A. Bakker

发表

Mechanisms of Osteocyte Mechanotransduction

J. Klein-Nulend, A. Bakker, 2010 .

Mechanosensation and transduction in osteocytes.

S. Weinbaum, R. Bacabac, J. Klein-Nulend, 2013, Bone.

Aging, Osteocytes, and Mechanotransduction

J. Klein-Nulend, G. V. van Lenthe, A. Bakker, 2017, Current Osteoporosis Reports.

Production and characterization of CaP and Ti scaffolds for bone tissue engineering

J. Schrooten, F. Luyten, J. Humbeeck, 2005 .

High shear stress amplitude in combination with prolonged stimulus duration determine induction of osteoclast formation by hematopoietic progenitor cells

J. Hoffman, A. Bakker, C. Bratengeier, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Biologically Relevant In Vitro 3D-Model to Study Bone Regeneration Potential of Human Adipose Stem Cells

J. Klein-Nulend, A. Bakker, Victor J. B. van Santen, 2022, Biomolecules.

CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2015, PloS one.

Increased Endoplasmic Reticulum Stress in Mouse Osteocytes with Aging Alters Cox-2 Response to Mechanical Stimuli

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2014, Calcified Tissue International.

Hypothermia reduces VEGF-165 expression, but not osteogenic differentiation of human adipose stem cells under hypoxia

J. Klein-Nulend, A. Bakker, P. Nolte, 2017, PloS one.

Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Connective tissue research.

Strontium ranelate affects signaling from mechanically-stimulated osteocytes towards osteoclasts and osteoblasts.

J. Klein-Nulend, B. Zandieh-Doulabi, A. Bakker, 2013, Bone.

Diet and Exercise: a Match Made in Bone

J. Klein-Nulend, R. Schoemaker, A. Bakker, 2017, Current Osteoporosis Reports.

Mechanical loading and the synthesis of 1,25(OH)2D in primary human osteoblasts

P. Lips, A. Heijboer, A. Bakker, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

CHAPTER 4 Mechanical Loading and the Synthesis of 1 , 25 ( OH ) 2 D in Primary Human Osteoblasts

P. Lips, A. Heijboer, A. Bakker, 2016 .

Mechanical Stimulation and IGF‐1 Enhance mRNA Translation Rate in Osteoblasts Via Activation of the AKT‐mTOR Pathway

J. Klein-Nulend, R. Jaspers, A. Bakker, 2016, Journal of cellular physiology.

Osteocytes and Osteoclasts, a Relationship Under Strain

V. Everts, A. Bakker, 2014, Clinical Reviews in Bone and Mineral Metabolism.

Mechanical Loading Stimulates BMP7, But Not BMP2, Production by Osteocytes

J. Klein-Nulend, A. Bakker, A. Bronckers, 2011, Calcified Tissue International.

Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro

J. Klein-Nulend, R. Jaspers, A. Bakker, 2022, Cell biochemistry and biophysics.

VDR dependent and independent effects of 1,25-dihydroxyvitamin D3 on nitric oxide production by osteoblasts

J. Klein-Nulend, G. Carmeliet, A. Bakker, 2012, Steroids.

J. Klein-Nulend, L. Deldicque, Nicolas Pierre, 2015, Biochemical and biophysical research communications.

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size

J. Klein-Nulend, C. Semeins, G. V. van Lenthe, 2018, Calcified Tissue International.

Effect of mechanical loading on the metabolic activity of cells in the temporomandibular joint: a systematic review

F. Lobbezoo, G. Langenbach, J. Ket, 2017, Clinical Oral Investigations.

Accuracy and reproducibility of mouse cortical bone microporosity as quantified by desktop microcomputed tomography

J. Klein-Nulend, G. V. van Lenthe, D. Vanderschueren, 2017, PloS one.

Fluid shear stress-induced mechanotransduction in myoblasts: Does it depend on the glycocalyx?

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2022, Experimental cell research.

