J. L. Gleason

发表

Amplification of screening sensitivity through selective destruction: theory and screening of a library of carbonic anhydrase inhibitors.

R. Kazlauskas, J. Cheeseman, Andrew D. Corbett, 2002, Journal of the American Chemical Society.

Highly Practical Methodology for the Synthesis of d- and l-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

J. L. Gleason, A. Myers, T. Yoon, 1997 .

Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones

Andrew Kopecky, J. L. Gleason, A. Myers, 1997 .

Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.

S. Mader, N. Moitessier, I. Jutras, 2015, Bioorganic & medicinal chemistry.

Pseudodynamic combinatorial libraries: a receptor-assisted approach for drug discovery.

R. Kazlauskas, J. Cheeseman, Andrew D. Corbett, 2004, Angewandte Chemie.

An o-aminoanilide analogue of 1α,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist.

John H. White, N. Moitessier, J. L. Gleason, 2010, Journal of medicinal chemistry.

A Spiroalkylation Method for the Stereoselective Construction of α-Quaternary Carbons and Its Application to the Total Synthesis of (R)-Puraquinonic Acid.

J. L. Gleason, Adam A. H. Elmehriki, J. Gleason, 2019, Organic letters.

Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer

John H. White, J. L. Gleason, Camille Barbier, 2022, Scientific Reports.

Efficacy of hybrid vitamin D receptor agonist/histone deacetylase inhibitors in vitamin D-resistant triple-negative 4T1 breast cancer

John H. White, Jie Su, D. Kaldre, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids.

John H. White, D. Kaldre, J. L. Gleason, 2015, Bioorganic & medicinal chemistry.

Hydrazide‐Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis ‐Decalins

D. Kaldre, J. L. Gleason, Josephine M. Warnica, 2019, Angewandte Chemie.

Hydrazide-Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis-Decalins.

D. Kaldre, J. L. Gleason, Josephine M. Warnica, 2019, Angewandte Chemie.

Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis

J. L. Gleason, A. Myers, Bryant H. Yang, 1994 .

Cobalt-catalyzed cycloisomerization of 1,6-enynes and allyl propargyl ethers.

J. L. Gleason, A. Ajamian, J. Gleason, 2003, Organic letters.

Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.

S. Mader, J. L. Gleason, David Cotnoir-White, 2018, Bioorganic & medicinal chemistry.

A robust synthesis of N-glycolyl muramyl dipeptide via azidonitration/reduction.

J. L. Gleason, Shuo Xing, 2015, Organic & biomolecular chemistry.

Application of Lewis acid catalyzed tropone [6+4] cycloadditions to the synthesis of the core of CP-225,917.

J. L. Gleason, J. Ashenhurst, L. Isakovic, 2001, Organic letters.

Synthesis of the 9,10-acetonide of 9-dihydro-FK-506

J. L. Gleason, L. Gegnas, T. Highsmith, 1992 .

CP-225,917 synthetic studies: unusual hydroboration regioselectivity influenced by remote functional groups

J. L. Gleason, J. Ashenhurst, J. Gleason, 2008 .

Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat.

A. Thomson, S. Mader, J. L. Gleason, 2021, Bioorganic & medicinal chemistry letters.

A Total Synthesis of FK-506.

J. L. Gleason, L. Gegnas, T. Highsmith, 1997 .

A Total Synthesis of FK-506(1).

J. L. Gleason, L. Gegnas, T. Highsmith, 1996, The Journal of organic chemistry.

A Practical Method for the Synthesis of D‐ or L‐α‐Amino Acids by the Alkylation of (+)‐ or (‐)‐Pseudoephedrine Glycinamide.

J. L. Gleason, A. Myers, T. Yoon, 1995 .

Practical method for the synthesis of D- or L-.alpha.-amino acids by the alkylation of (+)- or (-)-pseudoephedrine glycinamide.

J. L. Gleason, A. Myers, T. Yoon, 1995 .

Diastereoselective synthesis of 2H,5H-dihydrofurans by cobalt-mediated cycloisomerization of allyl propargyl ethers. Application to poly-THF molecules.

J. L. Gleason, A. Ajamian, J. Gleason, 2001, Organic letters.

Two birds with one metallic stone: single-pot catalysis of fundamentally different transformations.

J. L. Gleason, A. Ajamian, J. Gleason, 2004, Angewandte Chemie.

Total Synthesis of (-)-3-Oxoisotaxodione.

J. L. Gleason, S. Plamondon, 2022, Organic letters.

A bio-inspired cascade and a late-stage directed sp3 CH lithiation enables a concise total synthesis of (−)-virosaine A

J. L. Gleason, J. Hughes, J. Gleason, 2017 .

A Concise Enantioselective Total Synthesis of (-)-Virosaine A.

J. L. Gleason, J. Hughes, J. Gleason, 2017, Angewandte Chemie.

A practical chiral bicyclic thioglycolate lactam auxiliary for stereoselective quaternary carbon formation.

J. Manthorpe, J. L. Gleason, Azélie Arpin, 2006, Organic letters.

Stereoselective Formation of Quaternary Carbon Centers: Alkylation of α,α‐Disubstituted Amide Enolates

J. Manthorpe, J. L. Gleason, 2002 .

Total synthesis of FK-506. Part 2: Completion of the synthesis☆

J. L. Gleason, Longbin Liu, R. Ireland, 1997 .

Stable 5-substituted cyclopentadienes for the Diels-Alder cycloaddition and their application to the synthesis of palau'amine.

