D. Sigano

发表

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

P. Blumberg, M. Nicklaus, M. Peach, 2003, Journal of medicinal chemistry.

N‐Methyl‐Substituted Fluorescent DAG–Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity

P. Blumberg, R. Jelinek, S. Garfield, 2011, Chembiochem : a European journal of chemical biology.

Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.

Jeewoo Lee, K. Krajewski, P. Blumberg, 2004, Organic letters.

Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.

H. Garg, R. Blumenthal, V. Marquez, 2009, Bioorganic & medicinal chemistry.

An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).

P. Blumberg, M. Nicklaus, S. Garfield, 2001, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.

P. Blumberg, Y. Pu, M. Peach, 2007, Journal of medicinal chemistry.

Materials from peptide assembly: towards the treatment of cancer and transmittable disease

J. Schneider, D. Sigano, M. Branco, 2011, Current Opinion in Chemical Biology.

Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain

K. Gustafson, S. Bates, C. J. Henrich, 2019, Cancer biology & therapy.

CARBENE-ALKYNE-ALKENE CYCLIZATION REACTIONS

D. Sigano, D. Harvey, 1996 .

Synthesis of Cyclopropylpyrrolidines via Reaction of N-Allyl-N-propargylamides with a Molybdenum Carbene Complex. Effect of Substituents and Reaction Conditions

D. Sigano, D. Harvey, 1996 .

North‐ and South‐Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti‐HIV Activity

J. Deschamps, S. Hughes, M. González-Moa, 2009, ChemMedChem.

Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.

P. Blumberg, V. Marquez, D. Sigano, 2004, Journal of medicinal chemistry.

Rational Design of Drugs That Induce Human Immunodeficiency Virus Replication

D. Hamer, T. Chun, P. Blumberg, 2003, Journal of Virology.

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.

Megan L. Peach, J. Deschamps, N. Colburn, 2008, Journal of medicinal chemistry.

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.

Mitchell Ho, J. Grimm, E. Cahir-McFarland, 2017, Cell reports.

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

Megan L. Peach, P. Blumberg, Y. Pu, 2014, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.

Vladimir A. Pavlyukovets, P. Blumberg, S. Wincovitch, 2007, Journal of medicinal chemistry.

Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors

David E. Martin, E. Freed, J. Schneider, 2015, Antimicrobial Agents and Chemotherapy.

Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester*

Megan L. Peach, P. Blumberg, M. Peach, 2012, The Journal of Biological Chemistry.

Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.

P. Blumberg, H. Tamamura, V. Marquez, 2004, Journal of medicinal chemistry.