J. Andrés

发表

Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.

G. Bormans, X. Langlois, H. Lavreysen, 2012, Journal of medicinal chemistry.

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future.

D. Moechars, H. Kolb, Frederik J. R. Rombouts, 2015, Journal of medicinal chemistry.

What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2

Mark E. Schmidt, G. Bormans, X. Langlois, 2017, The Journal of Nuclear Medicine.

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011 .

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, ACS chemical neuroscience.

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, Sergio A Alonso de Diego, J. M. Alonso, 2012, Journal of medicinal chemistry.

Tau Positron Emission Tomography Imaging.

H. Kolb, J. Andrés, 2017, Cold Spring Harbor perspectives in biology.

triazolo [ 4 , 3 ‐ a ] pyrazines as Selective , Brain Penetrant Phosphodiesterase 2 ( PDE 2 ) Inhibitors

X. Langlois, M. Somers, G. Vanhoof, 2015 .

Negishi coupling reactions with [11C]CH3I: a versatile method for efficient 11C-C bond formation.

J. Llop, A. Arrieta, F. Cossío, 2018, Chemical communications.

Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.

Mark E. Schmidt, X. Langlois, J. M. Alonso, 2017, Journal of medicinal chemistry.

Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.

A. Megens, J. M. Alonso, J. Andrés, 2004, Chemical & pharmaceutical bulletin.

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

P. Bonaventure, N. Carruthers, Hong Ao, 2015, Bioorganic & medicinal chemistry letters.

Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

W. Vanduffel, G. Bormans, X. Langlois, 2016, The Journal of Nuclear Medicine.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2017, Journal of medicinal chemistry.

Biodistribution, dosimetry and kinetic modeling of [11C]JNJ-42491293, a PET tracer for the mGluR2 receptor in the human brain

Mark E. Schmidt, G. Bormans, X. Langlois, 2012 .

Recent advances in positron emission tomography (PET) radiotracers for imaging phosphodiesterases.

G. Bormans, S. Celen, J. Andrés, 2012, Current topics in medicinal chemistry.

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

M. Bakker, A. Megens, J. M. Alonso, 2005, Journal of medicinal chemistry.

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.

M. Bakker, A. Megens, R. Álvarez, 2004, Bioorganic & medicinal chemistry letters.

Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.

Julen Oyarzabal, Trevor Howe, I. van der Linden, 2009, Journal of medicinal chemistry.

Synthesis of 8-methyl-2-azainosine and related nucleosides

J. Andrés, R. Herranz, M. Lopez, 1984 .

Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery

J. Andrés, J. Alcázar, K. V. Emelen, 2003 .

Synthesis and biological evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of PDE10A.

G. Bormans, X. Langlois, K. Van Laere, 2014, Nuclear medicine and biology.

2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.

T. Meert, J. M. Alonso, J. Andrés, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of 2-(β-D-Ribofuranosyl)Thiazole-4-Carboxamide 5′-Phosphate Isosteres

M. García-López, J. Andrés, F. Heras, 1986 .

4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists

T. Meert, J. M. Alonso, T. Steckler, 2006 .

4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists.

T. Meert, J. M. Alonso, T. Steckler, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

A. Megens, J. M. Alonso, D. Peeters, 2002, Bioorganic & medicinal chemistry letters.

Novel analogues of 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: modifications in the dioxane ring

J. Andrés, J. Alcázar, K. V. Emelen, 2003 .

Novel Analogues of 3-Substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines: Modifications in the Dioxane Ring.

J. Andrés, J. Alcázar, K. V. Emelen, 2004 .

Synthesis and Biological Evaluation of Imidazol‐2‐one and 2‐Cyanoiminoimidazole Derivatives: Novel Series of PDE4 Inhibitors.

J. Andrés, 2002 .

Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer.

R. Vandenberghe, G. Bormans, D. Moechars, 2019, Journal of medicinal chemistry.

The value of PET ligand discovery to CNS drug development.

J. Andrés, M. Schmidt, 2017, Future medicinal chemistry.

Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging

W. Vanduffel, R. Vandenberghe, G. Bormans, 2017, The Journal of Nuclear Medicine.

Medicinal Chemistry strategies for PET tracer discovery.

J. Andrés, M. Schmidt, 2017, Drug discovery today. Technologies.

Preclinical evaluation of [18F]JNJ42259152 as a PET tracer for PDE10A

Mark Schmidt, Koen Van Laere, Guy Bormans, 2013, NeuroImage.

Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.

X. Langlois, G. Vanhoof, P. Buijnsters, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.

G. Bormans, X. Langlois, G. Vanhoof, 2011, Journal of medicinal chemistry.

Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain

Koen Van Laere, Guy Bormans, Sofie Celen, 2010, The Journal of Nuclear Medicine.

Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement.

X. Langlois, G. Vanhoof, G. Tresadern, 2014, ACS medicinal chemistry letters.

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

A. Megens, J. M. Alonso, J. Andrés, 2005, Journal of medicinal chemistry.

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, A. Megens, G. Macdonald, 2012, Journal of medicinal chemistry.

Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities.

A. Megens, J. M. Alonso, J. Andrés, 2006, Bioorganic & medicinal chemistry.

Synthesis and structure–Activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 2

A. Megens, T. Meert, J. M. Alonso, 2002 .

Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors.

X. Langlois, G. Vanhoof, G. Tresadern, 2015, ACS medicinal chemistry letters.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2014, Journal of medicinal chemistry.

Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

A. Megens, X. Langlois, G. Macdonald, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.

M. Bakker, A. Megens, X. Langlois, 2007, Bioorganic & medicinal chemistry.

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.

M. Bakker, A. Megens, J. M. Alonso, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide.

Luis Carrasco, M. García-López, J. Andrés, 1985, Journal of Medicinal Chemistry.

Synthesis of ribonucleosides of 4(5)‐cyano‐5(4)‐methylimidazole and related 4‐substituted‐5‐methylimidazole ribosides

M. García-López, J. Andrés, 1986 .