P. Baraldi

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Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines.

P. Brigidi, R. Gambari, B. Vitali, 2002, Bioorganic & medicinal chemistry.

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

E. De Clercq, P. Herdewijn, M. Froeyen, 2009, Antiviral research.

Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

L. C. López-Cara, P. Baraldi, R. Romagnoli, 2018, Journal of enzyme inhibition and medicinal chemistry.

Medicinal Chemistry of the A 3 Adenosine Receptor

K. Jacobson, Zhang-Guo Gao, P. Baraldi, 2018 .

Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study.

Francesca Deflorian, Cristina Ferrari, Barbara Cacciari, 2005, Journal of medicinal chemistry.

Current status of A1 adenosine receptor allosteric enhancers.

K. Varani, P. Borea, P. Baraldi, 2015, Future medicinal chemistry.

Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity.

J. Hartley, P. Baraldi, R. Romagnoli, 2002, Bioorganic & medicinal chemistry.

DNA minor groove alkylating agents structurally related to distamycin A

G. Spalluto, B. Cacciari, P. Baraldi, 2000 .

Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Journal of medicinal chemistry.

Synthetic approaches towards the marine alkyl purines.

P. Baraldi, M. Gordaliza, 2013, Current medicinal chemistry.

Adenosine receptors and human melanoma

K. Klotz, K. Varani, P. Mirandola, 2003 .

Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.

K. Klotz, K. Varani, D. Milani, 2002, The Journal of investigative dermatology.

A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.

K. Varani, S. Merighi, S. Gessi, 2002, Molecular pharmacology.

Design, synthesis and antiproliferative activity of methyl 4-iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds

A. Pani, S. Manfredini, P. Baraldi, 1996 .

A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.

K. Varani, P. Mirandola, S. Merighi, 2005, Neoplasia.

Bis-epoxyethyl derivatives of distamycin A modified on the amidino moiety: induction of production of fetal hemoglobin in human erythroid precursor cells.

R. Gambari, M. Borgatti, N. Bianchi, 2009, International journal of molecular medicine.

Pyrazolo[4,3‐e]1,2,4‐triazolo[1,5‐c]pyrimidine derivatives: A new pharmacological tool for the characterization of the human A3 adenosine receptor

G. Spalluto, B. Cacciari, K. Varani, 2001 .

Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.

G. Spalluto, B. Cacciari, K. Varani, 2000, Bioorganic & medicinal chemistry letters.

Chemistry of Cannabinoid Receptor Agonists

P. Baraldi, M. A. Tabrizi, M. Tabrizi, 2017 .

Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists.

K. Varani, P. Borea, P. Baraldi, 2016, Chemical reviews.

Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.

Pier Andrea Borea, K. Varani, S. Merighi, 2003, Journal of medicinal chemistry.

Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.

K. Varani, P. Borea, P. Baraldi, 2012, Bioorganic & medicinal chemistry.

Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.

K. Jacobson, A. Ivanov, P. Baraldi, 2009, Handbook of experimental pharmacology.

New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2.

P. Borea, P. Baraldi, R. Romagnoli, 2005, Farmaco.

Synthesis of the tritium labeled SCH 58261, a new non‐xanthine A2A adenosine receptor antagonist

G. Spalluto, B. Cacciari, S. Dionisotti, 1996 .

New potent and selective human adenosine A(3) receptor antagonists.

P. Borea, P. Baraldi, 2000, Trends in pharmacological sciences.

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents.

María Kimatrai Salvador, G. Basso, G. Viola, 2014, European journal of medicinal chemistry.

An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions

P. Baraldi, R. Romagnoli, A. Espinosa, 2002 .

TRR469, a potent A1 adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice

K. Varani, F. Vincenzi, M. Targa, 2014, Neuropharmacology.

Synthesis and evaluation of a thio analogue of duocarmycin SA.

D. Boger, P. Baraldi, R. Romagnoli, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders.

E. De Clercq, J. Balzarini, P. Baraldi, 2004, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A₁ adenosine receptor.

K. Varani, O. Cruz-López, F. Vincenzi, 2014, Bioorganic & medicinal chemistry.

Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.

