I. Küçükgüzel

发表

Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents.

P. Yogeeswari, D. Sriram, E. De Clercq, 2016, Biological & pharmaceutical bulletin.

Novel 4‐Thiazolidinones as Non‐Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA‐Dependent RNA Polymerase

Bhargav A. Patel, Neerja Kaushik-Basu, T. Talele, 2015, Archiv der Pharmazie.

Molecular modeling and assessment of cytotoxic and apoptotic potentials of imatinib analogues featuring (thio)urea motifs in human leukemia and lymphoma cells

I. Küçükgüzel, Özlem BİNGÖL ÖZAKPINAR, Aslı Türe, 2020 .

Synthesis, characterization and screening of antimicrobial, antituberculosis, antiviral and anticancer activity of novel1,3-thiazolidine-4-ones derived from 1-[2-(benzoylamino)-4-(methylthio)butyryl]-4-alkyl/arylalkyl thiosemicarbazides

F. Şahin, E. Clercq, M. Gulluce, 2008 .

A rapid, sensitive high performance liquid chromatographic method for the determination of meropenem in pharmaceutical dosage form, human serum and urine.

S. Ozkan, H. Aboul‐Enein, I. Küçükgüzel, 2001, Biomedical chromatography : BMC.

Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure

E. De Clercq, C. Pannecouque, M. Paci, 2019, Letters in Drug Design & Discovery.

In silico discovery of potential azole-containing mPGES-1 inhibitors by virtual screening, pharmacophore modeling and molecular dynamics simulations

I. Küçükgüzel, A. Ogan, Lalehan Ozalp, 2022, Structural Chemistry.

Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity.

J. Stables, I. Küçükgüzel, T. Altuğ, 2004, Farmaco.

Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of İnflammation and Cancer.

I. Küçükgüzel, Bahadır Bülbül, 2019, Anti-cancer agents in medicinal chemistry.

Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors.

O. Cevik, Neerja Kaushik-Basu, T. Talele, 2016, Biochemical and biophysical research communications.

Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1

K. Yelekçi, C. Zhan, F. Şahin, 2022, Journal of Molecular Structure.

Design, synthesis, and anticancer activity of novel 4-thiazolidinone-phenylaminopyrimidine hybrids

A. Altun, I. Küçükgüzel, Aslı Türe, 2020, Molecular Diversity.

Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery

Esra Tatar, I. Küçükgüzel, Gökçen Yaşayan, 2020, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells.

E. De Clercq, C. Pannecouque, Esra Tatar, 2016, European journal of medicinal chemistry.

Synthesis and antimycobacterial activity of some coupling products from 4-aminobenzoic acid hydrazones

Ş. Küçükgüzel, I. Küçükgüzel, S. Rollas,, 1999 .

Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis

I. Küçükgüzel, Banu Kaskatepe, Sevil Şenkardeş, 2021 .

Synthesis, characterization and biological evaluation of thioureas, acylthioureas and 4-thiazolidinones as anticancer and antiviral agents

J. Neyts, P. Leyssen, I. Küçükgüzel, 2017 .

Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.

E. De Clercq, Esra Tatar, Ş. Küçükgüzel, 2008, European journal of medicinal chemistry.

Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.

Ilkay Küçükgüzel, E. De Clercq, L. Kabasakal, 2007, European journal of medicinal chemistry.

Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials.

Ş. Küçükgüzel, I. Küçükgüzel, S. Rollas,, 2001, Bioorganic & medicinal chemistry letters.

In vitro hepatic microsomal metabolism of N-benzyl-N-methylaniline.

I. Küçükgüzel, J. Gorrod, M. Ulgen,, 1999, Il Farmaco.

Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents.

D. Sriram, I. Küçükgüzel, V. S. Krishna, 2019, Bioorganic chemistry.

Some Hydrazones of 2‐Aroylamino‐3‐methylbutanohydrazide: Synthesis, Molecular Modeling Studies, and Identification as Stereoselective Inhibitors of HIV‐1

E. De Clercq, C. Pannecouque, Neerja Kaushik-Basu, 2013, Archiv der Pharmazie.

Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.

E. De Clercq, C. Pannecouque, F. Şahin, 2009, European journal of medicinal chemistry.

Design, synthesis, and anticancer activity of novel 4-thiazolidinone-phenylaminopyrimidine hybrids

A. Altun, I. Küçükgüzel, Aslı Türe, 2020, Molecular Diversity.

Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials.

Ş. Küçükgüzel, I. Küçükgüzel, S. Rollas,, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of some new 1,3,4-thiadiazole and 1,2,4-triazole derivatives from L-methionine as antituberculosis and antiviral agents

C. Pannecouque, F. Şahin, T. Kocagöz, 2015 .

Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity.

