S. Ilangumaran

S. Ilangumaran, G. Ramu, V. Muthukkaruppan, 1994, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.

H. Wieden, J. Stankova, S. Ramanathan, 2013, The Biochemical journal.

Phosphorylation of SOCS1 inhibits the SOCS1-p53 tumor suppressor axis.

G. Ferbeyre, V. Bourdeau, F. Lessard, 2019, Cancer research.

Exposure to IL-15 and IL-21 Enables Autoreactive CD8 T Cells To Respond to Weak Antigens and Cause Disease in a Mouse Model of Autoimmune Diabetes

P. Ohashi, Xi-lin Chen, S. Ramanathan, 2011, The Journal of Immunology.

Model of Autoimmune Diabetes Weak Antigens and Cause Disease in a Mouse Autoreactive CD8 T Cells To Respond to Exposure to IL-15 and IL-21 Enables

P. Ohashi, Xi-lin Chen, S. Ramanathan, 2011 .

SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions.

D. Bobbala, M. Yeganeh, S. Ramanathan, 2013, The Journal of investigative dermatology.

AntigensProliferative Capacity toward Foreign Autoimmunity and Preserves Their of Cytokine Signaling 1 Controls Differentiation of CD8 T Cells by Suppressor Regulation of Cytokine-Driven Functional

G. Ferbeyre, P. Ohashi, R. Rottapel, 2010 .

SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.

G. Ferbeyre, M. Yeganeh, S. Ramanathan, 2011, Journal of hepatology.

SOCS1: Regulator of T Cells in Autoimmunity and Cancer.

D. Bobbala, S. Ramanathan, S. Ilangumaran, 2017, Current topics in microbiology and immunology.

An improved method for isolation and flow cytometric characterization of intrahepatic leukocytes from fatty and fibrotic liver tissues

R. Kandhi, S. Ramanathan, S. Ilangumaran, 2022, Anatomical record.

Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse

J. Stankova, D. Bobbala, S. Ramanathan, 2012, Diabetologia.

Signaling through sphingolipid microdomains of the plasma membrane: The concept of signaling platform

D. Hoessli, B. Borisch, S. Ilangumaran, 2000, Glycoconjugate Journal.

Mycobacterial lipoarabinomannans modulate cytokine production in human T helper cells by interfering with raft/microdomain signalling

D. Hoessli, C. Chizzolini, S. Ilangumaran, 2004, Cellular and Molecular Life Sciences CMLS.

Interleukin 15 in murine models of colitis

C. Asselin, L. Fortier, S. Ramanathan, 2022, Anatomical record.

IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes

M. Nandi, Sakina Orkhis, S. Ramanathan, 2021, Frontiers in Immunology.

Evaluation by dot-immunoassay of the differential distribution of cell surface and intracellular proteins in glycosylphosphatidylinositol-rich plasma membrane domains.

D. Hoessli, S. Ilangumaran, Y. Chicheportiche, 1996, Analytical biochemistry.

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes

K. Hoebe, Xi-lin Chen, S. Ramanathan, 2015, PloS one.

Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8 CD44 Memory T Lymphocytes

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2003 .

IL-15 Receptor Signaling in CD8 Suppressor of Cytokine Signaling 1 Regulates

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2022 .

Induction of autoimmune diabetes in non‐obese diabetic mice requires interleukin‐21‐dependent activation of autoreactive CD8+ T cells

D. Bobbala, S. Ramanathan, S. Ilangumaran, 2013, Clinical and experimental immunology.

Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes

D. Bobbala, S. Ramanathan, S. Ilangumaran, 2016, Cellular and Molecular Immunology.

Increased generation of CD8 single positive cells in SOCS1-deficient thymus does not proportionately increase their export.

S. Ramanathan, S. Ilangumaran, J. Gagnon, 2010, Immunology letters.

Increased antigen responsiveness of naive CD8 T cells exposed to IL‐7 and IL‐21 is associated with decreased CD5 expression

C. Raman, S. Ramanathan, S. Ilangumaran, 2010, Immunology and cell biology.

IL-15 trans-presentation regulates homeostasis of CD4+ T lymphocytes

D. Bobbala, Xi-lin Chen, S. Ramanathan, 2014, Cellular and Molecular Immunology.

Editorial: Cytokines in liver diseases.

