P. Jackson

发表

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

M. Drysdale, J. Murray, R. Hubbard, 2007, Bioorganic & medicinal chemistry letters.

Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked

N. Curtin, D. Newell, Lan Z. Wang, 2008, Cell cycle.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, ACS medicinal chemistry letters.

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Steven V. Ley, R. Ian Storer, Andrew G. Leach, 2000 .

A total synthesis of epothilones using solid-supported reagents and scavengers.

Steven V Ley, S. Ley, P. Jackson, 2003, Angewandte Chemie.

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Alan Robertson, J. Bower, J. Murray, 2005, Bioorganic & medicinal chemistry letters.

Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Chemistry.

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Siew K. Yeap, M. Ultsch, C. Eigenbrot, 2022, Journal of medicinal chemistry.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2016, Journal of medicinal chemistry.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Belen Dominguez-Fernandez, C. Eigenbrot, Ivana Yen, 2015, Journal of medicinal chemistry.

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2014, Journal of medicinal chemistry.

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

S. Steinbacher, Steve Price, E. Gancia, 2016, Journal of medicinal chemistry.

Analysis of nucleoproteins by direct injection of dissolved nuclei or chromosomes into a high-performance liquid chromatographic system.

L. R. Gurley, P. Jackson, 1985, Journal of chromatography.

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.

P. Savy, Steve Price, M. Belvin, 2012, Journal of medicinal chemistry.

NMR evidence for β-sultones as initial products in reactions of olefins with sulphur trioxide

D. Roberts, P. Jackson, C. Clemett, 1987 .

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.

P. Savy, Steve Price, M. Ultsch, 2014, Bioorganic & medicinal chemistry letters.

Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.

R. Gillespie, D. S. Williamson, P. Jackson, 2009, Bioorganic & medicinal chemistry.