W. Lubell

发表

Steric Effects on the Amide Isomer Equilibrium of Prolyl Peptides. Synthesis and Conformational Analysis of N-Acetyl-5-tert-butylproline N‘-Methylamides

E. Beausoleil, W. Lubell, 1996 .

Adiponectin has a pivotal role in the cardioprotective effect of CP‐3(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice

A. Carpentier, M. Febbraio, W. Lubell, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TETRAHEDRON REPORT NUMBER 426 Design and Synthesis of Conformationally Constrained Amino Acids as Versatile Scaffolds and Peptide Mimetics

S. Hanessian, W. Lubell, Henry-Georges Lombart, 1997 .

Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

Stephen Hanessian, William D. Lubell, S. Hanessian, 1997 .

De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.

W. Lubell, D. Chatenet, Julien Dufour-Gallant, 2015, Journal of medicinal chemistry.

Design, synthesis, and conformational analysis of azacycloalkane amino acids as conformationally constrained probes for mimicry of peptide secondary structures.

F. Gosselin, W. Lubell, L. Halab, 2001, Biopolymers.

Large Structural Modification with Conserved Conformation: Analysis of Δ3-Fused Aryl Prolines in Model β-Turns

Guillaume Jeannotte, W. Lubell, 2004 .

Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

W. Lubell, William D Lubell, J. Cluzeau, 2005, Biopolymers.

Design, Synthesis, and Application of Azabicyclo[X.Y.O]alkanone Amino Acids as Constrained Dipeptide Surrogates and Peptide Mimics

W. Lubell, J. Cluzeau, 2005 .

Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II.

W. Lubell, D. Chatenet, É. Billard, 2017, Bioorganic & medicinal chemistry letters.

Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity.

P. Grieco, F. Merlino, W. Lubell, 2016, Journal of medicinal chemistry.

Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics.

W. Lubell, A. Tomberg, C. Proulx, 2014, Organic letters.

Isolated α-turn and incipient γ-helix

C. Toniolo, M. Crisma, W. Lubell, 2019, Chemical science.

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.

T. Hébert, W. Lubell, D. Chatenet, 2017, Journal of medicinal chemistry.

Diversity-Oriented Synthesis of Cyclic Azapeptides by A3 -Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics.

W. Lubell, Jinqiang Zhang, Mukandila Mulumba, 2017, Angewandte Chemie.

Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)

S. Chemtob, W. Lubell, David Sabatino, 2020, Biomedicines.

Immunometabolic modulation of retinal inflammation by CD36 ligand

P. Hardy, S. Omri, S. Chemtob, 2019, Scientific Reports.

Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

S. Omri, S. Chemtob, W. Lubell, 2018, Biomedicines.

Aza‐propargylglycine installation by aza‐amino acylation: Synthesis and Ala‐scan of an azacyclopeptide CD36 modulator

Ahsanullah, W. Lubell, Ramesh M Chingle, 2018, Peptide Science.

Exploring side-chain diversity by submonomer solid-phase aza-peptide synthesis.

W. Lubell, David Sabatino, H. Ong, 2009, Organic letters.

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.

S. Chemtob, W. Lubell, H. Ong, 2012, Journal of medicinal chemistry.

Cyclic aza-peptide integrin ligand synthesis and biological activity.

H. Kessler, Jochen Spiegel, W. Lubell, 2012, The Journal of organic chemistry.

Synthesis and alkylation of aza‐glycinyl dipeptide building blocks

W. Lubell, Yesica Garcia-Ramos, 2013, Journal of peptide science : an official publication of the European Peptide Society.

Solid‐phase synthesis of C‐terminal azapeptides

W. Lubell, N. Doan, M. Traoré, 2015, Journal of peptide science : an official publication of the European Peptide Society.

Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics

C. Gamberi, W. Lubell, Ramesh M Chingle, 2019, Biomedicines.

Aza‐amino acid scanning of chromobox homolog 7 (CBX7) ligands

W. Lubell, Michael C. Gignac, F. Hof, 2017, Journal of Peptide Science.

Structure–Activity Analysis of the Growth Hormone Secretagogue GHRP‐6 by α‐ and β‐Amino γ‐Lactam Positional Scanning

W. Lubell, H. Ong, A. Jamieson, 2010, Chemical biology & drug design.

The influence of steric interactions on the conformation and biology of oxytocin. Synthesis and analysis of penicillamine(6)-oxytocin and penicillamine(6)-5-tert-butylproline(7)-oxytocin analogs.

L. Bélec, W. Lubell, J. Slaninová, 2001, The journal of peptide research : official journal of the American Peptide Society.

