M. Engel

R. Hartmann, A. Abadi, A. Kiemer, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Stress causes induction of MAP kinase-specific phosphatase and rapid repression of MAP kinase activity in Drosophila.

G. Cornelius, M. Engel, 1995, Cellular signalling.

Phosphorylation of nm23/nucleoside diphosphate kinase by casein kinase 2 in vitro.

S. Dooley, I. Lascu, O. Issinger, 1994, Biochemical and biophysical research communications.

Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ).

A. Abadi, M. Engel, Mohammad Abdel-Halim, 2018, MedChemComm.

An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications

A. Abadi, M. Engel, Mohammad Abdel-Halim, 2022, Medicinal research reviews.

Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors

A. Abadi, T. Hwang, M. Engel, 2022, Pharmaceuticals.

Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria.

Salma N Tammam, M. Engel, S. Mansour, 2022, Molecular pharmaceutics.

Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.

A. Abadi, G. Piazza, A. Keeton, 2020, Bioorganic chemistry.

Design of Novel β‐Carboline Derivatives with Pendant 5‐Bromothienyl and Their Evaluation as Phosphodiesterase‐5 Inhibitors

R. Hartmann, A. Abadi, B. Gary, 2013, Archiv der Pharmazie.

6‐Hydroxybenzothiophene Ketones: Potent Inhibitors of 17β‐Hydroxysteroid Dehydrogenase Type 1 (17β‐HSD1) Owing to Favorable Molecule Geometry and Conformational Preorganization

R. Hartmann, M. Engel, M. Frotscher, 2014, ChemMedChem.

The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.

S. Dooley, C. Welter, K. Zang, 1997, Genomics.

Involvement of Protein Kinase C in Activation of Drosophila fos and hsp 70

G. Cornelius, M. Engel, 1995 .

Squamous cell carcinoma of the lung: does the nm23 gene expression correlate to the tumor stage?

S. Dooley, C. Welter, H. Huwer, 1994, The Thoracic and cardiovascular surgeon.

High levels of NM23‐H1 and NM23‐H2 messenger RNA in human squamous‐cell lung carcinoma are associated with poor differentiation and advanced tumor stages

S. Dooley, C. Welter, K. Zang, 1993, International journal of cancer.

2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.

R. Biondi, K. Busschots, Huan Zhang, 2012, Journal of medicinal chemistry.

6‐Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib‐Sensitive and ‐Resistant Tumor Cell Lines

R. Hartmann, A. Abadi, G. Piazza, 2013, ChemMedChem.

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.

F. Belluti, A. Bisi, S. Gobbi, 2016, Journal of medicinal chemistry.

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.

H. Arthanari, Chantal D. Bader, A. Kiemer, 2022, Journal of medicinal chemistry.

Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.

A. Abadi, M. Engel, Mohammad Abdel-Halim, 2020, Bioorganic chemistry.

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.

R. Hartmann, A. Abadi, G. Piazza, 2021, Journal of medicinal chemistry.

Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.

Qingzhong Hu, R. Hartmann, M. Engel, 2013, Journal of medicinal chemistry.

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

R. Hartmann, R. Biondi, V. Hindié, 2009, Journal of medicinal chemistry.

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

A. Abadi, M. Engel, J. Herrmann, 2022, Bioorganic & Medicinal Chemistry Letters.

Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.

R. Hartmann, A. Abadi, H. Tinsley, 2020, Bioorganic chemistry.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action.

R. Abagyan, R. Hartmann, I. Kufareva, 2019, Journal of medicinal chemistry.

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

R. Hartmann, M. Engel, M. Empting, 2014, PloS one.

A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase.

S. Dooley, C. Welter, M. Lacombe, 1995, European journal of biochemistry.

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture

R. Biondi, O. Issinger, C. Welter, 1996, FEBS letters.

First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.

A. Abadi, M. Engel, J. Herrmann, 2017, Journal of medicinal chemistry.

Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR tyrosine kinase inhibitors: influence of the position 4 substituent

R. Hartmann, A. Abadi, G. Piazza, 2013 .

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

P. Alzari, R. Biondi, S. Zeuzem, 2012, Chemistry & biology.

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.

