J. Seegmiller

发表

Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.

R. Terkeltaub, G. McCabe, M. Lotz, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Utilization of hypoxanthine, adenine and 4-amino-5-imidazole-carboxamide for uric acid synthesis in man.

J. Wyngaarden, J. Seegmiller, L. Laster, 1959, Metabolism: clinical and experimental.

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

J. Kaye, D. Carson, L. Thompson, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Contributions of Lesch-Nyhan syndrome to the understanding of purine metabolism

J. Seegmiller, 1989, Journal of Inherited Metabolic Disease.

Hypoxanthine-guanine phosphoribosyltransferase deficiency and Xg blood group.

W. Nyhan, J. Seegmiller, M. L. Greene, 1970, American journal of human genetics.

Clinical correlations in partial hypoxanthine guanine phosphoribosyltransferase deficiency.

W. Nyhan, J. Seegmiller, T. Page, 1986, Pediatric neurology.

Xanthine oxidase activity in human tissues and its inhibition by allopurinol (4-hydroxypyrazolo[3,4-d] pyrimidine).

R. Watts, J. Seegmiller, J. Watts, 1965, The Journal of laboratory and clinical medicine.

The development and use of an intravenous preparation of allopurinol.

J. H. Wells, P. Carbone, J. Gallelli, 1968, The American journal of the medical sciences.

Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.

J. Seegmiller, P. Kostel, M. Becker, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Familial hyperglycinuria. New defect in renal tubular transport of glycine and imino acids.

L. Rosenberg, J. Seegmiller, P. Lietman, 1973, The American journal of medicine.

Stimulation of human purine synthesis de novo by fructose infusion.

K. Raivio, G. Nuki, J. Seegmiller, 1975, Metabolism: clinical and experimental.

CLINICAL, PHYSIOLOGICAL AND BIOCHEMICAL STUDIES OF A PATIENT WITH XANTHINURIA AND PHEOCHROMOCYTOMA.

A. Sjoerdsma, R. Watts, J. Seegmiller, 1964, The American journal of medicine.

G. Boss, J. Seegmiller, Seegmiller Je, 1981, The Western journal of medicine.

THE RENAL EXCRETION OF OXYPURINES.

J. Seegmiller, J. Klinenberg, S. Goldfinger, 1965, The Journal of clinical investigation.

The acute attack of gouty arthritis.

J. Seegmiller, 1965, Arthritis and rheumatism.

Inherited deficiency of hypoxanthine-guanine phosphoribosyltransferase in X-linked uric aciduria (the Lesch-Nyhan syndrome and its variants).

J. Seegmiller, 1976, Advances in human genetics.

Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis.

D. Carson, J. Seegmiller, Carson, 1976, The Journal of clinical investigation.

Reversion in expression of hypoxanthine‐guanine phosphoribosyltransferase in 6‐thioguanine resistant neuroblastoma: Evidence for reduced enzyme levels associated with unaltered catalytic activity

S. Skaper, E. Spector, J. Seegmiller, 1977, Journal of cellular physiology.

Hyperuricemia, a concomitant of congenital vasopressin-resistant diabetes insipidus in the adult.

P. Gorden, G. Robertson, J. Seegmiller, 1971, The New England journal of medicine.

Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.

J. Seegmiller, 1980, Annals of the rheumatic diseases.

Newer Developments in Tissue Culture: Further Aid in the Study of Inborn Errors of Metabolism

J. Seegmiller, 1977 .

Purine Metabolism in Man—II

J. Seegmiller, E. Kaiser, 1977, Advances in Experimental Medicine and Biology.

Dalmatian Dog Mutation in Man

J. Seegmiller, G. Aurbach, M. L. Greene, 1972 .

Hypouricemia due to isolated renal tubular defect. Dalmatian dog mutation in man.

J. Seegmiller, G. Aurbach, M. L. Greene, 1972, The American journal of medicine.

Adult cystinosis--a benign disorder.

J. Seegmiller, P. Lietman, D. Shotton, 1966, The American journal of medicine.

THE EFFECT OF PRETREATMENT WITH COLCHICINE ON THE INFLAMMATORY RESPONSE TO MICROCRYSTALLINE URATE: A MODEL FOR GOUTY INFLAMMATION.

S. Malawista, J. Seegmiller, 1965, Annals of internal medicine.

Intracellular 5-Phosphoribosyl-1-Pyrophosphate: Decreased Availability During Glutamine Limitation

J. Seegmiller, R. Willis, S. Skaper, 1976 .

Transport and Intracellular Fate of Cysteine-35S in Leukocytes from Normal Subjects and Patients with Cystinosis

J. Seegmiller, J. Schneider, K. Bradley, 1968, Pediatric Research.

A long-term study of the absorption of large oral doses of folic acid.

G. Boss, J. Seegmiller, A. Zettner, 1981, Annals of clinical and laboratory science.

The nature of the defect in tyrosine metabolism in alcaptonuria.

J. Seegmiller, L. Laster, B. La Du, 1958, The Journal of biological chemistry.

Suppression of metabolic accompaniments of phagocytosis by colchicine.

R. Howell, J. Seegmiller, S. Goldfinger, 1965, Arthritis and rheumatism.

An enzymatic determination of ammonia in biological fluids.

