B. Wiśniowska

发表

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

S. Polak, B. Wiśniowska, J. Brandys, 2009, Journal of applied toxicology : JAT.

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges.

S. Polak, K. Fijorek, A. Mendyk, 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.

S. Polak, B. Wiśniowska, 2017, Drug discovery today.

In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.

S. Polak, K. Fijorek, A. Mendyk, 2014, Drug discovery today.

Enhanced QSAR models for drug‐triggered inhibition of the main cardiac ion currents

S. Polak, J. Szlęk, A. Mendyk, 2015, Journal of applied toxicology : JAT.

Predictive model for L‐type channel inhibition: multichannel block in QT prolongation risk assessment

S. Polak, K. Fijorek, A. Mendyk, 2012, Journal of applied toxicology : JAT.

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment

S. Polak, K. Fijorek, A. Mendyk, 2012, Toxicology mechanisms and methods.

hERG in vitro interchange factors—development and verification

S. Polak, B. Wiśniowska, 2009, Toxicology mechanisms and methods.

Slow delayed rectifying potassium current (IKs) – analysis of the in vitro inhibition data and predictive model development

S. Polak, K. Fijorek, A. Mendyk, 2013, Journal of applied toxicology : JAT.

Drug–physiology interaction and its influence on the QT prolongation-mechanistic modeling study

S. Polak, B. Wiśniowska, 2018, Journal of Pharmacokinetics and Pharmacodynamics.

The knowledge of medical university students on the prevention of cardiovascular diseases

B. Wiśniowska, Beata Podsiadło, Mariola Czajkowska, 2015 .

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin

N. Patel, S. Polak, K. Romero, 2018, The AAPS Journal.

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry

S. Polak, P. Kułakowski, B. Wiśniowska, 2020, International journal of molecular sciences.

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm.

S. Polak, B. Wiśniowska, Zofia Tylutki, 2017, Drug discovery today.

Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters

S. Polak, C. Pollard, M. Holbrook, 2020, Journal of clinical pharmacy and therapeutics.

Irritant patch test reactions to cosmetic ingredients

B. Wiśniowska, R. Spiewak, Jadwiga Kalicińska, 2022, Alergologia Polska - Polish Journal of Allergology.

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

Sebastian Polak, Barbara Wiśniowska, Bartosz Lisowski, 2018, Journal of applied toxicology : JAT.

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, BMC Pharmacology and Toxicology.

From probiotics to psychobiotics - the gut-brain axis in psychiatric disorders.

P. Paśko, B. Wiśniowska, M. Marcinkowska, 2020, Beneficial Microbes.

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin

N. Patel, S. Polak, K. Romero, 2018, The AAPS Journal.

Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

S. Polak, B. Wiśniowska, A. Glinka, 2012, BMC Pharmacology and Toxicology.

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

S. Polak, P. Kułakowski, B. Wiśniowska, 2022, Pharmaceuticals.

Magnetic Core–Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma—Material Characterization, Theoretical Analysis and Pharmacokinetics

S. Polak, P. Luliński, M. Sobiech, 2021, International journal of molecular sciences.

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram

N. Patel, M. Jamei, S. Polak, 2017, The AAPS Journal.

In silico prediction of the drug overdose consequences at the heart electrophysiology level

K. Fijorek, A. Mendyk, B. Wiśniowska, 2012, 2012 Computing in Cardiology.

Virtual Thorough QT (TQT) Trial—Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine

N. Patel, S. Polak, B. Wiśniowska, 2018, The AAPS Journal.

Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example.

S. Polak, B. Wiśniowska, 2016, Journal of pharmaceutical sciences.

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation

Sebastian Polak, Barbara Wiśniowska, S. Polak, 2016, Current Pharmacology Reports.

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, BMC Pharmacology and Toxicology.

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

Sebastian Polak, Aleksander Mendyk, Jakub Szlek, 2018, Comput. Math. Methods Medicine.

Humans Vary, So Cardiac Models Should Account for That Too!

Barbara Wiśniowska, Sebastian Polak, Zofia Tylutki, 2017, Front. Physiol..

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

Sebastian Polak, Renata Jachowicz, Peter Kleinebudde, 2015, Comput. Math. Methods Medicine.

Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling.

S. Polak, A. Luch, Z. Bielecka, 2023, Data in brief.

Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems

R. Jachowicz, S. Polak, Adam Pacławski, 2020, Applied Sciences.

Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests—How Does the Infotechnomics Compare to Other “Omics” in the Cosmetics Safety Assessment?

S. Polak, B. Wiśniowska, R. Spiewak, 2023, International journal of molecular sciences.

Development of physiologically based pharmacokinetic model for the immediate release ropinirole tablets

P. Kulinowski, P. Dorożyński, S. Polak, 2021, Acta Poloniae Pharmaceutica - Drug Research.

BDTcomparator: a program for comparing binary classifiers

Kamil Fijorek, Sebastian Polak, Barbara Wisniowska, 2011, Bioinform..

The open-access dataset for insilico cardiotoxicity prediction system

S. Polak, K. Fijorek, A. Mendyk, 2011, Bioinformation.

Prediction of the hERG potassium channel inhibition potential with use of artificial neural networks

Sebastian Polak, Aleksander Mendyk, Barbara Wisniowska, 2011, Appl. Soft Comput..

Evaluation of patients’ adherence to statins in Poland

A. Skowron, B. Wiśniowska, 2011, Current medical research and opinion.

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, Current Pharmacology Reports.

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study

S. Polak, B. Wiśniowska, Zofia M Bielecka, 2021, Journal of Pharmacokinetics and Pharmacodynamics.

Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper.

A. Luch, Z. Bielecka, B. Wiśniowska, 2022, Toxicology and applied pharmacology.

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

S. Polak, N. Stockbridge, C. Garnett, 2015, The AAPS Journal.

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.

Sebastian Polak, Barbara Wiśniowska, Zofia Tylutki, 2019, Drug discovery today.

3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy: are we there yet?

B. Wiśniowska, S. Polak, Gabriela Wyszogrodzka-Gaweł, 2023, Drug discovery today.

An open-access data set of pig skin anatomy and physiology for modelling purposes

S. Polak, B. Wiśniowska, Laura Krumpholz, 2022, Database J. Biol. Databases Curation.

Correction to: Open-access database of literature derived drug-related Torsade de Pointes cases

S. Polak, B. Wiśniowska, Laura Krumpholz, 2022, BMC pharmacology & toxicology.

ToxComp ∔ In vitro-in vivo extrapolation system for drug proarrhythmic potency assessment

S. Polak, B. Wisniowska, K. Fijorek, 2012, 2012 Computing in Cardiology.

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

Sebastian Polak, Barbara Wiśniowska, Zofia Tylutki, 2016, Current Pharmacology Reports.

Computational Methods as Part of Scientific Research in Cosmetic Sciences—Are We Using the Opportunity?

B. Wiśniowska, Laura Krumpholz, Sebastian Polak, 2024, Cosmetics.