H. Finch

发表

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

M. Drysdale, J. Murray, R. Hubbard, 2007, Bioorganic & medicinal chemistry letters.

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

L. Pearl, X. Barril, M. Drysdale, 2008, Cancer research.

The conformational musings of a medicinal chemist.

H. Finch, 2014, Drug discovery today.

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.

G. Hardy, T. Skarzynski, O. Singh, 2001, Bioorganic & medicinal chemistry letters.

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

A. Tutt, A. Nussenzweig, S. Boulton, 2021, Nature Communications.

Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.

A. Capelli, G. Tedesco, G. Gaviraghi, 2000, Journal of medicinal chemistry.

Novel 1,5-benzodiazepindione gastrin/CCKB antagonists

R. Carr, H. Finch, P. Shah, 1997 .

Synthesis and structure-activity relationship of new 1,5 benzodiazepine CCK-B antagonists

G. Tedesco, G. Gaviraghi, A. Reggiani, 1996 .

Thrombin inhibitors based on [5,5] trans-fused indane lactams.

N. Ramsden, H. Jhoti, H. Finch, 1999, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.

Valentina Bagnacani, Christopher A. Hurley, P. Puccini, 2022, Journal of medicinal chemistry.

5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.

J. Montana, C. Dix, H. Finch, 1998, Bioorganic & medicinal chemistry letters.

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.

C. Wharton, S. Patel, M. Weir, 1998, Biochemistry.

α-Fluoromethyl-n-methyl-phenylsulphoximine: a new fluoromethylenation reagent

H. Finch, S. Swanson, M. Boys, 1988 .

Polymer-supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential application in combinatorial chemistry

S. Ley, H. Finch, A. Thomas, 1999 .

The synthesis of novel prostaglandin analogues via cycloaddition reactions

J. Montana, H. Finch, R. Taylor, 1990 .

The synthesis of a conformationally restrained, combined thromboxane antagonist / synthase inhibitor using an intramolecular ‘Stille’- or ‘Grigg’-palladium-catalysed cyclisation strategy

H. Finch, B. Evans, N. Pegg, 1993 .

Chapter 11. Thromboxane Synthase Inhibitors and Receptor Antagonists

H. Finch, E. W. Collington, E. Collington, 1990 .

3-substituted-1,2,4-oxadiazolin-5-one; A useful amidine precursor and protecting group

H. Finch, S. J. Coote, N. Pegg, 1995 .

Transition metal mediated asymmetric synthesis, part 151 directing group competition in organoiron intermediates in the synthesis of (±)-O-methyljoubertiamine

H. Finch, D. Owen, G. Stephenson, 1993 .

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

G. Hardy, D. Belton, T. Skarzynski, 2001, Bioorganic & medicinal chemistry letters.

The Synthesis of Novel Prostaglandin Analogues via Cycloaddition Reactions.

J. Montana, H. Finch, R. Taylor, 1990 .

Sulphone-mediated cyclobutanone to α-alkoxy-cyclopentanone ring expansion reactions ; scope, limitations and applications

J. Montana, A. Mjalli, H. Finch, 1990 .

Selective deprotection of alcoholic and phenolic silyl ethers

H. Finch, I. J. Smith, E. W. Collington, 1985 .

Asymmetric induction in the [2+2] cycloaddition of a keteniminium salt: an approach to chiral 13-oxa prostanoids

David J. Williams, H. Finch, T. J. Cholerton, 1988 .

Facile synthesis of 1-substituted c-norbenzomorphans

H. Finch, 1983 .

Organometallic equivalents of cyclohexenone di-cation synthons for the total synthesis of O-methyljoubertiamine☆

H. Finch, D. Owen, G. Stephenson, 1991 .

Preparation and some reactions of tricyclo[3.3.0.0]octan-2-ones and tricyclo[3.2.0.0]heptan-2-ones

R. Holt, H. Finch, M. Mahon, 1990 .

Intramolecular [3 + 2]cycloadditions: synthesis of 1-methylene-2,3,3a,4,5,9b-hexahydro-1H-benz[e]indenes and an unsuccessful approach to ergot alkaloids

M. Drew, H. Finch, J. Mann, 1992 .

Perkin communications. Intramolecular (3 + 2) cycloadditions

H. Finch, J. Mann, M. Collins, 1991 .

Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.

H. Finch, E. McDonald, C. Mooney, 1999, Bioorganic & medicinal chemistry letters.

An approach to the synthesis of 5,5-trans-fused lactam analogues of β-lactam antibiotics

Paul W Smith, H. Finch, K. Cobley, 2001 .

Aryl-substituted cyclohexadienyl complexes: Novel intermediates for an organometallic approach to and alkaloid synthesis.

H. Finch, D. Owen, G. Stephenson, 1990 .

Synthesis and pharmacological evaluation of combined thromboxane receptor antagonist/synthase inhibitors: pyridine-containing sulphonamido acids

N. Pike, H. Finch, G. Robertson, 1991 .

Phenyl directing groups in the demethoxylation route to tricarbonyl(η5-cyclohexadienyl)iron(1 +) complexes

H. Finch, D. Owen, G. Stephenson, 1990 .

Transition metal mediated organic synthesis, part 11: 2-aryl substituents: new directing groups in cyclohexadienyl π-complexes

H. Finch, D. Owen, G. Stephenson, 1989 .

Transition Metal‐Mediated Organic Synthesis. Part 11. 2‐Aryl‐Substituents: New Directing Groups in Cyclohexadienyl π‐Complexes.

H. Finch, D. Owen, G. Stephenson, 1989 .

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.

V. Grinkevich, A. Turnbull, N. Holliday, 2022, Journal of medicinal chemistry.

An efficient general route to furo-, pyrido- and thieno-[d][2]benzazepines via Pd0 catalysed cross coupling reactions and nitrile ylide cyclisations

J. Sharp, H. Finch, D. Reece, 1994 .

An Efficient General Route to Furo‐, Pyrido‐ and Thieno‐(d)(2) benzazepines via Pd(0) Catalyzed Cross Coupling Reactions and Nitrile Ylide Cyclizations.

J. Sharp, H. Finch, D. Reece, 1994 .

Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets

Brian Dymock, Xavier Barril, Fareed Aboul-Ela, 2004, J. Chem. Inf. Model..

Cycloadditions of 1,3-oxazolium-4-olates (isomünchnones) by rhodium(II)-induced decomposition of α-diazocarbonyl derivatives of (5R)- and (5S)-phenyloxazin-3-one as a chiral template

R. Angell, L. Harwood, H. Finch, 1997 .

Novel Chiral Templates for 1,3-Oxazolium-4-olate (Isomünchnone) Cycloadditions: (5 R)- and (5 S)-Phenyloxazin-2,3-dione

M. Drew, R. Angell, L. Harwood, 1997 .

Stereoselective synthesis of a 13-azaprostacyclin methyl ester

H. Finch, E. W. Collington, C. J. Wallis, 1983 .

A concise approach to the morphinan skeleton using a tandem intramolecular furan Diels-Alder/radical cyclisation strategy

L. Harwood, H. Finch, G. Robertson, 1989 .

A New Synthesis of Organofluorosilicon Hydrides

H. Finch, N. Viswanathan, L. Marcus, 1971 .

Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition

J. Montana, H. Finch, H. A. Kelly, 1998 .