Aminolactam, N-Aminoimidazolone, and N-Aminoimdazolidinone Peptide Mimics

W. Lubell, N. Doan, D. St-Cyr, 2017 .

Tetrahedron report number 776Pyrrole protection

E. E. Chapman, W. Lubell, A. Thompson, 2006 .

Conjugated C3 symmetric aryl tripyrroles and aryl bipyrroles: synthesis, optical and electronic properties

W. Skene, W. Lubell, Thomas J. G. Skalski, 2014 .

Amino acid-azetidine chimeras: synthesis of enantiopure 3-substituted azetidine-2-carboxylic acids.

W. Lubell, Z. Sajjadi, 2008, The journal of peptide research : official journal of the American Peptide Society.

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila

D. Hipfner, C. Gamberi, M. Trudel, 2017, PLoS genetics.

Antagonist of IL-1 Receptor Development of a Novel Noncompetitive

A. Pshezhetsky, N. Heveker, M. Leduc, 2013 .

Reversible and Competitive Cinnamoyl Triazole Inhibitors of Tissue Transglutaminase

W. Lubell, J. Keillor, I. Roy, 2008, Chemical biology & drug design.

4-Vinylproline.

W. Lubell, N. Atmuri, Ramakotaiah Mulamreddy, 2018, The Journal of organic chemistry.

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

X. Hou, J. Rivera, S. Chemtob, 2018, Scientific Reports.

Novel Noncompetitive IL-1 Receptor–Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth

X. Ni, X. Hou, J. Rivera, 2015, The Journal of Immunology.

Homoserine‐derived cyclic sulfamidate as chiral educt for the diversity‐oriented synthesis of lactam‐bridged dipeptides

W. Lubell, F. Galaud, 2005, Biopolymers.

Microglia and Interleukin-1&bgr; in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

P. Hardy, J. Rivera, T. Zhou, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

X. Hou, T. Hébert, S. Laporte, 2011, Journal of medicinal chemistry.

Application of constrained aza‐valine analogs for Smac mimicry

W. Lubell, A. Claing, Ramesh M Chingle, 2016, Biopolymers.

Prostaglandin F2α and angiotensin II type 1 receptors exhibit differential cognate G protein coupling regulation

S. Laporte, W. Lubell, D. Sedki, 2022, The Journal of biological chemistry.

Peptidomimetics I

W. Lubell, J. Cossy, N. Doan, 2017 .

Aza‐scanning of the Potent Melanocortin Receptor Agonist Ac‐His‐d‐Phe‐Arg‐Trp‐NH2

Michael S. Wood, W. Lubell, C. Haskell-Luevano, 2006, Chemical biology & drug design.

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

X. Hou, S. Chemtob, W. Lubell, 2019, Molecules.

Interleukin-1 Receptor Modulation Using β-Substituted α-Amino-γ-Lactam Peptides From Solid-Phase Synthesis and Diversification

X. Hou, I. Lahaie, S. Chemtob, 2020, Frontiers in Chemistry.

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth.

X. Hou, S. Chemtob, W. Lubell, 2019, Journal of medicinal chemistry.

Diversity-Oriented Syntheses of β-Substituted α-Amino γ-Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues.

W. Lubell, Azade Geranurimi, 2018, Organic letters.

N-(9-phenylfluoren-9-yl)-.alpha.-amino ketones and N-(9-phenylfluoren-9-yl)-.alpha.-amino aldehydes as chiral educts for the synthesis of optically pure 4-alkyl-3-hydroxy-2-amino acids. Synthesis of the C-9 amino acid MeBmt present in cyclosporin

T. Jamison, W. Lubell, H. Rapoport, 1990 .

Diversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine.

W. Lubell, N. Doan, M. Traoré, 2014, Organic letters.

Cinnamoyl inhibitors of tissue transglutaminase.

J. Pelletier, W. Lubell, J. Keillor, 2008, The Journal of organic chemistry.

Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor.

X. Hou, S. Laporte, S. Chemtob, 2015, Organic & biomolecular chemistry.

Synthesis and alkylation of Aza-Gly-Pro building blocks of peptidomimetic libraries for developing prostaglandin F2α receptor modulators as therapeutics to inhibit preterm labor.

W. Lubell, C. Bourguet, 2015, Methods in molecular biology.

Site-specific protein propargylation using tissue transglutaminase.

J. Pelletier, W. Lubell, J. Keillor, 2012, Organic & biomolecular chemistry.

Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation.

P. Schiller, T. M. Nguyen, N. N. Chung, 2019, The Journal of organic chemistry.

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

S. Omri, S. Chemtob, W. Lubell, 2017, Journal of medicinal chemistry.

THG113: a novel selective FP antagonist that delays preterm labor.