CHAPTER 3 Cytokines TNF-α , IL-6 , IL-17 F , and IL-4 differentially affect osteogenic differentiation of human adipose stem cells

J. Klein-Nulend, B. Zandieh-Doulabi, T. Forouzanfar, 2019 .

Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

J. Klein-Nulend, B. Zandieh-Doulabi, T. Forouzanfar, 2016, Stem cells international.

Mechanical loading prevents the stimulating effect of IL-1β on osteocyte-modulated osteoclastogenesis.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

MT1-MMP modulates the mechanosensitivity of osteocytes.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

Mechanically Loaded Myotubes Affect Osteoclast Formation

J. Klein-Nulend, R. Jaspers, A. Bakker, 2014, Calcified Tissue International.

CHAPTER 3 Mechanical loading induces expression of osteo-anabolic and osteo-catabolic factors by myotubes : Role in myogenic adaptation

J. Klein-Nulend, R. Jaspers, A. Bakker, 2013 .

Reaming debris as a novel source of autologous bone to enhance healing of bone defects.

R. D. de Kleine, J. Klein-Nulend, R. Kroeze, 2011, Journal of biomedical materials research. Part A.

Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2014, Osteoporosis International.

Histological and micro Computed Tomography analysis of a femoral stress fracture associated with prolonged bisphosphonate use.

P. Kloen, L. V. van Ruijven, A. Bakker, 2017, Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases.

IL-6 and IGF-1 Signaling Within and Between Muscle and Bone: How Important is the mTOR Pathway for Bone Metabolism?

R. Jaspers, A. Bakker, 2015, Current Osteoporosis Reports.

Osteoblast isolation from murine calvaria and long bones.

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2012, Methods in molecular biology.

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Calcified Tissue International.

Mechanical loading releases osteoclastogenesis‐modulating factors through stimulation of the P2X7 receptor in hematopoietic progenitor cells

A. Bakker, C. Bratengeier, A. Fahlgren, 2018, Journal of cellular physiology.

Polymethyl methacrylate does not adversely affect the osteogenic potential of human adipose stem cells or primary osteoblasts

J. Klein-Nulend, T. Forouzanfar, A. Bakker, 2019, Journal of biomedical materials research. Part B, Applied biomaterials.

IL-1β Damages Fibrocartilage and Upregulates MMP-13 Expression in Fibrochondrocytes in the Condyle of the Temporomandibular Joint

F. Lobbezoo, V. Everts, B. Zandieh-Doulabi, 2019, International journal of molecular sciences.

Juvenile porcine temporomandibular joint: Three different cartilaginous structures?

F. Lobbezoo, V. Everts, B. Zandieh-Doulabi, 2016, Archives of oral biology.

PLS3 mutations in X-linked osteoporosis with fractures

A. Hofman, A. Uitterlinden, B. Wirth, 2014 .

Cyclic Tensile Strain Reduces TNF‐α Induced Expression of MMP‐13 by Condylar Temporomandibular Joint Cells

F. Lobbezoo, V. Everts, A. Bakker, 2017, Journal of cellular physiology.

Comprehensive transcriptome analysis of fluid shear stress altered gene expression in renal epithelial cells

Tareq B. Malas, C. Semeins, D. Peters, 2017, Journal of cellular physiology.

Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts

C. Reijnders, S. Spiekstra, S. Gibbs, 2016, Tissue engineering. Part C, Methods.

The release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement

J. Schilcher, A. Bakker, C. Bratengeier, 2022, Scientific reports.

The Importance of Storage Time for Human Dental Pulp Cells Isolation

Elif, C. Semeins, A. Bakker, 2018 .