A. Cavalli, M. Recanatini, K. Varani, 2012, Journal of medicinal chemistry.

Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.

María Kimatrai Salvador, K. Varani, O. Cruz-López, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.

María Kimatrai Salvador, K. Varani, O. Cruz-López, 2012, Journal of medicinal chemistry.

Recent developments in A2B adenosine receptor ligands.

P. Baraldi, M. A. Tabrizi, J. Zablocki, 2009, Handbook of experimental pharmacology.

A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.

K. Varani, P. Mirandola, C. Simioni, 2009, Neoplasia.

1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.

K. Varani, A. Zaid, P. Borea, 2008, Bioorganic & medicinal chemistry.

Novel 8-heterocyclyl xanthine derivatives in drug development – an update

P. Baraldi, R. Romagnoli, D. Preti, 2007, Expert opinion on drug discovery.

Novel selective antagonist radioligands for the pharmacological study of A2B adenosine receptors

K. Varani, S. Merighi, S. Gessi, 2006, Purinergic Signalling.

Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.

K. Klotz, K. Varani, F. Vincenzi, 2005, Biochemical pharmacology.

[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors.

K. Varani, S. Merighi, S. Gessi, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.

J. Shryock, P. Borea, P. Baraldi, 2004, European journal of medicinal chemistry.

Allosteric modulators for the A1 adenosine receptor

P. Baraldi, M. Pavani, R. Romagnoli, 2004 .

Molecular modelling of the human A2b adenosine receptor and an analysis of the binding modes of its selective ligands

V. A. Palyulin, A. Ivanov, N. Zefirov, 2002 .

The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.

E. Ongini, A. Monopoli, S. Dionisotti, 1996, The Journal of pharmacology and experimental therapeutics.

Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A3 adenosine receptor

K. Varani, P. Mirandola, S. Merighi, 2006, Purinergic Signalling.

Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells.

R. Gambari, E. Fabbri, P. Baraldi, 2010, Letters in drug design & discovery.

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.

R. Gambari, E. Fabbri, O. Cruz-López, 2009, Letters in drug design & discovery.

Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions

M. Morelli, S. Fenu, N. Simola, 2004, Experimental Neurology.

Adenosine A3 receptor

P. Borea, P. Baraldi, 2001 .

Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models

K. Varani, C. Corciulo, F. Vincenzi, 2013, PAIN®.

New strategies for the synthesis of A3 adenosine receptor antagonists.

K. Varani, P. Borea, P. Baraldi, 2003, Bioorganic & medicinal chemistry.

Pyrazolo[4,3‐e]1,2,4‐triazolo[1,5‐c]pyrimidine derivatives as adenosine receptor ligands: A starting point for searching A2B adenosine receptor antagonists

K. Klotz, G. Spalluto, B. Cacciari, 2001 .

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

Ettore Novellino, Vittorio Limongelli, Luciana Marinelli, 2010, Journal of the American Chemical Society.

Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2‐(3′,4′,5′‐Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

A. Brancale, O. Cruz-López, J. Balzarini, 2011, ChemMedChem.

Involvement of globus pallidus in the antiparkinsonian effects of adenosine A2A receptor antagonists

M. Morelli, S. Fenu, N. Simola, 2006, Experimental Neurology.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.

G. Basso, G. Viola, Roberta Bortolozzi, 2010, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2009, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Chemical synthesis of [(13)c]daidzein.

G. Spalluto, B. Cacciari, K. Setchell, 1999, Journal of Medicinal Food.

Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety

K. Varani, F. Vincenzi, S. Merighi, 2016, Neuropharmacology.

Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A1 receptor

K. Varani, P. Borea, P. Baraldi, 2006 .

A 2A Adenosine Receptor: Structures, Modeling, and Medicinal Chemistry

K. Jacobson, P. Baraldi, Antonella Ciancetta, 2018 .

Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.

A. IJzerman, K. Varani, O. Cruz-López, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.

A. IJzerman, K. Varani, L. C. López-Cara, 2014, Journal of medicinal chemistry.

Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor.

K. Varani, F. Vincenzi, P. Borea, 2013, European journal of medicinal chemistry.

Hybrid molecules between distamycin A and active moieties of antitumor agents.