X. Hou, S. Chemtob, W. Lubell, 2002, Seminars in perinatology.

Uronium/Guanidinium Salts

J. Blankenship, W. Lubell, G. Fridkin, 2005 .

Influence of N-Methylation and Conformation on Almiramide Anti-Leishmanial Activity

M. Olivier, Anh Nguyen, W. Lubell, 2021, Molecules.

Poly(vinyl alcohol)-Graft-Poly(ethylene glycol)-Supported Hydroxyproline Catalysis of Stereoselective Aldol Reactions

X. Zhu, W. Lubell, X. Jia, 2010 .

Solution‐phase submonomer diversification of aza‐dipeptide building blocks and their application in aza‐peptide and aza‐DKP synthesis

W. Lubell, David Sabatino, C. Proulx, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors.

Sandy Shuo Zhao, Olivier R. Bolduc, J. Pelletier, 2011, The Analyst.

Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters.

W. Lubell, Antoine Douchez, Azade Geranurimi, 2018, Accounts of chemical research.

1,4-Diazepinone and Pyrrolodiazepinone Syntheses via Homoallylic Ketones from Cascade Addition of Vinyl Grignard Reagent to α-Aminoacyl-β-amino Esters

W. Lubell, Hassan S. Iden and, 2006 .

From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis.

W. Lubell, Simon Surprenant, 2006, Organic letters.

Influence of N‐terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5‐tert‐butylproline type VI β‐turn mimics

W. Lubell, L. Halab, Liliane Halab, 2001, Journal of peptide science : an official publication of the European Peptide Society.

An examination of the steric effects of 5-tert-butylproline on the conformation of polyproline and the cooperative nature of type II to type I helical interconversion.

E. Beausoleil, W. Lubell, 2000, Biopolymers.

Alcohols as Replacements of the Central Amide in β-Turns, Synthesis of Pro-Aib Hydroxyethylene Isostere and Analysis in Model β-Turn Peptides

W. Lubell, T. Lama, Susan E. Del Valle, 2007, International Journal of Peptide Research and Therapeutics.

Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.

W. Lubell, A. Claing, C. Bourguet, 2014, Bioorganic & medicinal chemistry letters.

Benzophenone semicarbazone protection strategy for synthesis of aza‐glycine containing aza‐peptides

W. Lubell, David Sabatino, C. Bourguet, 2008, Biopolymers.

Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice.

M. Febbraio, W. Lubell, H. Ong, 2020, Atherosclerosis.

Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands

X. Hou, J. Rivera, T. Zhu, 2019, Front. Chem..

Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides.

S. Chemtob, W. Lubell, H. Ong, 2009, Journal of the American Chemical Society.

Facile synthesis of hydrocarbon-stapled peptides.

E. Escher, W. Lubell, S. Valle, 2009, Advances in experimental medicine and biology.

Synthesis and peptide coupling of protected pyrrolylalanine.

W. Lubell, Aurelie A. Doerr, 2011, Advances in experimental medicine and biology.

Prodigiosin synthesis with electron rich 2,2'- bipyrroles

W. Lubell, Benoît Jolicoeur, Benoit Jolicoeur, 2008 .

X‐ray structure analysis reveals β‐turn mimicry by N‐amino‐imidazolidin‐2‐ones†

W. Lubell, N. Doan, 2015, Biopolymers.

Peptides for Youth : the proceedings of the 20th American Peptide Symposium

E. Escher, W. Lubell, S. Valle, 2009 .

Synthesis and Incorporation of Freidinger Lactam Analogs in GHRP-6

W. Lubell, H. Ong, A. Demers, 2006 .

1,3,5-trisubstituted 1,4-diazepin-2-ones.

W. Lubell, H. Iden, 2007, The Journal of organic chemistry.

Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2.

K. Hansford, W. Lubell, Z. Sajjadi, 2004, The Journal of organic chemistry.

SYNTHESIS OF (S)-2-AMINO-3-(3-TERT-BUTYL-5-OXO-2H-ISOXAZOL-4-YL)PROPIONIC ACID

W. Lubell, M. Atfani, 1995 .

Aza-amino acid scan for rapid identification of secondary structure based on the application of N-Boc-aza(1)-dipeptides in peptide synthesis.

W. Lubell, Rosa E. Meléndez, 2004, Journal of the American Chemical Society.

Synthesis and pharmacology of new enantiopure Δ3-4-arylkainoids

W. Lubell, K. Curry, D. Rondeau, 2000 .

Synthesis of enantiopure 7-[3-azidopyl]indolizidin-2-one amino acid. A constrained mimic of the peptide backbone geometry and heteroatomic side-chain functionality of the ala-lys dipeptide.

W. Lubell, Z. Feng, Zhe Feng, 2001, The Journal of organic chemistry.

Beta,beta-disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives.

W. Lubell, G. Fridkin, N. Boutard, 2009, The Journal of organic chemistry.

Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains.

W. Lubell, D. Boeglin, 2005, Journal of combinatorial chemistry.

Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.