R. Moriggl, D. Kalvakolanu, S. Ilangumaran, 2019, Cytokine.

Memory T Lymphocytes IL-15 Receptor Signaling in CD8+CD44high Suppressor of Cytokine Signaling 1 Regulates

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2013 .

Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation

S. Ramanathan, S. Ilangumaran, A. J. Quenum, 2022, International journal of molecular sciences.

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5)

K. Hoebe, Xi-lin Chen, S. Ramanathan, 2016, PloS one.

CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes.

D. Hoessli, S. Ilangumaran, A. Briol, 1998, Blood.

GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes

C. Lavoie, S. Ramanathan, S. Ilangumaran, 2017, Front. Immunol..

The 3BP2 Adapter Protein Is Required for Optimal B-Cell Activation and Thymus-Independent Type 2 Humoral Response

W. Yeh, J. Gommerman, José La Rose, 2007, Molecular and Cellular Biology.

Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer

G. Ferbeyre, D. Bobbala, S. Geha, 2017, BMC Cancer.

Cytokine synergy in antigen-independent activation and priming of naive CD8+ T lymphocytes.

M. Richter, S. Ramanathan, S. Ilangumaran, 2009, Critical reviews in immunology.

Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane.

D. Hoessli, S. Ilangumaran, 1998, The Biochemical journal.

Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte

Ramneek Gupta, D. Hoessli, S. Ilangumaran, 2003 .

Plasmodium falciparum merozoite surface protein 1 - Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte

Ramneek Gupta, Nasir-ud-din, D. Hoessli, 2003 .

Microdomains in lymphocyte signalling: beyond GPI-anchored proteins.

D. Hoessli, S. Ilangumaran, H. He, 2000, Immunology today.

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet

N. Rivard, N. Perreault, L. Fortier, 2022, Anatomical record.

Tumour-promoting role of SOCS1 in colorectal cancer cells

G. Ferbeyre, R. Klinck, P. Thibault, 2015, Scientific Reports.

IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation

T. Hoang, D. Bobbala, M. Nandi, 2023, Cancers.

The GIMAP Family Proteins: An Incomplete Puzzle

M. Nandi, S. Ramanathan, S. Ilangumaran, 2021, Frontiers in Immunology.

SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma

G. Ferbeyre, C. Dubois, D. Bobbala, 2016, Prostate Cancer and Prostatic Diseases.

Antigen-nonspecific activation of CD8+ T lymphocytes by cytokines: relevance to immunity, autoimmunity, and cancer

S. Ramanathan, S. Ilangumaran, J. Gagnon, 2008, Archivum Immunologiae et Therapiae Experimentalis.

Prognostic significance of SOCS1 and SOCS3 tumor suppressors in hepatocellular carcinoma and its correlation to key oncogenic signaling pathways

S. Ramanathan, S. Ilangumaran, A. Ihsan, 2020, bioRxiv.

IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes1

Alexandre Cloutier, S. Ramanathan, S. Ilangumaran, 2008, The Journal of Immunology.

Lymphocytes T + and Functional Differentiation of CD 8 Stimulates TCR-Independent Proliferation IL-6 , in Synergy with IL-7 or IL-15 ,

Alexandre Cloutier, S. Ramanathan, S. Ilangumaran, 2008 .

The hepatocyte growth factor (HGF)-MET receptor tyrosine kinase signaling pathway: Diverse roles in modulating immune cell functions.

D. Bobbala, S. Ramanathan, S. Ilangumaran, 2016, Cytokine.

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence

Frédérick A. Mallette, G. Ferbeyre, S. Ilangumaran, 2010, Aging.

Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

Avijit Chakrabartty, Robert Rottapel, A. Chakrabartty, 2003, Molecular and Cellular Biology.

Hepatocyte growth control by SOCS1 and SOCS3.

R. Kandhi, S. Ramanathan, S. Ilangumaran, 2019, Cytokine.

Inflammation in human adipose tissues-Shades of gray, rather than white and brown.