The novel endolysin XZ.700 effectively treats MRSA biofilms in two biofilm models without showing toxicity on human bone cells in vitro

J. Klein-Nulend, B. P. Krom, A. Bakker, 2021, Biofouling.

The intricate anatomy of the periodontal ligament and its development: Lessons for periodontal regeneration

T. H. Smit, T. de Jong, A. D. Bakker, 2017, Journal of periodontal research.

UvA-DARE ( Digital Academic Repository ) Mechanical loading and how it affects bone cells : the role of the osteocyte cytoskeleton in maintaining our skeleton

R. Bacabac, J. Klein-Nulend, A. Bakker, 2017 .

The role of osteocytes in bone mechanotransduction

A. D. Bakker, J. Klein-Nulend, J. Klein-Nulend, 2009, Osteoporosis International.

Supraphysiological loading induces osteocyte‐mediated osteoclastogenesis in a novel in vitro model for bone implant loosening

J. Klein-Nulend, C. Semeins, A. Bakker, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Temporomandibular joint synovial chondromatosis: An analysis of 7 cases and literature review

A. Bakker, J. Pathak, Qingbin Zhang, 2022, Science progress.

Pulsating fluid flow affects pre‐osteoblast behavior and osteogenic differentiation through production of soluble factors

J. Korfage, J. Klein-Nulend, R. Jaspers, 2021, Physiological reports.

Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents.

P. Dubruel, D. Schaubroeck, J. Vanfleteren, 2016, Macromolecular bioscience.

The 3D Printing of Calcium Phosphate with K-Carrageenan under Conditions Permitting the Incorporation of Biological Components—A Method

Jenneke Klein-Nulend, J. Klein-Nulend, D. Wismeijer, 2018, Journal of functional biomaterials.

Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis.

Jenneke Klein-Nulend, R. Bacabac, J. Klein-Nulend, 2015, Journal of biomechanics.

Shear loaded osteocyte-like-cells affect epithelial and mesenchymal gene expression in DU145 prostate cancer cells, while decreasing their invasion in vitro.

A. Bakker, Jianfeng Jin, J. Hogervorst, 2023, Biochemical and biophysical research communications.

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice.

J. Schrooten, F. Luyten, P. Tylzanowski, 2007, Arthritis and rheumatism.

Mechanosensitivity of aged muscle stem cells

J. Klein-Nulend, R. Jaspers, A. Bakker, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

IL‐6 counteracts the inhibitory effect of IL‐4 on osteogenic differentiation of human adipose stem cells

J. Klein-Nulend, P. Koolwijk, T. Forouzanfar, 2019, Journal of cellular physiology.

Shear stress inhibits while disuse promotes osteocyte apoptosis.

Jenneke Klein-Nulend, J. Klein-Nulend, E. Burger, 2004, Biochemical and biophysical research communications.

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model.

Yoshitaka Kameo, Taiji Adachi, Akio Takaoka, 2012, Integrative biology : quantitative biosciences from nano to macro.

Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide.

A. Kuijpers-Jagtman, J. Klein-Nulend, C. Semeins, 2008, Biochemical and biophysical research communications.

PLS3 mutations in X-linked osteoporosis with fractures.

A. Hofman, A. Uitterlinden, B. Wirth, 2013, The New England journal of medicine.

Cells Derived from Human Long Bone Appear More Differentiated and More Actively Stimulate Osteoclastogenesis Compared to Alveolar Bone-Derived Cells

A. Bakker, C. Kleverlaan, T. D. de Vries, 2020, International journal of molecular sciences.

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size

J. Klein-Nulend, C. Semeins, G. V. van Lenthe, 2018, Calcified Tissue International.

WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase ROCK.

Jenneke Klein-Nulend, J. Klein-Nulend, A. Bakker, 2010, Cytotherapy.

CHAPTER 2 THE ROLE OF OSTEOCYTES IN BONE MECHANOTRANSDUCTION

Hogervorst, J. Klein-Nulend, B. Zandieh-Doulabi, 2010 .

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

C. Poelma, C. Semeins, D. Peters, 2017, Cellular and Molecular Life Sciences.

Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice

S. Boonen, J. Schrooten, D. Vanderschueren, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells.

Elisabeth H Burger, Jenneke Klein-Nulend, J. Klein-Nulend, 2003, American journal of physiology. Endocrinology and metabolism.

