J. Northup

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The G‐protein coupling properties of the human sweet and amino acid taste receptors

J. Battey, E. Sainz, S. L. Sullivan, 2007, Developmental neurobiology.

Elucidation of the Role of Peptide Linker in Calcium-sensing Receptor Activation Process*

K. Adipietro, J. Northup, K. Ray, 2007, Journal of Biological Chemistry.

Calindol, a Positive Allosteric Modulator of the Human Ca2+ Receptor, Activates an Extracellular Ligand-binding Domain-deleted Rhodopsin-like Seven-transmembrane Structure in the Absence of Ca2+*

P. Dauban, J. Northup, M. Ruat, 2005, Journal of Biological Chemistry.

Evidence for Distinct Cation and Calcimimetic Compound (NPS 568) Recognition Domains in the Transmembrane Regions of the Human Ca2+ Receptor*

J. Northup, K. Ray, Kausik Ray, 2002, The Journal of Biological Chemistry.

Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors.

M. Glass, J. Northup, M Glass, 1999, Molecular pharmacology.

Differential activation of G‐proteins by μ‐opioid receptor agonists

M. Glass, D. Hay, J. Northup, 2006, British journal of pharmacology.

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

A. Gilman, J. Northup, M. Smigel, 1982, The Journal of biological chemistry.

Functional Reconstitution in Situ of 5-Hydroxytryptamine2c (5HT2c) Receptors with αq and Inverse Agonism of 5HT2c Receptor Antagonists*

J. Northup, J. L. Hartman, 1996, The Journal of Biological Chemistry.

The Bombesin Receptor Subtypes Have Distinct G Protein Specificities*

R. Jensen, J. Battey, E. Sainz, 1999, The Journal of Biological Chemistry.

The role of cysteines and charged amino acids in extracellular loops of the human Ca(2+) receptor in cell surface expression and receptor activation processes.

J. Northup, Sanchita P. Ghosh, K. Ray, 2004, Endocrinology.

Steady-state levels of G-proteins and beta-adrenergic receptors in rat fat cells. Permissive effects of thyroid hormones.

C. Malbon, J. Northup, M. Ros, 1988, The Journal of biological chemistry.

Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level*

J. Northup, K. Ray, X. Zhuang, 2011, The Journal of Biological Chemistry.

An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gαq Activation

Shoaib Chowdhury, K. C. Suddala, J. Northup, 2011, Nature Structural &Molecular Biology.

Functional expression of the taste specific G-protein, alpha-gustducin.

N. Ryba, R. Margolskee, M. Hoon, 1995, The Biochemical journal.

An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling.

R. Jensen, M. Akeson, J. Battey, 1999, Biochemistry.

Action of insulin modulated by pertussis toxin in rat adipocytes.

M. Hollenberg, J. Northup, H. Goren, 1985, Canadian journal of physiology and pharmacology.

The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.

A. Dromerick, P. Sternweis, E. Hanski, 1981, The Journal of biological chemistry.

Phosphorylation Uncouples the Gastrin-releasing Peptide Receptor from Gq *

J. Battey, J. Northup, X. Jian, 1999, The Journal of Biological Chemistry.

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

A. Gilman, P. Sternweis, J. Northup, 1983, The Journal of biological chemistry.

Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

T. K. Harden, J. Perkins, J. Northup, 1983, The Journal of biological chemistry.

Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I.

M. Hollenberg, D. Severson, J. Northup, 1988, The Journal of clinical investigation.

Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.

R. Kahn, A. Gilman, P. Sternweis, 1982, The Journal of biological chemistry.

Pertussis toxin treatment in vivo is associated with a decline in G-protein beta-subunits.

C. Malbon, J. Northup, D. C. Watkins, 1989, The Journal of biological chemistry.

Characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase.

A. Gilman, J. Northup, M. Smigel, 1982, Recent progress in hormone research.

Purification and properties of the regulatory component (G/F) of adenylate cyclase.

P. Sternweis, E. Hanski, J. Northup, 1981, Advances in cyclic nucleotide research.

The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.

P. Sternweis, J. Northup, J. Garrison, 1980, The Journal of biological chemistry.

Purification of the major GTP-binding proteins from human placental membranes.

J. Northup, T. Evans, M. Brown, 1986, The Journal of biological chemistry.

The regulatory component of adenylate cyclase. Purification and properties.

A. Gilman, P. Sternweis, J. Northup, 1981, The Journal of biological chemistry.

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

T. Katada, A. Gilman, G. Bokoch, 1984, The Journal of biological chemistry.

Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity.