J. Seegmiller, A. Mondzac, G. Ehrlich, 1965, The Journal of laboratory and clinical medicine.

The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate.

B. Horecker, J. Seegmiller, P. Z. Smyrniotis, 1951, The Journal of biological chemistry.

Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.

R. Terkeltaub, G. McCabe, M. Lotz, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of human lymphoblast ecto-5'-nucleotidase by zinc.

R. Pilz, J. Seegmiller, R. Willis, 1984, Advances in experimental medicine and biology.

Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.

G. Boss, L. Thompson, J. Seegmiller, 1981, Clinical immunology and immunopathology.

Adenosine deaminase deficiency and severe combined immunodeficiency disease.

L. Thompson, J. Seegmiller, 1980, Advances in enzymology and related areas of molecular biology.

Activity of ecto-5'-nucleotidase in lymphoblastoid cell lines derived from carriers of congenital X-linked agammaglobulinemia.

G. Boss, L. Thompson, J. Seegmiller, 1979, Advances in experimental medicine and biology.

The uricosuria and orotic aciduria induced by 6-azauridine.

J. Seegmiller, H. Fallon, E. Frei, 1961, The Journal of clinical investigation.

Hyperuricemia and Gout

G. Boss, J. Seegmiller, 1979 .

RENAL RETENTION OF URIC ACID INDUCED BY INFUSION OF BETA-HYDROXYBUTYRATE AND ACETOACETATE.

J. Seegmiller, E. Klinenberg, S. Goldfinger, 1965, The New England journal of medicine.

SHORT COMMUNICATION Determination of the Mutations Responsible for the Lesch-Nyhan Syndrome in 17 Subjects'

B. Davidson, J. Seegmiller, T. Palella, 1991 .

Age-dependency of lymphocyte ecto-5'-nucleotidase activity.

G. Boss, W. Pichler, L. Thompson, 1980, Journal of immunology.

Effects of nicotinic acid on human fibroblast purine biosynthesis.

J. Seegmiller, K. Raivio, J. A. Boyle, 1972, Biochimica et biophysica acta.

Kinetic studies of mutant human erythrocyte adenine phosphoribosyltransferases.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1968, Canadian journal of biochemistry.

Effects of orotic acid on purine and lipoprotein metabolism in man.

R. Levy, J. Seegmiller, W. N. Kelley, 1970, Metabolism: clinical and experimental.

Benign symmetric lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia.

C. Glueck, W. Fujimoto, J. Seegmiller, 1970, The American journal of medicine.

Cockayne's syndrome: report of a case with hyperlipoproteinemia, hyperinsulinemia, renal disease, and normal growth hormone.

W. Fujimoto, J. Seegmiller, M. Green, 1969, The Journal of pediatrics.

Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man.

R. Levy, J. Seegmiller, W. N. Kelley, 1968, The Journal of clinical investigation.

Intralysosomal cystine crystals in cystinosis.

J. Schulman, T. Kuwabara, J. Seegmiller, 1970, Investigative ophthalmology.

Alterations of pigment epithelium in cystinosis.

J. Seegmiller, P. Lietman, V. Wong, 1967, Archives of ophthalmology.

Increased Cystine in Leukocytes from Individuals Homozygous and Heterozygous for Cystinosis

J. Seegmiller, J. Schneider, K. Bradley, 1967, Science.

Purine metabolism.

J. Seegmiller, 1975, Arthritis and rheumatism.

Genetic considerations of gout.

J. Seegmiller, 1975, Arthritis and rheumatism.

Metabolic Cooperation between Genetically Marked Human Fibroblasts in Tissue Culture

T. Friedmann, J. Subak-Sharpe, J. Seegmiller, 1968, Nature.

Biochemical diagnosis of an X-linked disease in utero.

W. Fujimoto, J. Seegmiller, B. Uhlendorf, 1968, Lancet.

Ouabain‐resistant human lymphoblastoid lines altered in the (Na+ + K+)‐dependent ATPase membrane transport system

J. Seegmiller, Julia E. Lever, 1976, Journal of cellular physiology.

Insulin Secretion in Type I Glycogen Storage Disease

W. Fujimoto, R. Howell, D. Lockwood, 1969, Diabetes.

Altered regulation of Epstein-Barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells.

N. Zvaifler, J. Seegmiller, P. A. Bardwick, 1980, Arthritis & Rheumatism.

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency.

L. Thompson, J. Seegmiller, H. Bluestein, 1984, Cellular immunology.

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency.

J. Seegmiller, H. Bluestein, R. Willis, 1984, Cellular immunology.

Intracellular cystine content of leukocyte populations in cystinosis.

J. Schulman, T. Kuwabara, J. Seegmiller, 1970, Archives of internal medicine.

Uric acid production in gout.

A. Grayzel, J. Seegmiller, L. Laster, 1961, The Journal of clinical investigation.

Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes.

J. Seegmiller, F. Snyder, J. Mendelsohn, 1976, The Journal of clinical investigation.

Excessive production of uric acid in type I glycogen storage disease.

R. Howell, J. Seegmiller, W. N. Kelley, 1968, The Journal of pediatrics.

THE INFLAMMATORY RESPONSE TO INJECTED MICROCRYSTALLINE MONOSODIUM URATE IN NORMAL, HYPERURICEMIC, GOUTY, AND UREMIC SUBJECTS.