Nitric oxide signaling in mechanical adaptation of bone

R. Bacabac, J. Klein-Nulend, A. Bakker, 2013, Osteoporosis International.

Predictive value of femoral head heterogeneity for fracture risk.

B. van Rietbergen, J. Klein-Nulend, E. Tanck, 2009, Bone.

Osteocytes: Mechanosensors of Bone and Orchestrators of Mechanical Adaptation

Jenneke Klein-Nulend, J. Klein-Nulend, A. Bakker, 2007 .

Mechanical Loading by Fluid Shear Stress of Myotube Glycocalyx Stimulates Growth Factor Expression and Nitric Oxide Production

J. Klein-Nulend, R. Jaspers, A. Bakker, 2014, Cell Biochemistry and Biophysics.

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

J. Klein-Nulend, R. Jaspers, A. Bakker, 2020, bioRxiv.

Studies on Osteocytes in Their 3D Native Matrix Versus 2D In Vitro Models

J. Klein-Nulend, A. Bakker, N. Bravenboer, 2019, Current Osteoporosis Reports.

Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2022, Aging.

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

Jenneke Klein-Nulend, Richard M. Aspden, R. Aspden, 2012, Calcified Tissue International.

Mechanical Loading Reduces Inflammation-Induced Human Osteocyte-to-Osteoclast Communication

Frank P. Luyten, Patrick Verschueren, Jenneke Klein-Nulend, 2015, Calcified Tissue International.

UvA-DARE ( Digital Academic Repository ) CXCL 8 and CCL 20 enhance osteoclastogenesis via modulation of cytokine production by human primary osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2015 .

IL-6 Alters Osteocyte Signaling toward Osteoblasts but Not Osteoclasts

J. Klein-Nulend, A. Bakker, J Klein-Nulend, 2014, Journal of dental research.

Biocompatibility of Polypyrrole with Human Primary Osteoblasts and the Effect of Dopants

J. Klein-Nulend, C. Semeins, A. Gelmi, 2015, PloS one.

In Vivo Models of Mechanical Loading.

A. J. van der Veen, A. Pitsillides, L. Saxon, 2019, Methods in molecular biology.

Osteoblast isolation from murine calvariae and long bones.

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2003, Methods in molecular medicine.

Role of osteocytes in the adaptation of bone to mechanical loading

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2008 .

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes.

P. Lips, J. Klein-Nulend, R. Jaspers, 2012, American journal of physiology. Endocrinology and metabolism.

J. Klein-Nulend, G. V. van Lenthe, D. Vanderschueren, 2018, Bone.

Increased Endoplasmic Reticulum Stress in Mouse Osteocytes with Aging Alters Cox-2 Response to Mechanical Stimuli

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2015, Calcified Tissue International.

Shear Stress Modulates Osteoblast Cell and Nucleus Morphology and Volume

J. Korfage, J. Klein-Nulend, R. Jaspers, 2020, International Journal of Molecular Sciences.

Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase.

Jenneke Klein-Nulend, Behrouz Zandieh-Doulabi, J. Klein-Nulend, 2010, Biochemical and biophysical research communications.

Effect of cyclic uni-axial strain on IGF-I Ea and MGF gene expression by osteoblasts and osteocytes

P. Lips, J. Klein-Nulend, R. Jaspers, 2013 .

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

J. Klein-Nulend, C. Semeins, B. Zandieh-Doulabi, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Compressed Prostate Cancer Cells Decrease Osteoclast Activity While Enhancing Osteoblast Activity In Vitro

C. Semeins, B. Zandieh Doulabi, A. Bakker, 2023, International journal of molecular sciences.

Osteocyte isolation and culture methods.