W. Lubell, L. Mckerracher, C. Essagian, 2004, Bioorganic & medicinal chemistry letters.

Copper-catalyzed cascade addition route to 2,3,4-trisubstituted quinoline derivatives

W. Lubell, Cynthia Crifar, Aurelie A. Doerr, 2015 .

Insight into Transannular Cyclization Reactions To Synthesize Azabicyclo[X.Y.Z]alkanone Amino Acid Derivatives from 8-, 9-, and 10-Membered Macrocyclic Dipeptide Lactams.

W. Lubell, N. Atmuri, 2015, The Journal of organic chemistry.

Enantioselective synthesis of β-amino acids based on BINAP—ruthenium(II) catalyzed hydrogenation

R. Noyori, W. Lubell, M. Kitamura, 1991 .

Rigid Dipeptide Mimics: Synthesis of Enantiopure 5‐ and 7‐Benzyl and 5,7‐Dibenzyl Indolizidinone Amino Acids via Enolization and Alkylation of δ‐Oxo α,ω‐Di‐[N‐(9‐(9‐phenylfluorenyl))amino]azelate Esters.

W. Lubell, F. Polyak, 1999 .

Rigid Dipeptide Mimics: Synthesis of Enantiopure 5- and 7-Benzyl and 5,7-Dibenzyl Indolizidinone Amino Acids via Enolization and Alkylation of delta-Oxo alpha,omega-Di-[N-(9-(9-phenylfluorenyl))amino]azelate Esters.

W. Lubell, F. Polyak, 1998, The Journal of organic chemistry.

Asymmetric synthesis of α-amino β-hydroxy phosphonic acids via BINAP-ruthenium catalyzed hydrogenation

R. Noyori, M. Tokunaga, W. Lubell, 1995 .

Mimicry of peptide backbone geometry and heteroatomic side-chain functionality: synthesis of enantiopure indolizidin-2-one amino acids possessing alcohol, acid, and azide functional groups.

W. Lubell, F. Polyak, Felix Polyak, 2001, The Journal of organic chemistry.

Aminophenylpyrrole Synthesis and Application to Pyrrolo[1,2-c]quinazolinone Synthesis

W. Lubell, Aurelie A. Doerr, 2014 .

N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis

W. Lubell, C. Proulx, 2012, Organic letters.

Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker.

Frederik J. R. Rombouts, W. Lubell, G. Fridkin, 2005, Journal of combinatorial chemistry.

An Olefination Entry for the Synthesis of Enantiopure α,ω-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids†

F. Gosselin, W. Lubell, 1998 .

Efficient synthesis of enantiopure pyrrolizidinone amino acid.

W. Lubell, Evelyne Dietrich, 2003, The Journal of organic chemistry.

Influence of the C‐terminal substituent on the crystal‐state conformation of Adm peptides

C. Toniolo, M. Crisma, W. Lubell, 2020, Peptide Science.

Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates

W. Lubell, Ramakotaiah Mulamreddy, 2021, Molecules.

Analysis of N‐amino‐imidazolin‐2‐one peptide turn mimic 4‐position substituent effects on conformation by X‐ray crystallography

W. Lubell, C. Proulx, 2014, Biopolymers.

2-vinylpyrroles and pyrrolo[3,2-d]pyrimidines from direct addition of aldehydes to 4-amino-pyrrole-2-carboxylate derivatives.

W. Lubell, G. Fridkin, 2008, Organic letters.

N-Aminosulfamide peptide mimic synthesis by alkylation of aza-sulfurylglycinyl peptides.

W. Lubell, Stéphane Turcotte, Samir Bouayad‐Gervais, 2012, Organic letters.

Crystal Structure Analysis and Reactivity of N-Alkyl- and N-Acyldioxathiazinanes

J. Blankenship, W. Lubell, F. Galaud, 2008 .

Synthesis and reactivity of cyclic sulfamidites and sulfamidates

W. Lubell, Rosa E. Meléndez, 2003 .

N-(9-(9-Phenylfluorenyl))homoserine-Derived Cyclic Sulfamidates: Novel Chiral Educts for the Synthesis of Enantiopure γ-Substituted α-Amino Acids

W. Lubell, M. Atfani, A. Wei, 2001 .

.alpha.-Amino acids as chiral educts for asymmetric products. Alkylation of N-phenylfluorenyl .alpha.-amino ketones. Synthesis of optically pure .alpha.-alkyl carboxylic acids

W. Lubell, H. Rapoport, 1988 .

An effective new synthesis of 4-aminopyrrole-2-carboxylates.

W. Lubell, F. Marcotte, 2002, Organic letters.

Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates.

W. Lubell, Antoine Douchez, 2015, Organic letters.

5-tert-Butylproline

L. Bélec, E. Beausoleil, W. Lubell, 1996 .

Azapeptides and their therapeutic potential.

