D. Rampe

发表

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.

Roy J. Vaz, M. Preobrazhenskaya, R. Pearlstein, 2003, Bioorganic & medicinal chemistry letters.

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

T. Colatsky, B. Fermini, G. Gintant, 2016, Journal of biomolecular screening.

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.

Jiesheng Kang, Xiao-Liang Chen, D. Rampe, 2002, European journal of pharmacology.

Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels.

C R Benedict, Y. Kuryshev, A. Brown, 2000, The Journal of pharmacology and experimental therapeutics.

Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart.

A. Brown, B. Wible, D. Rampe, 1993, Molecular pharmacology.

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

Gary Gintant, Karluss Thomas, Alan S Bass, 2006, Journal of pharmacological and toxicological methods.

Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Roy J. Vaz, D. R. Compton, Jiesheng Kang, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide.

D. Rampe, D Rampe, J Kang, 2000, European journal of pharmacology.

Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.

Robert Pearlstein, Roy Vaz, R. Pearlstein, 2003, Journal of medicinal chemistry.

Human ether-a-go-go related gene (HERG): a chemist's perspective.

Roy J Vaz, Roy J. Vaz, D. Rampe, 2005, Progress in medicinal chemistry.

Predictive models for hERG potassium channel blockers.

Gabriele Cruciani, Roy J Vaz, Arnaldo Fravolini, 2005, Bioorganic & medicinal chemistry letters.

Cardiac Ion Channel Effects of Tolterodine

Jiesheng Kang, Xiao-Liang Chen, James Hendrix, 2004, Journal of Pharmacology and Experimental Therapeutics.

FUNCTIONAL INTERACTION BETWEEN DPI 201‐106, A DRUG THAT MIMICS CONGENITAL LONG QT SYNDROME, AND SEVOFLURANE ON THE GUINEA‐PIG CARDIAC ACTION POTENTIAL

Jiesheng Kang, Xiao-Liang Chen, D. Rampe, 2007, Clinical and experimental pharmacology & physiology.

Cardiovascular safety of fexofenadine HCl

A. Brown, C. Pratt, D. Rampe, 1999, Clinical and Experimental Allergy.

Benzodiazepine interactions at neuronal and smooth muscle Ca2+ channels.

D. Triggle, D. Rampe, 1987, European journal of pharmacology.

Oversulfated chondroitin sulfate and OSCS-contaminated heparin cause dose- and route-dependent hemodynamic effects in the rat.

M. Lorenz, D. Rampe, S. Potdevin, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo.

D. Rampe, A. M. Szczepanik, G. Ringheim, 2001, Journal of neurochemistry.

Characterization of the effects of a new Ca2+ channel activator, FPL 64176, in GH3 cells.

D. Kunze, D. Rampe, 1992, Molecular pharmacology.

Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.

D. Triggle, D. Rampe, W. Zheng, 1991, Molecular pharmacology.

A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176.

A. E. Lacerda, D. Rampe, 1991, The Journal of pharmacology and experimental therapeutics.

Verapamil blocks a rapidly activating delayed rectifier K+ channel cloned from human heart.

A. Brown, B. Wible, D. Fedida, 1993, Molecular pharmacology.

1,4-Dihydropyridine activators and antagonists: structural and functional distinctions.

D. Triggle, D. Rampe, 1989, Trends in pharmacological sciences.

Activators of voltage‐dependent L‐type calcium channels

H. Policy, D. Rampe, J. Michael Kane, 1994 .

New synthetic ligands for L-type voltage-gated calcium channels.

D. Triggle, D. Rampe, 1993, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Amyloid‐β peptide fragments p3 and p4 induce pro‐inflammatory cytokine and chemokine production in vitro and in vivo

D. Rampe, A. M. Szczepanik, G. Ringheim, 2001 .

A Festschrift in honor of David J. Triggle.

C. Triggle, M. Gopalakrishnan, D. Rampe, 2015, Biochemical pharmacology.

Voltage-Gated Ion Channels as Drug Targets: TRIGGLE: VOLTAGE-GATED ION CHANNELS AS DRUG TARGETS O-BK

D. Triggle, M. Gopalakrishnan, D. Rampe, 2006 .

Chemical Pharmacology of Ca2+ Channel Ligands

D. Triggle, D. Rampe, A. Skattebøl, 1986 .

Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart.

