A. J. Roecker

发表

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding

K. Nicolaou, J. Pfefferkorn, S. Barluenga, 2000 .

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Steven V. Fox, John D. Schreier, J. Renger, 2014, Bioorganic & medicinal chemistry letters.

Discovery and Optimization of Non‐steroidal FXR Agonists from Natural Product‐Like Libraries.

R. Evans, M. Downes, R. Hughes, 2003 .

Building a Culture of Medicinal Chemistry Knowledge Sharing.

Andrew M Haidle, I. Raheem, Yeon-Hee Lim, 2022, Journal of medicinal chemistry.

Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings.

A. J. Roecker, J. Qi, Jingjun Yin, 2020, Organic letters.

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

J. Renger, P. Coleman, A. Gotter, 2016, Nature Structural &Molecular Biology.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

John D. Schreier, Youwei Yan, P. Coleman, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.

John D. Schreier, S. Doran, G. McGaughey, 2010, Bioorganic & medicinal chemistry letters.

Proline bis-amides as potent dual orexin receptor antagonists.

J. Renger, P. Coleman, D. Reiss, 2008, Bioorganic & medicinal chemistry letters.

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

D. Henze, C. Regan, Yuxing Li, 2022, Channels.

Novel strategies for the solid phase synthesis of substituted indolines and indoles.

R. Hughes, K. Nicolaou, J. Pfefferkorn, 2003, Bioorganic & medicinal chemistry.

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

Helen J. Mitchell, Guo-Qiang Cao, Jeffrey A. Pfefferkorn, 2000 .

A Novel Strategy for the Solid-Phase Synthesis of Substituted Indolines

K. Nicolaou, A. J. Roecker, A. Pfefferkorn, 2000 .

Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry.

K. Nicolaou, M. Follmann, A. J. Roecker, 2002, Angewandte Chemie.

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.

John D. Schreier, S. Doran, G. McGaughey, 2010, Journal of medicinal chemistry.

Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry.

K. Nicolaou, M. Follmann, A. J. Roecker, 2002, Angewandte Chemie.

Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.

K. Nicolaou, A. J. Roecker, P. Sasmal, 2005, Angewandte Chemie.

Discovery of Novel Antibacterial Agents Active Against Methicillin‐Resistant Staphylococcus aureus from Combinatorial Benzopyran Libraries

K C Nicolaou, A. Roecker, K. Nicolaou, 2001, Chembiochem : a European journal of chemical biology.

Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.

P. Coleman, Christopher D. Cox, A. J. Roecker, 2016, Journal of medicinal chemistry.

Discovery of 5′′‐Chloro‐N‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia

Steven V. Fox, John D. Schreier, J. Renger, 2014, ChemMedChem.

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.

Zhaobin Zhang, Wei Zhou, Paraskevi Giannakakou, 2005, Cancer research.

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Steven V. Fox, J. Renger, P. Coleman, 2016, Scientific Reports.

Orexin receptors as therapeutic drug targets.

J. Renger, P. Coleman, A. Gotter, 2012, Progress in brain research.

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.

R. Evans, M. Downes, R. Hughes, 2003, Organic & biomolecular chemistry.

Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects.

K. Nicolaou, Florian Kaiser, A. J. Roecker, 2005, Angewandte Chemie.

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.

Edward C Sherer, John Majercak, Deping Wang, 2017, Bioorganic & medicinal chemistry letters.

Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions.

K. Nicolaou, H. Monenschein, M. Follmann, 2003, Angewandte Chemie.

Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement

J. Uslaner, J. Renger, P. Coleman, 2014, Behavioural Brain Research.

Orexin receptor antagonists: medicinal chemistry and therapeutic potential.

P. Coleman, A. J. Roecker, 2008, Current topics in medicinal chemistry.

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

Steven V. Fox, Kenneth S. Koblan, Jason M. Uslaner, 2010, Neuropharmacology.

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).

J. Renger, P. Coleman, S. Garson, 2013, Bioorganic & medicinal chemistry letters.

The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine

Steven V. Fox, J. Uslaner, J. Renger, 2017, Journal of neurochemistry.

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

M. Bowman, J. Noel, J. Hogenesch, 2003, Molecular cell.

Discovery of dual orexin receptor antagonists (DORAs) for the treatment of insomnia.

P. Coleman, Christopher D. Cox, A. J. Roecker, 2011, Current topics in medicinal chemistry.

Discovery of Novel Antibacterial Agents Active Against Methicillin‐Resistant Staphylococcus aureus from Combinatorial Benzopyran Libraries

J. Pfefferkorn, S. Barluenga, A. J. Roecker, 2001, Chembiochem : a European journal of chemical biology.

Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase.

J. Casida, A. Roecker, K. Nicolaou, 2000, Chemistry & biology.

Hydroformylation and Late-Stage Diversification on Densely Functionalized Cores of Influenza Endonuclease Inhibitors

A. J. Roecker, Marion H. Emmert, Tao Liang, 2024, Organic Process Research & Development.