Jochen Spiegel, W. Lubell, David Sabatino, 2011, Future medicinal chemistry.

Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

S. Senapati, B. Guérin, Kuldeep Tripathi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications.

W. Lubell, C. Proulx, Ramesh M Chingle, 2017, Accounts of chemical research.

Azopeptides: Synthesis and Pericyclic Chemistry.

W. Lubell, Ramesh M Chingle, 2015, Organic letters.

Peptide Scanning for Studying Structure‐Activity Relationships in Drug Discovery

W. Lubell, David Sabatino, A. Jamieson, 2013, Chemical biology & drug design.

Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis.

W. Lubell, David Sabatino, H. Ong, 2011, Journal of the American Chemical Society.

To Rink or Not to Rink Amide Link, that is the Question to Address for More Economical and Environmentally Sound Solid-Phase Peptide Synthesis

X. Zhu, W. Lubell, David Sabatino, 2009, International Journal of Peptide Research and Therapeutics.

Constrained Glu‐Gly and Gln‐Gly dipeptide surrogates from γ‐substituted α‐amino‐δ‐lactam synthesis

W. Lubell, Ramakotaiah Mulamreddy, 2020 .

Efficient Synthesis of 1-Benzyloxyphenyl-3-phenylacetones

D. Tourwé, W. Lubell, E. Mannekens, 2000 .

Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N'-Methylamides.

F. Gosselin, W. Lubell, M. Swarbrick, 1999, The Journal of organic chemistry.

RIGID DIPEPTIDE MIMETICS : EFFICIENT SYNTHESIS OF ENANTIOPURE INDOLIZIDINONE AMINO ACIDS

W. Lubell, Henry-Georges Lombart, 1996 .

Configurational stability of N-protected .alpha.-amino aldehydes

W. Lubell, H. Rapoport, 1987 .

One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters.

K. Hansford, W. Lubell, J. E. Dettwiler, 2003, Organic letters.

Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S.

R. Hancock, S. Farmer, W. Lubell, 2002, The journal of peptide research : official journal of the American Peptide Society.

Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine

W. Lubell, Eryk Thouin, 2000 .

Use of Steric Interactions To Control Peptide Turn Geometry. Synthesis of Type VI beta-Turn Mimics with 5-tert-Butylproline.

William D. Lubell, W. Lubell, L. Halab, 1999, The Journal of organic chemistry.

4-alkoxy- and 4-amino-2,2'-bipyrrole synthesis.

W. Lubell, Benoît Jolicoeur, Benoit Jolicoeur, 2006, Organic letters.

Synthesis of protected 2-pyrrolylalanine for peptide chemistry and examination of its influence on prolyl amide isomer equilibrium.

W. Lubell, Aurelie A. Doerr, 2012, The Journal of organic chemistry.

Synthesis of a new pi-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population.

W. Lubell, Aurelie A. Doerr, 2007, Biopolymers.

Peptidomimetic Synthesis by Way of Diastereoselective Iodoacetoxylation and Transannular Amidation of 7-9-Membered Lactams.

W. Lubell, David J. Reilley, N. Atmuri, 2017, Organic letters.

Systematic study of the synthesis of macrocyclic dipeptide beta-turn mimics possessing 8-, 9-, and 10- membered rings by ring-closing metathesis.

W. Lubell, Simon Surprenant, R. Kaul, 2005, The Journal of organic chemistry.

Synthesis of enantiopure .delta.-oxo .alpha.-amino esters and prolines via acylation of N-(phenylfluorenyl)glutamate enolates

W. Lubell, H. Ibrahim, 1993 .

Diversity-Oriented Synthesis of Enantiopure N-Protected β,β-Dialkylserines.

W. Lubell, J. E. Dettwiler, 2004 .

Remarkable asymmetric induction from remote stereocenters in conjugate addition chemistry for the synthesis of alkyl‐branched α, ω‐diaminoazelates

W. Lubell, J. Cluzeau, 2001 .

9‐Bromo‐9‐Phenylfluorene

T. Jamison, W. Lubell, M. Krische, 2003 .

Stereoconvergent approach for synthesizing enantiopure 5, 6-dialkylpipecolic acids.

W. Lubell, M. Swarbrick, 2000, Chirality.

Improved synthesis of (2S,5S)-5-tert-butylproline

L. Bélec, W. Lubell, L. Halab, 2001 .

Synthesis of 5-alkylprolines and their use in the design of X-proline cis-amide surrogates

E. Beausoleil, W. Lubell, M. Atfani, 1994 .

Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides.

W. Lubell, C. Proulx, 2010, Organic letters.

Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine.

