L. Cummins

发表

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.

P. D. Cook, E. Lesnik, S. Freier, 1993, Journal of medicinal chemistry.

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides.

P. D. Cook, R. Griffey, E. Lesnik, 1996, Journal of medicinal chemistry.

The Ibis T5000 Universal Biosensor: An Automated Platform for Pathogen Identification and Strain Typing

D. Ecker, R. Sampath, B. Libby, 2006 .

Characterization of Oligonucleotide MetabolismIn Vivovia Liquid Chromatography/Electrospray Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer

R. Griffey, L. Cummins, H. Gaus, 1997 .

Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras*

B. Monia, L. Cummins, H. Sasmor, 1996, The Journal of Biological Chemistry.

Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes

R. Griffey, L. Cummins, H. Gaus, 1995 .

PHOSPHOROTHIOATE OLIGONUCLEOTIDE METABOLISM: CHARACTERIZATION OF THE “N+”-MER BY CE AND HPLC-ES/MS

L. Cummins, H. Gaus, M. Winniman, 1997 .

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer.

R. Griffey, L. Cummins, H. Gaus, 1997, Journal of mass spectrometry : JMS.

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.

P. D. Cook, S. Freier, M. Zounes, 1993, Nucleic acids research.

Remarkable Enhancement of Binding Affinity of Heterocycle-Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine Modified Oligonucleotides.

P. D. Cook, R. Griffey, E. Lesnik, 1994 .

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes.

P. D. Cook, E. Lesnik, D. Ecker, 1993, Biochemistry.

Solution Phase Combinatorial Chemistry. Discovery of Novel Polyazapyridinophanes with Potent Antibacterial Activity by a Solution Phase Simultaneous Addition of Functionalities Approach

P. D. Cook, R. Griffey, J. Wyatt, 1997 .

Rapid deconvolution of combinatorial libraries using HPLC fractionation

P. D. Cook, R. Griffey, L. Cummins, 1998 .

Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis.

P. D. Cook, P. Kung, D. Brooks, 1998, Biotechnology and bioengineering.

TIGER: the universal biosensor

David J. Ecker, Rangarajan Sampath, Kristin A. Sannes-Lowery, 2005 .

Glutathione-mediated detoxification systems in plants.

R. Edwards, D. Dixon, L. Cummins, 1998, Current opinion in plant biology.

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity.

P. D. Cook, E. Lesnik, S. Freier, 1995, Nucleic acids research.

Synthesis, Biophysical and Biological Evaluations of Novel Antisense Oligonucleosides Containing Dephosphono-Internucleosidic Linkages

P. D. Cook, R. Griffey, S. Freier, 1995 .

Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications.

E. Lesnik, N. Dean, M. Graham, 1996, Nucleic acids research.

Chemical and Biochemical Studies with Dithioate DNA

M. Caruthers, P. Shankland, L. Cummins, 1991 .

Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-α Expression*

L. Miraglia, N. Dean, L. Cummins, 1999, The Journal of Biological Chemistry.

High throughput drug discovery with ESI-FTICR

L. Cummins, J. Drader, S. Hofstadler, 2004 .

Biochemical and physicochemical properties of phosphorodithioate DNA.

M. Caruthers, L. Cummins, G. Beaton, 1996, Biochemistry.

Remarkable enhancement of binding affinity of Heterocycle-modified DNA to DNA and RNA. Synthesis, characterization and biophysical evaluation of N2-imidazolylpropylguanine and N2-imidazolylpropyl-2-aminoadenine modified oligonucleotides

P. D. Cook, R. Griffey, E. Lesnik, 1994 .

Enhanced Diagnostic Yields of Bacteremia and Candidemia in Blood Specimens by PCR-Electrospray Ionization Mass Spectrometry

D. Ecker, R. Sampath, C. Stratton, 2013, Journal of Clinical Microbiology.

Rapid Diagnosis of Bloodstream Infections with PCR Followed by Mass Spectrometry

D. Ecker, R. Sampath, L. Blyn, 2013, PloS one.

Multitarget affinity/specificity screening of natural products: finding and characterizing high-affinity ligands from complex mixtures by using high-performance mass spectrometry.

R. Griffey, L. Blyn, L. Cummins, 2003, Journal of natural products.

Molecular Characterization of Drug-Resistant Mycobacterium tuberculosis Isolates Circulating in China by Multilocus PCR and Electrospray Ionization Mass Spectrometry

D. Ecker, R. Sampath, L. Blyn, 2011, Journal of Clinical Microbiology.

Quantitation of phosphorothioate oligonucleotides in human plasma.

M. Graham, J. Leeds, L. Cummins, 1996, Analytical biochemistry.

On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites.

L. Cummins, H. Gaus, S. Owens, 1997, Analytical chemistry.

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.

M. Zounes, L. Cummins, Y. Sanghvi, 1993, Nucleic acids research.