfred Liebsch, Dieter Traue, 1997, ALTEX.

Assessment of the Skin Irritation Potential of Chemicals by Using the SkinEthic Reconstructed Human Epidermal Model and the Common Skin Irritation Protocol Evaluated in the ECVAM Skin Irritation Validation Study

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2006, Alternatives to laboratory animals : ATLA.

Acute Toxicity Testing in Vitro and the Classification and Labelling of Chemicals

Michael Balls, Manfred Liebsch, Julia H. Fentem, 1996 .

3.2. Skin Irritation and Corrosion

Valérie Zuang, Chantra Eskes, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test a

Valérie Zuang, Andrew Worth, Sebastian Hoffmann, 2007, Alternatives to laboratory animals : ATLA.

Results of a Validation Study in Germany on Two in Vitro Alternatives to the Draize Eye Irritation Test, the HET-CAM Test and the 3T3 NRU Cytotoxicity Test

Reinhard Kreiling, Hermann-Georg Holzhütter, Horst Spielmann, 1996 .

The EpiDerm Test Protocol for the Upcoming ECVAM Validation Study on In Vitro Skin Irritation Tests — An Assessment of the Performance of the Optimised Test

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

Alternative (non-animal) methods for chemicals testing: Current status and future prospects - Overview

Valérie Zuang, Silvia Casati, Andrew P. Worth, 2002 .

The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin Potency Testing

Andreas Luch, Barbara Grune, Horst Spielmann, 2010, Alternatives to laboratory animals : ATLA.

Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431.

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

Markus Schulz, Andreas Luch, Sebastian Hoffmann, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

The Role of Prevalidation in the Development, Validation and Acceptance of Alternative Methods

Michael Balls, Horst Spielmann, Manfred Liebsch, 1995 .

Alternatives to the Animal Testing of Medical Devices

Horst Spielmann, Manfred Liebsch, J. C. Jensen, 1996 .

Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

Andreas Luch, Manfred Liebsch, Christian Riebeling, 2011, Archives of Toxicology.

Application of the Three Rs Principle in the Compilation of “Technical Guidance Document in Support of Directive 98/8/EC Concerning the Placing of Biocidal Products on the Market, Part I, Guidance on Data Requirements for Active Substances and Biocidal Products”

Manfred Liebsch, Roman Kolar, Ursula G. Sauer, 2000 .

Wind of Change Challenges Toxicological Regulators

Andreas Luch, Manfred Liebsch, Christian Riebeling, 2012, Environmental health perspectives.

Fetal Bovine Serum (FBS): Past - Present - Future.

Markus Schulz, Wilhelm G Dirks, Manfred Liebsch, 2018, ALTEX.

Assessment of the predictive capacity of the 3T3 Neutral Red Uptake cytotoxicity test method to identify substances not classified for acute oral toxicity (LD50>2000 mg/kg): results of an ECVAM validation study.

Hans Raabe, Manfred Liebsch, Maurice Whelan, 2013, Regulatory toxicology and pharmacology : RTP.

Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

Horst Spielmann, Manfred Liebsch, Ursula Gundert-Remy, 2004, Archives of Toxicology.

3.8. UV-induced Effects

Chantra Eskes, Horst Spielmann, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data

Manfred Liebsch, David Basketter, Helena Kandárová, 2010, Contact dermatitis.

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test

Michael Balls, Horst Spielmann, Manfred Liebsch, 1998, Alternatives to laboratory animals : ATLA.

Currently available in vitro methods used in the regulatory toxicology.

Horst Spielmann, Manfred Liebsch, H. Spielmann, 2002, Toxicology letters.

In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.

Robert Combes, Marianna Gaça, Manfred Liebsch, 2009, Alternatives to laboratory animals : ATLA.

Assessment of the Eye Irritating Properties of Chemicals by Applying Alternatives to the Draize Rabbit Eye Test: The Use of QSARs and In Vitro Tests for the Classification of Eye Irritation

Horst Spielmann, Manfred Liebsch, Ingrid Gerner, 2005, Alternatives to laboratory animals : ATLA.

Follow-up to the ECVAM Prevalidation Study on In Vitro Tests for Acute Skin Irritation

Valérie Zuang, Emanuela Corsini, Michael Balls, 2002, Alternatives to laboratory animals : ATLA.

Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2008, Alternatives to laboratory animals : ATLA.