G. Conn

发表

Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes.

A. Lane, T. Brown, J. I. Gyi, 1996, Biochemistry.

Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

S. Munger, S. Vigues, G. Conn, 2006, Chemical senses.

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

Ian Mitchelle S. de Vera, D. Kojetin, E. Ortlund, 2014, Nature Communications.

Critical residues in the aminoglycoside-resistance 16S rRNA (m7G1405) methyltransferase RmtC play distinct roles in 30S substrate recognition

S. Stagg, C. Dunham, G. Conn, 2019, bioRxiv.

Substrate Recognition and Modification by a Pathogen-Associated Aminoglycoside Resistance 16S rRNA Methyltransferase

G. Conn, Kellie Vinal, 2017, Antimicrobial Agents and Chemotherapy.

Raman and Raman optical activity (ROA) analysis of RNA structural motifs

E. Blanch, A. Hobro, G. Conn, 2008 .

Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES

E. Blanch, A. Hobro, G. Conn, 2007, Nucleic acids research.

Functional roles inS‐adenosyl‐l‐methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase

G. Conn, E. Kuiper, J. Honek, 2015, FEBS letters.

A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis*

G. Conn, E. Kuiper, M. Witek, 2016, The Journal of Biological Chemistry.

Use of a Grant Writing Class in Training PhD Students

A. Corbett, G. Pavlath, G. Conn, 2016, Traffic.

Substrate recognition by the Pseudomonas aeruginosa EF-Tu methyltransferase EftM

J. Goldberg, G. Conn, Debayan Dey, 2019 .

Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation

J. Goldberg, D. Duong, G. Conn, 2019, Scientific Reports.

A novel RNA molecular signature for activation of 2′-5′ oligoadenylate synthetase-1

G. Conn, Virginia K Vachon, Brenda M. Calderon, 2014, Nucleic acids research.

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS

S. Schwartz, Jie Jiang, S. Asress, 2022, bioRxiv.

RNA structure

D. Draper, G. Conn, 1977, Quarterly Reviews of Biophysics.

Systematic Deletion of the Adenovirus-associated RNAI Terminal Stem Reveals a Surprisingly Active RNA Inhibitor of Double-stranded RNA-activated Protein Kinase*

A. Wahid, G. Conn, Veronica K. Coventry, 2008, Journal of Biological Chemistry.

Analysis of adenovirus VA RNAI structure and stability using compensatory base pair modifications

G. Conn, Veronica K. Coventry, 2008, Nucleic acids research.

Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs

Anice C. Lowen, S. Schwartz, G. Conn, 2022, Proceedings of the National Academy of Sciences.

The solution structure of a DNA·RNA duplex containing 5-propynyl U and C; comparison with 5-Me modiﬁcations

A. Lane, D. Gao, J. Trent, 2022 .

Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases

G. Conn, J. Jackman, Sarah E. Strassler, 2022, The Journal of biological chemistry.

Identification of new inhibitors of protein kinase R guided by statistical modeling.

J. Griffin, C. Nathan, E. Anderson, 2011, Bioorganic & medicinal chemistry letters.

Recombinant RNA expression

C. Dunham, G. Conn, 2007, Nature Methods.

Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.

A. Lane, T. Brown, J. I. Gyi, 1998, Biochemistry.

Distinct Contributions of T1R2 and T1R3 Taste Receptor Subunits to the Detection of Sweet Stimuli

S. Munger, S. Vigues, G. Conn, 2005, Current Biology.

Application of Isothermal Titration Calorimetry (ITC) to Biomolecular Interactions

G. Conn, 2019, Biomolecular and Bioanalytical Techniques.

Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency

H. Kanegane, C. Klein, T. Morio, 2021, Science Immunology.

tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

Hyejeong Kim, G. Conn, J. Jackman, 2023, The Journal of biological chemistry.

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Ha An Nguyen, C. Dunham, G. Conn, 2021, bioRxiv.

The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications.

A. Lane, D. Gao, J. Trent, 2003, Nucleic acids research.

Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs

Anice C. Lowen, S. Schwartz, G. Conn, 2020, Nucleic acids research.

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase

S. Schwartz, G. Conn, 2019, Wiley interdisciplinary reviews. RNA.

Adenovirus VA RNA: An essential pro-viral non-coding RNA.

G. Conn, Virginia K Vachon, 2016, Virus research.

Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2

Andrew N. Lane, Graeme L. Conn, Tom Brown, 1997, Nucleic Acids Res..

Crystal structure of a conserved ribosomal protein-RNA complex.

E. Lattman, D. Draper, A. Gittis, 1999, Science.

Substrate recognition by the Pseudomonas aeruginosa EF-Tu–modifying methyltransferase EftM

J. Goldberg, G. Conn, Samantha M. Prezioso, 2019, The Journal of Biological Chemistry.

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

S. Stagg, C. Dunham, G. Conn, 2019, The Journal of Biological Chemistry.

Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization

G. Conn, M. Witek, 2015, Nucleic acids research.

A compact RNA tertiary structure contains a buried backbone-K+ complex.

Eaton E Lattman, David E Draper, E. Lattman, 2002, Journal of molecular biology.

Optimization of a ribosomal structural domain by natural selection.

D. Draper, G. Conn, C. Maeder, 2006, Biochemistry.

Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity

G. Conn, L. Kavanaugh, D. Dey, 2020, Antimicrobial Agents and Chemotherapy.

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast

A. van Hoof, A. Corbett, K. Mills-Lujan, 2016, Genetics.

General plasmids for producing RNA in vitro transcripts with homogeneous ends.

G. Conn, J. Avis, S. Walker, 2003, Nucleic acids research.

Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development

Graeme L. Conn, Suryanarayanarao Ramakumar, Debayan Dey, 2021, J. Chem. Inf. Model..

Targeted redesign of suramin analogs for novel antimicrobial lead development

S. Ramakumar, G. Conn, D. Dey, 2021, bioRxiv.

The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution.

G. Leonard, T. Brown, G. Conn, 1999, Nucleic acids research.

The dependence of DNase I activity on the conformation of oligodeoxynucleotides.

A. Lane, T. Brown, G. Conn, 1997, The Biochemical journal.

General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE.

G. Conn, Jo L Linpinsel, 2012, Methods in molecular biology.

Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation.

G. Conn, W. Wuest, D. Dey, 2023, RSC medicinal chemistry.

Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR

G. Conn, Brenda M. Calderon, 2017, RNA.

30S Subunit-Dependent Activation of the Sorangium cellulosum So ce56 Aminoglycoside Resistance-Conferring 16S rRNA Methyltransferase Kmr

Pooja M. Desai, M. Savic, S. Sunita, 2015, Antimicrobial Agents and Chemotherapy.

Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics

M. Savic, J. Lovrić, B. Vasiljević, 2009, Nucleic acids research.

Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site

B. Vasiljević, G. Conn, I. Moric, 2008, Research in microbiology.

NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element.

V. Ramesh, G. Conn, M. Phelan, 2004, Nucleic acids research.

Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain.

K. Hall, L. Pollack, M. Dunstan, 2019, Journal of molecular biology.

Recombinant and In Vitro RNA Synthesis

G. Conn, 2012, Methods in Molecular Biology.

Magnesium-dependent interaction of PKR with adenovirus VAI.

A. Wahid, J. Cole, G. Conn, 2010, Journal of molecular biology.

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

N. Jacobs, Anice C. Lowen, J. Steel, 2019, bioRxiv.

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

S. Schwartz, Jie Jiang, L. Van Den Bosch, 2023, eLife.

Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance

G. Conn, Zane T Laughlin, 2022, Frontiers in Microbiology.

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC

C. Dunham, G. Conn, M. Nosrati, 2023, bioRxiv.

Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G

G. Belsham, G. Conn, M. Robertson, 2003, Journal of Virology.

A human cellular noncoding RNA activates the antiviral protein 2′–5′-oligoadenylate synthetase 1

G. Conn, Brenda M. Calderon, 2018, The Journal of Biological Chemistry.

The PKR-binding domain of adenovirus VA RNAI exists as a mixture of two functionally non-equivalent structures

A. Wahid, G. Conn, Veronica K. Coventry, 2009, Nucleic acids research.

Dissection of the Adenoviral VA RNAI Central Domain Structure Reveals Minimum Requirements for RNA-mediated Inhibition of PKR*

S. Schwartz, S. Sunita, G. Conn, 2014, The Journal of Biological Chemistry.

Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix.

S. Munger, E. Blanch, G. Conn, 2011, Chemical senses.

Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

G. Conn, A. Mahoney, W. Wuest, 2023, bioRxiv.

A functional ribosomal RNA tertiary structure involves a base triple interaction.

R. Gutell, D. Draper, G. Conn, 1998, Biochemistry.

Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton Resistance Methyltransferase (Tsr)*

G. Conn, E. Kuiper, 2014, The Journal of Biological Chemistry.

Structure of the Thiostrepton Resistance Methyltransferase·S-Adenosyl-l-methionine Complex and Its Interaction with Ribosomal RNA*

Graeme L. Conn, Mark S. Dunstan, M. Dunstan, 2009, The Journal of Biological Chemistry.

Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes.

A. Lane, T. Brown, G. Conn, 1997, Biophysical journal.

The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids

Tom Brown, Jeffrey I. Gyi, Andrew N. Lane, 1998, Nucleic Acids Res..

Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR.

A. Lane, T. Brown, M. Conte, 1996, Nucleic acids research.

Structural and thermodynamic studies of RNA

Graeme Leslie Conn, G. Conn, 1996 .

The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs*

S. Schwartz, S. Sunita, G. Conn, 2015, The Journal of Biological Chemistry.

RNA Tertiary Structure and Protein Recognition in an L11-RNA Complex

E. Lattman, D. Draper, A. Gittis, 2000 .

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase*

N. Seyfried, J. Goldberg, D. Duong, 2015, The Journal of Biological Chemistry.

Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA

Pooja M. Desai, C. Dunham, J. Dunkle, 2014, Proceedings of the National Academy of Sciences.

tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

Hyejeong Kim, G. Conn, J. Jackman, 2023, bioRxiv.

Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments.

G. Conn, Virginia K Vachon, 2012, Methods in molecular biology.

Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

G. Conn, A. Mahoney, W. Wuest, 2023, bioRxiv.

Expansion of the aminoglycoside-resistance 16S rRNA (m(1)A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin.

G. Conn, M. Witek, 2014, Biochimica et biophysica acta.

Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR.

G. Conn, Brenda M. Calderon, 2017, RNA.

Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG

G. Conn, R. C. Picão, N. Zelinskaya, 2015, Antimicrobial Agents and Chemotherapy.

58nt RNA L11-binding domain from E. coli 23S rRNA

S. Pabit, G. Conn, Kathleen B. Hall, 2020 .

Dissection of the Adenoviral VA RNAI Central Domain Structure Reveals Minimum Requirements for RNA-mediated Inhibition of PKR*

S. Schwartz, S. Sunita, G. Conn, 2014, The Journal of Biological Chemistry.

Editorial: Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective

C. Davies, G. Conn, Vassiliy N. Bavro, 2019, Front. Mol. Biosci..

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.

Critical Residues for Cofactor Binding and Catalytic Activity in the Aminoglycoside Resistance Methyltransferase Sgm

M. Savic, B. Vasiljević, G. Conn, 2008, Journal of bacteriology.