T. Shaw

发表

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

M. Drysdale, N. Foloppe, J. Murray, 2009, Journal of medicinal chemistry.

Design of LRRK2 inhibitors using a CHK1-derived crystallographic surrogate

J. Murray, R. Hubbard, M. Hentzer, 2019 .

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Mike Wood, Terry Shaw, M. Drysdale, 2011, Journal of medicinal chemistry.

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

M. Drysdale, J. Murray, Rachel J Parsons, 2010, Cancer Chemotherapy and Pharmacology.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

J. Murray, R. Hubbard, M. Hentzer, 2017, Journal of medicinal chemistry.

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Mike Wood, Ben Davis, Terry Shaw, 2017, Journal of medicinal chemistry.

Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.

M. Hentzer, P. Dokurno, A. Surgenor, 2021, Journal of Medicinal Chemistry.

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

J. Murray, B. Davis, P. Brough, 2014, Oncotarget.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

M. Drysdale, J. Murray, Rachel J Parsons, 2011, Journal of medicinal chemistry.