H. Bulut

发表

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

P. Wingfield, H. Mitsuya, J. Mieyal, 2021, mBio.

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

P. Wingfield, H. Mitsuya, D. Davis, 2021, bioRxiv.

Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance

Arun K. Ghosh, H. Mitsuya, Y. Takamatsu, 2019, Antimicrobial Agents and Chemotherapy.

A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413

Arun K. Ghosh, H. Mitsuya, H. Bulut, 2016, Antimicrobial Agents and Chemotherapy.

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

J. Demeter, M. Selbach, S. Clare, 2022, The Journal of experimental medicine.

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

Arun K. Ghosh, H. Mitsuya, H. Bulut, 2019, Antimicrobial Agents and Chemotherapy.

Disruption of adaptor protein 2μ (AP‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

S. Rizzoli, T. Maritzen, V. Haucke, 2015, The EMBO journal.

Structures of carbohydrate, cysteine and cystine binding receptors of ATP-Binding Cassette (ABC) Transporters

H. Bulut, 2012 .

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

O. Shupliakov, W. Saenger, V. Haucke, 2011, Cell.

Potent and biostable inhibitors of the main protease of SARS-CoV-2

N. Kishimoto, K. Nakano, T. Okamura, 2022, iScience.

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

S. Savvides, V. Haucke, K. Gevaert, 2019, Nature Chemical Biology.

Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

D. Davis, H. Bulut, Prabha Shrestha, 2022, Antioxidants.

Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition

H. Mitsuya, Y. Koh, H. Bulut, 2019, Scientific Reports.

GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

Arun K. Ghosh, H. Mitsuya, N. Kishimoto, 2020, mBio.

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.

D. Venzon, H. Mitsuya, N. Kishimoto, 2020, Journal of hepatology.

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

O. Shupliakov, W. Saenger, V. Haucke, 2011, Cell.

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

M. Kiso, Y. Kawaoka, N. Kishimoto, 2023, Nature Communications.

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Arun K. Ghosh, A. Wlodawer, H. Mitsuya, 2021, Nature Communications.

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Arun K. Ghosh, H. Mitsuya, H. Jono, 2017, eLife.

Reducing Macro‐ and Microheterogeneity of N‐Glycans Enables the Crystal Structure of the Lectin and EGF‐Like Domains of Human L‐Selectin To Be Solved at 1.9 Å Resolution

A. Vahedi-Faridi, W. Saenger, J. Dernedde, 2017, Chembiochem : a European journal of chemical biology.

Crystal structures of the solute receptor GacH of Streptomyces glaucescens in complex with acarbose and an acarbose homolog: comparison with the acarbose-loaded maltose-binding protein of Salmonella typhimurium.

Erwin Schneider, Wolfram Saenger, A. Vahedi-Faridi, 2010, Journal of molecular biology.

Crystal structures of two solute receptors for L-cystine and L-cysteine, respectively, of the human pathogen Neisseria gonorrhoeae.

W. Saenger, S. Moniot, F. Scheffel, 2012, Journal of molecular biology.

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Arun K. Ghosh, H. Mitsuya, D. Davis, 2020, Scientific Reports.

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.

Irene T Weber, Yuan-Fang Wang, Debananda Das, 2017, Journal of medicinal chemistry.

Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

H. Bulut, Yuka Honda, Shuhei Imoto, 2023, RSC advances.

Does Mycoplasma sp. play role in small cell lung cancer?

H. Bulut, H. Onay, S. Pehlivan, 2004, Lung cancer.

Crystal structures of the bacterial solute receptor AcbH displaying an exclusive substrate preference for β-D-galactopyranose.

A. Vahedi-Faridi, W. Saenger, O. Daumke, 2011, Journal of molecular biology.

Disruption of adaptor protein 2μ (AP‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

S. Rizzoli, V. Haucke, H. Al-Moyed, 2015, The EMBO journal.

Reducing Macro‐ and Microheterogeneity of N‐Glycans Enables the Crystal Structure of the Lectin and EGF‐Like Domains of Human L‐Selectin To Be Solved at 1.9 Å Resolution

A. Vahedi-Faridi, W. Saenger, J. Dernedde, 2017, Chembiochem : a European journal of chemical biology.

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

Arun K. Ghosh, N. Kishimoto, K. Murayama, 2023, Science advances.