L. Pettus

发表

Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.

N. Chen, J. Treanor, C. Dominguez, 2007, Journal of medicinal chemistry.

MCC/SNAr methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines

C. Hulme, L. Pettus, P. Tempest, 2003 .

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2016, Bioorganic & medicinal chemistry letters.

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2015, Bioorganic & medicinal chemistry letters.

Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

E. Lobenhofer, Kristin L. Andrews, B. Herberich, 2015, ACS medicinal chemistry letters.

The Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in vivo Selectivity over BACE2.

D. Whittington, Michael G. Johnson, M. Bartberger, 2020, Journal of medicinal chemistry.

Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.

L. Pettus, Ryan P. Wurz, 2008, Current topics in medicinal chemistry.

Asymmetric synthesis and fragmentation reactions of 2-alkyl- and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones. Single enantiomer preparation of Δα, β-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones

L. Pettus, K. Thakkar, A. Schultz, 1998 .

Cycloadditions of o -quinone dimethides with p -quinol derivatives: regiocontrolled formation of anthracyclic ring systems

T. Pettus, L. Pettus, Junhua Wang, 2004 .

Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.

Matthew R. Lee, A. Tasker, Bin Wu, 2010, Journal of medicinal chemistry.

Desymmetrization of Benzoic Acid in the Context of the Asymmetric Birch Reduction−Alkylation Protocol. Asymmetric Total Syntheses of (−)-Eburnamonine and (−)-Aspidospermidine

L. Pettus, A. Schultz, 1997 .

Identification of triazolopyridazinones as potent p38α inhibitors.

S. Chmait, B. Herberich, Matthew R. Lee, 2012, Bioorganic & medicinal chemistry letters.

Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, K. Miner, Matthew R. Lee, 2010, Bioorganic & medicinal chemistry letters.

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

Christopher Mohr, Lisa Sherman, S. Chmait, 2010, Journal of medicinal chemistry.

Intermolecular Applications of o‐Quinone Methides (o‐QMs) Anionically Generated at Low Temperatures: Kinetic Conditions

T. Pettus, L. Pettus, 2009 .

Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.

J. Treanor, P. Chakrabarti, N. Gavva, 2007, Bioorganic & medicinal chemistry letters.

A 6-exo-trig radical cyclization approach to the hydrochrysene skeleton

T. Guzi, Xuqing Zhang, L. Pettus, 2002 .

Synthesis of (+/-)-epoxysorbicillinol using a novel cyclohexa-2,5-dienone with synthetic applications to other sorbicillin derivatives.

T. Pettus, L. Pettus, R. W. Van De Water, 2001, Organic letters.

Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide

L. Pettus, A. Schultz, 1997 .

Asymmetric Syn-Selective Aldol Reactions of γ-Oxygenated Vinylogous Urethane with a Second Generation Chiral Auxiliary: Application in Construction of (+)-3-Deoxy-d-manno-2-octulosonic Acid

L. Pettus, R. H. Schlessinger, 1998 .

Enantioselective hydride abstraction in organic substrates: a novel use for chiral carbenium ions.

T. Pettus, L. Pettus, D. Magdziak, 2001, Organic letters.

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.

L. Poppe, J. McCarter, Grace Chung, 2022, Journal of Medicinal Chemistry.

Cycloadditions of o-Quinone Dimethides with p-Quinol Derivatives: Regiocontrolled Formation of Anthracyclic Ring Systems.

T. Pettus, L. Pettus, Junhua Wang, 2004 .

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Journal of medicinal chemistry.

Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Xiaolin Hao, Ben Fisher, Andreas Reichelt, 2015, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Bioorganic & medicinal chemistry letters.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Daniel J. Freeman, J. McCarter, D. Whittington, 2012, Journal of medicinal chemistry.

Novel fragmentation reaction of 2-alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones.

Xuqing Zhang, L. Pettus, K. Thakkar, 2004, The Journal of organic chemistry.

Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.

R. Syed, B. Herberich, Matthew R. Lee, 2008, Journal of medicinal chemistry.

3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.

R. Syed, Matthew R. Lee, A. Tasker, 2008, Journal of medicinal chemistry.

Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

K. Rex, J. Canon, B. Herberich, 2019, Journal of medicinal chemistry.

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, Journal of medicinal chemistry.

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, ACS medicinal chemistry letters.

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Matthew R. Lee, A. Tasker, Bin Wu, 2015, Bioorganic & medicinal chemistry letters.

Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, K. Miner, Matthew R. Lee, 2009, Bioorganic & medicinal chemistry letters.

Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.

J. McCarter, D. Whittington, A. Tasker, 2014, Bioorganic & medicinal chemistry letters.

Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

E. Lobenhofer, B. Herberich, A. Tasker, 2015, ACS Medicinal Chemistry Letters.

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, B. Herberich, Matthew R. Lee, 2010, Journal of medicinal chemistry.