J. L. Gleason, T. Cernak, Jonathan Hudon, 2008, Angewandte Chemie.

Density functional theory guided design of exo-selective dehydroalanine dienophiles for application toward the synthesis of palau'amine.

J. L. Gleason, T. Cernak, 2008, The Journal of organic chemistry.

Diazepane Carboxylates as Organocatalysts in the Diels-Alder Reaction of α-Substituted Enals

D. Kaldre, J. L. Gleason, Benjamin Zank, 2018, European Journal of Organic Chemistry.

Organocatalytic Michael Addition of Indoles to α‐Substituted Enals by Using a Diazepane Carboxylate Catalyst

J. L. Gleason, J. Hughes, Damien F. Dewez, 2017 .

An Organocatalytic Cope Rearrangement.

D. Kaldre, J. L. Gleason, J. Gleason, 2016, Angewandte Chemie.

Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones

Andrew Kopecky, J. L. Gleason, A. Myers, 1997 .

Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines.

J. L. Gleason, J. Burch, J. Hughes, 2019, Organic letters.

Catalytic enantioselective homoaldol reactions using binol titanium(IV) fluoride catalysts

J. L. Gleason, Ngiap-Kie Lim, E. Burke, 2003 .

Application of a [6+4] cycloaddition strategy toward the total synthesis of CP-225,917

J. L. Gleason, J. Ashenhurst, L. Isakovic, 2010 .

Stereoselective Formation of α‐Quaternary Stereocenters in the Mannich Reaction.

J. L. Gleason, E. A. Tiong, 2009 .

Stereoselective formation of alpha-quaternary stereocenters in the Mannich reaction.

J. L. Gleason, E. A. Tiong, 2009, Organic letters.

Stereoselective Generation of E‐ and Z‐Disubstituted Amide Enolates. Reductive Enolate Formation from Bicyclic Thioglycolate Lactams.

J. Manthorpe, J. L. Gleason, 2001 .

Stereoselective generation of E- and Z-disubstituted amide enolates. Reductive enolate formation from bicyclic thioglycolate lactams.

J. Manthorpe, J. L. Gleason, 2001, Journal of the American Chemical Society.

Alpha,alpha-disubstituted boron enolates in the asymmetric synthesis of quaternary carbon centers.

J. L. Gleason, E. Burke, 2004, Organic letters.

An Organocatalytic Oxy-Cope/Michael Cascade Reaction.

J. L. Gleason, R. R. Barrett, Donald A Campbell, 2023, Organic letters.

Mechanism of an Organocatalytic Cope Rearrangement Involving Iminium Intermediates: Elucidating the Role of Catalyst Ring Size.

K. Houk, J. N. Sanders, J. L. Gleason, 2020, Journal of the American Chemical Society.

A one-step synthesis of pseudoephedrine glycinamide, a versatile precursor for the synthesis of α-amino acids

J. L. Gleason, A. Myers, T. Yoon, 1995 .

A Practical Synthesis of L-Azatyrosine.

J. L. Gleason, A. Myers, 1996, The Journal of organic chemistry.

Receptor-assisted combinatorial chemistry: thermodynamics and kinetics in drug discovery.

R. Kazlauskas, J. Cheeseman, Andrew D. Corbett, 2005, Chemistry.

Preparation of active esters on solid support for aqueous-phase peptide couplings

Andrew D. Corbett, J. L. Gleason, J. Gleason, 2002 .

A concise total synthesis of (R)-puraquinonic acid.

J. L. Gleason, Daniel Rivalti, Benjamin M Williams, 2013, Angewandte Chemie.

Asymmetric Synthesis of α‐Amino Acids by the Alkylation of Pseudoephedrine Glycinamide: L‐Allylglycine and N‐Boc‐L‐Allylglycine

J. L. Gleason, A. Myers, 2003 .

Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide

M. Reed, M. Behr, M. Kelliher, 2009, The Journal of experimental medicine.

Role of SUMOylation in Full Antiestrogenicity

M. Rozendaal, S. Mader, P. Thibault, 2012, Molecular and Cellular Biology.

Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist

John H. White, Luz E. Tavera-Mendoza, Xiaohong Liao, 2008, Proceedings of the National Academy of Sciences.

Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition.

John H. White, Dino Moras, Natacha Rochel, 2012, Chemistry & biology.

Antiestrogens: structure-activity relationships and use in breast cancer treatment

S. Mader, J. L. Gleason, M. El Ezzy, 2016, Journal of molecular endocrinology.

Homozygous Calcium-Sensing Receptor Polymorphism R544Q Presents as Hypocalcemic Hypoparathyroidism

R. Domingues, G. Hendy, J. L. Gleason, 2018, The Journal of clinical endocrinology and metabolism.

Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.

John H. White, Beum-Soo An, Marc Lamblin, 2010, Bioorganic & medicinal chemistry.

Docking Ligands into Flexible and Solvated Macromolecules. 6. Development and Application to the Docking of HDACs and other Zinc Metalloenzymes Inhibitors

Nicolas Moitessier, Joshua Pottel, Eric Therrien, 2014, J. Chem. Inf. Model..