R. Howes

发表

Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.

Andrew Potter, N. Foloppe, A. Surgenor, 2005, Journal of medicinal chemistry.

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

J. Murray, C. Torrance, P. Dokurno, 2006, Bioorganic & medicinal chemistry letters.

Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening.

Andrew Potter, N. Foloppe, A. Surgenor, 2006, Bioorganic & medicinal chemistry.

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

M. Drysdale, J. Murray, R. Hubbard, 2007, Bioorganic & medicinal chemistry letters.

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

M. Drysdale, N. Foloppe, J. Murray, 2009, Journal of medicinal chemistry.

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

L. Pearl, X. Barril, M. Drysdale, 2008, Cancer research.

Genome engineering using Adeno-Associated Virus (AAV).

R. Howes, C. Schofield, 2015, Methods in molecular biology.

Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays

R. Howes, T. Wilkinson, T. Vaughan, 2016, Journal of biomolecular screening.

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists.

M. Coghlan, M. Snaith, D. Baker, 2016, The Biochemical journal.

Pyruvate dehydrogenase deficiency. Clinical presentation and molecular genetic characterization of five new patients.

P. Matthews, G. Brown, M. Shevell, 1994, Brain : a journal of neurology.

4-Amino derivatives of the Hsp90 inhibitor CCT018159.

Xavier Barril, Paul Workman, Allan M Jordan, 2006, Bioorganic & medicinal chemistry letters.

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Alan Robertson, J. Bower, J. Murray, 2005, Bioorganic & medicinal chemistry letters.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Mike Wood, Terry Shaw, M. Drysdale, 2011, Journal of medicinal chemistry.

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)*

Joshua M. Korn, J. Korn, M. Korpal, 2012, The Journal of Biological Chemistry.

Genetic Evidence That Drosophila frizzled Controls Planar Cell Polarity and Armadillo Signaling by a Common Mechanism

R. Nusse, M. Fish, M. Povelones, 2005, Genetics.

A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site.

Nicolas Foloppe, I-Jen Chen, Ben Davis, 2004, Bioorganic & medicinal chemistry.

A fluorescence polarization assay for inhibitors of Hsp90.

X. Barril, M. Drysdale, P. Workman, 2006, Analytical biochemistry.

Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification.

Nicolas Foloppe, Andrew Potter, N. Foloppe, 2005, Bioorganic & medicinal chemistry.

Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective

Mei Ding, Roger Clark, Catherine Bardelle, 2018, SLAS discovery : advancing life sciences R & D.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

M. Drysdale, J. Murray, Rachel J Parsons, 2011, Journal of medicinal chemistry.

JBS Special Issue on Therapeutic Antibody Discovery and Development

R. Howes, J. McGivern, 2015, Journal of biomolecular screening.