M. Jacobs

发表

The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity*

M. Fleming, L. Swenson, K. Hayakawa, 2006, Journal of Biological Chemistry.

Probing microscopic diffusion by 2‐photon flash photolysis: Measurement of isotropic and anisotropic diffusion in lens fiber cells

C. Soeller, M. Cannell, P. Donaldson, 2004, Microscopy research and technique.

Classifying protein kinase structures guides use of ligand‐selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex

P. Caron, M. Jacobs, B. Hare, 2007, Proteins.

Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase.

A. Pierce, M. Jacobs, Marc Jacobs, 2008, Journal of medicinal chemistry.

ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.

M. Jacobs, Jeremy Green, U. Bandarage, 2018, Bioorganic & medicinal chemistry letters.

An Anatomically-Based Model of the Nerves in the Human Foot

Leo K. Cheng, P. Du, M. Jacobs, 2012 .

Visualization of transverse diffusion paths across fiber cells of the ocular lens by small animal MRI

P. Hunter, E. Vaghefi, P. Donaldson, 2009, Physiological measurement.

Visualizing ocular lens fluid dynamics using MRI: manipulation of steady state water content and water fluxes.

E. Vaghefi, P. Donaldson, M. Jacobs, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Functional imaging: New views on lens structure and function

C. Soeller, M. Cannell, P. Donaldson, 2004, Clinical and experimental pharmacology & physiology.

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.

P. Charifson, Tiansheng Wang, E. Perola, 2015, Bioorganic & medicinal chemistry letters.

MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3

T. Gonen, P. Donaldson, M. Jacobs, 2001, BMC Cell Biology.

Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.

K. Schey, P. Donaldson, Ling Li, 2009, Differentiation; research in biological diversity.

Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.

T. Gonen, P. Donaldson, M. Jacobs, 2003, Experimental eye research.

Design , Synthesis , and Structure − Activity Relationships of Pyridine-Based Rho Kinase ( ROCK ) Inhibitors

D. Newsome, P. Taslimi, M. Jacobs, 2015 .

Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors.

S. Mahajan, A. Aronov, M. Jacobs, 2020, ACS medicinal chemistry letters.

Structure of an IkappaBalpha/NF-kappaB complex.

S. Harrison, M. Jacobs, 1998, Cell.

Quantifying Changes in Gap Junction Structure as a Function of Lens Fiber Cell Differentiation

C. Soeller, P. Donaldson, M. Jacobs, 2001, Cell communication & adhesion.

ROCK enzymatic assay.

M. Jacobs, J. Doran, 2008, Methods in molecular biology.

Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002*

M. Fleming, L. Swenson, O. Futer, 2005, Journal of Biological Chemistry.

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase.

G. Bemis, A. Pierce, M. Jacobs, 2009, Bioorganic & medicinal chemistry letters.

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2.

P. Charifson, Alice Tsai, Tiansheng Wang, 2017, ACS medicinal chemistry letters.

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.

F. Maltais, P. Charifson, Alice Tsai, 2017, ACS medicinal chemistry letters.

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.

M. Jacobs, Jeremy Green, U. Bandarage, 2018, Bioorganic & medicinal chemistry letters.

Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core.

P. Donaldson, Ling Li, M. Jacobs, 2007, Investigative ophthalmology & visual science.

Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens.

Christian Soeller, Paul J Donaldson, Mark B Cannell, 2004, Investigative ophthalmology & visual science.

Resolving morphology and antibody labeling over large distances in tissue sections

Christian Soeller, Paul J Donaldson, Mark B Cannell, 2003, Microscopy research and technique.

Structure of an IκBα/NF-κB Complex

S. Harrison, M. Jacobs, 1998, Cell.

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).

J. Griffith, V. Damagnez, S. Mahajan, 2018, Journal of medicinal chemistry.

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

Xiaoling Xie, Jingrong Cao, Alex M Aronov, 2009, Journal of medicinal chemistry.

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

M. Murcko, P. Charifson, A. Kwong, 2014, Antimicrobial Agents and Chemotherapy.

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.

M. Murcko, F. Maltais, P. Charifson, 2014, Journal of medicinal chemistry.

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.

Xiaoling Xie, Jingrong Cao, Alex M Aronov, 2007, Journal of medicinal chemistry.

Stress and strain in staphylococcal nuclease

A. Hodel, R. Kautz, M. Jacobs, 1993, Protein science : a publication of the Protein Society.

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.

G. Bemis, F. Salituro, Edmund M. Harrington, 2009, Bioorganic & medicinal chemistry letters.

Magnetic resonance and confocal imaging of solute penetration into the lens reveals a zone of restricted extracellular space diffusion.

E. Vaghefi, P. Donaldson, M. Jacobs, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.

P. Charifson, T. Grossman, Tiansheng Wang, 2014, Journal of medicinal chemistry.

Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.

Jeffrey W. Peng, Xiaoling Xie, M. Jacobs, 2004, Journal of synchrotron radiation.

Structure of an IkBa/NF-kB Complex

S. Harrison, M. Jacobs, 1998 .

An Anatomically Realistic Geometrical Model of the Intra-epidermal Nerves in the Human Foot

Leo K. Cheng, Peng Du, M. Z. Ul Haque, 2014 .

Multiscale systems integration in the eye

Marc D Jacobs, M. Jacobs, 2009, Wiley interdisciplinary reviews. Systems biology and medicine.

Regulation of ERK-MAPK signaling in human epidermis

Edmund J. Crampin, Jerry Zeyu Gao, Marc Jacobs, 2015, BMC Systems Biology.

Application of two-photon flash photolysis to measure microscopic diffusion and calcium fluxes

Mark B. Cannell, Christian Soeller, Marc D. Jacobs, 2005, SPIE LASE.

Development of a 3D finite element model of lens microcirculation

Ehsan Vaghefi, Duane TK Malcolm, Marc D Jacobs, 2012, Biomedical engineering online.

Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.

G. Ellis‐Davies, C. Soeller, P. Donaldson, 2003, Journal of biomedical optics.

Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core.

P. Donaldson, Ling Li, M. Jacobs, 2007, Investigative ophthalmology & visual science.

Inference of an in situ epidermal intracellular signaling cascade

Edmund J. Crampin, Joseph Cursons, Catherine E. Angel, 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

Molecular identification of P-glycoprotein: a role in lens circulation?

P. Donaldson, M. Jacobs, J. Kistler, 2002, Investigative ophthalmology & visual science.

Uptake and distribution of gadolinium in the ocular lens

E. Vaghefi, M. Jacobs, 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis

Joseph Cursons, E. Crampin, D. Hurley, 2015, GigaScience.

Applications of SHAPES screening in drug discovery.

Jeffrey W. Peng, Xiaoling Xie, J. Pocas, 2002, Combinatorial chemistry & high throughput screening.

Crystal Structure of ROCK 1 bound to fasudil

M. Jacobs, 2005 .

Magnetic resonance and confocal imaging of solute penetration into the lens reveals a zone of restricted extracellular space diffusion.

E. Vaghefi, P. Donaldson, M. Jacobs, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Staphylococcal nuclease folding intermediate characterized by hydrogen exchange and NMR spectroscopy.

M. Jacobs, R. Fox, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Protein Folding Intermediates Characterized by Pulsed Hydrogen Exchange

M. Jacobs, R. Fox, 1994 .