T. Katada, A. Gilman, G. Bokoch, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

Modification of human 5-HT2C receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution

D. Goldman, M. Linnoila, J. Russell, 2004, Molecular Psychiatry.

G-protein beta gamma forms: identity of beta and diversity of gamma subunits.

H. Tamir, J. Northup, T. Evans, 1991, Biochemistry.

The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes.

M. Simon, N. Gautam, J. Northup, 1988, The Journal of biological chemistry.

Purification of a beta 35 form of the beta gamma complex common to G-proteins from human placental membranes.

J. Northup, T. Evans, M. Brown, 1987, The Journal of biological chemistry.

In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor (bb2) Ligand Binding and G-Protein Coupling

J. Battey, R. Jensen, M. Akeson, 1998 .

Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes.

J. Northup, J. Garrison, P. Bauer, 1991, Molecular pharmacology.

Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor.

K. Adipietro, J. Northup, K. Ray, 2010, Endocrinology.

The helical domain of a G protein alpha subunit is a regulator of its effector.

W. Liu, J. Northup, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Selective reconstitution of gastrin-releasing peptide receptor with Gαq

J. Battey, J. Northup, M. Hellmich, 1997 .

Selective reconstitution of gastrin-releasing peptide receptor with G alpha q.

J. Battey, J. Northup, M. Hellmich, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Adipocyte G-proteins and adenylate cyclase. Effects of adrenalectomy.

C. Malbon, J. Northup, M. Ros, 1989, The Biochemical journal.

Measuring rhodopsin-G-protein interactions by surface plasmon resonance.

J. Northup, 2004, Methods in molecular biology.

G protein diversity is increased by associations with a variety of gamma subunits.

M. Simon, Melvin I. Simon, H. Tamir, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

M. Wigler, A. Fujiyama, F. Tamanoi, 1985, Cell.

Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits.

T. K. Harden, C. Downes, J. Northup, 1989, The Journal of biological chemistry.

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go.

T. K. Harden, J. Northup, M. Martin, 1987, The Biochemical journal.

Mechanism of Allosteric Regulation of the Rod cGMP Phosphodiesterase Activity by the Helical Domain of Transducin α Subunit*

J. Northup, W. Clark, Wei Liu, 1998, The Journal of Biological Chemistry.

Purification of the regulatory component of adenylate cyclase.

A. Gilman, E. Ross, P. Sternweis, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Potential problems in using [35S]-dATP-tailed oligonucleotides for detecting mRNAs in certain cells of the immune system.

M. Palkovits, É. Mezey, G. Harta, 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Functional characterization of human bitter taste receptors.

James F Battey, J. Battey, E. Sainz, 2007, The Biochemical journal.

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

T. Katada, A. Gilman, G. Bokoch, 1984, The Journal of biological chemistry.

Guanine nucleotide binding characteristics of transducin: essential role of rhodopsin for rapid exchange of guanine nucleotides.

J. Northup, A. Fawzi, 1990, Biochemistry.

ADP-RIBOSYLATION OF THE REGULATORY COMPONENTS OF ADENYLATE CYCLASE1,2

T. Katada, R. Kahn, A. Gilman, 1983 .

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

E. Hewlett, T. Katada, A. Gilman, 1983, The Journal of biological chemistry.

Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.

C. Malbon, J. Northup, D. C. Watkins, 1987, The Journal of biological chemistry.

Isolation of a major human placental substrate for the epidermal growth factor (urogastrone) receptor kinase: immunological cross-reactivity with transducin and sequence homology with lipocortin.

M. Hollenberg, J. Northup, K. A. Valentine-Braun, 1987, Archives of biochemistry and biophysics.

G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate.

C. Malbon, P. Rapiejko, J. Northup, 1986, The Biochemical journal.

Signal Transduction Mediated by Heptahelical Receptors and Heterotrimeric G Proteins

T. Hébert, J. Northup, R. V. Rebois, 2006 .

Adenosine cyclic 3',5'-monophosphate in the liver fluke, Fasciola hepatica. I. Activation of adenylate cyclase by 5-hydroxytryptamine.

J. Northup, T. Mansour, S. L. Abrahams, 1976, Molecular pharmacology.

Adenylate cyclase from Fasciola hepatica. 1. Ligand specificity of adenylate cyclase-coupled serotonin receptors.

J. Northup, T. Mansour, 1978, Molecular pharmacology.

Adenylate cyclase from Fasciola hepatica. 2. Role of guanine nucleotides in coupling adenylate cyclase and serotonin receptors.