M. Langlois, S. Ramanathan, S. Ilangumaran, 2018, Cytokine & growth factor reviews.

The tumor suppressor activity of SOCS-1

M. H. Nguyen, C. Neale, D. Barber, 2002, Oncogene.

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1

C. Dubois, D. Bobbala, S. Ramanathan, 2017, World journal of gastroenterology.

Interleukin-15 in autoimmunity.

M. Nandi, S. Ramanathan, S. Ilangumaran, 2020, Cytokine.

Regulation of cytokine receptor signaling by SOCS1

R. Rottapel, S. Ilangumaran, 2003, Immunological reviews.

Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma

M. Yeganeh, S. Ramanathan, S. Ilangumaran, 2015, Oncogene.

Regulation of the immune system by SOCS family adaptor proteins.

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2004, Seminars in immunology.

SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation.

F. Boisvert, S. Ramanathan, S. Ilangumaran, 2021, Biochimie.

SILAC proteomics implicates the ubiquitin conjugating enzyme UBE2D in SOCS1-mediated downmodulation of the MET receptor in hepatocytes

F. Boisvert, S. Ramanathan, S. Ilangumaran, 2020, bioRxiv.

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes.

José La Rose, R. Rottapel, S. Ramanathan, 2003, Blood.

Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes.

D. Hoessli, B. Borisch, G. van Echten-Deckert, 1999, Molecular biology of the cell.

Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1.

D. Bobbala, M. Yeganeh, R. Kandhi, 2016, Cytokine.

Flow Cytometric Analysis of CD2 Modulation on Human Peripheral Blood T Lymphocytes by Dharmendra Preparation of Mycobacterium leprae

S. Ilangumaran, R. Sheela, V. Muthukkaruppan, 1991, Scandinavian journal of immunology.

A Positive Regulatory Role for Suppressor of Cytokine Signaling 1 in IFN-γ-Induced MHC Class II Expression in Fibroblasts1

José La Rose, R. Rottapel, S. Ilangumaran, 2002, The Journal of Immunology.

Class II Expression in Fibroblasts-Induced MHC γ Cytokine Signaling 1 in IFNA Positive Regulatory Role for Suppressor of

R. Rottapel, S. Ilangumaran, D. Finan, 2002 .

The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy

S. Ramanathan, S. Ilangumaran, Maryse Cloutier, 2021, International journal of molecular sciences.

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

Denis Gris, Pavel Gris, D. Bobbala, 2015, Journal of Neuroinflammation.

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

S. Ramanathan, S. Ilangumaran, Bhavesh C. Variya, 2020, BMC Cancer.

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

P. Calabresi, A. Sadovnick, Denis Gris, 2019, PLoS biology.

Cytokine priming of naïve CD8+ T lymphocytes modulates chromatin accessibility that partially overlaps with changes induced by antigen simulation

S. Ramanathan, S. Ilangumaran, Maryse Cloutier, 2020, bioRxiv.

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

M. Lathrop, K. Knobeloch, J. Berghout, 2016, Nature Immunology.

Regulation of Cytokine-Driven Functional Differentiation of CD8 T Cells by Suppressor of Cytokine Signaling 1 Controls Autoimmunity and Preserves Their Proliferative Capacity toward Foreign Antigens

G. Ferbeyre, P. Ohashi, R. Rottapel, 2010, The Journal of Immunology.

Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8+CD44high Memory T Lymphocytes 1

José La Rose, R. Rottapel, S. Ramanathan, 2003, The Journal of Immunology.

Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer.

D. Kalvakolanu, S. Ilangumaran, Bryan R. G. Williams, 2017, Cytokine.

Signal transduction via CD44: role of plasma membrane microdomains.

D. Hoessli, B. Borisch, S. Ilangumaran, 1999, Leukemia & lymphoma.

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

Denis Gris, Pavel Gris, D. Bobbala, 2015, Journal of Neuroinflammation.

Bezlotoxumab for the prevention of Clostridium difficile recurrence

L. Valiquette, S. Ilangumaran, A. Carignan, 2017, Expert opinion on biological therapy.

Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes.

