C. Beuckmann

发表

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Jon T. Willie, T. Sakurai, M. Yanagisawa, 2001, Neuron.

Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation

M. Yanagisawa, C. Beuckmann, 2002, Journal of Molecular Medicine.

Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase.

H. Toh, Y. Urade, O. Hayaishi, 1999, Biochemistry.

Lipocalin-Type Prostaglandin D Synthase (β-Trace) Is Located in Pigment Epithelial Cells of Rat Retina and Accumulates within Interphotoreceptor Matrix

W. Gordon, Y. Urade, O. Hayaishi, 1996, The Journal of Neuroscience.

Characterization of a major secretory protein in the cane toad (Bufo marinus) choroid plexus as an amphibian lipocalin-type prostaglandin D synthase.

Y. Urade, Tsuyoshi Inoue, C. Beuckmann, 2006, Journal of biochemistry.

Chapter 18: Development of an in vitro cell culture system to mimic the blood-brain barrier

Jörg Meyer, H. Galla, C. Beuckmann, 1992 .

Development of an in vitro cell culture system to mimic the blood-brain barrier.

H. Galla, C. Beuckmann, J. Rauh, 1992, Progress in brain research.

Nonclinical evaluation of abuse liability of the dual orexin receptor antagonist lemborexant.

D. Gauvin, S. Asakura, M. Moline, 2021, Regulatory toxicology and pharmacology : RTP.

Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids.

W. Gordon, Y. Urade, O. Hayaishi, 1998, Investigative ophthalmology & visual science.

Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist.

C. Beuckmann, Shunsuke Ozaki, K. Sorimachi, 2015, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists.

C. Beuckmann, I. Kushida, T. Terauchi, 2014, Bioorganic & medicinal chemistry.

Induction of the blood/brain-barrier-associated enzyme alkaline phosphatase in endothelial cells from cerebral capillaries is mediated via cAMP.

H. Galla, C. Beuckmann, S. Hellwig, 1995, European journal of biochemistry.

Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites

T. Ishida, S. Asakura, C. Beuckmann, 2020, Drug Metabolism and Disposition.

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

Takeshi Sakurai, Akihiro Yamanaka, Masashi Yanagisawa, 2003, Neuron.

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

W. Gordon, Y. Urade, O. Hayaishi, 1998, Journal of neurochemistry.

Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

R. Hammer, T. Sakurai, M. Yanagisawa, 2004 .

A new astrocytic cell line which is able to induce a blood-brain barrier property in cultured brain capillary endothelial cells

H. Galla, C. Beuckmann, A. Hakvoort, 1997, Cytotechnology.

Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro.

H. Galla, C. Beuckmann, H Franke, 2000, Brain research. Brain research protocols.

An improved low-permeability in vitro-model of the blood–brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol

Hans-Joachim Galla, H. Galla, C. Beuckmann, 1999, Brain Research.

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.

R. Hammer, M. Yanagisawa, J. Richardson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Orexin (Hypocretin) Neurons Contain Dynorphin

Jon T. Willie, C. Saper, Jun Lu, 2001, The Journal of Neuroscience.

In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

C. Beuckmann, H. Higashiyama, T. Arai, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Prostaglandin D Synthase (β-Trace) in Human Arachnoid and Meningioma Cells: Roles as a Cell Marker or in Cerebrospinal Fluid Absorption, Tumorigenesis, and Calcification Process

T. Yamashima, Y. Urade, O. Hayaishi, 1997, The Journal of Neuroscience.

N-Type Calcium Channel α1B Subunit (CaV2.2) Knock-Out Mice Display Hyperactivity and Vigilance State Differences

M. Yanagisawa, C. Sinton, C. Beuckmann, 2003, The Journal of Neuroscience.

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

Takeshi Sakurai, Christopher M. Sinton, Masashi Yanagisawa, 2004, The Journal of Neuroscience.

Perineuronal Oligodendrocytes Protect against Neuronal Apoptosis through the Production of Lipocalin-Type Prostaglandin D Synthase in a Genetic Demyelinating Model

Y. Urade, I. Mohri, M. Taniike, 2002, The Journal of Neuroscience.

Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer's Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant.

E. Musiek, Toshitaka Sato, M. Bando, 2021, Journal of Alzheimer's disease : JAD.

Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior

H. Ogura, C. Beuckmann, K. Shikata, 2005, Brain Research.

Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

C. Beuckmann, S. Akasofu, Michiyuki Suzuki, 2019, Sleep.

Identification of Mu-Class Glutathione Transferases M2-2 and M3-3 as Cytosolic Prostaglandin E Synthases in the Human Brain

Y. Urade, O. Hayaishi, K. Fujimori, 2000, Neurochemical Research.

Cellular localization of lipocalin‐type prostaglandin D synthase (β‐trace) in the central nervous system of the adult rat

T. Kaneko, N. Mizuno, S. Nomura, 2000, The Journal of comparative neurology.

Title Page Title In Vitro and In Silico Characterization of Lemborexant ( E 2006 ) , a Novel Dual Orexin Receptor Antagonist Authors

C. Beuckmann, H. Higashiyama, T. Arai, 2017 .

Introduction to the Blood–Brain Barrier: Tissue culture of brain endothelial cells – induction of blood–brain barrier properties by brain factors

C. Beuckmann, H. Franke, 1998 .

Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist.

C. Beuckmann, Shunsuke Ozaki, K. Sorimachi, 2015, Journal of medicinal chemistry.

A deep learning algorithm for sleep stage scoring in mice based on a multimodal network with fine-tuning technique

K. Aoshima, T. Yagi, C. Beuckmann, 2021, Neuroscience Research.