M. Mandal

发表

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency.

W. Olson, S. Danishefsky, V. Dudkin, 2004, Journal of the American Chemical Society.

Probing competitive pathways in building a hydroazulene moiety by reductive cyclization

S. Danishefsky, M. Mandal, 2004 .

Probing the formation and chemistry of enoxyoxirane derivatives in the C-ring en route to guanacastepene

S. Danishefsky, M. Mandal, 2004 .

Stereoselective Nucleophilic Trifluoromethylation of N-(tert-Butylsulfinyl)imines by Using Trimethyl(trifluoromethyl)silane.

G. Olah, G. Prakash, M. Mandal, 2001, Angewandte Chemie.

Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement

A. Stamford, J. Cumming, P. Orth, 2021, European Journal of Organic Chemistry.

Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

T. Oskarsson, J. Massagué, O. Ouerfelli, 2010, Journal of the American Chemical Society.

In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments.

S. Danishefsky, V. Dudkin, X. Geng, 2004, Angewandte Chemie.

Total synthesis of (+)-isomigrastatin.

S. Danishefsky, M. Mandal, I. Krauss, 2007, Angewandte Chemie.

Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.

Walter A. Korfmacher, W. Greenlee, A. Cheng, 2022, Journal of medicinal chemistry.

Nucleophilic trifluoromethylation tamed

G. Prakash, M. Mandal, 2001 .

12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.

S. Adler, C. Nast, J. Lapage, 2005, Prostaglandins, leukotrienes, and essential fatty acids.

On the power of super acid—iodination of aromatic ring in the presence of imidazole moiety of the potent gamma secretase modulators (GSM) en route to tritium labeling

A. Stamford, Zhaoning Zhu, M. Mandal, 2012 .

Facile synthesis of TMS-protected trifluoromethylated alcohols using trifluoromethyltrimethylsilane (TMSCF3) and various nucleophilic catalysts in DMF.

G. Olah, G. Prakash, M. Mandal, 2006, The Journal of organic chemistry.

Stereoselective synthesis of trifluoromethylated vicinal ethylenediamines with alpha-amino N-tert-butanesulfinimines and TMSCF3.

G. Prakash, M. Mandal, 2002, Journal of the American Chemical Society.

Asymmetric synthesis of trifluoromethylated allylic amines using alpha,beta-unsaturated N-tert-butanesulfinimines.

G. Olah, G. Prakash, G. Prakash, 2001, Organic letters.

Stereoselective synthesis of anti-α-(difluoromethyl)-β-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S, 3R)-difluorothreonine

G. Olah, N. Petasis, G. Prakash, 2002 .

Nucleophilic Trifluoromethylation of N-Tosyl Aldimines

G. Olah, G. Prakash, M. Mandal, 2001 .

Total synthesis of guanacastepene a: a route to enantiomeric control.

Derek S. Tan, S. Danishefsky, M. Mandal, 2005, The Journal of organic chemistry.

Aroylation of aromatics with aryl carboxylic acids over Nafion-H (polymeric perfluoroalkanesulfonic acid), an environmentally friendly solid acid catalyst

G. Olah, G. Prakash, M. Mandal, 2005 .

Nucleophilic Trifluoromethylation of N-Tosyl Aldimines

G. Olah, G. Prakash, M. Mandal, 2001 .

Preparation of TMS protected trifluoromethylated alcohols using trimethylamine N-oxide and trifluoromethyltrimethylsilane (TMSCF3)

G. Olah, G. Prakash, M. Mandal, 2003 .

A facile stereocontrolled synthesis of anti-alpha-(trifluoromethyl)-beta-amino alcohols.

N. Petasis, G. Prakash, M. Mandal, 2000, Organic letters.

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.

Lynn A. Hyde, W. Greenlee, Wei Zhou, 2012, ACS medicinal chemistry letters.

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

D. Wyss, A. Therien, T. Fischmann, 2022, Journal of Medicinal Chemistry.

In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence.

S. Danishefsky, V. Dudkin, X. Geng, 2004, Angewandte Chemie.

Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.

William Greenlee, Lynn Hyde, Xia Chen, 2012, Journal of medicinal chemistry.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

Generation of Leads for γ-Secretase Modulation.

Lynn A. Hyde, A. Palani, Zhaoning Zhu, 2020, Journal of medicinal chemistry.

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2016, Journal of medicinal chemistry.

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.

Lynn A. Hyde, W. Greenlee, A. Palani, 2011, Bioorganic & medicinal chemistry letters.

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.

Lynn A. Hyde, A. Stamford, J. Cumming, 2018, Journal of medicinal chemistry.