W. Lubell, C. Proulx, 2010, The Journal of organic chemistry.

crystal structure analyses of azasulfuryltripeptides reveal potential for γ‐turn mimicry†

W. Lubell, Stéphane Turcotte, 2015, Biopolymers.

Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: a head-to-head comparison of soluble versus insoluble supports.

W. Lubell, Julien Dufour-Gallant, N. Boutard, 2011, The Journal of organic chemistry.

Aza-peptides with Multiple Aza-amino Acids, Synthesis and Preliminary Conformational Analysis of Glu-azaAla-Ala-azaAla-Leu-azaAla-Lys-azaAla-NH2

J. Demers, W. Lubell, D. Boeglin, 2006 .

Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.

W. Lubell, A. Khashper, 2014, Organic & biomolecular chemistry.

Employing the Steric Interactions of 5-tert-Butylproline to Control Peptide Folding and Biology

L. Bélec, W. Lubell, L. Halab, 2001 .

Scope and limitations in the use of N-(PhF)serine-derived cyclic sulfamidates for amino acid synthesis

W. Lubell, Lan Wei, 2001 .

Racemization in the Use of N-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of δ-Keto α-Amino Carboxylates and Prolines

W. Lubell, Lan Wei, 2000 .

Unsymmetric electronic push-pull bipyrroles - synthesis, spectroelectrochemical, and photophysical investigation.

S. Dufresne, W. Skene, W. Lubell, 2009, The Journal of organic chemistry.

Photoacoustic FTIR Spectroscopy, a Nondestructive Method for Sensitive Analysis of Solid-Phase Organic Chemistry.

T. Ellis, F. Gosselin, W. Lubell, 1996, The Journal of organic chemistry.

Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond

John F. Trant, W. Lubell, S. Taimoory, 2019 .

Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors.

J. Pelletier, P. Thibault, W. Lubell, 2009, Biochemistry.

The bioorganic chemistry of transglutaminase — from mechanism to inhibition and engineering

J. Pelletier, N. Chabot, W. Lubell, 2008 .

Surrogates for chiral aminomalondialdehyde. Synthesis of N-(9-phenylfluoren-9-yl)serinal and N-(9-phenylfluoren-9-yl)vinylglycinal

W. Lubell, H. Rapoport, 1989 .

Emerging Peptide Science in Canada

W. Lubell, 2019, Peptide Science.

Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

B. Ellezam, W. Lubell, L. Mckerracher, 2002, The Journal of Neuroscience.

Preparation of N-(Boc)-Allylglycine Methyl Ester Using a Zinc-Mediated, Palladium-Catalyzed Cross-Coupling Reaction

W. Lubell, N. Atmuri, 2015 .

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.

E. Novellino, P. Grieco, D. Brancaccio, 2019, Journal of medicinal chemistry.

Stereo- and regiochemical transannular cyclization of a common hexahydro-1H-azonine to afford three different indolizidinone dipeptide mimetics.

W. Lubell, N. Atmuri, 2020, The Journal of organic chemistry.

9-Fluorenylmethoxycarbonyl Group

J. Blankenship, W. Lubell, G. Fridkin, 2005 .

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

K. Itoh, S. Kasai, W. Lubell, 2021, Oxidative medicine and cellular longevity.

Examination of structural characteristics of the potent oxytocin antagonists [dPen1,Pen6]‐OT and [dPen1,Pen6, 5‐tBuPro7]‐OT by NMR, raman, CD spectroscopy and molecular modeling

J. Blankenship, L. Bélec, W. Lubell, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis of fused heteroarylprolines and pyrrolopyrroles.

Guillaume Jeannotte, W. Lubell, 2004, The Journal of organic chemistry.

Aza-Residue Modulation of Cyclic d,l-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity.

S. Senapati, B. Guérin, W. Lubell, 2023, Journal of medicinal chemistry.

1.6 Peptides and Chirality Effects on the Conformation and the Synthesis of Medicinally Relevant Peptides

W. Lubell, F. Polyak, K. Beauregard, 2012 .

Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate.

W. Lubell, J. Cluzeau, 2004, The Journal of organic chemistry.

Synthesis of Enantiopure .alpha.,.omega.-Diamino Dicarboxylates and Azabicycloalkane Amino Acids by Claisen Condensation of .alpha.-[N-(Phenylfluorenyl)amino] Dicarboxylates

William D. Lubell, W. Lubell, Henry-Georges Lombart, 1994 .

Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin‐1 receptor, by positional scanning using β‐amino γ‐lactams

S. Chemtob, W. Lubell, C. Quiniou, 2011, Journal of peptide science : an official publication of the European Peptide Society.

Development of a Novel Noncompetitive Antagonist of IL-1 Receptor1

A. Pshezhetsky, N. Heveker, M. Leduc, 2008, The Journal of Immunology.

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

S. Omri, J. Rivera, S. Chemtob, 2020, Journal of neuroinflammation.

Chemistry in the comics: Molecular marvels of Iron Man

W. Lubell, Yann Brouillette, 2019 .

A critical role of interleukin-1 in preterm labor.

