A. M. Kawasaki

发表

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.

P. D. Cook, E. Lesnik, S. Freier, 1993, Journal of medicinal chemistry.

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

P. D. Cook, E. Lesnik, S. Freier, 1993, The Journal of biological chemistry.

2'-O-[2-(amino)-2-oxoethyl] oligonucleotides.

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2003, Organic letters.

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2000, Organic letters.

Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl (2′-O-AOE) modified oligonucleotides

P. D. Cook, M. Manoharan, A. M. Kawasaki, 1999 .

Aminooxy functionalized oligonucleotides: preparation, on-support derivatization, and postsynthetic attachment to polymer support.

M. Manoharan, A. M. Kawasaki, H. Hakala, 1999, Bioconjugate chemistry.

New Twists on Nucleic Acids: Structural Properties of Modified Nucleosides Incorporated into Oligonucleotides

P. D. Cook, R. Griffey, E. Lesnik, 1994 .

Zwitterionic oligonucleotides with 2′-O-[3-(N,N-dimethylamino)propyl]-RNA modification: synthesis and properties

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2000 .

Carbohydrate Modifications in Antisense Oligonucleotide Therapy: New Kids on the Block

P. D. Cook, M. Manoharan, A. M. Kawasaki, 1999 .

2′-DMAOE RNA: Emerging Oligonucleotides with Promising Antisense Properties

P. D. Cook, M. Manoharan, A. M. Kawasaki, 1999 .

Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides.

M. Manoharan, B. Monia, A. M. Kawasaki, 2008, Journal of medicinal chemistry.

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes.

P. D. Cook, E. Lesnik, D. Ecker, 1993, Biochemistry.

Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.

M. Manoharan, A. M. Kawasaki, T. P. Prakash, 2002, The Journal of organic chemistry.

Synthesis of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: hybridization affinity, resistance to nuclease, and protein binding characteristics

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2003 .

An efficient method for the synthesis of 2′-O-modified nucleosides via double alkylation using cyclic sulfates

M. Manoharan, M. Jung, A. M. Kawasaki, 2000 .

Purine based combinatorial chemistry: solution phase simultaneous addition of functionalities. Iterative deconvolution by orthogonal protection to a single compound with potent antibacterial activity.

P. D. Cook, A. M. Kawasaki, A. Fraser, 1999, Nucleosides & nucleotides.

2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.

E. Lesnik, M. Manoharan, M. Teplova, 2002, Biochemistry.

Zwitterionic Oligonucleotides with 2′-O-[3-(N,N-Dimethylamino)propyl]-RNA Modification: Synthesis and Properties.

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2000 .

2′‐O‐{2‐[N,N‐(Dialkyl)aminooxy]ethyl}‐Modified Antisense Oligonucleotides.

E. Lesnik, M. Manoharan, A. M. Kawasaki, 2001 .