A. E. Lacerda, D. Rampe, M. Roy, 1997, Molecular pharmacology.

Blockade of the human cardiac K+ channel Kv1.5 by the antibiotic erythromycin

D. Rampe, M. Murawsky, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel.

Jiesheng Kang, D. Rampe, J. Kang, 2001, Biochemical and biophysical research communications.

High affinity [3H]glibenclamide binding sites in rat neuronal and cardiac tissue: localization and developmental characteristics.

J. Miller, D. Rampe, R. C. Dage, 1991, The Journal of pharmacology and experimental therapeutics.

Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking

Y. Kuryshev, A. Brown, B. Wible, 2005, Journal of Pharmacology and Experimental Therapeutics.

Comparative aspects and temperature dependence of [3H]1,4-dihydropyridine Ca2+ channel antagonist and activator binding to neuronal and muscle membranes.

D. Triggle, D. Rampe, R. Janis, 1987, Canadian journal of physiology and pharmacology.

[3H]PN200-110 binding in a fibroblast cell line transformed with the alpha 1 subunit of the skeletal muscle L-type Ca2+ channel.

A. Brown, L. Birnbaumer, A. E. Lacerda, 1990, Biochemical and biophysical research communications.

New advances in molecular pharmacology of Ca2+ channels.

D. Triggle, D. Rampe, 1989, Trends in pharmacological sciences.

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

D J Triggle, D. Triggle, Jiesheng Kang, 2001, Molecular pharmacology.

Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.

D. Rampe, P. Shum, J. Sabol, 2005, Bioorganic & medicinal chemistry letters.

Calcium channel antagonists: pharmacological considerations.

D. Triggle, D. Rampe, C. Su, 1985, British journal of clinical pharmacology.

Effects of protein kinase C activators on cardiac Ca2+ channels

A. Brown, A. E. Lacerda, D. Rampe, 1988, Nature.

Observations on conducting whole‐cell patch clamping of the hERG cardiac K+ channel in pure human serum

Jiesheng Kang, D. Rampe, M. Searles, 2017, Journal of applied toxicology : JAT.

An extremely short synthesis of benzoylpyrrole-type calcium channel activators

J. Kane, D. Rampe, R. DaltonChristopher, 1992 .

New ligands for L-type Ca2+ channels.

D. Triggle, D. Rampe, 1990, Trends in pharmacological sciences.

Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

A. Brown, K. Campbell, L. Birnbaumer, 1989, Nature.

Contraction of reptile, amphibian, and fish blood vessels by endothelin-1.

S. Silberberg, D. Rampe, T. Poder, 1991, Canadian journal of physiology and pharmacology.

Mechanisms Underlying the QT Interval–prolonging Effects of Sevoflurane and Its Interactions with Other QT-prolonging Drugs

Jiesheng Kang, D. Rampe, Hongge Wang, 2006, Anesthesiology.

Specific binding of a calcium channel activator, [3H]BAY k 8644, to membranes from cardiac muscle and brain.

J. G. Sarmiento, D. Triggle, D. Rampe, 1984, Biochemical and biophysical research communications.

Control of expression of the 1,4-dihydropyridine receptor in BC3H1 cells.

A. Brown, D. Rampe, M. Schneider, 1988, Biochemical and biophysical research communications.

Ontogeny of calcium channels in myogenic cell lines: Regulation by growth factors and transfected oncogenes

A. Brown, D. Rampe, J. M. Caffrey, 1987 .

Electrophysiologic and biochemical studies on the putative Ca++ channel blocker MDL 12,330A in an endocrine cell.

A. Brown, D. Triggle, D. Rampe, 1987, The Journal of pharmacology and experimental therapeutics.

BAY K 8644, a 1,4‐Dihydropyridine Ca2+ Channel Activator: Dissociation of Binding and Functional Effects in Brain Synaptosomes

D. Triggle, D. Rampe, R. Janis, 1984, Journal of Neurochemistry.

P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia

D. Rampe, G. Ringheim, Lin Wang, 2004, Journal of Neuroimmunology.

Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.

Jiesheng Kang, D. Rampe, D Rampe, 2001, The Journal of pharmacology and experimental therapeutics.

On Becoming a Pharmacologist: Channeling David Triggle.

M. Gopalakrishnan, D. Rampe, 2015, Biochemical pharmacology.

In Vitro Electrocardiographic and Cardiac Ion Channel Effects of (−)-Epigallocatechin-3-Gallate, the Main Catechin of Green Tea

Jiesheng Kang, D. Rampe, J. Ji, 2010, Journal of Pharmacology and Experimental Therapeutics.

