I. McNae

发表

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Su-Ying Wu, P. Taylor, D. Lane, 2003, Structure.

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

A. Osnowski, Su-Ying Wu, M. Walkinshaw, 2004, Journal of medicinal chemistry.

An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase.

Kun-Yi Hsin, M. Walkinshaw, P. Michels, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.

Peter M Fischer, Darren Gibson, Campbell McInnes, 2006, Chemistry & biology.

Pushing the limits of detection of weak binding using fragment based drug discovery: identification of new cyclophilin binders

J. Michel, M. Walkinshaw, M. Wear, 2017, bioRxiv.

Pushing the limits of detection of weak binding using fragment based drug discovery: identification of new cyclophilin binders

J. Michel, M. Walkinshaw, M. Wear, 2017, bioRxiv.

Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200

M. Walkinshaw, Elizabeth A Blackburn, M. Wear, 2017, FEBS open bio.

Explorer 11-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto-and 7-hydroxy-oxysterols in vivo

B. Walker, S. Shave, R. Andrew, 2013 .

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site*

D. Auld, M. Walkinshaw, P. Michels, 2011, The Journal of Biological Chemistry.

A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpressTM

Elizabeth A Blackburn, M. Wear, I. McNae, 2015, PloS one.

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2014, Royal Society Open Science.

The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2009, Journal of molecular biology.

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis

M. Walkinshaw, P. Michels, M. Wear, 2019, The FEBS Journal.

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites§

D. Fidock, R. Carter, V. do Rosário, 2007, Molecular microbiology.

Some physico-chemical properties of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

Apparent chemical composition of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Elizabeth A. Blackburn, J. Mottram, M. Walkinshaw, 2021, Nature communications.

A recombinant C121S mutant of bovine beta-lactoglobulin is more susceptible to peptic digestion and to denaturation by reducing agents and heating.

C. Holt, L. Sawyer, T. Haertlé, 2004, Biochemistry.

Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme.

Simon Parsons, Peter J Sadler, P. Sadler, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors.

M. Walkinshaw, C. Midgley, P. Fischer, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis.

M. Walkinshaw, P. Michels, V. Hannaert, 2008, Bioorganic & medicinal chemistry.

Bivalent enzyme inhibitors discovered using dynamic covalent chemistry.

Dominic J Campopiano, D. Campopiano, A. Caniard, 2012, Chemistry.

Pyruvate kinases have an intrinsic and conserved decarboxylase activity.

J. Bella, M. Walkinshaw, P. Michels, 2014, The Biochemical journal.

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.

J. Bartek, M. Walkinshaw, M. Strnad, 2011, Journal of medicinal chemistry.

MeCP2 binding to DNA depends upon hydration at methyl-CpG.

A. Bird, R. Klose, M. Walkinshaw, 2008, Molecular cell.

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

Montserrat G. Vásquez-Valdivieso, M. Walkinshaw, P. Michels, 2017, Journal of molecular biology.

Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity.

R. Baxter, M. Walkinshaw, A. Cooper, 2009, Journal of molecular biology.

Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium.

M. P. Gallagher, M. Walkinshaw, M. Wear, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

Montserrat G. Vásquez-Valdivieso, A. Simeonov, D. Auld, 2014, ACS medicinal chemistry letters.

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

M. Walkinshaw, T. Hupp, P. Michels, 2018, The Biochemical journal.

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

T. Le Bihan, M. Walkinshaw, G. Loake, 2018, The Biochemical journal.

Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo.

M. Walkinshaw, P. Michels, L. J. Eades, 2011, Metallomics : integrated biometal science.

Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2009, Journal of molecular biology.

Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension.

M. Walkinshaw, W. Tan, I. McNae, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

M. Walkinshaw, P. Michels, I. McNae, 2020, The Biochemical journal.

Cloning, expression, purification, crystallization and preliminary X-ray characterization of the full-length single-stranded DNA-binding protein from the hyperthermophilic bacterium Aquifex aeolicus.

L. Sawyer, D. Campopiano, I. McNae, 2004, Acta crystallographica. Section D, Biological crystallography.

Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

M. Walkinshaw, P. Fischer, I. McNae, 2007, Journal of molecular biology.

Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model*

M. Walkinshaw, P. Michels, V. Hannaert, 2010, The Journal of Biological Chemistry.

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

D. Auld, M. Boxer, M. Walkinshaw, 2012, The Biochemical journal.

Configurations of nickel-cyclam antiviral complexes and protein recognition.

Simon Parsons, Daniel P. Simpson, Peter J Sadler, 2007, Chemistry.

Half-sandwich arene ruthenium(II)-enzyme complex.

Peter J Sadler, Fuyi Wang, P. Sadler, 2004, Chemical communications.

Explorer A streamlined , automated protocol for the production of milligram quantities of untagged recombinant rat lactate dehydrogenase A using ÄKTAxpress

M. Wear, I. McNae, Matthew W. Nowicki, 2017 .

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2013, Acta crystallographica. Section D, Biological crystallography.

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

F. Bringaud, M. Walkinshaw, P. Michels, 2018, The Biochemical journal.

The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2007, Journal of molecular biology.

Studying protein–ligand interactions using protein crystallography

Malcolm D. Walkinshaw, Paul Taylor, Liam J. Worrall, 2005 .