P. Baraldi, R. Romagnoli, D. Preti, 2007, Bioorganic & medicinal chemistry.

[3H]-MRE 3008-F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors.

K. Klotz, G. Spalluto, B. Cacciari, 2000 .

Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivity.

D. Boger, B. Cacciari, P. Baraldi, 1996, The Journal of organic chemistry.

Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.

K. Varani, S. Merighi, S. Gessi, 2004, Journal of medicinal chemistry.

7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.

P. Baraldi, R. Romagnoli, S. Baraldi, 2012, Bioorganic & medicinal chemistry.

A1 and A3 adenosine receptor agonists: an overview

G. Spalluto, B. Cacciari, P. Baraldi, 1999 .

Inhibition of NF‐kB/DNA Interactions and HIV‐1 LTR Directed Transcription by Hybrid Molecules Containing Pyrrolo [2,1‐c] [1,4] Benzodiazepine (PBD) and Oligopyrrole Carriers

R. Gambari, M. Borgatti, N. Bianchi, 2003 .

Selective binding to human genomic sequences of two synthetic analogues structurally related to U‐71184 and adozelesin

G. Spalluto, R. Gambari, N. Bianchi, 1999 .

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

María Kimatrai Salvador, J. Balzarini, P. Baraldi, 2013, European journal of medicinal chemistry.

Agonists and antagonists acting at P2X7 receptor.

F. Di Virgilio, P. Baraldi, R. Romagnoli, 2004, Current topics in medicinal chemistry.

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2014, Bioorganic & medicinal chemistry.

Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.

A. Brancale, G. Basso, Su-zhan Zhang, 2013, Journal of medicinal chemistry.

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Journal of medicinal chemistry.

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.

A. Brancale, G. Basso, Su-zhan Zhang, 2011, European journal of medicinal chemistry.

Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

G. Basso, G. Viola, Roberta Bortolozzi, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

A. Brancale, G. Basso, G. Viola, 2010, Journal of medicinal chemistry.

Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.

R. Gambari, E. Fabbri, G. Basso, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of hybrid distamycin-cysteine labeled with 99mTc: a model for a novel class of cancer imaging agents.

R. Gambari, N. Bianchi, A. Duatti, 2000, Bioorganic & medicinal chemistry letters.

Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.

M. Botta, T. Tuccinardi, A. Martinelli, 2006, Journal of medicinal chemistry.

One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.

K. Varani, F. Vincenzi, P. Borea, 2015, Journal of medicinal chemistry.

Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.

K. Varani, C. Corciulo, F. Vincenzi, 2013, Journal of medicinal chemistry.

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.

K. Varani, F. Vincenzi, M. Targa, 2012, Journal of medicinal chemistry.

Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.

J. Shryock, S. Merighi, P. Borea, 2003, Journal of medicinal chemistry.

Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.

B. Cacciari, E. Ongini, K. Varani, 1998, Life sciences.

Carboxyl activation in peptide synthesis using 4-oximino-pyrazol-5-ones.

P. Baraldi, M. Guarneri, C. B. Vicentini, 2009, International journal of peptide and protein research.

P. la Colla, A. Pani, S. Manfredini, 2000, Nucleosides, nucleotides & nucleic acids.

Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

A. Brancale, G. Basso, G. Viola, 2011, Journal of medicinal chemistry.

Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole

A. Brancale, G. Basso, G. Viola, 2016, Scientific Reports.

A2A-adenosine receptor reserve for coronary vasodilation.

G. Spalluto, B. Cacciari, E. Ongini, 1998, Circulation.

CC-1065 and the duocarmycins: recent developments

G. Spalluto, B. Cacciari, T. D. Ros, 2000 .

Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity.

D. Boger, G. Spalluto, B. Cacciari, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and Properties of Substituted CBI Analogues of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a- tetrahydrocyclopropa(c)benz(e)indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivity.

D. Boger, B. Cacciari, P. Baraldi, 1996 .

Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.

K. Varani, F. Vincenzi, P. Borea, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.

K. Varani, P. Borea, P. Baraldi, 2007, Journal of medicinal chemistry.

Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide.

