Natasha Thorne

发表

Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology.

D. Auld, James Inglese, Natasha Thorne, 2010, Chemistry & biology.

Phenotypic screens as a renewed approach for drug discovery.

Wei Zheng, John C McKew, Natasha Thorne, 2013, Drug discovery today.

A specific mechanism for nonspecific activation in reporter-gene assays.

James Inglese, Dac-Trung Nguyen, Natasha Thorne, 2008, ACS chemical biology.

Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

James Inglese, Natasha Thorne, D. Auld, 2010, Current opinion in chemical biology.

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

Anton Simeonov, James Inglese, Robert P Hanzlik, 2010, Proceedings of the National Academy of Sciences.

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Anton Simeonov, James Inglese, Natasha Thorne, 2012, Chemistry & biology.

High-Throughput Viability Assay Using an Autonomously Bioluminescent Cell Line with a Bacterial Lux Reporter

Noel Southall, Wei Zheng, John C McKew, 2015, Journal of laboratory automation.

Understanding Enzymes as Reporters or Targets in Assays Using Quantitative High-throughput Screening (qHTS)

Noel Southall, D. Auld, James Inglese, 2010 .

Molecular Sensors for Transcriptional and Post-Transcriptional Assays

D. Auld, H. Fu, Natasha Thorne, 2011 .

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

A. Wang, Wei Zheng, N. Longo, 2019, Pharmacology research & perspectives.

ML309: A potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells

Mindy I. Davis, S. Gross, L. Dang, 2013 .

Reply to Peltz et al: Post-translational stabilization of the firefly luciferase reporter by PTC124 (Ataluren)

D. Auld, James Inglese, Natasha Thorne, 2009, Proceedings of the National Academy of Sciences.

A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation

Mindy I. Davis, L. Cantley, A. Simeonov, 2013, PloS one.

Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism

Catherine Z. Chen, Wei Zheng, G. Tawa, 2018, British journal of pharmacology.

A robotic platform for quantitative high-throughput screening.

Sam Michael, Christopher P Austin, Anton Simeonov, 2008, Assay and drug development technologies.

The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins

H. Amrein, Dushyant Mishra, Natasha Thorne, 2018, PLoS biology.

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

D. Auld, James Inglese, Natasha Thorne, 2009, Proceedings of the National Academy of Sciences.

The Drosophila gustatory receptor genes: The molecular basis of taste perception and coding

Natasha Thorne, 2007 .

Gustatory Perception and Behavior in Drosophila melanogaster

H. Amrein, Natasha Thorne, 2005, Current Biology.

Taste Perception and Coding in Drosophila

H. Amrein, Natasha Thorne, Steve Bray, 2004, Current Biology.

Targeting Wolman Disease and Cholesteryl Ester Storage Disease: Disease Pathogenesis and Therapeutic Development

Wei Zheng, Natasha Thorne, Francis Aguisanda, 2017, Current chemical genomics and translational medicine.

Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

Catherine Z. Chen, Wei Zheng, Natasha Thorne, 2017, Orphanet Journal of Rare Diseases.

Astrocytes as targets for drug discovery

Wei Zheng, Natasha Thorne, Francis Aguisanda, 2018, Drug discovery today.

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1*

Mindy I. Davis, S. Gross, B. Delabarre, 2014, The Journal of Biological Chemistry.

Mutant Isocitrate Dehydrogenase IDH 1 Characterization of a Potent Inhibitor of Biochemical , Cellular , and Biophysical Molecular Bases of Disease

S. Gross, B. Delabarre, L. Dang, 2014 .

Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons

H. Amrein, Natasha Thorne, 2008, The Journal of comparative neurology.

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

Sonia Shah, Noel Southall, M. Xia, 2016, Stem cells translational medicine.

Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum

Xin Hu, S. d'Auria, D. Auld, 2013, PloS one.

Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes

C. Austin, Wei Zheng, M. Swaroop, 2012, Journal of biomolecular screening.

Function and expression of the Drosophila gr genes in the perception of sweet, bitter and pheromone compounds.

H. Amrein, Natasha Thorne, Steve Bray, 2005, Chemical senses.

Vomeronasal Organ: Pheromone Recognition with a Twist

H. Amrein, Natasha Thorne, 2003, Current Biology.

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

D. Auld, James Inglese, Natasha Thorne, 2009, Proceedings of the National Academy of Sciences.

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

A. Simeonov, D. Auld, James Inglese, 2010, Proceedings of the National Academy of Sciences.

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

A. Simeonov, D. Auld, James Inglese, 2012, Chemistry & biology.