Benzodiazepines and calcium channel function

D. Triggle, D. Rampe, 1986 .

Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

Jiesheng Kang, D. Rampe, M. Tabart, 2005, Molecular Pharmacology.

Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Roy J. Vaz, D. R. Compton, Jiesheng Kang, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Interactions of the narcotic l-α-acetylmethadol with human cardiac K+ channels

Jiesheng Kang, D. Rampe, Hongge Wang, 2003 .

Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents

W. Crumb, B. Wible, D. Rampe, 1997, Brain Research.

Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel.

Roy J Vaz, Roy J. Vaz, Jiesheng Kang, 2017, Bioorganic & medicinal chemistry letters.

Heterocyclic guanidines as calcium antagonists

J. Kane, D. Rampe, A. Carr, 1994 .

Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels.

Jiesheng Kang, D. Rampe, Hongge Wang, 2003, European journal of pharmacology.

A history of the role of the hERG channel in cardiac risk assessment.

A. Brown, D. Rampe, 2013, Journal of pharmacological and toxicological methods.

Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels

M. Bleich, K. Steinmeyer, A. Busch, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular Interaction Fields in ADME and Safety

Yi Li, Meng Zhang, Roy J. Vaz, 2006 .

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG

A. Brown, D. Rampe, A M Brown, 1997, FEBS letters.

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat.

Jiesheng Kang, D. Rampe, Xiaoyou Ying, 2012, Toxicology letters.

Ca2+ Channel Activators Reveal Differential L-Type Ca2+ Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes

Jiesheng Kang, D. Rampe, Q. Lei, 2012, Journal of Pharmacology and Experimental Therapeutics.

Channel Activators Reveal Differential L-Type Ca Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes

Jiesheng Kang, D. Rampe, Q. Lei, 2012 .

Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176.

D. Rampe, R. C. Dage, B. Anderson, 1993, The Journal of pharmacology and experimental therapeutics.

The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG.

D. Rampe, D Rampe, M K Murawsky, 1998, The Journal of pharmacology and experimental therapeutics.

Chemical and pharmacological approaches to the definition and quantitation of calcium channels.

A M Triggle, D J Triggle, R A Janis, 1983, Cold Spring Harbor symposia on quantitative biology.

Parathyroid hormone: An endogenous modulator of cardiac calcium channels

A. Brown, A. E. Lacerda, D. Rampe, 1991 .

Deuterated analogs of verapamil and nifedipine. Synthesis and biological activity

D. Rampe, L. Skattebol, B. Borretzen, 1993 .

The actions of diazepam and diphenylhydantoin on fast and slow Ca2+ uptake processes in guinea pig cerebral cortex synaptosomes.

D. Triggle, D. Rampe, J. Ferrante, 1987, Canadian Journal of Physiology and Pharmacology.

The ontogeny of [3H]nitrendipine binding sites and 45Ca2+ uptake processes in brain synaptosomes from spontaneously hypertensive rats.

D. Triggle, D. Rampe, J. Ferrante, 1986, Brain research.

Development and Evaluation of High Throughput Functional Assay Methods for hERG Potassium Channel

T. Garyantes, Jiesheng Kang, D. Rampe, 2001, Journal of biomolecular screening.

Calcium channel agonist and antagonist binding in a highly enriched sarcolemma preparation obtained from canine ventricle.

D. Rampe, W. Schilling, T. Poder, 1989, Journal of cardiovascular pharmacology.

Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.

R. Pearlstein, D. Rampe, Roy Vaz, 2003, Journal of medicinal chemistry.

Parathyroid hormone: an endogenous modulator of cardiac calcium channels.

A. Brown, A. E. Lacerda, D. Rampe, 1991, The American journal of physiology.

Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle.

D. Rampe, R. C. Dage, 1992, Molecular pharmacology.

Voltage- and time-dependent block by perhexiline of K+ currents in human atrium and in cells expressing a Kv1.5-type cloned channel.

B. Fermini, S. Nattel, B. Wible, 1995, Journal of Pharmacology and Experimental Therapeutics.

In Vitro electrophysiological activity of nerispirdine, a novel 4‐aminopyridine derivative

Jiesheng Kang, D. Rampe, S. Kongsamut, 2009, Clinical and experimental pharmacology & physiology.