Lakshman K Bindu

发表

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.

D. Morrison, M. Holderfield, A. Stephen, 2016, Molecular cell.

Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology.

Yun Hee Cho, Siming Wang, Rosemarie Wilton, 2006, Analytical biochemistry.

Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.

Robert J Fisher, Zhen-Dan Shi, Sang-Uk Kang, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).

Yves Pommier, Keli Agama, Martin Conda-Sheridan, 2013, Journal of medicinal chemistry.

Design and synthesis of 4-(alpha-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 src-homology 2 (Grb2 SH2) domain-binding peptides.

Dajun Yang, Robert J Fisher, Sang-Uk Kang, 2005, Journal of medicinal chemistry.

Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain‐Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction

Marc C Nicklaus, Robert J Fisher, Zhen-Dan Shi, 2005, Chemistry & biodiversity.

Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Marc C Nicklaus, Shinya Oishi, Robert J Fisher, 2005, Journal of medicinal chemistry.

Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

P. Roller, R. Fisher, P. Li, 2006, Biochemical and biophysical research communications.

Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.

R. Fisher, T. Burke, M. Nicklaus, 2005, Bioorganic & medicinal chemistry letters.

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

R. Fisher, T. Burke, W. J. Choi, 2006, Bioorganic & medicinal chemistry letters.

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

R. Ghirlando, D. Esposito, F. McCormick, 2016, Proceedings of the National Academy of Sciences of the United States of America.

Ring‐Closing Metathesis of C‐Terminal Allylglycine Residues with an N‐Terminal β‐Vinyl‐Substituted Phosphotyrosyl Mimetic as an Approach to Novel Grb2 SH2 Domain‐Binding Macrocycles

R. Fisher, T. Burke, S. Oishi, 2005, Chembiochem : a European journal of chemical biology.

High Affinity Grb2 SH2 Domain-Binding Macrocycles Derived from Ring-Closing Methathesis of Alkenylglyicne Residues with β-Vinyl Phosphotyrosyl Mimetics

R. Fisher, Fa Liu, T. Burke, 2006 .

Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.

Kevin B. Turner, A. Stephen, R. Fisher, 2007, Journal of biomolecular techniques : JBT.

Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.

P. Roller, R. Fisher, T. Burke, 2009, Bioorganic & medicinal chemistry letters.

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.

Marc C Nicklaus, Shinya Oishi, Robert J Fisher, 2005, Bioorganic & medicinal chemistry.

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

C. Alam, A. Stephen, A. Papageorgiou, 2019, ACS omega.

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Avik Banerjee, Andrew G. Stephen, Maria Abreu-Blanco, 2018, Science Signaling.

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

R. Ghirlando, D. Esposito, F. McCormick, 2016, Proceedings of the National Academy of Sciences.

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

D. Esposito, F. McCormick, T. Tran, 2021, Nature Communications.

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

D. Esposito, F. McCormick, T. Tran, 2020, bioRxiv.

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

P. Alexander, R. Ghirlando, D. Esposito, 2015, Scientific Reports.

HER2‐ and EGFR‐Specific Affiprobes: Novel Recombinant Optical Probes for Cell Imaging

I. Lyakhov, J. Capala, G. Kramer-Marek, 2010, Chembiochem : a European journal of chemical biology.

Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids.

Iwona E. Weidlich, A. Stephen, R. Fisher, 2009, Journal of medicinal chemistry.

Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.

R. Fisher, T. Burke, W. J. Choi, 2007, Journal of Medicinal Chemistry.

Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist.

E. Appella, L. Jenkins, R. Fisher, 2008, Journal of medicinal chemistry.

Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.

R. Fisher, Fa Liu, T. Burke, 2007, Organic & biomolecular chemistry.

Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity.

Dajun Yang, Robert J Fisher, Zhen-Dan Shi, 2005, Bioorganic & medicinal chemistry.

KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner

R. Ghirlando, F. McCormick, T. Tran, 2019, Biophysical journal.

Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.

R. Fisher, Fa Liu, T. Burke, 2007, The Journal of organic chemistry.