S. Chemtob, W. Lubell, D. Obari, 2016, Cytokine & growth factor reviews.

A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway*

D. Devost, H. Zingg, M. Bouvier, 2010, The Journal of Biological Chemistry.

Conjugated 4-methoxybipyrrole thiophene azomethines: synthesis, opto-electronic properties, and crystallographic characterization.

S. Dufresne, W. Skene, W. Lubell, 2011, Chemistry.

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis.

M. Grøtli, T. Groth, M. Meldal, 2002, Journal of combinatorial chemistry.

Heumann Indole Flow Chemistry Process.

W. Lubell, Sacha Nguyen Thanh, Fenja Leena Dücker, 2019, The Journal of organic chemistry.

1,3,5,8-Tetrasubstituted 1,3,4-Benzotriazepin-2-one Scaffolds for β-Turn Mimicry without Stereogenic Carbon Centers: Synthesis and Conformational Analysis.

W. Lubell, Antoine Douchez, Xiaozheng Wei, 2023, The Journal of organic chemistry.

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.

F. Hamdan, M. Bouvier, W. Lubell, 2007, Journal of medicinal chemistry.

Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids.

W. Lubell, M. H. V. R. Rao, E. Pinyol, 2007, Journal of Organic Chemistry.

γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone Intermediate.

W. Lubell, Aurelie A. Doerr, 2015, Organic letters.

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

W. Lubell, Samir Bouayad‐Gervais, 2013, Molecules.

Mimics of peptide turn backbone and side-chain geometry by a general approach for modifying azabicyclo[5.3.0]alkanone amino acids.

W. Lubell, Tanya A. Godina, 2011, The Journal of organic chemistry.

CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits

P. Hardy, S. Chemtob, M. Febbraio, 2010, Aging.

Practical Enantioselective Synthesis of α-Amino Dicarboxylates. Preparation of D- and L-α-Aminoadipate, α-Aminopimelate, and α-Aminosuberate.

W. Lubell, T. Pham, 1994 .

Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis.

X. Zhu, Juntao Luo, W. Lubell, 2007, Chemical communications.

Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation.

Ahsanullah, S. Chemtob, W. Lubell, 2019, Journal of medicinal chemistry.

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice

X. Hou, S. Chemtob, W. Lubell, 2017, The Journal of Immunology.

This information is current as Outcomes in Mice and Improves Neonatal and Developmental against Inflammation-Induced Fetal Injury Antenatal Suppression of IL-1 Protects

X. Hou, S. Chemtob, W. Lubell, 2017 .

O‐(3,4‐Dihydro‐4‐oxo‐1,2,3‐benzotriazin‐3‐yl)‐N,N,N′,N′‐tetramethyluronium Tetrafluoroborate

W. Lubell, C. Proulx, 2013 .

Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly(2)-Gly(3) surrogate in a leucine-enkephalin mimic.

M. Jurzak, T. Meert, F. Gosselin, 2001, The journal of peptide research : official journal of the American Peptide Society.

Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics.

W. Lubell, L. Halab, Liliane Halab, 2002, Journal of the American Chemical Society.

A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice

W. Lubell, H. Ong, S. Marleau, 2023, Frontiers in Pharmacology.

Native Chemical Ligation

J. Blankenship, W. Lubell, G. Fridkin, 2005 .

HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine

M. Grøtli, T. Groth, M. Meldal, 2000 .

Rigid dipeptide surrogates: syntheses of enantiopure quinolizidinone and pyrroloazepinone amino acids from a common diaminodicarboxylate precursor.

F. Gosselin, W. Lubell, 2000, The Journal of organic chemistry.

Crystal-state structure analysis of β-hydroxy-γ-lactam constrained Ser/Thr peptidomimetics

W. Lubell, D. St-Cyr, Thierry Maris, 2010 .

Regioselective Enolization and Alkylation of 4-Oxo-N-(9-phenylfluoren-9-yl)proline: Synthesis of Enantiopure Proline−Valine and Hydroxyproline−Valine Chimeras

W. Lubell, Raman K. Sharma, 1996 .

Synthesis of enantiomerically enriched 4,5-disubstituted N-aminoimidazol-2-one (Nai) peptide turn mimics

W. Lubell, J. Poupart, Yousra Hamdane, 2020 .

Interleukin-1 and ischemic brain injury in the newborn: development of a small molecule inhibitor of IL-1 receptor.