W. W. Buchanan, J. Seegmiller, J. Klinenberg, 1965, Arthritis and rheumatism.

Hyperuricemia and gout. Classification, complications and management.

G. Boss, J. Seegmiller, 1979, New England Journal of Medicine.

Cystine, cysteine, and glutathione metabolism in normal and cystinotic fibroblasts in vitro, and in cultured normal amniotic fluid cells.

J. Schulman, J. Seegmiller, J. Schneider, 1971, Clinica chimica acta; international journal of clinical chemistry.

Benign cystinosis. The clinical, biochemical and morphologic findings in a family with two affected siblings.

J. Schulman, T. Kuwabara, J. Seegmiller, 1970, The American journal of medicine.

Identification of heterozygous genotype for cystinosis in utero by a new pulse-labeling technique: preliminary report.

W. Fujimoto, J. Schulman, J. Seegmiller, 1970, The Journal of pediatrics.

Lysosomal site of crystalline deposits in cystinosis as shown by ferritin uptake.

J. Schulman, J. Seegmiller, W. Olson, 1970, Archives of pathology.

Heterozygote studies in cystinosis.

J. Schulman, J. Seegmiller, J. Schneider, 1970, Clinica chimica acta; international journal of clinical chemistry.

A simple technique for the biochemical diagnosis of cystinosis.

J. Schulman, J. Seegmiller, V. Wong, 1970, The Journal of pediatrics.

Cystine: Compartmentalization within Lysosomes in Cystinotic Leukocytes

J. Schulman, J. Seegmiller, K. Bradley, 1969, Science.

The early diagnosis of cystinosis.

J. Seegmiller, J. Schneider, V. Wong, 1969, The Journal of pediatrics.

Biochemical comparisons of the adult and childhood forms of cystinosis.

J. Seegmiller, J. Schneider, V. Wong, 1968, The New England journal of medicine.

Cystinosis: Plasma cystine and cysteine concentrations and the effect of D-penicillamine and dietary treatment

J. Seegmiller, J. Crawhall, P. Lietman, 1968 .

Increased free-cystine content of fibroblasts cultured from patients with cystinosis.

J. Seegmiller, J. Schneider, K. Bradley, 1967, Biochemical and biophysical research communications.

Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity.

J. Seegmiller, H. Gruber, P. Laikind, 1986, Analytical biochemistry.

The Role of Phosphoribosyltransferases in Purine Metabolism

K. Raivio, J. Seegmiller, 1970 .

Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line.

D. Carson, J. Seegmiller, R. Willis, 1978, Proceedings of the National Academy of Sciences of the United States of America.

The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies.

K. Melmon, J. Seegmiller, S. Goldfinger, 1967, Arthritis and rheumatism.

Evidence of a generalized metabolic defect in patients with hereditary chondrocalcinosis. Increased inorganic pyrophosphate in cultured fibroblasts and lymphoblasts.

G. Lust, A. Gaucher, J. Seegmiller, 1981, Arthritis and rheumatism.

THE EFFECTIVENESS OF THE XANTHINE OXIDASE INHIBITOR ALLOPURINOL IN THE TREATMENT OF GOUT.

J. Seegmiller, J. Klinenberg, J R KLINENBERG, 1965, Annals of internal medicine.

Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point.

J E Seegmiller, M. Hershfield, J. Seegmiller, 1976, The Journal of biological chemistry.

Regulation of human lymphoblast plasma membrane 5'-nucleotidase by zinc.

R. Pilz, J. Seegmiller, R. Willis, 1982, The Journal of biological chemistry.

Zinc uptake by cultured human lymphoblasts

J. Seegmiller, P. Saltman, R. Willis, 1986, Biological Trace Element Research.

The adenosine‐like effect of exogenous cyclic AMP upon nucleotide and PP‐ribose‐P concentrations of cultured human lymphoblasts

J. Seegmiller, F. Snyder, Floyd F. Snyder, 1976, FEBS letters.

Effects of Ascorbic Acid in Alkaptonuria: Alterations in Benzoquinone Acetic Acid and an Ontogenic Effect in Infancy

W. Nyhan, B. Barshop, M. Garst, 1989, Pediatric Research.

Ochronosis: a report of a case and a review of literature.

S. Santavirta, Y. Konttinen, J. Seegmiller, 1989, Clinical and experimental rheumatology.

Genetic defects in human purine and pyrimidine metabolism.

G. Boss, J. Seegmiller, 1982, Annual review of genetics.

Synthesis of phosphoribosylpyrophosphate in mammalian cells.

J. Seegmiller, K. Raivio, M. Becker, 1979, Advances in enzymology and related areas of molecular biology.

Kinetic studies of hypoxanthine-guanine phosphoribosyltransferase.

J E Seegmiller, W N Kelley, J. Seegmiller, 1968, The Journal of biological chemistry.

Xanthine stone formation.

J. Seegmiller, 1968, The American journal of medicine.

Biochemistry of uric acid and its relation to gout.

R. Howell, J. Seegmiller, L. Laster, 1963, The New England journal of medicine.

The Inflammatory Reaction to Sodium Urate: Its Possible Relationship to the Genesis of Acute Gouty Arthritis

S. Malawista, R. Howell, J. Seegmiller, 1962 .

X-ray diffraction studies of the tophaceous deposits in gout.

R. Howell, J. Seegmiller, E. Eanes, 1963, Arthritis and rheumatism.

An enzymatic basis for variation in response to allopurinol. Hypoxanthine-guanine phosphoribosyltransferase deficiency.

J. Seegmiller, W. N. Kelley, J. Miller, 1968, The New England journal of medicine.

An enzymatic spectrophotometric method for the determination of xanthine and hypoxanthine.

J. Seegmiller, J. Klinenberg, S. Goldfinger, 1967, Clinical chemistry.

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Seegmiller, William N. Kelley, W. N. Kelley, 1967, Science.

Enzyme Defect in a Case of Xanthinuria

A. Sjoerdsma, R. Watts, J. Seegmiller, 1964, Nature.

Disorders of Purine and Pyrimidine Metabolism

J. Seegmiller, 1978 .

Purine Metabolism in Man—II

Mathias M. Müller, J. Seegmiller, E. Kaiser, 1977, Advances in Experimental Medicine and Biology.

2,8-dihydroxyadenine urolithiasis: report of a case first diagnosed after renal transplant.

A. Matas, J. Seegmiller, G. Karwa, 1988, The Quarterly journal of medicine.

Gas chromatography--mass spectrometry studies of tetramethyl uric acids.

J. Seegmiller, U. Langenbeck, 1973, Analytical biochemistry.

The plasma ammonia and glutamine content in patients with hepatic coma.

C. S. Davidson, J. Seegmiller, R. Schwartz, 1954, The Journal of clinical investigation.

Relationships between glycogen storage disease and tophaceous gout.

R. Howell, J. Seegmiller, J. Klinenberg, 1967, The American journal of medicine.

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Gout

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1969 .

Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia.

T. Waldmann, G. Boss, L. Thompson, 1979, Journal of immunology.

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).

J. Kaye, D. Carson, J. Seegmiller, 1977, Proceedings of the National Academy of Sciences of the United States of America.

The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism.

J. Seegmiller, W. N. Kelley, F. Rosenbloom, 1967, The Journal of clinical investigation.

Urine uric acid to creatinine ratio—a screening test for inberited disorders of purine metabolism

J. Seegmiller, M. L. Greene, J. Kaufman, 1968 .

Detection of human inborn errors of metabolism by examination of urinary metabolites.

J. Seegmiller, 1968, Clinical chemistry.

Genetic and molecular basis of human hereditary diseases.

J. Seegmiller, 1967, Clinical chemistry.

The old and new concepts of acute gouty arthritis.

R. Howell, J. Seegmiller, 1962, Arthritis and rheumatism.

Uricolysis by Human Leucocytes

R. Howell, J. Seegmiller, 1962, Nature.

Biochemical Abnormalities in Hereditary Diseases

J. J. Bunim, R. Howell, J. Seegmiller, 1962 .

THE RENAL EXCRETION OF URIC ACID IN GOUT.

R. Howell, A. Grayzel, J. Seegmiller, 1962, The Journal of clinical investigation.

Diagnostic significance of hyperuricemia in arthritis.

A. Grayzel, J. Seegmiller, L. Liddle, 1961, The New England journal of medicine.

Uric acid metabolism in psoriasis.

A. Eisen, J. Seegmiller, 1961, The Journal of clinical investigation.

Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.

A. Grayzel, J. Seegmiller, E. Love, 1960, The Journal of clinical investigation.

Excessive Uric Acid Production in the Human induced by 2-Ethylamino-1,3,4-thiadiazole

A. Grayzel, J. Seegmiller, L. Liddle, 1959, Nature.

Incorporation of 4-amino-5-imidazolecarboxamide-4-C13 into uric acid in the normal human.

J. Seegmiller, L. Laster, D. Stetten, 1955, The Journal of biological chemistry.

Toward a Unitary Concept of Gout

J. Seegmiller, 1966 .

Biochemistry of uric acid and its relation to gout.

R. Howell, J. Seegmiller, L. Laster, 1963, The New England journal of medicine.

Disorders of Purine and Pyrimidine Metabolism Basic and Clinical Considerations

J. Seegmiller, 1982 .

Cystinosis. Combined clinical staff conference at the National Institutes of Health.

J. Seegmiller, H. Harrison, J. Schneider, 1968, Annals of internal medicine.

New prospects for understanding and control of genetic diseases.

J. Seegmiller, 1972, Archives of internal medicine.

Uptake of α-ketoisocaproic acid in lymphoblast line WI-L2

M. Tarpey, J. Seegmiller, R. Willis, 1977 .

Urinary xanthine stones--a rare complications of allopurinol therapy.

W. Fujimoto, J. Seegmiller, M. L. Greene, 1969, The New England journal of medicine.

[82] TPN-linked aldehyde dehydrogenase from yeast: CH3CHO + TPN+ + H2O → CH3COOH + TPNH + H+

J. Seegmiller, 1955 .

A comparison of purine metabolism and nucleotide pools in normal and hypoxanthine-guanine phosphoribosyltransferase-deficient neuroblastoma cells.

J. Seegmiller, F. Snyder, M. Cruikshank, 1978, Biochimica et biophysica acta.

Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects.

J. Seegmiller, W. N. Kelley, J. Miller, 1967, JAMA.

Xanthine phosphoribosyltransferase in man: relationship to hypoxanthine-guanine phosphoribosyltransferase.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1967, Biochemical and biophysical research communications.

Conjunctival biopsy for the biochemical diagnosis of cystinosis.

J. Schulman, J. Seegmiller, V. Wong, 1970, American journal of ophthalmology.

Identification and measurement of cysteine-homocysteine mixed disulfide in plasma.

J. Seegmiller, K. Bradley, J. A. Schneider, 1968, The Journal of laboratory and clinical medicine.

Dietary protein in the genesis of hepatic coma.

C. S. Davidson, G. B. Phillips, J. Seegmiller, 1954, The New England journal of medicine.

Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.

M. Hershfield, J. Seegmiller, F. Snyder, 1977, Science.

Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

M. Hershfield, J. Seegmiller, 1977, Journal of Biological Chemistry.

Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine.

J. Kaye, D. Carson, J. Seegmiller, 1978, Journal of immunology.

In vitro stabilization of the unoccupied glucocorticoid receptor by adenosine 5'-diphosphate.

R. Palmour, G. Litwack, J. Seegmiller, 1983, Endocrinology.

The enzymatic defect in histidinemia.

G. Jacoby, R. Howell, J. Seegmiller, 1962, Biochemical and biophysical research communications.

Genetic diseases of metabolism.

K. Raivio, J. Seegmiller, 1972, Annual review of biochemistry.

Synthesis of a Metabolic Product of Histidine

H. Tabor, J. Seegmiller, A. Mehler, 1954 .

Elucidation of aberrant purine metabolism: application to hypoxanthine-guanine phosphoribosylstransferase- and adenosine kinase-deficient mutants, and IMP dehydrogenase- and adenosine deaminase-inhibited human lymphoblasts.

M. Hershfield, J. Seegmiller, F. Snyder, 1980, Biochimica et biophysica acta.

Increases in purine excretion and rate of synthesis by drugs inhibiting IMP dehydrogenase or adenylosuccinate synthetase activities.

J. Seegmiller, R. Willis, 1979, Advances in experimental medicine and biology.

Purine reutilization and synthesis de novo in long-term human lymphocyte cell lines deficient in adenine phosphoribosyltransferase activity

M. Hershfield, E. Spector, J. Seegmiller, 1978, Somatic cell genetics.

A filtration assay specific for the determination of small quantities of L-glutamine.

J. Seegmiller, R. Willis, 1976, Analytical biochemistry.

Increased concentrations of glycine in hypoxanthine-guanine phosphoribosyltransferase-deficient mouse neuroblastoma cells.

S. Skaper, J. Seegmiller, 1976 .

Lesch-Nyhan Syndrome: Preventive Control by Prenatal Diagnosis

K. Raivio, J. Schulman, J. Seegmiller, 1970, Science.

Substrate Stabilization: Genetically Controlled Reciprocal Relationship of Two Human Enzymes

J. Seegmiller, M. L. Greene, James A. Boyle, 1970, Science.

A specific enzyme defect in gout associated with overproduction of uric acid.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1967, Proceedings of the National Academy of Sciences of the United States of America.

Alterations of inosinate branchpoint enzymes in cultured human lymphoblasts.

J. Seegmiller, H. Gruber, R. Willis, 1985, Biochimica et biophysica acta.

Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1968, The Journal of biological chemistry.

Adenine Therapy for Lesch-Nyhan Syndrome

W. Fujimoto, J. Schulman, J. Seegmiller, 1971, Pediatric Research.

Preventive Control of the Lesch‐Nyhan Syndrome

J. Seegmiller, C. Jacobson, C. H. Blank, 1972, Obstetrics and gynecology.

Accelerated purine biosynthesis de novo in skin fibroblasts deficient in hypoxanthine--guanine phosphoribosyltransferase activity.

J. Seegmiller, J. F. Henderson, F. Rosenbloom, 1968, Biochimica et biophysica acta.

Biochemical characteristics of 8-azaguanine resistant human lymphoblast mutants selected in vitro.

G. Nuki, J. Seegmiller, Julia E. Lever, 1973, Advances in experimental medicine and biology.

Inheritance of purine phosphoribosyltransferases in man.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1969, American journal of human genetics.

Effects of glutamine on purine metabolism in the lesch-Nyhan syndrome

K. Raivio, J. Seegmiller, 1971, Pediatric Research.

Hypoxanthine-guanine phosphoribosyltransferase deficiency: chemical agents selective for mutant or normal cultured fibroblasts in mixed and heterozygote cultures.

W. Fujimoto, J. Subak-Sharpe, J. Seegmiller, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Hypoxanthine-guanine phosphoribosyltransferase deficiency: activity in normal, mutant, and heterozygote-cultured human skin fibroblasts.

W. Fujimoto, J. Seegmiller, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture.

T. Friedmann, J. Subak-Sharpe, J. Seegmiller, 1969, Experimental cell research.

LYON HYPOTHESIS AND X-LINKED DISEASE

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1967 .

Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.

J. Seegmiller, M. Becker, L. Meyer, 1973, The American journal of medicine.

Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase

J. Kaye, D. Carson, J. Seegmiller, 1979 .

Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts.

J. Seegmiller, A. Wood, 1973, The Journal of biological chemistry.

Thymidine as a chemotherapeutic agent: pharmacologic, cytokinetic, and biochemical studies in a patient with T-cell acute lymphocytic leukemia.

S. Howell, F. Kung, D. Carson, 1980, Journal of the National Cancer Institute.

Cytotoxic and metabolic effects of adenosine and adenine on human lymphoblasts.

M. Hershfield, J. Seegmiller, F. Snyder, 1978, Cancer research.

AN ENZYMATIC SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF OROTIC ACID.

J. Seegmiller, F. Rosenbloom, 1964, The Journal of laboratory and clinical medicine.

Synthesis of (14C)-ribose-5-phosphate and (14C)-phosphoribosylpyrophosphate and their use in new enzyme assays.

G. Boss, J. Seegmiller, R. Willis, 1984, Advances in experimental medicine and biology.

Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate.

G. Boss, J. Seegmiller, R. Willis, 1983, Analytical biochemistry.

GENETIC DEFECTS IN HUMAN PURINE METABOLISM LEADING TO UROLITHIASIS

J. Seegmiller, 1976 .

Recent advances in the identification of enzyme abnormalities underlying excessive purine synthesis in man.

J. Seegmiller, M. Becker, 1975, Arthritis and rheumatism.

Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity

J. Seegmiller, A. Wood, M. Becker, 1973, Science.

Alterations in the activity of hypoxanthine and adenine phosphoribosyltransferase in patients with hyperuricaemia and gout.

J. Seegmiller, J. A. Boyle, M. L. Greene, 1971, The Quarterly journal of medicine.

Variations in purine metabolism of cultured skin fibroblasts from patients with gout.

J. Seegmiller, W. N. Kelley, J. F. Henderson, 1968, The Journal of clinical investigation.

Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects.

R. Watts, J. Seegmiller, J. Klinenberg, 1968, The Journal of clinical investigation.

Evaluation of the role of 5-phosphoribosyl-alpha-1-pyrophosphate synthetase in congenital hyperuricemia and gout: a simple isotopic assay and an activity stain for the enzyme.

M. G. Johnson, R. Switzer, J. Seegmiller, 1974, Biochemical medicine.

Alcaptonuria; clinical staff conference at the National Institutes of Health.

J. J. Bunim, J. Seegmiller, B. La Du, 1957, Annals of internal medicine.

Metabolism and toxicity of 9-beta-D-arabinofuranosyladenine in human malignant T cells and B cells in tissue culture.

J. Kaye, D. Carson, J. Seegmiller, 1979, Advances in experimental medicine and biology.

Purine and pyrimidine nucleotides in some mutant human lymphoblasts.

G. Nuki, J. Seegmiller, K. Astrin, 1977, Ciba Foundation symposium.

Purine and pyrimidine nucleotide concentrations in cells with decreased hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) activity.

G. Nuki, J. Seegmiller, K. Astrin, 1977, Advances in experimental medicine and biology.

Gout and uric acid metabolism.

J. Seegmiller, J. Talbott, T. Yü, 1970, Arthritis and rheumatism.

Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells.

T. Friedmann, R. Hershberg, J. Seegmiller, 1985, Science.

METABOLISM OF BIOGENIC AMINES IN NEUROBLASTOMA AND GLIOMA CELLS IN CULTURE 1

J. Seegmiller, G. Adelson, S. Skaper, 1976, Journal of neurochemistry.

Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus.

T. Friedmann, R. Hershberg, J. Seegmiller, 1986, Advances in experimental medicine and biology.

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

E. Shelton, J. Seegmiller, N. Dewji, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.

R C Willis, D J Jolly, A D Miller, 1984, The Journal of biological chemistry.

GLIAL CELLS METABOLICALLY COOPERATE: A POTENIAL REQUIREMENT FOR GENE REPLACEMENT THERAPY: 102

J. Seegmiller, H. Gruber, R. Willis, 1985, Pediatric Research.

Uniqueness of deoxyribonucleotide metabolism in human malignant T cell lines.

J. Kaye, D. Carson, L. Thompson, 1979, Advances in experimental medicine and biology.

Use of the newer uricosuric agents in the management of gout.

A. Grayzel, J. Seegmiller, 1960, JAMA.

Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation.

R. Terkeltaub, G. McCabe, M. Lotz, 1997, Arthritis and rheumatism.

Metabolism of 6-phosphogluconic acid in liver and bone marrow.

B. Horecker, J. Seegmiller, 1952, The Journal of biological chemistry.

Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation.

J. Seegmiller, K. Raivio, S. Matsumoto, 1979, The Journal of biological chemistry.

An in Vivo and in Vitro Evaluation of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine: An Inhibitor of Human Lymphoblast Purine Nucleoside Phosphorylase

R. K. Robins, J. Seegmiller, R. Willis, 1980 .

An in vivo and in vitro evaluation of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine: an inhibitor of human lymphoblast purine nucleoside phosphorylase.

R. K. Robins, J. Seegmiller, R. Willis, 1980, Molecular pharmacology.

The effect of adenosine on lymphoid cell proliferation and antibody formation.

T. Watanabe, M. Schreier, J. Seegmiller, 1977, Ciba Foundation symposium.

The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.

B. Migeon, J. Felsenstein, U. Francke, 1976, American journal of human genetics.

Gas chromatography—mass spectrometry studies of hipuric acid derivatives

J. Seegmiller, U. Langenbeck, 1973 .

DESTRUCTIVE POLYARTHRITIS DUE TO A PHOTOCHROMOGENIC MYCOBACTERIUM.

J. Seegmiller, J. Klinenberg, P. Grimley, 1965, The New England journal of medicine.

Thin-layer chromatography of L-carnosine and -alanine.

J. Seegmiller, A. Wood, P. J. van Heeswijk, 1971, Journal of Chromatography A.

Increased pyrophosphate in fibroblasts and lymphoblasts from patients with hereditary diffuse articular chondrocalcinosis.

G. Lust, J. Seegmiller, P. Netter, 1981, Science.

A rapid, enzymatic assay for measurement of inorganic pyrophosphate in biological samples.

G. Lust, J. Seegmiller, 1976, Clinica chimica acta; international journal of clinical chemistry.

Heberden Society

J. Seegmiller, 1970 .

[17] Preparation and processing of small samples of human material

J. A. Boyle, J. Seegmiller, 1971 .

Processing of Alzheimer's disease-associated β-amyloid precursor protein

E. Shelton, H. Chan, J. Seegmiller, 2008, Journal of Molecular Neuroscience.

Mental retardation, self-mutilation and hyperuricemia in females.

J. Seegmiller, M. Bazelon, H. Stevens, 1968, Transactions of the American Neurological Association.

Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome.

S. Goss, J. Seegmiller, P. Itkin, 1979, Science.

THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM

G. R. Bartlett, J. Seegmiller, E. Barron, 1948, The Journal of experimental medicine.

X-linked uric aciduria with neurological disease and self-mutilation: diagnostic test for the enzyme defect.

W. Fujimoto, J. Seegmiller, M. L. Greene, 1968, Jornal de Pediatria.

Maple syrup urine disease: Branched-chain amino acid concentrations and metabolism in cultured human lymphoblasts

S. Skaper, J. Seegmiller, D. Molden, 1976, Biochemical Genetics.

The enzyme defect in maple syrup urine disease (branched chain ketoaciduria).

J. Seegmiller, R. Westall, 2008, Journal of mental deficiency research.

CLINICAL AND BIOCHEMICAL STUDIES ON TWO CASES OF HISTIDINEMIA.

G. Jacoby, R. Howell, B. N. Ladu, 1963, Pediatrics.

Molecular aspects of the Lesch-Nyhan syndrome.

J. Seegmiller, 1972, Biochimie.

Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity.

S. Skaper, J. Seegmiller, 1976, Science.

A new variant of maple syrup urine disease (branched chain ketoaciduria). Clinical and biochemical evaluation.

J. Schulman, J. Seegmiller, J. L. Kennedy, 1970, The American journal of medicine.

Colorimetric assay of cystine using noradrenochrome.

J. Seegmiller, J. Schneider, K. Bradley, 1968, Analytical biochemistry.

Decreased Binding of 14C-Homogentisic Acid induced by Ascorbic Acid in Connective Tissues of Rats with Experimental Alcaptonuria

J. Schulman, J. Seegmiller, THOMAS J. LUSTBERG, 1970, Nature.

Urine uric acid to creatinine rtio--a screening test for inherited disorders of purine metabolism. Phosphoribosyltransferase (PRT) deficiency in X-linked cerebral palsy and in a variant of gout.

J. Seegmiller, M. L. Greene, J. Kaufman, 1968, The Journal of pediatrics.

Role of glutamine in purine synthesis and in guanine nucleotide formation in normal fibroblasts and in fibroblasts deficient in hypoxanthine phosphoribosyltransferase activity.

K. Raivio, J. Seegmiller, 1973, Biochimica et biophysica acta.

Purine metabolism in cultured human fibroblasts derived from patients deficient in hypoxanthine phosphoribosyltransferase, purine nucleoside phosphorylase, or adenosine deaminase.

L. Thompson, J. Seegmiller, J. W. Stoop, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase.

B. Barshop, F. Rosen, J. Seegmiller, 1991, Analytical biochemistry.

Purine metabolism in normal and thioguanine-resistant neuroblastoma.

J. Minna, J. Seegmiller, A. Wood, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Lesch-Nyhan Syndrome and the X-Linked Uric Acidurias

J. Seegmiller, 1972 .

Nature of the Defect in Alcaptonuria

J. Seegmiller, B. Du, V. Zannoni, 1962, Nature.

Immunoreactive adenosine deaminase (ADA) in cultured fibroblasts from patients with combined immunodeficiency disease.

R. Goldblum, D. Carson, J. Seegmiller, 1977, Advances in experimental medicine and biology.

Measurement of free nucleotides in cultured human lymphoid cells using high pressure liquid chromatography.

J. Seegmiller, K. Astrin, D. Brenton, 1977, Biochemical medicine.

Substrate inhibition of adenosine phosphorylation in adenosine deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine phosphoribosyltransferase deficient erythrocytes

G. C. Mills, R. Goldblum, J. Seegmiller, 1988, Journal of Inherited Metabolic Disease.

Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome

J. Seegmiller, A. Wood, M. Becker, 1973, Biochemical Genetics.

ELEVATED INTRACELLULAR GLYCINE ASSOCIATED WITH HYPOXANTHINE‐GUANINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY IN GLIOMA CELLS 1

J. Seegmiller, S. Skaper, 1977, Journal of neurochemistry.

Increased PP-ribose-P synthetase activity: a genetic abnormality leading to excessive purine production and gout.

J. Seegmiller, P. Kostel, M. Becker, 1973, Advances in experimental medicine and biology.

Plasma Concentrations of the Urate‐Binding Alpha1–2‐Globulin in Patients with Different Types of Primary Gout as Compared to Healthy Control Subjects

J. Seegmiller, J. O. Alvsaker, J. O. Alvsaker, 1972, European journal of clinical investigation.

Biochemical considerations of the renal damage of gout.

J. Seegmiller, P. Frazier, 1966, Annals of the rheumatic diseases.

An enzymatic spectrophotometric method for the determination of homogentisic acid in plasma and urine.

J. Seegmiller, L. Laster, B. La Du, 1961, Journal of Biological Chemistry.

The preparation and identification of various adducts of oxidized homogentisic acid and the development of a new sensitive colorimetric assay for homogentisic acid.

J. Schulman, J. Seegmiller, T. Lustberg, 1971, Clinica chimica acta; international journal of clinical chemistry.

Overview of Possible Relation of Defects in Purine Metabolism to Immune Deficiency a

J. Seegmiller, 1985, Annals of the New York Academy of Sciences.

The enzymatic spectrophotometric method for determination of uric acid.

J. Seegmiller, L. Laster, L. Liddle, 1959, The Journal of laboratory and clinical medicine.

SERUM URATE VALUES CORRELATED WITH THE ESTIMATED PERCENTAGE OF SKIN INVOLVED WITH PSORIASIS

A. Eisen, J. Seegmiller, 2022 .

Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout.

J. Seegmiller, L. Laster, L. Liddle, 1958, Metabolism: clinical and experimental.

The present-day treatment of gout.

J. Seegmiller, 1961, The Medical clinics of North America.

Uricolysis by human leukocytes.

R. Howell, J. Seegmiller, 1962, Nature.

Detection of Lesch‐Nyhan Syndrome Carriers: Analysis of hair roots for HPRT by agarose gel electrophoresis and autoradiography

J. Seegmiller, B. Bakay, Charmaine Tucker‐Pian, 1980, Clinical genetics.

Experience with detection of heterozygous carriers and prenatal diagnosis of Lesch-Nyhan disease.

U. Francke, W. Nyhan, J. Seegmiller, 1977, Advances in experimental medicine and biology.

Genetic aspects of gout.

J. Seegmiller, M. A. Becker, 1974, Annual Review of Medicine.

Evidence for intergenic complementation in hybrid cells derived from two human diploid strains each carrying an X-linked mutation.

H. Klinger, W. Fujimoto, H. Koprowski, 1969, Proceedings of the National Academy of Sciences of the United States of America.

Radiochemical assay for glutaminase and glutamic acid decarboxylase.

J. Seegmiller, A. Wood, M. McCrea, 1972, Analytical biochemistry.

Expression of purine overproduction in a series of 8-azaguanine-resistant diploid human lymphoblast lines.

G. Nuki, J. Seegmiller, Julia E. Lever, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Directions and prospects for future research on gout.

J. Seegmiller, 1975, Arthritis and rheumatism.

Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT).

M. Hershfield, E. Spector, J. Seegmiller, 1977, Advances in experimental medicine and biology.

Fructose-induced aberration of metabolism in familial gout identified by 31P magnetic resonance spectroscopy.

G. Radda, G. Kemp, B. Rajagopalan, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The synthesis of glucose-6-phosphate and 6-phosphogluconate.

B. Horecker, J. Seegmiller, 1951, The Journal of biological chemistry.

The biochemical mechanism of metabolic cooperation.

J. Seegmiller, H. Gruber, R. Willis, 1986, Advances in experimental medicine and biology.

Purine nucleotide reutilization by human lymphoblast lines with aberrations of the inosinate cycle.

J. Seegmiller, R. Willis, A. Kaufman, 1984, The Journal of biological chemistry.

Inorganic pyrophosphate and proteoglycan metabolism in cultured human articular chondrocytes and fibroblasts.

G. Lust, G. Nuki, J. Seegmiller, 1976, Arthritis and rheumatism.

Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia.

G. Boss, J. Seegmiller, R. Ragsdale, 1980, The Journal of laboratory and clinical medicine.

Quantitative immunoassay of adenosine deaminase in combined immunodeficiency disease.

R. Goldblum, D. Carson, J. Seegmiller, 1977, Journal of immunology.

The pathogenesis of gout.

J. Wyngaarden, J. Seegmiller, L. Laster, 1961, Metabolism: clinical and experimental.

The uricosuria and orotic aciduria induced by 6-azauridine.

J. Seegmiller, H. Fallon, E. Frei, 1961, The Journal of clinical investigation.

Cholera toxin-peroxidase: changes in surface labeling of glioblastoma cells with increased time in tissue culture.

S. Skaper, J. Seegmiller, R. Willis, 1976, Science.