M. Stern, Karan M. Shah, A. Bakker, 2016, BoneKEy reports.

Molecular mechanisms involved in a differential association of Frzb biology with osteoarthritis and osteoporosis

J. Schrooten, F. Luyten, A. Bakker, 2007, Arthritis Research & Therapy.

Physicochemical Niche Conditions and Mechanosensing by Osteocytes and Myocytes

J. Klein-Nulend, R. Jaspers, A. Bakker, 2019, Current Osteoporosis Reports.

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Calcified Tissue International.

Inhibition of Osteoclastogenesis by Mechanically Loaded Osteocytes: Involvement of MEPE

Jenneke Klein-Nulend, Vincent Everts, J. Klein-Nulend, 2010, Calcified Tissue International.

The 3rd National Festival & International Congress on Stem Cell & Regenerative Medicine

A. Seifalian, H. Ahmadieh, H. Poustchi, 2018, BioImpacts : BI.

Correlation of clinical manifestations and condylar morphology of patients with temporomandibular degenerative joint diseases.

J. Klein-Nulend, A. Bakker, J. Pathak, 2022, Cranio : the journal of craniomandibular practice.

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

R. Aspden, A. Hughes, J. Klein-Nulend, 2013, Calcified Tissue International.

Isolation of primary avian osteocytes.

J. Klein-Nulend, C. Semeins, A. Bakker, 2012, Methods in molecular biology.

Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro.

J. Klein-Nulend, M. Helder, A. Bakker, 2013, Biochimie.

Quantitative screening of engineered implants in a long bone defect model in rabbits.

Peter Dubruel, Jan Schrooten, Johan Lammens, 2008, Tissue engineering. Part C, Methods.

Alterations in osteocyte lacunar morphology affect local bone tissue strains.

J. Klein-Nulend, G. V. van Lenthe, A. Bakker, 2021, Journal of the mechanical behavior of biomedical materials.

Burst, Short, and Sustained Vitamin D3 Applications Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

D. Wismeijer, A. Bakker, C. Kleverlaan, 2020, International Journal of Molecular Sciences.

Stem cell technology for in vivo bone repair

M. Helder, A. Bakker, 2014 .

Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro

J. Klein-Nulend, R. Jaspers, A. Bakker, 2022, Cell Biochemistry and Biophysics.

Rgd-Functionalized Supported Lipid Bilayers Modulate Pre-Osteoblast Adherence and Promote Osteogenic Differentiation.

J. Klein-Nulend, R. Jaspers, P. Jonkheijm, 2020, Journal of biomedical materials research. Part A.

The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent.

E H Burger, J. Klein-Nulend, E. Burger, 2001, Journal of biomechanics.

J. Klein-Nulend, D. Vanderschueren, M. Laurent, 2018, Bone.

Mechanosensation and transduction in osteocytes.

S. Weinbaum, R. Bacabac, J. Klein-Nulend, 2013, Bone.

MT1-MMP modulates the mechanosensitivity of osteocytes.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes.

P. Lips, J. Klein-Nulend, R. Jaspers, 2012, American journal of physiology. Endocrinology and metabolism.

Mechanical stimulation of bone cells using fluid flow.

A. Bakker, C. Huesa, 2012, Methods in molecular biology.

Guided Bone Engineering: Healing of Large Bone Defects

J. Schrooten, F. Luyten, J. Luyten, 2006 .

Fluoride inhibits the response of bone cells to mechanical loading

J. Klein-Nulend, A. Bakker, A. Bronckers, 2011, Odontology.

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

J. Klein-Nulend, C. Semeins, B. Zandieh-Doulabi, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Quantitative screening of engineered implants in a long bone defect model in rabbits.

P. Dubruel, J. Schrooten, F. Luyten, 2008, Tissue engineering. Part C, Methods.

PLS3 mutations in X-linked osteoporosis with fractures.

B. Wirth, G. Pals, Q. Waisfisz, 2013, The New England journal of medicine.

Predictive value of femoral head heterogeneity for fracture risk.

J. Klein-Nulend, V. Rietbergen, A. Bakker, 2009, Bone.