Anthony P. Williams

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Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD

S. Wootton, S. Clarke, N. Coombs, 2018, Respiratory Research.

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

S. Wootton, S. Schoonbroodt, S. Clarke, 2017, Thorax.

A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I (MHC I) Proteins*

T. Elliott, J. Kaufman, Anthony P. Williams, 2013, The Journal of Biological Chemistry.

Exploring the RNA Gap for Improving Diagnostic Yield in Primary Immunodeficiencies

D. Baralle, Anthony P. Williams, Jed J. Lye, 2019, Front. Genet..

Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412.

M. Cragg, M. Glennie, Anthony P. Williams, 2015, Blood.

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

Bodo Grimbacher, James Curtis, Siobhan O. Burns, 2017, The Journal of allergy and clinical immunology.

Ileal Transcriptomic Analysis in Paediatric Crohn’s Disease Reveals IL17- and NOD-signalling Expression Signatures in Treatment-naïve Patients and Identifies Epithelial Cells Driving Differentially Expressed Genes

J. J. Ashton, K. Boukas, S. Ennis, 2020, Journal of Crohn's & colitis.

Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease

R. Döffinger, B. Marshall, Anthony P. Williams, 2016, Case reports in immunology.

Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.

P. Calder, K. Godfrey, M. Erlewyn-Lajeunesse, 2012, The American journal of clinical nutrition.

Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort

S. Wootton, S. Clarke, E. Aris, 2019, ERJ Open Research.

Role of Innate T Cells in Anti-Bacterial Immunity

Anthony P. Williams, Yifang Gao, 2015, Front. Immunol..

Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase δ syndrome.

R. Pengelly, S. Ennis, S. Faust, 2016, Clinical immunology.

The optimization of peptide cargo bound to MHC class I molecules by the peptide‐loading complex

T. Elliott, Anthony P. Williams, 2005, Immunological reviews.

Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19

D. Baralle, James P R Schofield, Fabio Strazzeri, 2022, Frontiers in Immunology.

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.

R. Djukanović, T. Hinks, T. Wilkinson, 2016, American journal of respiratory and critical care medicine.

Absence of Tapasin Alters Immunodominance against a Lymphocytic Choriomeningitis Virus Polytope

T. Elliott, Anthony P. Williams, E. James, 2009, The Journal of Immunology.

A novel FOXP3 mutation causing fetal akinesia and recurrent male miscarriages.

D. Wellesley, K. Gilmour, Anthony P. Williams, 2015, Clinical immunology.

Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19

D. Baralle, James P R Schofield, Fabio Strazzeri, 2022, Frontiers in Immunology.

Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis

B. Marshall, S. Faust, M. Tebruegge, 2017, Thorax.

Autoimmunity/inflammation in a monogenic primary immunodeficiency cohort

C. Mattocks, R. Pengelly, S. Ennis, 2017, Clinical & translational immunology.

TAP deficiency syndrome: chronic rhinosinusitis and conductive hearing loss

H. Bonel, M. Caversaccio, Anthony P. Williams, 2008, European Archives of Oto-Rhino-Laryngology.

Tapasin enhances MHC class I peptide presentation according to peptide half-life.

T. Elliott, A. Tolstrup, M. Howarth, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification of novel Tapasin polymorphisms and linkage disequilibrium to MHC class I alleles

T. Elliott, R. Houlston, K. Welsh, 2000, Immunogenetics.

Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation.

R. Döffinger, R. Pengelly, S. Ennis, 2017, The Journal of allergy and clinical immunology.

Common variable immunodeficiency is associated with a functional deficiency of invariant natural killer T cells.

T. Elliott, B. Grimbacher, Anthony P. Williams, 2014, The Journal of allergy and clinical immunology.

Immune reconstitution in children following chemotherapy for acute leukemia

S. Clarke, S. Faust, A. Vora, 2020, EJHaem.

The Synthesis and in vivo Evaluation of 2′,2′‐Difluoro KRN7000

D. Elewaut, C. Ottensmeier, Anthony P. Williams, 2009, ChemMedChem.

T-cell receptor molecular diagnosis of T-cell lymphoma.

Anthony P. Williams, E. Hodges, John L. Smith, 2005, Methods in molecular medicine.

Hanging in the balance: KIR and their role in disease

S. Khakoo, A. Bateman, Anthony P. Williams, 2005 .

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry

A. Fischer, C. Picard, P. Soler-Palacín, 2018, Front. Immunol..

Human Mutation

A. Vanderver, H. Brunner, P. Fockens, 2019 .

Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease

K. Boukas, S. Ennis, N. Afzal, 2022, Inflammatory bowel diseases.

A novel germline gain-of-function variant in PIK3CD.

C. Mattocks, Anthony P. Williams, W. Rae, 2017, Clinical Immunology.

Expression profile of the matricellular protein periostin in paediatric inflammatory bowel disease

D. Riethmacher, S. Ennis, N. Afzal, 2021, Scientific Reports.

Immuno-Genomic Profiling of Patients with Inflammatory Bowel Disease: A Systematic Review of Genetic and Functional In Vivo Studies of Implicated Genes

R. Pengelly, S. Ennis, Anthony P. Williams, 2014, Inflammatory bowel diseases.

Mutations in RPSA and NKX2‐3 link development of the spleen and intestinal vasculature

H. Brunner, P. Fockens, S. Faust, 2019, Human mutation.

Omenn's syndrome occurring in patients without mutations in recombination activating genes.