P. Hardy, X. Hou, I. Lahaie, 2008, Seminars in perinatology.

Synthesis and application of L-N-Boc-N-methyl-β-hydroxyvaline in the preparation of a depsipeptide

L. Bélec, W. Lubell, J. E. Dettwiler, 2005 .

Regioselective Enolization and Alkylation of 4‐Oxo‐N‐(9‐phenylfluoren‐ 9‐yl)proline: Synthesis of Enantiopure Proline‐Valine and Hydroxyproline‐Valine Chimeras.

W. Lubell, Raman K. Sharma, 1996 .

Synthesis of pyrrolo[3,2-e][1,4]diazepin-2-ones as potential γ-turn mimetics

W. Lubell, Philippe Deaudelin, 2009 .

The use of 5-tert-butylproline to study nucleation of polyproline type I conformation

E. Beausoleil, W. Lubell, 2002 .

Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.

N. Heveker, J. Mancini, M. Leduc, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity.

E. Purisima, K. Gehring, J. Blankenship, 2010, Chemistry & biology.

VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist.

N. Heveker, F. Hamdan, G. Guillon, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides.

W. Lubell, Tong He, Jinqiang Zhang, 2022, Organic and biomolecular chemistry.

Diversity-Oriented A3-Macrocyclization for Studying Influences of Ring-Size and Shape of Cyclic Peptides: CD36 Receptor Modulators.

Ahsanullah, S. Chemtob, W. Lubell, 2021, Journal of medicinal chemistry.

Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters.

K. Hansford, W. Lubell, Aurelie A. Doerr, 2004, Journal of combinatorial chemistry.

N-Amino-imidazol-2-one (Nai) Residues as Tools for Peptide Mimicry: Synthesis, Conformational Analysis and Biomedical Applications

W. Lubell, J. Poupart, Yousra Hamdane, 2022, Synthesis.

5-Substituted N-Aminoimidazolone Peptide Mimic Synthesis by Organocatalyzed Reactions of Azopeptides and Use in the Analysis of Biologically Active Backbone and Side-Chain Topology.

P. Chauhan, W. Lubell, H. Ong, 2021, Organic letters.

Pharmacodynamic Characterization of Rytvela, a Novel Allosteric Anti-Inflammatory Therapeutic, to Prevent Preterm Birth and Improve Fetal/Neonatal Outcome.

X. Hou, S. Chemtob, W. Lubell, 2022, American Journal of Obstetrics and Gynecology.

Peptide-Based Drug Development

W. Lubell, 2022, Biomedicines.

Alkyl 3-Position Substituents Retard the Isomerization of Prolyl and Hydroxyprolyl Amides in Water

S. Michnick, E. Beausoleil, W. Lubell, 1998 .

Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides.

W. Lubell, C. Proulx, 2010, Organic letters.

Hydrazine derivative synthesis by trifluoroacetyl hydrazide alkylation

P. Chauhan, Anh Nguyen, W. Lubell, 2020 .

Microglia and Interleukin-1&bgr; in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

P. Hardy, J. Rivera, T. Zhou, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Interleukin-1 and ischemic brain injury in the newborn: development of a small molecule inhibitor of IL-1 receptor.

P. Hardy, X. Hou, I. Lahaie, 2008, Seminars in perinatology.

Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.

F. Simonin, D. Tourwé, W. Lubell, 2004, Journal of medicinal chemistry.

Synthesis of azabicycloalkanone amino acid and azapeptide mimics and their application as modulators of the prostaglandin F2α receptor for delaying preterm birth

S. Laporte, S. Chemtob, W. Lubell, 2014 .

Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.

F. Simonin, B. Kieffer, Z. Darula, 2002, Journal of medicinal chemistry.

Fluorometric assay for tissue transglutaminase-mediated transamidation activity.

J. Pelletier, W. Lubell, J. Keillor, 2009, Bioorganic & medicinal chemistry.

Insertion of multiple α‐amino γ‐lactam (Agl) residues into a peptide sequence by solid‐phase synthesis on synphase lanterns

S. Chemtob, W. Lubell, Luisa Ronga, 2010, Biopolymers.

Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics.

W. Lubell, D. Chatenet, Antoine Douchez, 2023, Journal of medicinal chemistry.

Reversible and Competitive Cinnamoyl Triazole Inhibitors of Tissue Transglutaminase

W. Lubell, J. Keillor, I. Roy, 2008, Chemical biology & drug design.

Synthesis of 5‐ and 7‐hydroxy indolizidin‐2‐one prostaglandin‐F2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth

X. Hou, S. Chemtob, W. Lubell, 2022, Journal of peptide science : an official publication of the European Peptide Society.

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.

S. Chemtob, W. Lubell, H. Ong, 2012, Journal of medicinal chemistry.

Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator

W. Lubell, H. Ong, S. Marleau, 2024, Frontiers in pharmacology.

Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters.

W. Lubell, Antoine Douchez, Azade Geranurimi, 2018, Accounts of chemical research.