L. Arnold

发表

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF

I. Tsigelny, S. Anand, P. Vogt, 2010, Proceedings of the National Academy of Sciences.

Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.

K. Glaser, S. Davidsen, V. Stoll, 2005, Journal of medicinal chemistry.

Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate dehydrogenase and LL-diaminopimelate epimerase.

J. Vederas, M. Palcic, M. Pickard, 1988, The Journal of biological chemistry.

1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.

S. Davidsen, G. Gintant, Eric F. Johnson, 2007, Journal of medicinal chemistry.

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.

S. Ratnofsky, L. Arnold, D. J. Calderwood, 2000, Bioorganic & medicinal chemistry letters.

Structural analyses of various Cu2+, Zn2+-superoxide dismutases by differential scanning calorimetry and Raman spectroscopy.

J. Lepock, J. Kruuv, L. Arnold, 1985, Archives of biochemistry and biophysics.

The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization

I. Weinstein, G. Gundersen, L. Arnold, 2006, Molecular Cancer Therapeutics.

A 13C NMR approach to categorizing potential limitations of α, β-unsaturated carbonyl systems in drug-like molecules

G. Gaza-Bulseco, E. Tarcsa, C. Barberis, 2004 .

A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase

F. Barany, D. Werner, S. Giardina, 2018, Pharmacology.

Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

F. Barany, D. Werner, S. Giardina, 2018, ACS medicinal chemistry letters.

Preclinical Development Preclinical Characterization of OSI-027 , a Potent and Selective Inhibitor of mTORC 1 and mTORC 2 : Distinct from Rapamycin

P. Houghton, P. Gokhale, D. Epstein, 2011 .

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production

C. Combet, F. Zoulim, B. Chabot, 2020, bioRxiv.

The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance.

A. Brossi, P. Gros, D. Tang‐Wai, 1993, Biochemistry.

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

N. Gibson, L. Arnold, J. Pachter, 2007, Molecular Cancer Therapeutics.

Interaction of superoxide dismutase with phospholipid liposomes. An uptake, spin label and calorimetric study.

J. Lepock, L. Arnold, A. Petkau, 1981, Biochimica et biophysica acta.

Reversibility of the thermal denaturation of yeast superoxide dismutase

J. Lepock, L. Arnold, 1982, FEBS letters.

The use of bis(mercaptoacetato-S,O)hydroxoiron(III) complex for the determination of hydroxamates.

L. Arnold, T. Viswanatha, 1983, Journal of biochemical and biophysical methods.

Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease

A. Krantz, L. Arnold, Roger A. Smith, 1996 .

Polymer-supported alkyl azodicarboxylates for Mitsunobu reactions

J. Vederas, L. Arnold, H. I. Assil, 1989 .

Synthesis of optically pure .alpha.-amino acids via salts of .alpha.-amino-.beta.-propiolactone

J. Vederas, L. Arnold, R. G. May, 1988 .

Conversion of serine .beta.-lactones to chiral .alpha.-amino acids by copper-containing organolithium and organomagnesium reagents

J. Vederas, L. Arnold, J. Drover, 1987 .

Conversion of serine to stereochemically pure .beta.-substituted .alpha.-amino acids via .beta.-lactones

J. Vederas, L. Arnold, T. Kalantar, 1985 .

Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate decarboxylase from Bacillus sphaericus and wheat germ.

J. Vederas, M. Palcic, M. Pickard, 1986, The Journal of biological chemistry.

Structure Activity Relationship in the Colchicine Molecule with Respect to Interaction with the Mammalian Multidrug Transporter, P-Glycoprotein

A. Brossi, P. Gros, D. Tang‐Wai, 1994 .

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.

N. Gibson, L. Arnold, K. Foreman, 2009, Future medicinal chemistry.

OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.

G. Wynne, N. Gibson, D. Emerson, 2006, Cancer research.

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

L. Pustilnik, P. Miller, B. Boman, 1997, Cancer research.

Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3

S. Emtage, Mark A. Brown, L. Arnold, 2011, PloS one.

Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin

P. Houghton, P. Gokhale, D. Epstein, 2011, Molecular Cancer Therapeutics.

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

F. Barany, Jutta Wanner, D. Werner, 2015, PloS one.

Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice.

L. Pustilnik, M. Morin, T. Smolarek, 1999, The Journal of pharmacology and experimental therapeutics.

Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

D. Werner, P. Gokhale, N. Gibson, 2011, Bioorganic & medicinal chemistry letters.

Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase.

F. Barany, D. Werner, S. Giardina, 2020, Journal of medicinal chemistry.

Inhibition of β-lactamase-I by 6-β-sulfonamidopenicillanic acid sulfones: Evidence for conformational change accompanying the inhibition process

M. Savard, L. Arnold, T. Viswanatha, 1985 .

1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.

S. Davidsen, I. Akritopoulou‐Zanze, M. Michaelides, 2006, Bioorganic & Medicinal Chemistry Letters.

Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.

I. Akritopoulou‐Zanze, M. Michaelides, T. Sowin, 2006, Bioorganic & medicinal chemistry letters.

Thermal denaturation of native and cross-linked bacillus cereus 569/II β-lactamase I

L. Arnold, T. Viswanatha, 1983 .

Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats.

R. Raghupathi, T. Mcintosh, K. Saatman, 2004, Restorative neurology and neuroscience.

Molecular interactions in crystal structures of potent inhibitors bound to the kinase domain of Tie-2

R. Dixon, Yajun Xu, C. Bellamacina, 2002 .

Synthesis of Optically Pure α-Amino Acids via Salts of α-Amino-β-propiolactone.

J. Vederas, L. Arnold, R. G. May, 1988 .

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.

N. Gibson, L. Arnold, K. Foreman, 2009, Future medicinal chemistry.