E. Ongini, M. Paul-Clark, M. Perretti, 2004, Journal of Medicinal Chemistry.

Allosteric enhancers for A1 adenosine receptor.

P. Baraldi, R. Romagnoli, D. Preti, 2007, Mini reviews in medicinal chemistry.

Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon

E. Ongini, P. Borea, P. Baraldi, 2007 .

1 Synthesis , Antimitotic and Antivascular Activity of 1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-3-Arylamino-5-Amino-1 , 2 , 4-Triazoles

María Kimatrai Salvador, A. Brancale, P. Baraldi, 2015 .

Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast

S. Manfredini, P. Baraldi, R. Romagnoli, 1992 .

DNA minor groove binders as potential antitumor and antimicrobial agents

P. Baraldi, M. Pavani, R. Romagnoli, 2004, Medicinal research reviews.

Synthesis of 3-Substituted-7-alkoxy-5H-pyrazolo[4,3-d]-1,2,3- triazin-4-(3H)-ones

M. Roberti, P. Baraldi, L. Garuti, 1994 .

Synthesis of 6-substituted-4,5-dihydro-3(2H)-pyridazinones

A. Chiarini, S. Manfredini, P. Baraldi, 1990 .

An unusual trimethylsilyltriflate catalyzed transformation of 6-[3-aryl-2-hydroxypropyl]-4,5-dihydro-3(2H-pyridazinones into 3-(1-naphthyl)propionic acid esters

G. Spalluto, S. Manfredini, P. Baraldi, 1993 .

Facile access to 2′-O-acyl prodrugs of 1- (β-d-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′-triesters1

S. Manfredini, P. Baraldi, D. Simoni, 1993 .

Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H) furanones and 3(2H) furanimines

S. Manfredini, P. Baraldi, S. Benetti, 1987 .

Ethyl 5-substituted-3-isoxazolecarboxylates as starting materials for a convenient route to 3(2H)furanones and 3(2H)iminofuranes.

S. Manfredini, P. Baraldi, S. Benetti, 1984 .

Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells.

O. Cruz-López, J. Heilmann, P. Baraldi, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.

R. Gambari, M. Borgatti, P. Baraldi, 2006, Journal of medicinal chemistry.

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds.

J. Balzarini, S. Liekens, P. Baraldi, 2015, European journal of medicinal chemistry.

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

K. Jacobson, Zhang-Guo Gao, K. Varani, 2018, Medicinal research reviews.

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

S. Merighi, S. Gessi, P. Borea, 2017, Medicinal research reviews.

Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-Butyrolactones and α-Bromoacryloyl Moieties

R. Gambari, M. Borgatti, P. Baraldi, 2005 .

An improved preparation of enaminones from 1,3-diketones and ammonium acetate or amine acetates

S. Manfredini, P. Baraldi, D. Simoni, 1983 .

Regioselective one-pot synthesis of 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of aliphatic and aromatic hydrazides.

A. Unciti-Broceta, P. Baraldi, R. Romagnoli, 2005, The Journal of organic chemistry.

Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.

G. Spalluto, J. Balzarini, T. Bando, 2001, Journal of medicinal chemistry.

The intramolecular nitrile oxide cycloaddition route to forskolin

P. Baraldi, S. Benetti, G. Pollini, 1986 .

Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chain.

E. De Clercq, J. Balzarini, S. Manfredini, 1994, Journal of Medicinal Chemistry.

Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor.

I. Lampronti, A. Zaid, J. Shryock, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Jan Balzarini, John A Hadfield, Andrea Brancale, 2007, Journal of medicinal chemistry.

A. Pani, S. Manfredini, E. Tramontano, 1992, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

R. Gambari, A. Brancale, O. Cruz-López, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

H. Hsieh, A. Brancale, O. Cruz-López, 2008, Journal of medicinal chemistry.

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.

G. Spalluto, B. Cacciari, E. Ongini, 1996, Journal of medicinal chemistry.

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility.

S. Gessi, P. Borea, P. Baraldi, 2008, Chemical reviews.

Synthesis of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines and related heterocycles

P. Baraldi, H. El-Kashef, P. Vanelle, 2004 .

Synthesis of 1-Phthalimidoalkanephosphonates

P. Baraldi, G. Pollini, D. Simoni, 1982 .

Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies.

