D. S. Williamson

发表

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

J. Murray, C. Torrance, P. Dokurno, 2006, Bioorganic & medicinal chemistry letters.

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

M. Drysdale, J. Murray, R. Hubbard, 2007, Bioorganic & medicinal chemistry letters.

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

M. Drysdale, N. Foloppe, J. Murray, 2009, Journal of medicinal chemistry.

Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked

N. Curtin, D. Newell, Lan Z. Wang, 2008, Cell cycle.

LRRK2 exonic variants associated with Parkinson’s disease augment phosphorylation levels for LRRK2-Ser1292 and Rab10-Thr73

Sarah Elschenbroich, F. Oppermann, M. Hentzer, 2018, bioRxiv.

Design of LRRK2 inhibitors using a CHK1-derived crystallographic surrogate

J. Murray, R. Hubbard, M. Hentzer, 2019 .

Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.

A. Lawrence, R. Gillespie, C. Dourish, 2008, Bioorganic & medicinal chemistry letters.

Practical radical cyclisations leading to the construction of near-stereopure quaternary carbon stereogenic centres

D. S. Williamson, R. Pritchard, R. J. Stoodley, 1998 .

Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.

R. Gillespie, C. Dourish, D. S. Williamson, 2008, Bioorganic & medicinal chemistry letters.

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Alan Robertson, J. Bower, J. Murray, 2005, Bioorganic & medicinal chemistry letters.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Mike Wood, Terry Shaw, M. Drysdale, 2011, Journal of medicinal chemistry.

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

M. Drysdale, J. Murray, Rachel J Parsons, 2010, Cancer Chemotherapy and Pharmacology.

Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

F. Oppermann, D. S. Williamson, K. Thirstrup, 2017, Scientific Reports.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

J. Murray, R. Hubbard, M. Hentzer, 2017, Journal of medicinal chemistry.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.

A. Lawrence, R. Gillespie, S. Ward, 2008, Bioorganic & medicinal chemistry letters.

Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease.

D. S. Williamson, G. Smith, G. Smith, 2017, Progress in medicinal chemistry.

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

B. Davis, J. Murray, R. Hubbard, 2019, ACS omega.

Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.

M. Hentzer, P. Dokurno, A. Surgenor, 2021, Journal of Medicinal Chemistry.

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.

M. Hentzer, D. S. Williamson, I. Chen, 2017, Bioorganic & medicinal chemistry letters.

Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.

R. Gillespie, D. S. Williamson, P. Jackson, 2009, Bioorganic & medicinal chemistry.

Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches.

R. Gillespie, A. Fink, C. Richardson, 2006, Bioorganic & medicinal chemistry letters.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

M. Drysdale, J. Murray, Rachel J Parsons, 2011, Journal of medicinal chemistry.

The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline.

D. S. Williamson, J. Baldwin, G. J. Pritchard, 2000, Bioorganic & medicinal chemistry letters.