J. G. Cumming

发表

Chemical predictive modelling to improve compound quality

S. Muresan, A. Davis, Hongming Chen, 2013, Nature Reviews Drug Discovery.

The total synthesis of swinholide A. Part 3: A stereocontrolled synthesis of (−)-pre-swinholide A.

K. Yeung, J. G. Cumming, I. Paterson, 1995 .

Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

John G Cumming, J. Breed, P. Jewsbury, 2004, Bioorganic & medicinal chemistry letters.

Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.

D. Brown, J. G. Cumming, S. Wells, 2012, Bioorganic & medicinal chemistry letters.

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

Peter D Smith, Chris Davies, S. Lamont, 2011, Bioorganic & medicinal chemistry letters.

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity.

J. Bower, J. G. Cumming, Michael James, 2012, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of the octahydroisobenzofuran skeleton of the eunicellins

S. Marsden, J. G. Cumming, Tito Akindele, 2005 .

Studies in marine macrolide synthesis: Boron and silicon-mediated coupling strategies for Swinholide A

J. G. Cumming, I. Paterson, R. Ward, 1994 .

(S)-2-(Dibenzylamino)-3-phenylpropanal as a chiral auxiliary: a new strategy for the asymmetric synthesis of 2-substituted alcohols

J. G. Cumming, J. Clayden, Catherine McCarthy, 1998 .

Total Synthesis of (-)-Preswinholide A

J. G. Cumming, I. Paterson, R. Ward, 1994 .

The total synthesis of swinholide A. Part 1: A stereocontrolled synthesis of a C19-C32 segment

J. G. Cumming, I. Paterson, R. Ward, 1995 .

Total Synthesis of Swinholide A and Hemiswinholide A

K. Yeung, J. G. Cumming, I. Paterson, 1994 .

Stereocontrolled assembly of tetrasubstituted tetrahydrofurans: a concise synthesis of virgatusin.

S. Marsden, J. G. Cumming, Tito Akindele, 2005, Organic letters.

A stereocontrolled synthesis of a C19-C32 / C17-C30 Segment for swinholide A and misakinolide A, Cytotoxic dimeric macrolides from theonella swinhoei.

J. G. Cumming, I. Paterson, 1992 .

Synthesis and antiviral evaluation of enantiomeric 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3′-dideoxy-4′-thionucleosides

J. Miller, J. G. Cumming, P. Rider, 1995 .

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

John G Cumming, Jeremy N Burrows, J. G. Cumming, 2005, Bioorganic & medicinal chemistry letters.

A novel method of myeloablation to enhance engraftment of adult bone marrow cells in newborn mice.

D. Williams, M. Yoder, J. G. Cumming, 1996, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (−)-pre-swinholide A

K. Yeung, J. G. Cumming, I. Paterson, 1994 .

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

R. Pauptit, S. Gerhardt, D. Brown, 2012, Bioorganic & medicinal chemistry letters.

Potential strategies for increasing drug-discovery productivity.

Fabrizio Giordanetto, John G Cumming, M Raymond V Finlay, 2014, Future medicinal chemistry.

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.

J. Debreczeni, J. G. Cumming, S. Wells, 2015, Journal of medicinal chemistry.

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

Simon J Brown, D. Whittaker, J. G. Cumming, 2006, Bioorganic & medicinal chemistry letters.

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

Chris Davies, S. Gerhardt, David J. Milne, 2011, Bioorganic & medicinal chemistry letters.

Automated QSAR with a Hierarchy of Global and Local Models

Ulf Norinder, David J Wood, Sarah L. Rodgers, 2011, Molecular informatics.

Beyond the Scope of Free-Wilson Analysis. 2 Can Distance Encoded R-Group Fingerprints Provide Interpretable Nonlinear Models?

Lars Carlsson, Hongming Chen, Mats Eriksson, 2014, J. Chem. Inf. Model..

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.

D. Whittaker, J. G. Cumming, K. Grime, 2005, Bioorganic & medicinal chemistry letters.