J. Hartley, P. Baraldi, R. Romagnoli, 2004, Bioorganic & medicinal chemistry.

Synthesis, solvolytic stability and cytotoxicity of a modified derivative of CPzI, a pyrazole analog of the alkylation subunit of the antitumor agent CC-1065: effect of the nitrogen substitution on the functional reactivity.

G. Spalluto, B. Cacciari, A. Zaid, 1997, Farmaco.

Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin.

G. Spalluto, R. Gambari, N. Bianchi, 1997, Anti-cancer drug design.

Synthesis, chemical solvolytic stability and preliminary biological evaluation of (+/-)-N-Boc-CPzI: a pyrazole analog of the left-hand segment of the antitumor agent CC-1065.

G. Spalluto, B. Cacciari, P. Baraldi, 1997, Anti-cancer drug design.

[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1

G. Spalluto, R. Gambari, N. Bianchi, 2000, Nucleosides, nucleotides & nucleic acids.

A glance at adenosine receptors: novel target for antitumor therapy.

K. Varani, P. Mirandola, S. Merighi, 2003, Pharmacology & therapeutics.

Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain.

E. De Clercq, J. Balzarini, S. Manfredini, 1992, Journal of medicinal chemistry.

Synthesis of natural products via isoxazoles

P. Baraldi, S. Benetti, G. Pollini, 1987 .

Synthesis and Anti-HSV-1 Activity of 6 Substituted Pyrazolo[3,4-d]Pyridazin-7-one Nucleosides

A. Zaid, R. Manservigi, L. Stevanato, 1998 .

Design, synthesis, and biological evaluation of thiophene analogues of chalcones.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates

B. Cacciari, R. Budriesi, A. Chiarini, 1992 .

α-Halogenoacrylic Derivatives of Antitumor Agents

O. Cruz-López, P. Baraldi, R. Romagnoli, 2009 .

Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters

S. Manfredini, P. Baraldi, D. Simoni, 1984 .

Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3-carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid

P. Baraldi, S. Benetti, G. Pollini, 1985 .

New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.

K. Varani, S. Merighi, P. Borea, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.

J. Balzarini, M. Jordan, P. Baraldi, 2006, Journal of medicinal chemistry.

Recent developments in the field of A3 adenosine receptor antagonists

K. Varani, S. Merighi, S. Gessi, 2003 .

Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates.

E. De Clercq, J. Balzarini, S. Manfredini, 1991, Journal of medicinal chemistry.

Synthesis and cytostatic activity of geiparvarin analogues.

E. De Clercq, J. Balzarini, S. Manfredini, 1989, Journal of medicinal chemistry.

A novel α-acrylate anion equivalent: a useful synthon for α-substituted acrylic esters

P. Baraldi, S. Benetti, G. Pollini, 1983 .

Synthesis of (±)15-Hydroxy-Prosta-2, 4, 8(12), 13-Tetraen-1-Oic Acid Methyl Esters

P. Baraldi, S. Benetti, G. Pollini, 1977 .

Synthesis of 3-Substituted 7-Methyl-5H-pyrazole[4,3-d]-1,2,3-triazin- 4(3H)-ones and Amide-N-Substituted 3-Methyl-4-diazopyrazole-5-carboxamides

S. Manfredini, P. Baraldi, G. Pollini, 1988 .

Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A.

R Gambari, R. Gambari, N. Bianchi, 2000, Journal of medicinal chemistry.

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.

S. Moro, K. Klotz, G. Spalluto, 2000, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

María Kimatrai Salvador, A. Brancale, G. Basso, 2017, Scientific Reports.

Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

B. Cacciari, S. Rault, L. Kèlland, 1999, Journal of medicinal chemistry.

Synthesis and Anti‐HSV‐1 Activity of 6 Substituted Pyrazolo[3,4‐d]pyridazin‐7‐one Nucleosides.

A. Zaid, R. Manservigi, S. Manfredini, 1999 .

Synthesis of a New Series of Pyrazolo[1,5-a]pyrimidines Structurally Related to Zaleplon.