J. Stables, I. Küçükgüzel, T. Altuğ, 2004, Farmaco.

Synthesis and Characterization of Certain Thiourea Derivatives Starting from 1,2,4-Triazoline-3-Thiones as Potential Antibacterial and Antifungal Agents

I. Küçükgüzel, S. Rollas,, A. Çevikbaş, 1995, Drug metabolism and drug interactions.

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Neerja Kaushik-Basu, T. Talele, Esra Tatar, 2013, European journal of medicinal chemistry.

Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity

K. Yelekçi, C. Zhan, F. Şahin, 2022, Molecular Diversity.

Synthesis and characterization of flurbiprofen hydrazide derivatives as potential anti-HCV, anticancer and antimicrobial agents

F. Şahin, Neerja Kaushik-Basu, Esra Tatar, 2013, Medicinal Chemistry Research.

Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors

Ş. Küçükgüzel, I. Küçükgüzel, Sevil Şenkardeş, 2019, Molecular Diversity.

Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors

Ammar D. Elmezayen, K. Yelekçi, C. Zhan, 2020 .

Metabolic and chemical studies on N-(4-chlorobenzyl)-N'-benzoylhydrazine.

Ş. Küçükgüzel, I. Küçükgüzel, M. Ulgen,, 2000, Farmaco.

Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors

Ş. Küçükgüzel, I. Küçükgüzel, Sevil Şenkardeş, 2019, Molecular Diversity.

Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from $N$-(arylsulfonyl)methionine

C. Pannecouque, E. Clercq, Esra Tatar, 2016 .

Development and Validation of a Stability-Indicating HPLC Method for Determination of Ciprofloxacin Hydrochloride and its Related Compounds in Film-Coated Tablets

I. Küçükgüzel, B. Aksoy, S. Rollas,, 2007 .

Synthesis and standardization of an impurity of acetaminophen, development and validation of liquid chromatographic method.

I. Küçükgüzel, Necla Kulabaş, C. Arikan, 2022, Journal of pharmaceutical and biomedical analysis.

Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine - (thio)urea hybrids as potential kinase inhibitors

Rengül Çetin-Atalay, Deniz Cansen Kahraman, Asli Türe, 2019, Comput. Biol. Chem..

Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms.

S. Karakuş, Ş. Küçükgüzel, I. Küçükgüzel, 2008, Journal of pharmaceutical and biomedical analysis.

Synthesis and characterization of flurbiprofen hydrazide derivatives as potential anti-HCV, anticancer and antimicrobial agents

F. Şahin, Neerja Kaushik-Basu, Esra Tatar, 2013, Medicinal Chemistry Research.

Development and validation of a RP-HPLC method for quality control of oxantel pamoate, pyrantel pamoat and praziquantel in tablets

Esra Tatar, I. Küçükgüzel, Gokhan Ates, 2015 .

Identification of some novel amide conjugates as potent and gastric sparing anti-inflammatory agents: In vitro, in vivo, in silico studies and drug safety evaluation

I. Küçükgüzel, A. Ogan, G. Aktay, 2023, Journal of Molecular Structure.

Detection of nimesulide metabolites in rat plasma and hepatic subcellular fractions by HPLC-UV/DAD and LC-MS/MS studies

Ş. Küçükgüzel, I. Küçükgüzel, S. Rollas,, 2012, European Journal of Drug Metabolism and Pharmacokinetics.

Synthesis and Anticancer and Antimicrobial Evaluation of Novel Ether-linked Derivatives of Ornidazole

F. Şahin, Ş. Küçükgüzel, S. Kalayci, 2020, Turkish journal of pharmaceutical sciences.

In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines

I. Küçükgüzel, J. Gorrod, M. Ülgen, 1997, European Journal of Drug Metabolism and Pharmacokinetics.

Synthesis and structure–activity relationship of L‐methionine‐coupled 1,3,4‐thiadiazole derivatives with activity against influenza virus

L. Naesens, E. Vanderlinden, Esra Tatar, 2021, Chemical biology & drug design.

Novel fluoroquinolones containing 2‐arylamino‐2‐oxoethyl fragment: Design, synthesis, evaluation of antibacterial and antituberculosis activities and molecular modeling studies

D. Sriram, I. Küçükgüzel, S. Karaoglu, 2021, Journal of Heterocyclic Chemistry.

The structure--antituberculosis activity relationships study in a series of 5-(4-aminophenyl)-4-substituted-2,4-dihydro-3h-1,2,4-triazole-3-thione derivatives. A combined electronic-topological and neural networks approach.

A. Dimoglo, V. Kovalishyn, I. Küçükgüzel, 2006, Medicinal chemistry.

Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.

L. Kabasakal, E. Clercq, M. Gulluce, 2007, European journal of medicinal chemistry.

Evaluation of molnupiravir analogues as novel coronavirus (SARS CoV-2) RNA-dependent RNA polymerase (RdRp) inhibitors – an in silico docking and ADMET simulation study

I. Küçükgüzel, Necla Kulabaş, Tugce Yesil, 2021, Journal of Research in Pharmacy.

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Neerja Kaushik-Basu, T. Talele, Esra Tatar, 2013, European journal of medicinal chemistry.