B. Holt

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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

M. Inouye, S. Johnston, K. Holt, 2015, Cell Host & Microbe.

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis.

P. Sly, P. Holt, Denise Anderson, 2019, American journal of respiratory and critical care medicine.

Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic th1 function.

P. Sly, J. Poolman, B. Holt, 2001, The Journal of infectious diseases.

Development of Interleukin-12-Producing Capacity throughout Childhood

P. Sly, P. Holt, J. Upham, 2002, Infection and Immunity.

Functional Maturation of CD4+CD25+CTLA4+CD45RA+ T Regulatory Cells in Human Neonatal T Cell Responses to Environmental Antigens/Allergens1

P. Sly, P. Holt, J. Upham, 2004, The Journal of Immunology.

Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study

P. Sly, P. Holt, P. Hart, 2011, European Respiratory Journal.

Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study.

P. Sly, P. Holt, N. de Klerk, 2010, The Journal of allergy and clinical immunology.

Allergen recognition in the origin of asthma.

P. Sly, P. Holt, B. Björkstén, 1997, Ciba Foundation symposium.

T‐cell “priming” against environmental allergens in human neonates: sequential deletion of food antigen reactivity during infancy with concomitant expansion of responses to ubiquitous inhalant allergens

W. Thomas, P. Holt, B. Holt, 1995, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Genetic ‘risk’ for atopy is associated with delayed postnatal maturation of T‐cell competence

W. Thomas, B. Holt, P. G. Holt, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T‐cells from infants at low versus high genetic risk for atopy

P. Sly, P. Holt, B. Holt, 1995, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Development of allergen-specific T-cell memory in atopic and normal children

P. Sly, P. Holt, B. Holt, 1999, The Lancet.

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk

M. Inouye, K. Holt, C. Khor, 2019, bioRxiv.

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

M. Inouye, K. Holt, C. Khor, 2020, Nature Communications.

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

P. Holt, P. Jacoby, P. Hart, 2014, Archives of Women's Mental Health.

Fish oil supplementation in early infancy modulates developing infant immune responses

Tracey F Lee-Pullen, T. Mori, M. Serralha, 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Rewiring of mite allergen-specific Th-memory-associated gene networks during immunotherapy

P. Holt, Denise Anderson, M. Serralha, 2019 .

Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development

R. Rabin, P. Sly, P. Holt, 2019, The Journal of allergy and clinical immunology.

Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.

P. Sly, P. Holt, B. Holt, 1998, Journal of immunology.

Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5 years of life

R. Ware, P. Sly, P. Holt, 2021, Pediatric pulmonology.

TH2‐polarized immunological memory to inhalant allergens in atopies is established during infaney and early childhood

P. Sly, P. Holt, B. Holt, 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Th2-associated immunity to bacteria in teenagers and susceptibility to asthma

C. Bachert, P. Sly, W. Thomas, 2010, European Respiratory Journal.

Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma

C. Bachert, P. Sly, W. Thomas, 2010 .

Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling.

P. Sly, P. Holt, M. Deverell, 2009, The Journal of allergy and clinical immunology.

Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancy

J. Denburg, S. Johnston, K. Holt, 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.

P. Sly, P. Holt, A. Rudin, 2000, The Journal of allergy and clinical immunology.

Developing patterns of T cell memory to environmental allergens in the first two years of life.

P. Sly, P. Holt, B. Holt, 1997, International archives of allergy and immunology.

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

G. Morahan, P. Sly, P. Holt, 2002, The Lancet.

CpG methylation patterns in the IFNγ promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non‐atopics

P. Sly, P. Holt, M. Kusel, 2006, Pediatric Allergy and Immunology.

Immunoregulation of asthma: control of T-lymphocyte activation in the respiratory tract.

P. Holt, P. McMenamin, B. Holt, 1991, The European respiratory journal. Supplement.

Reciprocal patterns of allergen‐induced GATA‐3 expression in peripheral blood mononuclear cells from atopics vs. non‐atopics

P. Sly, P. Holt, B. Holt, 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort.

P. Sly, P. Holt, S. Ahlstedt, 2007, The Journal of allergy and clinical immunology.

Primary sensitization to inhalant allergens.

P. Sly, P. Holt, B. Holt, 2000, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

THE SEVERITY OF BOTH ATOPIC AND NONATOPIC ASTHMA IN CHILDREN IS ASSOCIATED WITH IL12B POLYMORPHISM

G. Morahan, P. Sly, P. Holt, 2002 .

Environmental Antigens/Allergens Human Neonatal T Cell Responses to T Regulatory Cells in + CD45RA+ CTLA4 + CD25+ Functional Maturation of CD4

P. Sly, J. Upham, B. Holt, 2004 .

“Bystander” amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children

P. Holt, A. Rudin, B. Holt, 2001, Allergy.

Allergen‐induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses

P. Holt, M. Jenmalm, B. Björkstén, 1999, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Antigen-Specific Responses to Diphtheria-Tetanus-Acellular Pertussis Vaccine in Human Infants Are Initially Th2 Polarized

P. Sly, J. Poolman, B. Holt, 2000, Infection and Immunity.

Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life

P. Sly, D. Mok, M. Serralha, 2022, Frontiers in Immunology.

Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM85.