E. Ongini, P. Borea, P. Baraldi, 2007 .

An Efficient Procedure for the Synthesis of 5H-6-Substituted-pyrazolo[1,5-d]-1,2,4-triazine-4,7-diones

G. Spalluto, B. Cacciari, P. Baraldi, 1999 .

Geiparvarin Analogues. Part 4. Synthesis and Cytostatic Activity of Geiparvarin Analogues Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain.

J. Balzarini, E. Clercq, S. Manfredini, 1994 .

Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.

G. Spalluto, R. Gambari, N. Bianchi, 1999, Journal of medicinal chemistry.

Synthesis of some isoxazole analogues of retinoids: biological effects toward tumor cell lines

R. Gambari, C. Nastruzzi, S. Manfredini, 1990 .

A [3+2] nitrile oxide cycloaddition approach to retinoids

S. Manfredini, P. Baraldi, S. Benetti, 1988 .

Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene

S. Manfredini, P. Baraldi, S. Benetti, 1988 .

Synthesis of Natural Products via Isoxazoles

P. Baraldi, S. Benetti, G. Pollini, 1988 .

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.

A. Brancale, G. Basso, G. Viola, 2013, Journal of medicinal chemistry.

A new, elegant route to a key intermediate for the synthesis of 9(0)-methanoprostacyclin

P. Baraldi, S. Benetti, G. Pollini, 1980 .

Azaprostaglandin analogues. Synthesis and biological properties of 11-azaprostaglandin derivatives.

P. Baraldi, S. Benetti, G. Pollini, 1981, Journal of medicinal chemistry.

Ring Cleavage of 3,5-Disubstituted 2-lsoxazolines by Molybdenum Hexacarbonyl and Water to ß-Hydroxy Ketones

S. Manfredini, P. Baraldi, S. Benetti, 1987 .

Active γ-Manganese Dioxide Promoted Conversion of 4,5-Dihydro-1,2-oxazoles to 1,2-Oxazoles

P. Baraldi, S. Benetti, G. Pollini, 1977 .

1,4-Diketones via isoxazole intermediates

P. Baraldi, S. Benetti, G. Pollini, 1979 .

SYNTHESIS OF AN 11-DEOXY-8-AZAPROSTAGLANDIN E1 INTERMEDIATE

P. Baraldi, S. Benetti, G. Pollini, 1979 .

Synthesis of 14-Hydroxy-8-Azaprostanoic Acids Methyl Ester

P. Baraldi, S. Benetti, G. Pollini, 1978 .

Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.

E. De Clercq, J. Balzarini, P. Baraldi, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs)

B. Cacciari, S. Manfredini, P. Baraldi, 1993 .

DNA minor-groove binders: results and design of new antitumor agents.

G. Spalluto, B. Cacciari, A. Zaid, 1999, Farmaco.

A3 Adenosine Receptor Antagonists: History and Future Perspectives

P. Baraldi, R. Romagnoli, S. Baraldi, 2010 .

Synthetic studies towards forskolin

P. Baraldi, V. Ferretti, S. Benetti, 1989 .

A New Synthetic Approach to Indazole Synthesis

G. Spalluto, B. Cacciari, P. Baraldi, 1997 .

New Synthesis of Diazepino[3,2,1‐ij]quinoline and Pyrido[1,2,3‐de]quinoxalines via Addition–Elimination Followed by Cycloacylation

P. Baraldi, E. Ruggiero, M. A. Tabrizi, 2014 .

The Intramolecular Nitrile Oxide Cycloaddition Route to Forskolin.

P. Baraldi, S. Benetti, G. Pollini, 1986 .

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.

D. Boger, A. Zaid, P. Baraldi, 2007, Journal of the American Chemical Society.

DNA minor groove binders as potential antitumor and antimicrobial agents

P. Baraldi, M. Pavani, R. Romagnoli, 2004, Medicinal research reviews.

α‐Bromoacrylamido N‐Substituted Isatin Derivatives as Potent Inducers of Apoptosis in Human Myeloid Leukemia Cells

O. Cruz-López, P. Baraldi, R. Romagnoli, 2009, ChemMedChem.

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.

Barbara Cacciari, Giampiero Spalluto, Tatiana Da Ros, 2002, Journal of medicinal chemistry.

