P. Kuehl

发表

Respiratory Tract Deposition of HFA-Beclomethasone and HFA-Fluticasone in Asthmatic Patients.

J. McDonald, C. Leach, P. Kuehl, 2016, Journal of aerosol medicine and pulmonary drug delivery.

Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Claus-Michael Lehr, William Doub, Per Bäckman, 2016 .

Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications

Stuart Williams, Joseph M. DeSimone, Andres Garcia, 2012, Journal of drug delivery.

Formulation Development and In Vivo Evaluation of a New Dry Powder Formulation of Albuterol Sulphate in Beagle Dogs

Dan E. Dobry, J. McDonald, P. Kuehl, 2010, Pharmaceutical Research.

Formulation and in vivo evaluation of chlorpropham (CIPC) oral formulations.

S. Yalkowsky, Parijat Jain, P. Kuehl, 2008, Journal of pharmaceutical sciences.

Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products.

D. Bailey, J. Fleming, J. Conway, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Pharmacokinetic and pharmacodynamic modeling of gut hormone peptide YY(3–36) after pulmonary delivery

P. Kuehl, Jie Shao, G. Hochhaus, 2019, Drug development and industrial pharmacy.

Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products.

J. Fleming, O. Usmani, M. Dolovich, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Imaging Pulmonary Drug Delivery

P. Kuehl, 2011 .

Lung Deposition of Droplet Aerosols in Monkeys

Y. Cheng, C. Hobbs, Yung-sung Cheng, 2008 .

An ethanol solvate of Beclomethasone dipropionate

M. Carducci, P. Kuehl, P. Myrdal, 2003 .

Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.

Y. Tesfaigzi, Y. Mebratu, P. Kuehl, 2017, The Journal of allergy and clinical immunology.

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

William A. Lee, A. Gigliotti, R. Mackman, 2021, Science Translational Medicine.

AUG-3387, a Human-Derived Monoclonal Antibody Neutralizes SARS-CoV-2 Variants and Reduces Viral Load from Therapeutic Treatment of Hamsters In Vivo

Steven J. Henry, Christopher J. Emig, R. Williams, 2021, bioRxiv.

NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury.

J. Seagrave, J. McDonald, P. Kuehl, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Inhaled PYY(3–36) dry-powder formulation for appetite suppression

Dan E. Dobry, J. McDonald, M. Doyle-Eisele, 2016, Drug development and industrial pharmacy.

Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques

Andrew T. Russo, R. Baker, D. Hruby, 2018, The Journal of infectious diseases.

Characterization of respiratory deposition of fluticasone-salmeterol hydrofluoroalkane-134a and hydrofluoroalkane-134a beclomethasone in asthmatic patients.

J. McDonald, L. Ketai, J. Norenberg, 2012, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Lung deposition of droplet aerosols in monkeys.

Y. Cheng, C. Hobbs, P. Kuehl, 2008, Inhalation toxicology.

GS-424020 – A Novel Mutual Prodrug Of Salmeterol And Desisobutrylciclesonide Attenuates Acute Bronchoconstriction In The Absence Of Cardiovascular Side-Effects In Ragweed Sensitized And Naïve Dogs

P. Kuehl, K. Rudolph, M. Campen, 2010, ATS 2010.

Regional particle size dependent deposition of inhaled aerosols in rats and mice

J. Hoppin, J. McDonald, J. Norenberg, 2012, Inhalation toxicology.

Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats.

M. Corboz, Zhili Li, J. Brower, 2018, Pulmonary pharmacology & therapeutics.

Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets

J. McDonald, W. Dehaan, P. Kuehl, 2019, AAPS PharmSciTech.

iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes

B. Forbes, C. Ehrhardt, A. Hickey, 2022, Molecular pharmaceutics.

iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System

B. Forbes, C. Ehrhardt, A. Hickey, 2022, Molecular pharmaceutics.

Introduction: Aerosol delivery of orally inhaled agents.

