Lingfeng Chen

发表

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Gaozhi Chen, G. Liang, Weitao Fu, 2016, Drug design, development and therapy.

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.

P. Zou, J. Ji, Gaozhi Chen, 2016, Cancer letters.

Theoretical studies on FGFR isoform selectivity of FGFR1/FGFR4 inhibitors by molecular dynamics simulations and free energy calculations.

G. Liang, Weitao Fu, Lingfeng Chen, 2017, Physical chemistry chemical physics : PCCP.

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

Xiaokun Li, G. Liang, Lingfeng Chen, 2016, Scientific Reports.

Structural basis of FGF23 hormone signaling

M. Mohammadi, R. Goetz, Lingfeng Chen, 2021 .

Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury.

G. Liang, Lingfeng Chen, Chenglong Li, 2019, Journal of medicinal chemistry.

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

G. Liang, Lingfeng Chen, Zhiguo Liu, 2018, Drug design, development and therapy.

Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3

Yan Hu, G. Liang, Lingfeng Chen, 2016, Tumor Biology.

Synthesis and Anti‐Inflammatory Evaluation of Novel C66 Analogs for the Treatment of LPS‐Induced Acute Lung Injury

Fengli Xu, G. Liang, Lingfeng Chen, 2015, Chemical biology & drug design.

Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

Lingfeng Chen, Yi Wang, Wu Luo, 2022, Acta pharmaceutica Sinica. B.

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury.

Gaozhi Chen, G. Liang, Weitao Fu, 2018, European journal of medicinal chemistry.

Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors.

Lin-jiang Tong, Ting Peng, Yi Chen, 2022, European journal of medicinal chemistry.

Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.

Xiaokun Li, Gaozhi Chen, Lili Fu, 2017, European journal of medicinal chemistry.

New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity.

H. Lum, Zhongxiang Xiao, G. Liang, 2018, European journal of medicinal chemistry.

Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

M. Mohammadi, M. Falasca, C. Dustin, 2020, Journal of experimental & clinical cancer research : CR.

Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2‐a]pyrimidine Derivatives with Anti‐inflammatory Activity in Acute Lung Injury

G. Liang, Weitao Fu, Lingfeng Chen, 2017, ChemMedChem.

Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury.

G. Liang, Lingfeng Chen, Lulu Zheng, 2019, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Quinazoline Derivatives as Anti‐inflammatory Agents against Lipopolysaccharide‐induced Acute Lung Injury in Rats

G. Liang, Lingfeng Chen, Zhe Wang, 2015, Chemical biology & drug design.

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells.

P. Zou, G. Liang, Lingfeng Chen, 2016, Cancer letters.

Novel fabrication of marizomib-loaded chitosan-coated hydroxyapatite nanocarriers as a promising system for effective treatment of ovarian cancer

Lingfeng Chen, Mei-Xiang Liao, Jia Xu, 2022, Materials Research Express.

Inhibition of SHP2 by the Small Molecule Drug SHP099 Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice

Shuhui Ye, Lingfeng Chen, Yue Wu, 2023, Inflammation.

Myeloid Differentiation Primary Response Protein 88 (MyD88): the central hub of TLR/IL-1R signaling.

G. Liang, Lingfeng Chen, Lulu Zheng, 2020, Journal of medicinal chemistry.

Recent progress in the discovery of myeloid differentiation 2 (MD2) modulators for inflammatory diseases.

G. Liang, Weitao Fu, Lingfeng Chen, 2018, Drug discovery today.

Ang II (Angiotensin II)–Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury

Xiaokun Li, X. Guan, Lingfeng Chen, 2022, Hypertension.

Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers

Gaozhi Chen, G. Liang, Lingfeng Chen, 2020, Frontiers in Pharmacology.

Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer.

Guang Liang, Weitao Fu, G. Liang, 2017, Journal of medicinal chemistry.

Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC.

Jian Ding, Lin-jiang Tong, G. Liang, 2017, European journal of medicinal chemistry.

Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation

H. Erdjument-Bromage, M. Mohammadi, Yingkai Zhang, 2020, Nature Chemical Biology.

Fibroblast growth factor receptor fusions in cancer: opportunities and challenges

Yanmei Zhang, Xiaokun Li, Lingfeng Chen, 2021, Journal of experimental & clinical cancer research : CR.

Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats.

Bin Zhou, G. Liang, Lingfeng Chen, 2016, European journal of medicinal chemistry.

Discovery of a Novel Fusarium Graminearum Mitogen-Activated Protein Kinase (FgGpmk1) Inhibitor for the Treatment of Fusarium Head Blight.

Tingjun Hou, Lei Xu, Ercheng Wang, 2021, Journal of medicinal chemistry.

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation

Gaojun Wu, Lingfeng Chen, Yi Wang, 2022, Advanced science.

Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment.

Weitao Fu, Lingfeng Chen, Zhengyu Jiang, 2023, European journal of medicinal chemistry.

Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Gaozhi Chen, Lingfeng Chen, Lina Yin, 2023, Frontiers in Pharmacology.

Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer.

Weitao Fu, Lingfeng Chen, Lulu Zheng, 2023, Journal of medicinal chemistry.

Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation

G. Liang, Yuchen Jiang, Lingfeng Chen, 2022, Molecules.

Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway

Lingfeng Chen, Lina Yin, Xiangwei Xu, 2023, Frontiers in Pharmacology.

Structural basis for FGF hormone signalling

M. Mohammadi, Xiaokun Li, Gaozhi Chen, 2023, Nature.

Crystal structure of (2E,6E)-2,6-bis[2-(trifluoromethyl)benzylidene]cyclohexanone, C22H16F6O

Lingfeng Chen, Guang Liang, K. Pan, 2015 .

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.

P. Zou, J. Ji, Gaozhi Chen, 2016, Cancer letters.