P. Sly, P. Holt, N. Troy, 2019, The Journal of allergy and clinical immunology.

Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles.

P. Sly, P. Holt, Denise Anderson, 2019, The Journal of allergy and clinical immunology.

Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells.

P. Holt, B. Holt, G. P. White, 2002, Journal of immunology.

Low‐level exposure to house dust mites stimulates T‐cell responses during early childhood independent of atopy

P. Holt, B. Björkstén, B. Holt, 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Primary sensitization to inhalant allergens

P. Sly, P. Holt, B. Holt, 2000, American journal of respiratory and critical care medicine.

A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals.

N. Mavaddat, P. Holt, R. Bowman, 1992, Immunology.

High IFN-γ production by CD8+ T cells and early sensitization among infants at high risk of atopy

P. Sly, P. Holt, N. Klerk, 2004 .

Skewing of Initial T Cell Responses Toward the System to Environmental Allergens: Universal Transplacental Priming of the Human Immune

P. Sly, P. Holt, B. Holt, 1998 .

High IFN-gamma production by CD8+ T cells and early sensitization among infants at high risk of atopy.

P. Sly, P. Holt, N. de Klerk, 2004, The Journal of allergy and clinical immunology.

Polarized Vaccine in Human Infants Are Initially Th 2 Diphtheria-Tetanus-Acellular Pertussis Antigen-Specific Responses to

P. Sly, J. Poolman, B. Holt, 2000 .

In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.

P. Holt, B. Holt, K. Turner, 1983, Clinical and experimental immunology.

Functional heterogeneity within the human peripheral blood B cell pool engaged in IgE synthesis.

P. Holt, B. Holt, K. Turner, 1987, International archives of allergy and applied immunology.

In vitro synthesis of IgE by human peripheral blood leucocytes: relationship to serum titre of leucocyte donor.

P. Holt, B. Holt, K. Turner, 1981, Clinical and experimental immunology.

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

Stephen C. Watts, M. Inouye, S. Johnston, 2018, Cell Host & Microbe.

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

Stephen C. Watts, M. Inouye, S. Johnston, 2017, bioRxiv.

Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

P. Holt, P. Hart, A. Whitehouse, 2012, Pediatrics.

Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study

J. Blackwell, P. Holt, C. Pennell, 2014, Genes and Immunity.

Differential Patterns of Methylation of the IFN-γ Promoter at CpG and Non-CpG Sites Underlie Differences in IFN-γ Gene Expression Between Human Neonatal and Adult CD45RO− T Cells1

P. Holt, B. Holt, G. P. White, 2002, The Journal of Immunology.

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

P. Holt, P. Hart, A. Whitehouse, 2013, Journal of autism and developmental disorders.

Distinguishing benign from pathologic TH2 immunity in atopic children.

Adnan Custovic, Angela Simpson, Danielle Belgrave, 2016, The Journal of allergy and clinical immunology.

Inhalant allergen‐specific T‐cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum‐free medium

L. Palmer, P. Sly, W. Thomas, 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

Michael Inouye, Merci Kusel, M. Inouye, 2017, The Journal of allergy and clinical immunology.

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

P. Hart, A. Whitehouse, M. Kusel, 2012, Journal of Autism and Developmental Disorders.

The infant airway microbiome in health and disease impacts later asthma development

M. Inouye, S. Johnston, K. Holt, 2014, bioRxiv.

A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium.

P. Holt, P. McMenamin, B. Holt, 1990, International archives of allergy and applied immunology.

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A. Custovic, D. Belgrave, P. Sly, 2015 .

Rewiring of gene networks underlying mite allergen‐induced CD4 + Th‐cell responses during immunotherapy

P. Holt, Denise Anderson, M. Serralha, 2020, Allergy.

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

P. Holt, Denise Anderson, M. Serralha, 2018, bioRxiv.

Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies.

P. Sly, P. Holt, M. Serralha, 2022, The Journal of allergy and clinical immunology.

Resource The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development Graphical

M. Inouye, S. Johnston, K. Holt, 2015 .

Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

P. Holt, P. Hart, A. Whitehouse, 2012, Pediatrics.

Early‐onset atopy is associated with enhanced lymphocyte cytokine responses in 11‐year‐old children

J. Goldblatt, P. N. Souëf, M. Serralha, 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Platelet serotonin release by human polymorphonuclear leucocytes stimulated by cotton dust bacteria.

R. Rylander, P. Holt, B. Holt, 1983, Clinical and experimental immunology.

Association between antenatal cytokine production and the development of atopy and asthma at age 6 years

Martin J Firth, B. Holt, C. Macaubas, 2003, The Lancet.

Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Tcr alpha-/beta- lymphocytes (putative gamma/delta T cells).

W. Thomas, P. Holt, U. Kees, 1991, Immunology.

An immunoepidemiological approach to asthma: identification of in-vitro T cell response patterns associated with different wheezing phenotypes in children

J. Goldblatt, P. N. Souëf, M. Serralha, 2005, The Lancet.