Joelle Le

发表

Bringing kinases into focus: efficient drug design through the use of chemogenomic toolkits.

C. Harris, A. Stevens, V. Birault, 2006, Current medicinal chemistry.

An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.

Joelle Le, S. Macdonald, R. Hatley, 2018, Angewandte Chemie.

Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery

Paul N. Mortenson, Melanie V. Leveridge, S. Teague, 2014 .

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.

M. Fray, T. Mcinally, Joelle Le, 2014, ACS medicinal chemistry letters.

From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.

B. Bax, Joelle Le, Yoshiaki Washio, 2017, ACS medicinal chemistry letters.

Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.

C. Harris, Kei Imaizumi, J. Frearson, 2012, Journal of medicinal chemistry.

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.

P. Jones, P. Rowland, N. Parr, 2015, Journal of medicinal chemistry.

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.

Joelle Le, S. Lynn, S. Macdonald, 2019, Journal of medicinal chemistry.

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.

Joelle Le, S. Macdonald, J. Pritchard, 2018, Journal of medicinal chemistry.

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

D. Flint, R. Chambers, S. Pyne, 2020, Nature Communications.

Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.

V. Birault, Joelle Le, G. Dixon, 2012, Bioorganic & medicinal chemistry letters.

The discovery of an orally bioavailable pan-αv integrin inhibitor for idiopathic pulmonary fibrosis.

Joelle Le, S. Macdonald, Sebastien Campos, 2019, Journal of medicinal chemistry.

An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.

Joelle Le, S. Macdonald, R. Hatley, 2018, Angewandte Chemie.