A. Gennery, B. Angus, A. Villa, 2005, Clinical immunology.

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function

T. Elliott, S. Khakoo, A. Mant, 2016, The Journal of allergy and clinical immunology.

IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection

T. Wilkinson, Anthony P. Williams, K. Staples, 2017, The Journal of allergy and clinical immunology.

Optimization of the MHC class I peptide cargo is dependent on tapasin.

James McCluskey, Chen Au Peh, Anthony W Purcell, 2002, Immunity.

Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood.

D. Baralle, Fabio Strazzeri, P. Skipp, 2021, medRxiv.

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

R. Döffinger, S. Faust, C. Ottensmeier, 2016, PloS one.

Immunological Profiling of Paediatric Inflammatory Bowel Disease Using Unsupervised Machine Learning.

S. Ennis, Anthony P. Williams, R. M. Beattie, 2020, Journal of pediatric gastroenterology and nutrition.

Validation and comparison of two multiplex technologies, Luminex and Mesoscale Discovery, for human cytokine profiling.

Ferdousi Chowdhury, Anthony Williams, Peter Johnson, 2009, Journal of immunological methods.

Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort

S. Ennis, N. Afzal, Anthony P. Williams, 2016, Scientific Reports.

The pathway of cross‐presentation is influenced by the particle size of phagocytosed antigen

T. Elliott, A. Mant, Anthony P. Williams, 2012, Immunology.

Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia.

P. Byrd, A. Taylor, A. Exley, 2011, Clinical immunology.

Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

M. Glennie, C. Ottensmeier, Anthony P. Williams, 2015, Clinical Cancer Research.

Calreticulin‐dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

T. Elliott, E. Ghanem, M. Al-Balushi, 2009, The EMBO journal.

Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer’s disease: an observational clinical study

C. Holmes, J. Teeling, D. Boche, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Nervous and Muscular Adverse Events after COVID-19 Vaccination: A Systematic Review and Meta-Analysis of Clinical Trials

J. Zeng, Anthony P. Williams, Yicong Chen, 2021, Vaccines.

Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.

R. Pengelly, S. Ennis, S. Faust, 2016, The journal of allergy and clinical immunology. In practice.

Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays.

B. Marshall, S. Faust, M. Tebruegge, 2015, The Journal of infection.

LONG-TERM OUTCOMES FOR ADULTS WITH CHRONIC GRANULOMATOUS DISEASE IN THE UNITED KINGDOM.

A. Gennery, D. Goldblatt, S. Burns, 2020, The Journal of allergy and clinical immunology.

A Cancer Research UK phase I study evaluating safety, tolerability, and biological effects of chimeric anti-CD40 monoclonal antibody (MAb), Chi Lob 7/4.

M. Glennie, C. Ottensmeier, Anthony P. Williams, 2010 .

Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort

S. Wootton, S. Clarke, E. Aris, 2019, ERJ Open Research.

Immunological Profiling of Paediatric Inflammatory Bowel Disease Using Unsupervised Machine Learning.

S. Ennis, Anthony P. Williams, R. M. Beattie, 2020, Journal of Pediatric Gastroenterology and Nutrition - JPGN.

Clinical and laboratory features of seventy‐eight UK patients with Good’s syndrome (thymoma and hypogammaglobulinaemia)

Smita Y. Patel, S. Burns, Anthony P. Williams, 2018, Clinical and experimental immunology.

Hanging in the balance: KIR and their role in disease

S. Khakoo, A. Bateman, Anthony P. Williams, 2005 .

Clinical spectrum and features of activated phosphoinositide 3-kinase syndrome: Alarge patient cohort study

J. Casanova, S. Nejentsev, P. Palma, 2016 .

Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort

S. Ennis, N. Afzal, Anthony P. Williams, 2016, Scientific Reports.

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

C. Plass, T. Zenz, G. Packham, 2015 .

Defects in lymphocyte subsets and serological memory persist a median of 10 years after high-dose therapy and autologous progenitor cell rescue for malignant lymphoma

P. Johnson, A. Williams, A. Davies, 2012, Bone Marrow Transplantation.

Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

M. Glennie, C. Ottensmeier, Anthony P. Williams, 2015, Clinical Cancer Research.

Multi‐centre retrospective analysis of anaphylaxis during general anaesthesia in the United Kingdom: aetiology and diagnostic performance of acute serum tryptase

L. Diwakar, Anthony P. Williams, M. York, 2014, Clinical and experimental immunology.

UKPIN 2015 Meeting Abstracts, December 2015: Oral Presentations

F. Rieux-Laucat, R. Döffinger, J. Casanova, 2015, Clinical and experimental immunology.

Laboratory diagnostics for hereditary angioedema: an economic, evidence-based standpoint.

A. Frew, Anthony P. Williams, M. Krishna, 2005, The Journal of allergy and clinical immunology.