T. Corcoran, P. Kuehl, S. Devadason, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Symposium Summary

K. Nikula, P. Kuehl, J. Tepper, 2016, International journal of toxicology.

Nasal Deposition of HFA-Beclomethasone, Aqueous Fluticasone Propionate and Aqueous Mometasone Furoate in Allergic Rhinitis Patients.

J. McDonald, C. Leach, P. Kuehl, 2015, Journal of aerosol medicine and pulmonary drug delivery.

Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection

M. Valderas, M. Reed, P. Kuehl, 2015, PloS one.

Safety, Tolerance and Pharmacokinetics of HFA-152a in Healthy Volunteers

C. Leach, P. Kuehl, S. Corr, 2022 .

Erratum to: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

W. Doub, M. Sakagami, C. Lehr, 2016 .

Use Behaviors, Dependence, and Nicotine Exposure Associated with Ad Libitum Cigar Smoking.

Juan C. Vivar, E. Claus, B. Moeller, 2018, Tobacco regulatory science.

Comparative effects of parent and heated cinnamaldehyde on the function of human iPSC-derived cardiac myocytes.

P. Lorkiewicz, J. McDonald, A. Bhatnagar, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products.

H. Chan, P. Kuehl, S. Devadason, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

E. Dora, P. Kuehl, S. Tucker, 2022, Science Translational Medicine.

The pharmacokinetics of ketamine following intramuscular injection to F344 rats.

J. McDonald, M. Doyle-Eisele, C. Garner, 2018, Drug testing and analysis.

Chiral separation of lipoxygenase metabolites utilizing high-performance liquid chromatography.

P. Kuehl, K. Karlage, P. Myrdal, 2006, Journal of chromatography. A.

Prophylaxis of Mycobacterium tuberculosis H37Rv Infection in a Preclinical Mouse Model via Inhalation of Nebulized Bacteriophage D29

R. Coler, W. Finlay, G. Hatfull, 2019, Antimicrobial Agents and Chemotherapy.

RMV data analysis and conclusions by AIT Working Party

P. Kuehl, 2009, Inhalation toxicology.

Preformulation Studies on Imexon

P. Kuehl, P. Myrdal, W. Hoye, 2006, Drug development and industrial pharmacy.

Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model

S. Khader, P. Kuehl, C. Fox, 2022, Frontiers in Pharmacology.

Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation

P. Kuehl, David T. Vodak, Yue Zhou, 2021, AAPS PharmSciTech.

5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming

S. Belinsky, M. Tessema, T. March, 2020, British Journal of Cancer.

Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer

S. Belinsky, A. Gigliotti, P. Kuehl, 2019, Journal of aerosol medicine and pulmonary drug delivery.

Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac®) in a Rodent Model

S. Belinsky, A. Gigliotti, P. Kuehl, 2019, Journal of aerosol medicine and pulmonary drug delivery.

Development and Validation of an HPLC Assay For Dual Detection of Gentamicin Sulfate and Leucine From a Novel Dry Powder For Inhalation

M. Reed, J. Marsters, P. Kuehl, 2012 .

Particle Dynamics and Bioaerosol Viability of Aerosolized Bacillus Calmette-Guérin Vaccine Using Jet and Vibrating Mesh Clinical Nebulizers.

D. Kaushal, P. Kuehl, C. Roy, 2021, Journal of aerosol medicine and pulmonary drug delivery.

Particle Dynamics and Bioaerosol Viability of Aerosolized BCG Vaccine Using Jet and Vibrating Mesh Clinical Nebulizers

D. Kaushal, P. Kuehl, C. Roy, 2021, bioRxiv.

Deposition of Aerosolized Lucinactant in Nonhuman Primates

P. Kuehl, Ramesh Chand, T. Gregory, 2020, Journal of aerosol medicine and pulmonary drug delivery.

Clofazimine Inhalation Suspension Demonstrates Promising Toxicokinetics in Canines for Treating Pulmonary Nontuberculous Mycobacteria Infection