1 3-Aryl / Heteroaryl-5-Amino-1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-1 , 2 , 4-Triazoles as Antimicrotubule Agents . Design , Synthesis , Antiproliferative Activity and Inhibition of Tubulin Polymerization

A. Brancale, G. Viola, Roberta Bortolozzi, 2018 .

Preparation of 3,4-Dihydroxy-1-benzeneethanol: A Reinvestigation

S. Manfredini, P. Baraldi, D. Simoni, 1983 .

Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.

F. Fazio, G. Spalluto, B. Cacciari, 2000, Journal of medicinal chemistry.

Binding of the radioligand [3H]‐SCH 58261, a new non‐xanthine A2A adenosine receptor antagonist, to rat striatal membranes

E. Ongini, S. Dionisotti, P. Baraldi, 1996, British journal of pharmacology.

Hybrid molecules based on distamycin A as potential antitumor agents

A. Zaid, P. Baraldi, M. Pavani, 2005 .

Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.

F. Di Virgilio, S. Gessi, P. Borea, 2004, Bioorganic & medicinal chemistry letters.

TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis

G. Basso, G. Viola, Roberta Bortolozzi, 2013, Angiogenesis.

Cosmetic preservation and structure‐activity relationships of 4‐diazo‐pyrazole‐5‐carboxamides

P. Brigidi, G. Spalluto, B. Cacciari, 1995, International journal of cosmetic science.

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners

S. Marchini, P. Baraldi, R. Romagnoli, 2004 .

Synthesis and antiproliferative activity of 2′-O-allyl-1-β-D-arabinofuranosyl-uracil, -cytosine and -adenine

J. Balzarini, E. Clercq, S. Manfredini, 1997 .

Recent progress in the discovery of antagonists acting at P2X7 receptor

F. Di Virgilio, P. Baraldi, R. Romagnoli, 2005 .

Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.

E. De Clercq, J. Balzarini, S. Manfredini, 1995, Journal of medicinal chemistry.

Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.

K. Varani, S. Di Maro, L. Marinelli, 2012, Journal of medicinal chemistry.

Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides.

E. De Clercq, J. Balzarini, A. Karlsson, 1999, Nucleosides & nucleotides.

Synthesis and Antiproliferative Activity of 2′‐O‐Allyl‐1‐β‐D‐ arabinofuranosyl‐uracil, ‐cytosine and ‐adenine.

J. Balzarini, E. Clercq, S. Manfredini, 1997 .

Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.

María Kimatrai Salvador, A. Brancale, G. Basso, 2014, Journal of medicinal chemistry.

A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol

G. Giannini, R. Baruchello, M. Roberti, 2003 .

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

L. Porcu, J. Balzarini, A. Karlsson, 2001, Bioorganic & Medicinal Chemistry Letters.

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.

Jan Balzarini, Andrea Brancale, Ernest Hamel, 2011, Bioorganic & Medicinal Chemistry Letters.

A3 Adenosine Receptor Ligands: History and Perspectives

G. Spalluto, B. Cacciari, K. Varani, 2000, Medicinal research reviews.

Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.

G. Spalluto, K. Jacobson, B. Cacciari, 1996, Journal of medicinal chemistry.

The Use of Phase-Transfer Catalysis for theN-Alkylation of Indole

P. Baraldi, S. Benetti, G. Pollini, 1976 .

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.

A. Brancale, G. Basso, G. Viola, 2009, Journal of medicinal chemistry.

Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation.

P. Baraldi, R. Romagnoli, E. Hamel, 2016, European journal of medicinal chemistry.

Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.

K. Varani, P. Borea, P. Baraldi, 2012, Journal of medicinal chemistry.

Recent improvements in the development of A2B adenosine receptor agonists

P. Baraldi, R. Romagnoli, D. Preti, 2009, Purinergic Signalling.

Recent improvements in the development of A2B adenosine receptor agonists

P. Baraldi, R. Romagnoli, D. Preti, 2008, Purinergic Signalling.

Recent developments in the field of A2A and A3 adenosine receptor antagonists.

