D. Coe

发表

D. Coe, R. Storer, 2010, Molecular Diversity.

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

I. McLay, Shawn P. Williams, I. Uings, 2009, Proceedings of the National Academy of Sciences.

A practical drug discovery project at the undergraduate level.

J. Liddle, M. Fray, D. Coe, 2013, Drug discovery today.

Parallel synthesis techniques in the identification of new chiral dirhodium(II) carboxylates for asymmetric carbenoid insertion reactions

M. Drysdale, D. Coe, C. Moody, 1998 .

Reaction of 1,1'-divinyl ferrocene with one-electron oxidants: entry into functionalised [4]ferrocenophanes and observation of an isotope-dependent chemoselectivity effect.

B. Kariuki, M. Tremayne, L. Male, 2010, Chemistry.

A simple method for the quantitative analysis of resin bound thiol groups

G. Øye, N. Cameron, B. G. Davis, 2001 .

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.

I. McLay, Helen T Horsley, D. Coe, 2010, Journal of medicinal chemistry.

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.

H. T. Jones, I. McLay, G. Hardy, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.

Stephen A. Smith, L. Lazarides, D. Mallett, 2016, Journal of medicinal chemistry.

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Birgit Dümpelfeld, James M. Woolven, S. Teague, 2021, Journal of medicinal chemistry.

Synthesis of compounds active against HIV. Part 2. Preparation of some 2′,3′-dideoxy-6′-fluorocarbocyclic nucleosides

D. Coe, S. Roberts, D. Parry, 1990 .

Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles.

D. Coe, S. Harrison, V. Aggarwal, 2014, The Journal of organic chemistry.

Synthesis of some mimics of nucleoside triphosphates

M. Peel, D. Coe, R. Storer, 1991 .

Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.

H. T. Jones, James M. Woolven, I. McLay, 2009, Bioorganic & medicinal chemistry letters.

MEDICINES RESEARCH: CURRENT TRENDS AND CASE HISTORIES HIGHLIGHTS OF THE SOCIETY FOR MEDICINES RESEARCH SYMPOSIUM

D. Coe, A. Ratcliffe, R. Armer, 2009 .

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.

H. T. Jones, I. McLay, G. Hardy, 2007, Journal of medicinal chemistry.

The potential of carbocyclic nucleosides for the treatment of AIDS: synthesis of carbocyclic 6′-fluoro-2′,3′-dideoxythymidine

D. Coe, R. Storer, S. Roberts, 1991 .

Preparation of nucleotide mimics with potent inhibitory activity against HIV reverse transcriptase

D. Coe, R. Storer, S. Roberts, 1991 .

Multimodal imaging of drug and excipients in rat lungs following an inhaled administration of controlled-release drug laden PLGA microparticles.

Peter S Marshall, R. Havelund, D. Coe, 2021, The Analyst.

Asymmetric Allylation of Aldehydes with Chiral Lewis Bases

S. Denmark, D. Coe, B. Griedel, 1994 .

2,2′-Bipyridine-3,3′-dicarboxylic carbohydrate esters and amides. Synthesis and preliminary evaluation as ligands in Cu(II)-catalysed enantioselective electrophilic fluorination

B. Langlois, D. Coe, Y. Queneau, 2009 .

Solid‐supported reagents in organic synthesis

D. Drewry, D. Coe, D H Drewry, 1999, Medicinal research reviews.

A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides**

D. Coe, E. McGarrigle, David Benito-Alifonso, 2014, Angewandte Chemie.

α-Selective organocatalytic synthesis of 2-deoxygalactosides.

D. Coe, E. McGarrigle, M. Galán, 2012, Angewandte Chemie.

Chiral phosphoramide-catalyzed enantioselective addition of allylic trichlorosilanes to aldehydes. Preparative and mechanistic studies with monodentate phosphorus-based amides.

S. Denmark, D. Coe, Jiping Fu, 2006, The Journal of organic chemistry.

Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst

D. Coe, E. McGarrigle, M. Galán, 2016, Organic letters.

α‐Selective Organocatalytic Synthesis of 2‐Deoxygalactosides.

D. Coe, E. McGarrigle, M. Galán, 2013 .

Potassium trimethylsilanolate induced cleavage of 1,3-oxazolidin-2- and 5-ones, and application to the synthesis of (R)-salmeterol.

D. Coe, R. Perciaccante, P. Procopiou, 2003, Organic & biomolecular chemistry.

Extension of the “ring switch” approach to glutamate antagonists to δ-lactam urethanes

M. Drysdale, D. Coe, R. West, 2002 .

Chemistry of Enoxysilacyclobutanes - Highly Selective Uncatalyzed Aldol Additions

S. Denmark, M. Schnute, D. Coe, 1994 .

Synthesis of Phosphoramides for the Lewis Base-Catalyzed Allylation and Aldol Addition Reactions.

