P. S. Burton

发表

Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume.

J. Goodwin, R. Conradi, N. Ho, 2001, Journal of medicinal chemistry.

Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.

Patrizia Crivori, Alan G. E. Wilson, Alan G E Wilson, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Computational Models Supporting Lead Optimization in Drug Discovery

I. Poggesi, J. Goodwin, P. S. Burton, 2006 .

Predicting Drug Absorption: How Nature Made It a Difficult Problem

Thomas J. Vidmar, Jay T. Goodwin, T. Vidmar, 2002, Journal of Pharmacology and Experimental Therapeutics.

Letters to the Editor

R. Guy, R. Potts, R. Conradi, 2004, Pharmaceutical Research.

Epithelial cell permeability of a series of peptidic HIV protease inhibitors: aminoterminal substituent effects.

R. Conradi, P. S. Burton, Allen R. Hilgers, 1994, Journal of drug targeting.

Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin(9-39).

J. Colca, P. S. Burton, Å. Elhammer, 1999, Metabolism: clinical and experimental.

Novel membrane localized iron chelators as inhibitors of iron-dependent lipid peroxidation.

D. Ayer, P. S. Burton, E. Jacobsen, 1988, Biochemical pharmacology.

Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease ( HIV‐PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy, and Cell Permeability Properties.

D. Decamp, C. Craik, W. Lowther, 1995 .

The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved Permeability

R. Conradi, N. Ho, P. S. Burton, 1992, Pharmaceutical Research.

The Influence of Peptide Structure on Transport Across Caco-2 Cells

R. Conradi, N. Ho, P. S. Burton, 1991, Pharmaceutical Research.

Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.

Li Xing, Patrizia Crivori, Alan G. E. Wilson, 2004, Journal of medicinal chemistry.

Reagents for the Selective Acylation of Spermidine, Homospermidine, and Bis[3-aminopropyl]-amine

S. Kline, R. Bergeron, P. S. Burton, 1981 .

Synthesis of N4-acylated N1,N8-bis(acyl)spermidines. An approach to the synthesis of siderophores

R. Bergeron, M. Channing, P. S. Burton, 1980 .

Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring.

R. Conradi, P. S. Burton, S. J. Brickner, 1998, Journal of medicinal chemistry.

ROLE OF CYCLOHEXAAMYLOSE C-3 HYDROXYLS IN CATALYTIC HYDROLYSIS

R. Bergeron, P. S. Burton, 1982 .

Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood–Brain Barrier Permeability of Peptides

Ronald T. Borchardt, R. Borchardt, K. Ng, 1994, Pharmaceutical Research.

An NMR study of conformations of substituted dipeptides in dodecylphosphocholine micelles: Implications for drug transport

J. Blinn, B. Stockman, J. Goodwin, 2000, Biopolymers.

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

R. Conradi, P. S. Burton, Philip S. Burton, 1990, Pharmaceutical Research.

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.

Ronald T Borchardt, Philip S Burton, K. Audus, 2002, Journal of pharmaceutical sciences.

Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

Thomas J. Raub, K. Audus, N. Ho, 1995, Journal of pharmaceutical sciences.

Citric acid as an adjuvant for transepithelial transport

P. S. Burton, M. Cho, J. Scieszka, 1989 .

In vitro permeability of peptidomimetic drugs : the role of polarized efflux pathways as additional barriers to absorption

J. Goodwin, R. Conradi, N. Ho, 1997 .

The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System

R. Borchardt, P. S. Burton, M. Nerurkar, 1996, Pharmaceutical Research.

Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator.

R. Bergeron, P. S. Burton, K. Mcgovern, 1980, Journal of medicinal chemistry.

Physico‐Chemical and Biological Factors that Influence a Drug's Cellular Permeability by Passive Diffusion

R. Borchardt, R. Conradi, P. S. Burton, 2008 .

Automated analysis of polyethylene glycol-induced inhibition of P-glycoprotein activity in vitro.

Thomas J. Raub, R. Borchardt, P. S. Burton, 2003, Journal of pharmaceutical sciences.

Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells.

R. Borchardt, T. Vidmar, N. Ho, 1997, Journal of pharmaceutical sciences.

How structural features influence the biomembrane permeability of peptides.

R. Borchardt, R. Conradi, N. Ho, 1996, Journal of pharmaceutical sciences.

Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides.

A. Tomasselli, R. Heinrikson, K. Koeplinger, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells.

R. Conradi, N. Ho, P. S. Burton, 1993, Biochemical and biophysical research communications.

B) Mechanisms of peptide and protein absorption

R. Conradi, P. S. Burton, Allen R. Hilgers, 1991 .

In Vitro/in Vivo Models for Peptide Oral Absorption: Comparison of Caco-2 Cell Permeability with Rat Intestinal Absorption of Renin Inhibitory Peptides

R. Conradi, P. S. Burton, B. Rush, 1993, Pharmaceutical Research.

Peptides Are Better Absorbed from the Lung than the Gut in the Rat

T. Vidmar, P. S. Burton, B. Rush, 1992, Pharmaceutical Research.

Predicting Oral Absorption of Drugs: A Case Study with a Novel Class of Antimicrobial Agents

Joe Palandra, P. S. Burton, J. Palandra, 2003, Pharmaceutical Research.

A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell.

R. Conradi, N. Ho, P. S. Burton, 1995, Journal of pharmaceutical sciences.

A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa

Ronald T. Borchardt, R. Borchardt, P. S. Burton, 1993, Pharmaceutical Research.

Strategies toward predicting peptide cellular permeability from computed molecular descriptors.

T. Vidmar, J. Goodwin, R. Conradi, 1999, The journal of peptide research : official journal of the American Peptide Society.

Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities.

Mei-Ling Chen, Guohua Zhang, Lawrence X. Yu, 2004, Journal of pharmaceutical sciences.

(D) Routes of delivery: Case studies

H. Merkle, N. Ho, P. S. Burton, 1992 .

Biophysical model approaches to mechanistic transepithelial studies of peptides

Thomas J. Raub, N. Ho, P. S. Burton, 1990 .

Flexible synthesis of polyamine catecholamides

S. Kline, R. Bergeron, P. S. Burton, 1981 .

Biomimetic synthesis of a Paracoccus denitrificans siderophore analog

S. Kline, R. Bergeron, P. S. Burton, 1981 .

The relationship between peptide structure and transport across epithelial cell monolayers

R. Conradi, N. Ho, P. S. Burton, 1992 .

Transport of model peptides across Ascaris suum cuticle.

T. Geary, B. Sheehy, N. Ho, 2000, Molecular and biochemical parasitology.

Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties

D. Decamp, C. Craik, W. Lowther, 1993 .

Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study.

Alan G. E. Wilson, M. Rocchetti, I. Poggesi, 2005, Basic & clinical pharmacology & toxicology.

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism.

R T Borchardt, R. Borchardt, P. S. Burton, 1995, The Journal of pharmacology and experimental therapeutics.

Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers.

N. Ho, P. S. Burton, James Nielsen, 2016, Journal of pharmaceutical sciences.

A non-aqueous partitioning system for predicting the oral absorption potential of peptides

Thomas J. Vidmar, D. Paterson, T. Vidmar, 1994 .