Chulho Choi

发表

P2Y1 receptor antagonists as novel antithrombotic agents.

G. Lu, J. Pfefferkorn, M. Leininger, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

J. Pfefferkorn, Chulho Choi, Yun-Song Song, 2007 .

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.

G. Lu, J. Pfefferkorn, Chulho Choi, 2007, Bioorganic & medicinal chemistry.

Structurally Divergent Lithium Catalyzed Friedel–Crafts Reactions on Oxetan‐3‐ols: Synthesis of 3,3‐Diaryloxetanes and 2,3‐Dihydrobenzofurans

J. Mousseau, Chulho Choi, Rosemary A Croft, 2016, Chemistry.

Lithium‐Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3‐Sulfanyl‐Oxetanes as Bioisosteres

J. Mousseau, Chulho Choi, J. Bull, 2017, Chemistry.

Oxetan-3-ols as 1,2-bis-Electrophiles in a Brønsted-Acid-Catalyzed Synthesis of 1,4-Dioxanes

Maryne A. J. Dubois, J. Mousseau, Chulho Choi, 2022, Organic letters.

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

G. Lu, J. Pfefferkorn, M. Harris, 2007, Bioorganic & medicinal chemistry letters.

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

A. Gopalsamy, E. Hett, L. R. Hoth, 2017, ACS chemical biology.

Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage.

Maryne A. J. Dubois, J. Mousseau, Chulho Choi, 2020, Organic Letters.

Oxetane ethers are formed reversibly in the lithium-catalyzed Friedel–Crafts alkylation of phenols with oxetanols: Synthesis of dihydrobenzofurans, diaryloxetanes, and oxetane ethers

J. Mousseau, Chulho Choi, J. Bull, 2018, Tetrahedron.

Visible-Light-Initiated Manganese Catalysis for C-H Alkylation of Heteroarenes: Applications and Mechanistic Studies.

N. Sach, Y. M. Fobian, Chulho Choi, 2017, Angewandte Chemie.

Aminocarbonylation of aryl tosylates to carboxamides.

S. Wright, N. Sach, Chulho Choi, 2015, Organic letters.

Development of an Early Enabling Synthesis for PF-03052334-02: A Novel Hepatoselective HMG-CoA Reductase Inhibitor

Jeffrey A. Pfefferkorn, Chulho Choi, J. Pfefferkorn, 2011 .

Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments: Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments

Maryne A. J. Dubois, J. Mousseau, R. Bureau, 2019 .

Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2Coupling of Medicinally Relevant Fragments

Maryne A. J. Dubois, J. Mousseau, R. Bureau, 2019, European Journal of Organic Chemistry.

Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel-Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity.

Maryne A. J. Dubois, J. Mousseau, R. Bureau, 2018, Organic letters.

Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2007, Bioorganic & medicinal chemistry letters.

Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.

S. Wright, J. Mousseau, Chulho Choi, 2015, Organic letters.

Automated Nanomole-Scale Reaction Screening toward Benzoate Bioisosteres: A Photocatalyzed Approach to Highly Elaborated Bicyclo[1.1.1]Pentanes

N. Sach, R. Hicklin, J. Mousseau, 2021, ACS Catalysis.

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Stephen J. Wright, Hong Wang, K. Parris, 2021, Journal of medicinal chemistry.

A Formal Catalytic Asymmetric Synthesis of (+)-Biotin with Modified Cinchona Alkaloids

Chulho Choi, L. Deng, S. Tian, 2001 .

Synthesis of Chiral Azabicycles from Pyroglutaminols.

S. Wright, J. Mousseau, Chulho Choi, 2016, Organic letters.

Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides

P. Haycock, A. Sterling, J. Mousseau, 2022, Nature Chemistry.

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.

Roger M. Howard, S. Liras, K. Beaumont, 2020, Journal of medicinal chemistry.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.

K. Parris, D. Powell, S. Nagpal, 2017, Journal of medicinal chemistry.

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.

Jason M. Edmonds, David R. Anderson, R. Kurumbail, 2014, The Biochemical journal.

Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.

Bruce Auerbach, Lisa Dillon, Jeffrey A Pfefferkorn, 2008, Journal of medicinal chemistry.

Visible Light Photoredox-Catalyzed Decarboxylative Alkylation of 3-Aryl-Oxetanes and Azetidines via Benzylic Tertiary Radicals and Implications of Benzylic Radical Stability

Maryne A. J. Dubois, A. Sterling, J. Mousseau, 2023, The Journal of organic chemistry.

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.

A. Kalgutkar, K. Farley, M. Munchhof, 2011, Bioorganic & Medicinal Chemistry Letters.

Synthesis of oxetane and azetidine ethers as ester isosteres by Brønsted acid catalysed alkylation of alcohols with 3-aryl-oxetanols and 3-aryl-azetidinols.

Chulho Choi, J. Bull, A. White, 2023, Organic & biomolecular chemistry.

Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.

S. Wright, A. Carlo, Chulho Choi, 2022, ACS medicinal chemistry letters.

Synthesis of 3-Aryl-3-Sulfanyl Azetidines by Iron-Catalyzed Thiol Alkylation with N-Cbz Azetidinols.

Maryne A. J. Dubois, J. Mousseau, Chulho Choi, 2019, The Journal of organic chemistry.

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis

Maryne A. J. Dubois, Yujie Ding, J. Mousseau, 2021, RSC Medicinal Chemistry.