P. Alzari, R. Biondi, S. Zeuzem, 2011, Chemistry & biology.

Regulation of the Interaction between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)*

R. Biondi, S. Zeuzem, Silvina V. Sonzogni, 2009, The Journal of Biological Chemistry.

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

R. Abagyan, P. Brear, I. Kufareva, 2019, Scientific Reports.

Synthesis and CYP17α hydroxylase inhibition activity of new 3α- and 3β-ester derivatives of pregnenolone and related ether analogues

M. Engel, N. Al-Masoudi, Rawaa A. Kadhim, 2016, Medicinal Chemistry Research.

New biaryl-chalcone derivatives of pregnenolone via Suzuki–Miyaura cross-coupling reaction. Synthesis, CYP17 hydroxylase inhibition activity, QSAR, and molecular docking study

M. Engel, N. Al-Masoudi, Rawaa A. Kadhim, 2015, Steroids.

New CYP17 Hydroxylase Inhibitors: Synthesis, Biological Evaluation, QSAR, and Molecular Docking Study of New Pregnenolone Analogs

R. Hartmann, A. Saeed, Sajid Rashid, 2014, Archiv der Pharmazie.

Expression of calpain I messenger RNA in human renal cell carcinoma: Correlation with lymph node metastasis and histological type

C. Welter, K. Zang, M. Engel, 1999, International journal of cancer.

Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound.

H. Stark, E. Proschak, R. Biondi, 2014, Chemistry & biology.

Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives.

A. Abadi, W. Becker, M. Engel, 2018, European journal of medicinal chemistry.

Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF.

A. Levitzki, M. Engel, I. Posner, 1992, The Journal of biological chemistry.

Isolation and characterization of new microsatellites at the nm23-H1 and nm23-H2 gene loci and application for loss of heterozygosity (LOH) analysis

M. Stolte, C. Welter, M. Engel, 1997, Human Genetics.

Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.

R. Hartmann, A. Abadi, M. Engel, 2016, European journal of medicinal chemistry.

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

R. Hartmann, A. Abadi, A. Kiemer, 2014, Journal of medicinal chemistry.

Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification.

A. Abadi, W. Becker, M. Engel, 2018, European journal of medicinal chemistry.

Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1

S. Dooley, C. Welter, K. Zang, 2004, Human Genetics.

Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2.

R. Hartmann, M. Engel, Marica Mariano, 2016, European journal of medicinal chemistry.

Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.

A. Abadi, W. Becker, M. Gabr, 2021, ACS chemical neuroscience.

Presence of regulatory sequences within intron 4 of human and murine c-myb genes.

S. Dooley, C. Welter, M. Engel, 1994, Biochimica et biophysica acta.

Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker.

A. Abadi, T. Hwang, M. Engel, 2022, European journal of medicinal chemistry.

Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity.

A. Abadi, T. Hwang, M. Engel, 2022, European journal of medicinal chemistry.

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

A. Abadi, T. Hwang, M. Engel, 2021, Molecules.

Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.

A. Abadi, M. Engel, Mohammad Abdel-Halim, 2017, Journal of medicinal chemistry.

Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.

A. Levitzki, A. Gazit, M. Engel, 1994, Molecular pharmacology.

Synthesis, biological evaluation and molecular docking studies of indeno [1, 2-c] pyrazol derivatives as inhibitors of mitochondrial malate dehydrogenase 2 (MDH2).

M. Engel, Farzaneh Ahmadi, M. M. Baradarani, 2021, Bioorganic chemistry.

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

R. Hartmann, A. Abadi, B. Gary, 2013, Bioorganic & medicinal chemistry.

PIF-pocket as a target for C. albicans Pkh selective inhibitors.

A. Casamayor, R. Biondi, M. Engel, 2013, ACS chemical biology.

Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core.

M. Engel, Mohamed Salah, Mohammad Abdel-Halim, 2018, MedChemComm.

Overexpression of nm23-H4 RNA in colorectal and renal tumours.

C. Welter, M. Engel, M. Seifert, 2001, Anticancer Research.

Screening Dyrk1A inhibitors by MALDI-QqQ mass spectrometry: systematic comparison to established radiometric, luminescence, and LC–UV–MS assays

D. Volmer, David Gode, M. Engel, 2014, Analytical and Bioanalytical Chemistry.

4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.

R. Biondi, Adriana Stroba, Huan Zhang, 2011, Journal of medicinal chemistry.

Expression of the candidate tumor suppressor gene nm23 in the bronchial system of patients with squamous cell lung cancer.

S. Dooley, C. Welter, H. Huwer, 1997, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

High levels of NM23‐H1 and NM23‐H2 messenger RNA in human squamous‐cell lung carcinoma are associated with poor differentiation and advanced tumor stages

S. Dooley, C. Welter, K. Zang, 1993, International journal of cancer.

Targeting the binding pocket of the fluorophore 8‐anilinonaphthalene‐1‐sulfonic acid in the bacterial enzyme MurA

M. Engel, C. Ducho, Reem K Fathalla, 2023, Archiv der Pharmazie.