J. Cid

发表

Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.

G. Bormans, X. Langlois, H. Lavreysen, 2012, Journal of medicinal chemistry.

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2

G. Tresadern, H. Lavreysen, J. Cid, 2015, British journal of pharmacology.

mGluR2 positive allosteric modulators: an updated patent review (2013–2018)

J. Cid, A. A. Trabanco, J. Bartolomé, 2019, Expert opinion on therapeutic patents.

QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators.

G. Tresadern, J. Cid, A. A. Trabanco, 2014, Journal of molecular graphics & modelling.

mGluR2 positive allosteric modulators: a patent review (2009 – present)

J. Cid, A. A. Trabanco, A. Trabanco, 2013, Expert opinion on therapeutic patents.

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011 .

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, ACS chemical neuroscience.

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, Sergio A Alonso de Diego, J. M. Alonso, 2012, Journal of medicinal chemistry.

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization

A. IJzerman, L. Heitman, M. Doornbos, 2018, Journal of medicinal chemistry.

Progress in the developement of positive allosteric modulators of the metabotropic glutamate receptor 2.

G. Macdonald, G. Tresadern, H. Lavreysen, 2011, Current medicinal chemistry.

Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.

A. Megens, J. M. Alonso, J. Andrés, 2004, Chemical & pharmaceutical bulletin.

Potassium iodide catalysed monoalkylation of anilines under microwave irradiation

J. Cid, A. A. Trabanco, J. L. Romera, 2004 .

Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).

María Lourdes Linares, G. Macdonald, M. Somers, 2016, Journal of medicinal chemistry.

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

M. Bakker, A. Megens, J. M. Alonso, 2005, Journal of medicinal chemistry.

Selective α-monoallylation of phenyl ketones and benzocycloalkanones under microwave irradiation

J. Cid, J. L. Romera, A. Trabanco, 2004 .

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.

M. Bakker, A. Megens, R. Álvarez, 2004, Bioorganic & medicinal chemistry letters.

Selective α-Monoallylation of Phenyl Ketones and Benzocycloalkanones under Microwave Irradiation.

J. Cid, J. L. Romera, A. Trabanco, 2004 .

Metabotropic Glutamate Receptor 2 Activators

H. Lavreysen, J. Cid, A. Trabanco, 2014 .

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

A. Megens, J. M. Alonso, J. Andrés, 2005, Journal of medicinal chemistry.

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, A. Megens, G. Macdonald, 2012, Journal of medicinal chemistry.

Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

María Lourdes Linares, G. Tresadern, H. Lavreysen, 2021, ACS omega.

Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men

Vikash K. Sinha, P. Boer, G. Macdonald, 2016, Neuropharmacology.

Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring.

A. Megens, J. M. Alonso, J. Cid, 2005, Il Farmaco.

Synthesis of 2‐N,N‐Dimethylaminomethyl‐2,3,3a,12b‐tetrahydrodibenzo[b,f]furo [2,3‐d]oxepine Derivatives as Potential Anxiolytic Agents. Part 2. Substitutions by Methyl Groups on the Tetrahydrofuran Ring.

A. Megens, J. M. Alonso, J. Cid, 2005 .

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs.

María Lourdes Linares, G. Tresadern, H. Lavreysen, 2019, ACS medicinal chemistry letters.

Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2.

A. IJzerman, T. Mulder-Krieger, L. Heitman, 2017, Journal of medicinal chemistry.

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

A. IJzerman, T. Mulder-Krieger, L. Heitman, 2016, British journal of pharmacology.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2014, Journal of medicinal chemistry.

Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

A. Megens, X. Langlois, G. Macdonald, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.

M. Bakker, A. Megens, X. Langlois, 2007, Bioorganic & medicinal chemistry.

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.

M. Bakker, A. Megens, J. M. Alonso, 2003, Bioorganic & medicinal chemistry letters.

mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats

G. Tresadern, H. Lavreysen, W. Drinkenburg, 2015, PloS one.

Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor.

A. Fontana, G. Tresadern, H. Lavreysen, 2018, ACS chemical neuroscience.

Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.

G. Bormans, X. Langlois, H. Lavreysen, 2012, Journal of medicinal chemistry.

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.