J. Northup, T. Mansour, 1978, Molecular pharmacology.

Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid.

R. Ghirlando, J. Gvozdenovic-Jeremic, J. Northup, 2012, Journal of molecular biology.

Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

Joseph Shiloach, Reinhard Grisshammer, J. Louis, 2007, Proceedings of the National Academy of Sciences.

The Regulatory Component of Adenylate Cyclase

A. Dromerick, P. Sternweis, J. Northup, 1981 .

Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human

J. R. Holt, H. Kremer, C. Srisailapathy, 2011, Nature communications.

Activation of a small GTP-binding protein by nucleoside diphosphate kinase.

R. Kahn, J. Northup, P. Randazzo, 1991, Science.

Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic.

P. Novick, B. Goud, J. Northup, 1990, The Journal of biological chemistry.

Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists*

N. Kaur, M. Gershengorn, S. Neumann, 2006, Journal of Biological Chemistry.

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.

A. Gilman, P. Sternweis, J. Northup, 1983, The Journal of biological chemistry.

Rhodopsin and the retinal G-protein distinguish among G-protein beta gamma subunit forms.

H. Tamir, D. Fay, E. A. Murphy, 1991, The Journal of biological chemistry.

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

T. Katada, A. Gilman, G. Bokoch, 1984, The Journal of biological chemistry.

Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex.

M. Hollenberg, J. Northup, K. A. Valentine-Braun, 1986, Proceedings of the National Academy of Sciences of the United States of America.

D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase.

T. Hébert, P. Fishman, J. Northup, 2012, Cellular signalling.

Gβγ Affinity for Bovine Rhodopsin Is Determined by the Carboxyl-terminal Sequences of the γ Subunit*

Sanford P. Markey, William F. Simonds, Jeffrey A. Kowalak, 2001, The Journal of Biological Chemistry.

Independent and synergistic interaction of retinal G-protein subunits with bovine rhodopsin measured by surface plasmon resonance.

J. Northup, W A Clark, J K Northup, 2001, The Biochemical journal.

Purification, Characterization, and Partial Amino Acid Sequence of a G Protein-activated Phospholipase C from Squid Photoreceptors (*)

J. Northup, Jane Mitchell, J K Northup, 1995, The Journal of Biological Chemistry.

Nucleotide exchange factors

J. Northup, P. Randazzo, X. Jian, 2012, Cellular logistics.

Elucidating kinetic and thermodynamic constants for interaction of G protein subunits and receptors by surface plasmon resonance spectroscopy.

Peter Schuck, P. Schuck, J. Northup, 2002, Methods in enzymology.

Functional Analysis and Genomics of G-Protein-Coupled Receptors

J. Northup, K. Ray, Kausik Ray, 2008 .

Prenyl modification of guanine nucleotide regulatory protein gamma 2 subunits is not required for interaction with the transducin alpha subunit or rhodopsin.

H. Tamir, E. Leberer, J. Northup, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

D. Clapham, E. Neer, D. Logothetis, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes

J. Northup, P. Randazzo, O. Soubias, 2013, Cellular logistics.

Serotonin-activated adenylate cyclase from Fasciola hepatica. Properties of the solubilized enzyme.

J. Northup, T. Mansour, J. Grove, 1979, Journal of Biological Chemistry.

Quantitative a nalysis of Guanine Nucleotide exchange Factors (G eFs) as e nzymes

J. Northup, X. Jian, P. Zhai, 2013 .

Regulatory GTP-binding proteins (ADP-ribosylation factor, Gt, and RAS) are not activated directly by nucleoside diphosphate kinase.

R. Kahn, J. Northup, P. Randazzo, 1992, The Journal of biological chemistry.

Nucleoside diphosphate kinase: conclusions withdrawn.

R. Kahn, J. Northup, P. Randazzo, 1992, Science.

Defective guanyl nucleotide-binding protein beta gamma subunits in a forskolin-resistant mutant of the Y1 adrenocortical cell line.

B. Schimmer, J. Northup, J. Mitchell, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Two amino acids in the sixth transmembrane segment of the mouse gastrin-releasing peptide receptor are important for receptor activation.

R. Jensen, J. Battey, J. Northup, 2000, The Journal of pharmacology and experimental therapeutics.

Comparison of G‐Protein Selectivity of Human 5‐HT2C and 5‐HT1A Receptors

N. Iwata, N. Ozaki, M. Linnoila, 2004, Annals of the New York Academy of Sciences.

Activation of a small GTP-binding protein by nucleoside diphosphate kinase

R. Kahn, J. Northup, P. Randazzo, 1992 .