K. Varani, P. Borea, P. Baraldi, 2003, European journal of medicinal chemistry.

Novel N6‐(Substituted‐phenylcarbamoyl)adenosine‐5′‐uronamides as Potent Agonists for A3 Adenosine Receptors.

G. Spalluto, K. Jacobson, B. Cacciari, 1996 .

Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c] pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c] pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists.

Stefano Manfredini, Daniele Simoni, E. Ongini, 1994 .

Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.

K. Varani, P. Borea, P. Baraldi, 2004, Journal of medicinal chemistry.

A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives

S. Manfredini, P. Baraldi, D. Simoni, 1994 .

Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils.

G. Spalluto, B. Cacciari, G. Perra, 1996, Anti-cancer drug design.

Synthesis of 2‐(5′‐substituted isoxazol‐3′‐yl)‐4‐oxo‐3‐thiazolidinylalkanoic acids

S. Manfredini, P. Baraldi, F. D. Vecchia, 1982 .

Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A.

Alberto Martínez, J. Hartley, P. Baraldi, 2002, Journal of medicinal chemistry.

Synthesis, Biological Activity and Molecular Modeling Studies of 1,2,3,4-Tetrahydroiso-quinoline Derivatives as Conformationally Constrained Analogues of KN62, a Potent Antagonist of the P2X7-Receptor Containing a Tyrosine Moiety

F. Virgilio, S. Moro, G. Spalluto, 2002, Arzneimittelforschung.

Stereoselective Synthesis of 8-Aza-9,11-ethenoprostaglandin H1

P. Baraldi, S. Benetti, G. Pollini, 1982 .

Synthesis of syn- and anti-tricyclo [4.1.0.02,4] heptan-5-ones and related compounds

P. Baraldi, S. Benetti, G. Pollini, 1984 .

Synthesis and prostaglandin-like activity of 2-(trans-3-hydroxy-1-octenyl)-3-indoleheptanoic acid.

P. Baraldi, S. Benetti, G. Pollini, 1978, Journal of medicinal chemistry.

A PLE-BASED RESOLUTION OF COCAINE, PSEUDOCOCAINE, AND 6- AND 7-METHOXYLATED COCAINE ANALOGUES

I. Lampronti, A. Kozikowski, S. Manfredini, 1996 .

Hypoxia Inhibits Paclitaxel-Induced Apoptosis through Adenosine-Mediated Phosphorylation of Bad in Glioblastoma Cells

K. Varani, P. Mirandola, S. Merighi, 2007, Molecular Pharmacology.

Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA.

R. Gambari, M. Borgatti, A. Finotti, 2004, Biochemical pharmacology.

N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.

R. Gambari, R. Piva, P. Baraldi, 2005, Journal of biomedical science.

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.

A. Brancale, G. Viola, Roberta Bortolozzi, 2019, Journal of medicinal chemistry.

Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy.

F. Di Virgilio, O. Baricordi, P. Baraldi, 2005, Current drug targets. Cardiovascular & haematological disorders.

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Pierangelo Geppetti, P. Baraldi, Delia Preti, 2010, Journal of medicinal chemistry.

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

D. Massi, C. Créminon, N. Bunnett, 2008, The Journal of clinical investigation.

The A3 Adenosine Receptor: History and Perspectives

K. Varani, F. Vincenzi, S. Merighi, 2015, Pharmacological Reviews.

Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

A. Brancale, O. Cruz-López, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.

María Kimatrai Salvador, G. Basso, G. Viola, 2017, European journal of medicinal chemistry.

Trapping of cyclopentadienone as a 4π component in Diels–Alder reactions with ethyl acrylate: a simple synthesis of (±)-sarkomycin

P. Baraldi, S. Benetti, G. Pollini, 1984 .

Antimicrobial and Antitumor Activity of N-Heteroimine-1,2,3-dithiazoles and Their Transformation in Triazolo-, Imidazo-, and Pyrazolopirimidines.

P. Brigidi, R. Gambari, B. Vitali, 2002 .

Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity.

G. Spalluto, P. Baraldi, R. Romagnoli, 1999, Bioorganic & medicinal chemistry.

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

K. Varani, S. Gessi, P. Borea, 2007 .

N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.

K. Varani, S. Gessi, P. