T. Koch

发表

Silencing of microRNA families by seed-targeting tiny LNAs

J. Stenvang, G. Hannon, S. Kauppinen, 2011, Nature Genetics.

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells

H. Soifer, J. Rossi, Zhigang Wang, 2015, Nucleic acids research.

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

C. Wahlestedt, Zicai Liang, M. Westergaard, 2005, Nucleic acids research.

Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target

R. Pieters, W. Evans, M. D. Den Boer, 2012, Leukemia.

Managing the sequence-specificity of antisense oligonucleotides in drug discovery

Troels Koch, Morten Lindow, M. Lindow, 2017, Nucleic acids research.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

M. Lindholm, H. Ørum, E. Straarup, 2010, Nucleic acids research.

Locked nucleic acid: modality, diversity, and drug discovery.

R. Persson, H. Hansen, T. Koch, 2018, Drug discovery today.

Effect of LNA Modifications on Small Molecule Binding to Nucleic Acids

B. Armitage, H. Hansen, T. Koch, 2004, Journal of biomolecular structure & dynamics.

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells.

C. Stein, D. Castanotto, T. Koch, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Silencing of gene expression by gymnotic delivery of antisense oligonucleotides.

H. Soifer, C. Stein, T. Koch, 2012, Methods in molecular biology.

LNA guanine and 2,6-diaminopurine. Synthesis, characterization and hybridization properties of LNA 2,6-diaminopurine containing oligonucleotides.

S. Larsen, D. S. Pedersen, S. Arent, 2004, Bioorganic & medicinal chemistry.

Synthesis and antiviral evaluation of novel conformationally locked nucleosides and masked 5′-phosphate derivatives thereof

J. Wengel, P. Nielsen, T. Koch, 2002 .

SPC3042: a proapoptotic survivin inhibitor

M. Westergaard, H. Ørum, H. Hansen, 2008, Molecular Cancer Therapeutics.

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides

Brian R. Anderson, A. Cacace, J. Thompson, 2020, Molecular therapy. Nucleic acids.

On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti‐H‐Ras Antisense Oligonucleotide

F. Baas, K. Fluiter, H. Ørum, 2005, Chembiochem : a European journal of chemical biology.

Synthesis of 2'-amino-LNA: a new strategy.

J. Wengel, D. S. Pedersen, T. Koch, 2003, Organic & biomolecular chemistry.

Synthesis of 2′-Amino-LNA Purine Nucleosides

T. Koch, Christoph Rosenbohm, Jacob Ravn, 2006, Nucleosides, nucleotides & nucleic acids.

Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

M. Andersen, T. Koch, P. Hagedorn, 2019, Molecular therapy. Nucleic acids.

Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.

R. Versteeg, H. Caron, J. Koster, 2011, Endocrine-related cancer.

In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations

H. Bohr, H. Hansen, T. Koch, 2021, Scientific Reports.

Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides

T. Koch, H. Pendergraff, J. Vikeså, 2020, Nucleic acid therapeutics.

Detection of the factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids.

J. Vuust, M. Jakobsen, H. Ørum, 1999, Clinical chemistry.

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

H. Soifer, C. Stein, L. Benimetskaya, 2009, Nucleic acids research.

Electronic Structures of LNA Phosphorothioate Oligonucleotides

H. Bohr, C. Stein, H. Ørum, 2017, Molecular therapy. Nucleic acids.

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

H. Hansen, T. Koch, M. Frieden, 2003, Nucleosides, nucleotides & nucleic acids.

Peptide nucleic acid-anthraquinone conjugates: strand invasion and photoinduced cleavage of duplex DNA.

B. Armitage, T. Koch, H. Orum, 1997, Nucleic acids research.

Synthesis and Biological Evaluation of LNA Phosphoramidates

T. Koch, J. Hansen, Christoph Rosenbohm, 2008, Nucleosides, nucleotides & nucleic acids.

Synthesis and Antiviral Evaluation of Novel Conformationally Locked Nucleosides and Masked 5′-Phosphate Derivatives Thereof.

J. Wengel, P. Nielsen, T. Koch, 2002 .

Enzymatic reaction with unnatural substrates: DNA photolyase (Escherichia coli) recognizes and reverses thymine [2+2] dimers in the DNA strand of a DNA/PNA hybrid duplex.

D. Ramaiah, T. Koch, H. Orum, 1998, Proceedings of the National Academy of Sciences of the United States of America.

PNA synthesis using a novel Boc/acyl protecting group strategy

H. Ørum, H. Hansen, T. Koch, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions.

J. Wengel, V. Rajwanshi, T. Koch, 2001, The Biochemical journal.

Long Range Electron Transfer in PNA/DNA Duplexes

B. Armitage, H. Ørum, H. Hansen, 1999 .

Chapter 5:Locked Nucleic Acid: Properties and Therapeutic Aspects

S. Kauppinen, E. Straarup, H. Hansen, 2008 .

Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

K. Bleicher, J. Wengel, T. Koch, 2022, Molecular therapy. Nucleic acids.

Chemistry of Locked Nucleic Acids (LNA)

J. Wengel, T. Koch, M. Frieden, 2006 .

Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

J. Wengel, T. Koch, M. Frieden, 2003, Letters in Peptide Science.

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

M. Westergaard, H. Ørum, H. Hansen, 2003, Nucleic acids research.

New Standards in LNA Synthesis

H. Hansen, T. Koch, O. Olsen, 2003, Nucleosides, nucleotides & nucleic acids.

Improved Synthesis of 2′-Amino-LNA

J. Wengel, T. Koch, Christoph Rosenbohm, 2003, Nucleosides, nucleotides & nucleic acids.

Locked nucleic acids: a family of high affinity nucleic acid probes

T. Koch, 2003 .

Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone.

B. Armitage, T. Koch, H. Orum, 1998, Nucleic acids research.

PHOTOCLEAVAGE OF DNA: IRRADIATION OF QUINONE‐CONTAINING REAGENTS CONVERTS SUPERCOILED TO LINEAR DNA

S. Sligar, J. D. Ropp, T. Koch, 1993, Photochemistry and photobiology.

Peptide Nucleic Acid

H. Ørum, T. Koch, C. Kessler, 1997 .

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

K. Bleicher, J. Wengel, H. Hansen, 2019, Nucleic acids research.

Quantum mechanical studies of DNA and LNA.

H. Bohr, M. Lindow, H. Ørum, 2014, Nucleic acid therapeutics.

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

M. Lindow, M. Meldgaard, T. Koch, 2013, Nucleic acid therapeutics.

Biological activity and biotechnological aspects of locked nucleic acids.

J. Kjems, K. E. Lundin, J. Wengel, 2013, Advances in genetics.

Solid‐Phase synthesis of peptide nucleic acids

R. H. Berg, M. Egholm, P. Nielsen, 1995, Journal of peptide science : an official publication of the European Peptide Society.

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Christopher B. Stanley, P. Nielsen, H. Ørum, 1995, BioTechniques.

Pitfalls in characterization of protein interactions using radioiodinated crosslinking reagents. Preparation and testing of a novel photochemical 125I-label transfer reagent.

O. Buchardt, T. Koch, U. Henriksen, 1994, Bioconjugate chemistry.

The oxidative cleavability of protein cross-linking reagents containing organoselenium bridges.

O. Buchardt, T. Koch, U. Henriksen, 1990, Bioconjugate chemistry.

Peptide nucleic acid-DNA duplexes: long range hole migration from an internally linked anthraquinone.

B. Armitage, T. Koch, H. Orum, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

J. Rossi, C. Stein, D. Castanotto, 2020, Molecular therapy. Nucleic acids.

Locked Nucleic Acids

Z. Størling, T. Koch, Zenia M. Størling, 2008 .

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

M. Lindholm, Joacim Elmén, R. Persson, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

PNA Synthesis by Boc Chemistry

T. Koch, 2005 .

The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance

W. Evans, M. D. Den Boer, R. Pieters, 2013, Haematologica.

Locked nucleic acid aptamers.

J. Barciszewski, V. Erdmann, J. Kurreck, 2009, Methods in molecular biology.

Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.

F. Baas, K. Fluiter, T. Koch, 2005, Oligonucleotides.

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

M. Lindow, M. Ebeling, H. Hansen, 2018, Nucleic acids research.

Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides

M. Lindow, T. Koch, P. Hagedorn, 2019, Molecular therapy. Nucleic acids.

Improvements in automated PNA synthesis using Boc/Z monomers.

H. Hansen, T. Koch, H. Orum, 2009, The journal of peptide research : official journal of the American Peptide Society.

Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides.

Lykke Pedersen, Peter H Hagedorn, Troels Koch, 2019, Methods in molecular biology.

Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.

D. Ramaiah, T. Koch, H. Orum, 1998, Nucleic acids research.

Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands.

T. Koch, Christoph Rosenbohm, Jacob Ravn, 2007, Bioorganic & medicinal chemistry.

Photolabeling Reagent Design

P. Nielsen, O. Buchardt, T. Koch, 1989 .

Refining LNA safety profile by controlling phosphorothioate stereochemistry

T. Koch, A. Moisan, Nanna Albæk, 2020, PloS one.

Locked nucleic acid: modality, diversity, and drug discovery.

R. Persson, H. Hansen, T. Koch, 2018, Drug discovery today.

Apr 27, 2019 Locked nucleic acid: modality, diversity,

R. Persson, H. Hansen, T. Koch, 2018 .

Hairpin-forming peptide nucleic acid oligomers.

B. Armitage, T. Koch, H. Orum, 1998, Biochemistry.

SPC3042: a proapoptotic survivin inhibitor

M. Westergaard, H. Ørum, H. Hansen, 2008, Molecular Cancer Therapeutics.

Locked nucleic acid synthesis.

J. Wengel, C. Lomholt, T. Koch, 2005, Methods in molecular biology.