S. Ufer, P. Kuehl, T. Hofmann, 2023, Antimicrobial agents and chemotherapy.

Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

M. D. Reed, S. Belinsky, M. Tessema, 2013, British Journal of Cancer.

Reducing Aerosol-Related Risk of Transmission in the Era of COVID-19: An Interim Guidance Endorsed by the International Society of Aerosols in Medicine

Andrew R. Martin, T. Corcoran, B. Rothen‐Rutishauser, 2020, Journal of aerosol medicine and pulmonary drug delivery.

Composition of aerosols from thermal degradation of flavors used in ENDS and tobacco products

J. McDonald, A. Khlystov, D. Conklin, 2022, Inhalation toxicology.

Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation.

P. Kuehl, K. Karlage, P. Myrdal, 2006, Carcinogenesis.

Development of an HPLC method for the analysis of Apomine in a topical cream formulation.

P. Kuehl, P. Myrdal, S. Stratton, 2006, Journal of pharmaceutical and biomedical analysis.

Mechanistic models facilitate efficient development of leucine containing microparticles for pulmonary drug delivery.

P. Kuehl, M. Boraey, R. Vehring, 2011, International journal of pharmaceutics.

Characterization of aerosols from hemp-derived pre-roll joints

J. McDonald, P. Kuehl, Justyna E Kulpa, 2023, Inhalation toxicology.

In Memoriam: Dr. Paul B. Myrdal

H. Smyth, R. Williams, P. Kuehl, 2019, AAPS PharmSciTech.

Preformulation, formulation, and in vivo efficacy of topically applied apomine.

M. Powell, P. Kuehl, P. Myrdal, 2009, International journal of pharmaceutics.

The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β2-adrenoceptor agonist in preclinical animal species

J. McDonald, M. Salmon, Kim Hartsough, 2014, Pharmacology research & perspectives.

Erratum to: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

W. Doub, M. Sakagami, C. Lehr, 2016 .

Changes in HPBMC markers of immmune function following controlled short-term inhalation exposures of humans to hardwood smoke

F. Lauer, S. Burchiel, D. Mackenzie, 2016, Inhalation toxicology.

Biologic Comparison of Inhaled Insulin Formulations: ExuberaTM and Novel Spray-Dried Engineered Particles of Dextran-10

Dan E. Dobry, D. Edgerton, A. Cherrington, 2014, AAPS PharmSciTech.

HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations.

J. McDonald, P. Kuehl, J. Farrar, 2023, Journal of pharmacological and toxicological methods.

Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

S. Belinsky, M. Tessema, Wenshu Chen, 2021, Drug delivery.

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

S. Belinsky, A. Gigliotti, M. Tessema, 2018, Drug delivery.

Inhalation delivery of nucleic acid gene therapies in preclinical drug development

P. Kuehl, H. Irshad, Conor A Ruzycki, 2023, Expert opinion on drug delivery.

Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets

J. McDonald, W. Dehaan, P. Kuehl, 2019, AAPS PharmSciTech.

Biologic Comparison of Inhaled Insulin Formulations: ExuberaTM and Novel Spray-Dried Engineered Particles of Dextran-10

Dan E. Dobry, D. Edgerton, A. Cherrington, 2014, AAPS PharmSciTech.

Oral and intranasal Ad5 SARS-CoV-2 vaccines decrease disease and viral transmission in a golden hamster model

E. Dora, P. Kuehl, A. Werts, 2021, bioRxiv.

Symposium Summary

K. Nikula, P. Kuehl, J. Tepper, 2016, International journal of toxicology.

Targeting aENaC with an epithelial RNAi trigger delivery platform for the treatment of cystic fibrosis

T. Schluep, P. Kuehl, Xiaokai Li, 2018, Cystic fibrosis.