D. Lala

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Liver X receptors interact with corepressors to regulate gene expression.

X. Hu, Suzhen Li, Jun Wu, 2003, Molecular endocrinology.

Liver X Receptors

D. Lala, 2002 .

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.

K. Fan, R. Gregg, Suresh B. Singh, 2016, Bioorganic & medicinal chemistry letters.

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.

K. Fan, R. Gregg, Zhijie Liu, 2016, Journal of medicinal chemistry.

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.

Suresh B. Singh, B. McKeever, Andrew P. Marcus, 2016, Bioorganic & medicinal chemistry.

The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.

W. Shen, H. Ingraham, M. Nachtigal, 1994, Genes & development.

Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis: A randomized controlled trial.

Anders B. Dohlman, Avi Ma’ayan, R. Gregg, 2018, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Steroidogenic factor 1: an essential mediator of endocrine development.

N. Hanley, Liping Zhao, C. Frigeri, 2002, Recent progress in hormone research.

Steroidogenic factor 1 (SF-1) is essential for endocrine development and functionProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

K. Parker, Xunrong Luo, D. Lala, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells.

J. Richards, K. Parker, D. Lala, 1994, Endocrinology.

The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.

X. Hu, Suzhen Li, Chunsheng Xia, 2005, Molecular endocrinology.

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

D. Mangelsdorf, K. Parker, R. Heyman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The Human Medium Chain Acyl-CoA Dehydrogenase Gene Promoter Consists of a Complex Arrangement of Nuclear Receptor Response Elements and Sp1 Binding Sites (*)

D. Kelly, S. Cresci, D. Lala, 1995, The Journal of Biological Chemistry.

Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.

B. White, J. Peluso, J. Lynch, 1993, Molecular endocrinology.

An Activin Receptor-Like Kinase 5 Inhibitor Reduces Collagen Deposition in a Rat Dermal Incision Wound Healing Model

J. Render, D. Lala, D. Pocalyko, 2011, Plastic and reconstructive surgery.

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes.

H. Nar, B. Hamilton, D. Lala, 2015, European journal of pharmacology.

The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.

R. Heyman, D. Lala, H. Razzaghi, 2001, Molecular endocrinology.

First evidence of efficacy of an orally active RORγt inhibitor in the treatment of patients with moderate to severe plaque psoriasis

S. Palmer, R. Gregg, G. Tarrasón, 2016 .

Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys.

B. Hamilton, D. Lala, D. Claremon, 2016, European journal of pharmacology.

Activity of the CYP17 promoter in bovine adrenocortical cells before and after phenotypic switching

P. Hornsby, D. Lala, 1992, Molecular and Cellular Endocrinology.

Orphan Nuclear Receptors

R. Heyman, D. Lala, 2000 .

A modified procedure for replica plating of mammalian cells allowing selection of clones based on gene expression.

C. Cheng, P. Hornsby, Brian Salmons, 1992, BioTechniques.

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.

Suresh B. Singh, B. Hamilton, D. Lala, 2017, Bioorganic & medicinal chemistry.

The medicinal chemistry of liver X receptor (LXR) modulators.

K. Fan, Suresh B. Singh, D. Lala, 2014, Journal of medicinal chemistry.

The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor.

X. Hu, Suzhen Li, Jun Wu, 2002, Molecular endocrinology.

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.

K. Parker, D. Lala, D. Rice, 1992, Molecular endocrinology.

Changes in gene expression during senescence of adrenocortical cells in culture

P. Hornsby, D. Lala, Charles Y. Cheng, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.

M. Moisan, K. Parker, Xunrong Luo, 1993, Molecular endocrinology.

Demethylation of specific sites in the 5'-flanking region of the CYP17 genes when bovine adrenocortical cells are placed in culture.

P. Hornsby, D. Lala, F. S. Nallaseth, 1992, DNA and cell biology.

Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism

Suzhen Li, Chunsheng Xia, D. Lala, 2002 .

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

L. Dardashti, R. Evans, R. Heyman, 1996, Nature.

Pharmacological characterization of the new bace1 inhibitor bi 1181181

S. Venkatraman, S. Hobson, M. Bauer, 2015, Alzheimer's & Dementia.

Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

S. Hobson, M. Lenter, L. W. Dillard, 2015, Alzheimer's & Dementia.

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Mostofa A Hena, B. Finzel, R. Gilbertsen, 2012, Bioorganic & medicinal chemistry letters.

Recent Advances in Mineralocorticoid Receptor Antagonists

D. Lala, Yajun Zheng, K. Leftheris, 2011 .

Multiplexing Nuclear Receptors for Agonist Identification in a Cell-Based Reporter Gene High-Throughput Screen

C. Parker, D. Lala, B. Turner, 2003, Journal of biomolecular screening.

Repression of p65 transcriptional activation by the glucocorticoid receptor in the absence of receptor-coactivator interactions.

Jun Wu, D. Lala, Jessica D Dietz, 2004, Molecular endocrinology.

Discovery of Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Using a Novel Growth-Based Protocol of in Silico Screening and Optimization in CONTOUR

Yi Zhao, Robert Cain, Yajun Zheng, 2019, J. Chem. Inf. Model..

A cell-specific nuclear receptor regulates the steroid hydroxylases

K. Parker, Xunrong Luo, D. Lala, 1995, Steroids.

Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors

D. Lala, P. Noto, Y. Bukhtiyarov, 2012, Molecular Pharmacology.

Function of steroidogenic factor 1 (SF1) ligand-binding domain in gene activation and interaction with AP1.

D. Lala, L. Li, B. C. Chung, 1998, Biochemical and biophysical research communications.

Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.

Suzhen Li, Chunsheng Xia, D. Lala, 2002, Molecular endocrinology.

Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone.

X. Hu, Suzhen Li, D. Lala, 2005, Mini reviews in medicinal chemistry.

Orphan Nuclear Receptors

R. Heyman, D. Lala, 2000 .

A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.

K. Parker, D. Lala, J. Meade, 1995, Endocrine research.