S. Ramanathan, S. Ilangumaran, J. Gagnon, 2007, Cellular signalling.

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation*

R. Rottapel, S. Ilangumaran, P. de Sepulveda, 2000, The Journal of Biological Chemistry.

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

G. Ferbeyre, D. Bobbala, S. Ilangumaran, 2017, Aging.

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver

G. Ferbeyre, D. Bobbala, M. Yeganeh, 2016, Oncogene.

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p 21 CIP 1 / WAF 1 in the liver

G. Ferbeyre, D. Bobbala, M. Yeganeh, 2016 .

Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes

G. Lacraz, J. Fradette, M. Langlois, 2018, EBioMedicine.

Suppressor of Cytokine Signaling 1 Stringently Regulates Distinct Functions of IL-7 and IL-15 In Vivo during T Lymphocyte Development and Homeostasis1

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2006, Journal of Immunology.

Suppressor of Cytokine Signaling 1 Stringently Regulates Distinct Functions of IL-7 and IL-15 In Vivo during T Lymphocyte Development and Homeostasis

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2006 .

Development and Homeostasis IL-7 and IL-15 In Vivo during T Lymphocyte Stringently Regulates Distinct Functions of Suppressor of Cytokine Signaling 1

R. Rottapel, S. Ramanathan, S. Ilangumaran, 2006 .

Editorial: Cytokines in inflammation, aging, cancer and obesity.

G. Ferbeyre, S. Ilangumaran, 2016, Cytokine.

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition

Jean-François Lucier, L. Premkumar, Y. Durocher, 2023, bioRxiv.

SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

A. Yoshimura, G. Ferbeyre, M. Yeganeh, 2023, Cancers.

NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity

F. Boisvert, S. Ramanathan, S. Ilangumaran, 2023, International journal of molecular sciences.

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

S. Ramanathan, S. Ilangumaran, A. Ihsan, 2020, BMC Cancer.

Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer

G. Ferbeyre, D. Bobbala, S. Geha, 2017, BMC Cancer.

NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis

S. Ramanathan, S. Ilangumaran, Maryse Cloutier, 2021, Frontiers in Immunology.

Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes.

D. Hoessli, K. Sandhoff, G. van Echten-Deckert, 1996, Biochemical and biophysical research communications.

SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma

A. Yoshimura, G. Ferbeyre, M. Yeganeh, 2021, bioRxiv.

Ileal antimicrobial peptide expression is dysregulated in old age

L. Fortier, S. Ilangumaran, A. Menendez, 2017, Immunity & Ageing.

T lymphocyte reactivity of leprosy patients and healthy contacts from a leprosy-endemic population to delipidified cell components of Mycobacterium leprae.

P. Mahadevan, S. Ilangumaran, P. Robinson, 1994, Leprosy review.

Regulation of High-fat Diet-induced Liver Fibrosis by SOCS1 Expression in Hepatic Stellate Cells.

R. Kandhi, S. Ramanathan, S. Ilangumaran, 2023, Journal of clinical and experimental hepatology.

Plasmodium falciparum merozoite surface protein 1.

Ramneek Gupta, Nasir-ud-din, D. Hoessli, 2003, European Journal of Biochemistry.

Increased antigen responsiveness of naive CD8 T cells exposed to IL‐7 and IL‐21 is associated with decreased CD5 expression

C. Raman, S. Ramanathan, S. Ilangumaran, 2010, Immunology and cell biology.

Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis

R. Kandhi, S. Ramanathan, S. Ilangumaran, 2023, Frontiers in immunology.

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver

G. Ferbeyre, D. Bobbala, R. Kandhi, 2016, Oncogene.

SOCS1: Regulator of T Cells in Autoimmunity and Cancer.

D. Bobbala, S. Ramanathan, S. Ilangumaran, 2017, Current topics in microbiology and immunology.

SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions.

D. Bobbala, M. Yeganeh, S. Ramanathan, 2013, The Journal of investigative dermatology.

Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1.

D. Bobbala, M. Yeganeh, R. Kandhi, 2016, Cytokine.

Editorial: Mesenchymal and immune cell crosstalk in fibrotic diseases

S. Ilangumaran, Kinji Asahina, 2023, Frontiers in Immunology.

SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity

S. Ramanathan, S. Ilangumaran, Y. Gui, 2024, Frontiers in immunology.

The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma

Jean-François Lucier, F. Boisvert, S. Ramanathan, 2024, Cancers.