S. Denmark, Ken‐Tsung Wong, D. Coe, 1999, The Journal of organic chemistry.

The carbenoid approach to peptide synthesis.

M. Drysdale, D. Haigh, D. Coe, 2000, Chemistry.

Asymmetric rhodium carbene insertion into the SiH bond: identification of new dirhodium(II) carboxylate catalysts using parallel synthesis techniques

M. Drysdale, D. Haigh, D. Coe, 2003 .

Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols

H. T. Jones, G. Hardy, D. Coe, 2008 .

The potential of carbocyclic nucleosides for the treatment of AIDS: synthesis of some diphosphorylphosphonates possessing potent activity against HIV-coded reverse transcriptase

D. Coe, R. Storer, S. Roberts, 1992 .

Synthesis of (2-aminoethyl)ferrocenes from the reaction of lithium amides with vinylferrocene

D. Coe, L. Cox, R. M. Gleixner, 2007 .

The chemistry of enoxysilacyclobutanes : highly selective, uncatalyzed aldol additions

S. Denmark, D. Coe, B. Griedel, 1993 .

Catalytic enantioselective cyclopropanation with bis(halomethyl)zinc reagents. I. Optimization of reaction protocol

Scott E. Denmark, S. Denmark, D. Coe, 1995 .

Chiral Phosphoramide‐Catalyzed Enantioselective Addition of Allylic Trichlorosilanes to Aldehydes. Preparative and Mechanistic Studies with Monodentate Phosphorus‐Based Amides.

S. Denmark, D. Coe, Jiping Fu, 2006 .

Application of the 2,5-Dimethylpyrrole Group as a New and Orthogonal Amine-Protecting Group in Oligosaccharide Synthesis

G. Boons, D. Coe, Simeon G. Bowers, 1998 .

Effect of the TRPV1 antagonist SB‐705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig

A. Busza, D. Coe, K. Biggadike, 2013, British journal of pharmacology.

Trityl ethers in oligosaccharide synthesis: A novel strategy for the convergent assembly of oligosaccharides

G. Boons, D. Coe, Simeon G. Bowers, 1997 .

SYNTHESIS OF THE PHOSPHONATE ISOSTERE OF CARBOCYCLIC 5-BROMOVINYLDEOXYURIDINE MONOPHOSPHATE

A. Garofalo, D. Coe, R. Storer, 1994 .

Electrochemical Synthesis of Isoxazolines: Method and Mechanism

Darren L. Poole, Alfie G. Wills, L. Berlouis, 2020, Chemistry.

Comparison of the effect of pore architecture and bead size on the extent of plasmachemical amine functionalisation of poly(styrene-co-divinylbenzene) permanently porous resins

Neil R. Cameron, Benjamin G. Davis, Patrick G. Steel, 2004 .

Synthesis of the Phosphonate Isostere of Carbocyclic 5‐ Bromovinyldeoxyuridine Monophosphate.

A. Garofalo, D. Coe, R. Storer, 1995 .

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.

I. McLay, D. Coe, K. Biggadike, 2009, Journal of medicinal chemistry.

Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics.

H. T. Jones, I. McLay, G. Hardy, 2007, Bioorganic & medicinal chemistry letters.

Plasmachemical Amine Functionalization of Porous Polystyrene Beads: The Importance of Pore Architecture

G. Øye, N. Cameron, B. G. Davis, 2002 .

RECENT DISCLOSURES OF CLINICAL CANDIDATES HIGHLIGHTS OF THE SOCIETY FOR MEDICINES RESEARCH SYMPOSIUM HELD DECEMBER 10 TH 2009 AT THE NATIONAL HEART AND LUNG INSTITUTE , LONDON , UK

D. Coe, D. Fox, 2010 .

Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity.

I. McLay, Hawa Diallo, I. Uings, 2011, Bioorganic & medicinal chemistry letters.

Plasmachemical surface functionalised beads: versatile tailored supports for polymer assisted organic synthesis.

N. Cameron, B. G. Davis, D. Coe, 2004, Chemical Communications.

Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.

D. Coe, John A. Murphy, Malini Menon, 2020, Bioorganic & medicinal chemistry.

Recent disclosures of clinical candidates

D. Coe, D. Fox, 2010, Drug News & Perspectives.

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

I. McLay, D. Coe, K. Biggadike, 2009 .

A re-investigation of the Fries rearrangement of 3-chlorophenyl acetate and synthesis of 2-azido-1-(4-(benzyloxy)-2-chlorophenyl)ethanone from 4-bromo-3-chlorophenol

D. Coe, P. Procopiou, George Procopiou, 2017 .

One-pot synthesis of 1,1 '-bis(2-amino)ethyl-Substituted ferrocenes from the reaction of spiro[2.4]hepta-4,6-diene with lithium amides: An expedient route into functionalized ferrocenophanes

B. Kariuki, D. Coe, L. Cox, 2005 .