W. Redfern

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

A. Camm, R. Wallis, T. Hammond, 2003, Cardiovascular research.

Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?

Rob Wallis, Jean-Pierre Valentin, Matthew J Winter, 2008, Journal of pharmacological and toxicological methods.

Spectrum of effects detected in the rat functional observational battery following oral administration of non-CNS targeted compounds.

J. Valentin, T. Hammond, W. Redfern, 2005, Journal of pharmacological and toxicological methods.

Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials.

S. Jackson, Kathryn L Chapman, J. Valentin, 2016, Regulatory toxicology and pharmacology : RTP.

Further validation of an automated gait analysis system for applications in safety pharmacology

Jean-Pierre Valentin, Graham Vickery, Helen Prior, 2011 .

Trends in safety pharmacology: posters presented at the annual meetings of the Safety Pharmacology Society 2001-2010.

J. Valentin, W. Redfern, 2011, Journal of pharmacological and toxicological methods.

The role of α2‐adrenoceptors in the vasculature of the rat tail

M. Maclean, W. Redfern, J. McGrath, 1995 .

Validation of the use of zebrafish larvae in visual safety assessment.

T. Hutchinson, J. Valentin, W. Alderton, 2008, Journal of pharmacological and toxicological methods.

Effects of a monocarboxylate transport 1 inhibitor, AZD3965, on retinal and visual function in the rat

R. Lucas, W. Redfern, E. A. Martin, 2020, British journal of pharmacology.

The role of catecholamines in the production of ischaemia‐induced ventricular arrhythmias in the rat in vivo and in vitro

K. Frayn, A. Daugherty, B. Woodward, 1986, British journal of pharmacology.

An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

Matthew M. Abernathy, S. Authier, T. Wisialowski, 2020, International journal of toxicology.

RS‐45041‐190: a selective, high‐affinity ligand for I2 imidazoline receptors

M. Spedding, W. Redfern, A. Mackinnon, 1995, British journal of pharmacology.

[3H]‐RS‐45041‐190: a selective high‐affinity radioligand for I2 imidazoline receptors

A. MacKinnon, C. Brown, W. Redfern, 1995, British journal of pharmacology.

The pharmacology of RS‐15385‐197, a potent and selective α2‐adrenoceptor antagonist

M. Spedding, A. MacKinnon, C. Brown, 1993 .

Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.

Rowland R. Sillito, J. D. Armstrong, N. Karp, 2018, Journal of pharmacological and toxicological methods.

Contribution of the periaqueductal grey matter to the development of hypertension in the spontaneously hypertensive rat.

W. Redfern, C. Yardley, 1990, Journal of the autonomic nervous system.

Components of injury (haemorrhage and tissue ischaemia) affecting cardiovascular reflexes in man and rat.

H. B. Stoner, R. Little, P. Randall, 1984, Quarterly journal of experimental physiology.

Safety pharmacology investigations on the nervous system: An industry survey.

J. Arezzo, S. Authier, J. Valentin, 2016, Journal of pharmacological and toxicological methods.

Rodent big brother: Development and validation of a home cage automated behavioural monitoring system for use in repeat-dose toxicity studies in rats

J. D. Armstrong, T. Lukins, Kathryn L Chapman, 2014 .

Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.

Jean-Pierre Valentin, Matthew J Winter, Stewart F Owen, 2008, Journal of pharmacological and toxicological methods.

Functional assessments in repeat-dose toxicity studies: the art of the possible

Jean-Pierre Valentin, Sally Robinson, Lorna Ewart, 2013 .

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

Claire Grant, David J. Simpson, Natasha A Karp, 2017, PloS one.

Approaches to seizure risk assessment in preclinical drug discovery.

Jean-Pierre Valentin, Matthew J Winter, Russell A Bialecki, 2009, Drug discovery today.

A framework to assess the translation of safety pharmacology data to humans.

Rob Wallis, Jean-Pierre Valentin, Lorna Ewart, 2009, Journal of pharmacological and toxicological methods.

Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish

W. Redfern, T. Whitfield, M. Winter, 2012, Hearing Research.

The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods.

N. Karp, W. Redfern, I. Strang, 2019, Journal of pharmacological and toxicological methods.

A search for brain stem cell groups integrating the defence reaction in the rat.

W. Redfern, S. Hilton, 1986, The Journal of physiology.

Inclusion of Safety Pharmacology Endpoints in Repeat-Dose Toxicity Studies.

W. Redfern, 2015, Handbook of experimental pharmacology.

Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice.

Jean-Pierre Valentin, Dan Heathcote, J. S. McKay, 2011, Journal of pharmacological and toxicological methods.

Safety pharmacology – a progressive approach

Helen Prior, J. Valentin, C. Pollard, 2002, Fundamental & clinical pharmacology.

Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.

Jean-Pierre Valentin, Hugo M Vargas, Simon Authier, 2017, Journal of pharmacological and toxicological methods.

A re‐evaluation of the role of α2‐adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat

W. Redfern, A. Williams, 1995, British journal of pharmacology.

The role of alpha 2-adrenoceptors in the vasculature of the rat tail.

M. Maclean, W. Redfern, J. McGrath, 1995, British Journal of Pharmacology.

Thepharmacology ofRS-15385-197, a potentandselective M2-adrenoceptor antagonist

D. Clark, M. Spedding, A. MacKinnon, 1993 .

A potential algorithm for predicting drug-induced nausea in man

J. Valentin, R. Wallis, W. Redfern, 2011 .

The application of in vitro methods to safety pharmacology

J. Valentin, C. Pollard, T. Hammond, 2002, Fundamental & clinical pharmacology.

Impact and prevalence of safety pharmacology-related toxicities throughout the pharmaceutical life cycle

Jean-Pierre Valentin, Lorna Ewart, J. Valentin, 2010 .

The Diplomate in Safety Pharmacology (DSP) certification scheme.

R. Hamlin, S. Authier, J. Koerner, 2015, Journal of pharmacological and toxicological methods.

An overview of the safety pharmacology society strategic plan.

S. Authier, J. Koerner, J. Valentin, 2018, Journal of pharmacological and toxicological methods.

Cardiovascular safety risk assessment for new candidate drugs from functional and pathological data: Conference report.

W. Redfern, S. Klein, 2015, Journal of pharmacological and toxicological methods.

intheanxiogenic effects ofyohimbine, using theselective antagonist delequamine intherat

W. Redfern, 1995 .

Effect of limb ischaemia on blood pressure and the blood pressure-heart rate reflex in the rat.

H. B. Stoner, R. Little, W. Redfern, 1984, Quarterly journal of experimental physiology.

The guinea‐pig ileum preparation as a model for 5‐HT1A receptors: anomalous effects with RS‐30199–193

M. Spedding, W. Redfern, C. Brown, 1991, British journal of pharmacology.

Modulation of central noradrenergic function by RS‐15385‐197

M. Spedding, A. MacKinnon, W. Redfern, 1993, British journal of pharmacology.