S. Blake

发表

Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.

A. Grodzinsky, E. Frank, A. Badger, 2000, Archives of biochemistry and biophysics.

A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.

D. Veber, S. Kumar, D. Yamashita, 2007, Bone.

Small-molecule inhibitors of NF-κB for the treatment of inflammatory joint disease

A. Roshak, S. Blake, J. Callahan, 2002 .

What next for rheumatoid arthritis therapy?

B. Swift, S. Blake, 2004, Current opinion in pharmacology.

Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.

P. Patwari, A. Cole, A. Grodzinsky, 2003, Arthritis and rheumatism.

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

Y. Ru, D. Veber, K. Erhard, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro.

L. Lohmander, F. Baribaud, T. Ort, 2007, Osteoarthritis and cartilage.

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.

Y. Ru, D. Veber, K. Erhard, 2002, Bone.

Recommendations for the use of preclinical models in the study and treatment of osteoarthritis.

K. Pritzker, J. McDougall, S. Goldring, 2010, Osteoarthritis and cartilage.

Disease-modifying activity of SB 273005, an orally active, nonpeptide αvβ3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis

S. Sarkar, A. Badger, M. Lark, 2001 .

CHAPTER 37 – RANKL (Receptor activator of NFκB ligand)

I. James, S. Blake, 2003 .

Role of TNF alpha in the induction of antigen induced arthritis in the rabbit and the anti-arthritic effect of species specific TNF alpha neutralising monoclonal antibodies.

T. Hardingham, B. Henderson, A. Nesbitt, 1995, Annals of the rheumatic diseases.

The effect of recombinant human interleukin 1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit.

T. Hardingham, B. Henderson, S. Blake, 1994, The Journal of rheumatology.

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13

R. Loeser, M. Lark, S. Blake, 2008, Arthritis research & therapy.

Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.

E B Hunziker, P. Patwari, A. Grodzinsky, 2004, Osteoarthritis and cartilage.

24 – Antigen-induced Arthritis

E. Pettipher, S. Blake, 1995 .

Effects of theophylline and rolipram on antigen‐induced airway responses in neonatally immunized rabbits

C. Page, M. Holbrook, S. Blake, 1996, British journal of pharmacology.

Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen‐induced airway responses in neonatally immunised rabbits

C. Page, M. Holbrook, S. Blake, 1996, British journal of pharmacology.

Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.

P. Bornstein, M. Lark, I. James, 2005, Matrix biology : journal of the International Society for Matrix Biology.

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro *

Y. Ru, D. Veber, D. Yamashita, 2001, The Journal of Biological Chemistry.

Antifibrotic action of interleukin-1 receptor antagonist in lapine monoarticular arthritis.

T. Hardingham, R. Thompson, B. Henderson, 1995, Annals of the rheumatic diseases.

Therapeutic potential of cytokine manipulation.

B. Henderson, S. Blake, 1992, Trends in pharmacological sciences.

Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis.

A. Badger, S. Hoffman, B. Swift, 1999, The Journal of pharmacology and experimental therapeutics.

Azepanone-based inhibitors of human and rat cathepsin K.

Y. Ru, D. Veber, K. Ward, 2001, Journal of medicinal chemistry.

Uridine diphosphoglucose dehydrogenase activity in synovial lining cells in the experimental antigen induced model of rheumatoid arthritis: an indication of synovial lining cell function.

A. Pitsillides, S. Blake, 1992, Annals of the rheumatic diseases.

Intracellular signaling pathways as a target for the treatment of rheumatoid arthritis.

S. Kumar, S. Blake, J. Emery, 2001, Current opinion in pharmacology.

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis.

J. Boehm, John C. Lee, J. Adams, 2000, Arthritis and rheumatism.

FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.

S. Kumar, I. James, D. Campbell, 2000, Osteoarthritis and cartilage.

Amelioration by menadione of the experimental chronic immune arthritis in the rabbit

A. Pitsillides, S. Blake, J. Chayen, 1990, Cell biochemistry and function.

Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.

Xiao-Yu Song, Alan J. Grodzinsky, Anna Plaas, 2009, Arthritis and rheumatism.

Pharmacological Potential of p38 MAPK Inhibitors

S. Kumar, S. Blake, S. Kumar, 2005 .

antagonist in lapine monoarticular arthritis . Antifibrotic action of interleukin-1 receptor

T. Hardingham, B. Henderson, S. Blake, 2004 .

Experimental arthritis models in the study of the mechanisms of articular cartilage loss in rheumatoid arthritis.

B. Henderson, S. Blake, J. Lewthwaite, 1993, Agents and actions. Supplements.

Small-molecule inhibitors of NF-kappaB for the treatment of inflammatory joint disease.

A. Roshak, S. Blake, J. Callahan, 2002, Current opinion in pharmacology.

The effect of menadione epoxide on the experimental immune arthritis in the rabbit.

A. Pitsillides, G. Frost, S. Blake, 1991, International journal of experimental pathology.

The in vivo and in vitro characterisation of an engineered human antibody to E-selectin.

S. Albelda, W. Buurman, M. Robinson, 1997, Immunotechnology : an international journal of immunological engineering.

Inhibitors of Protein Kinases and Protein Phosphates Contributors

L. Meijer, D. Fabbro, M. Yacoub, 2005 .

Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis.

S. Sarkar, A. Badger, M. Lark, 2001, Arthritis and rheumatism.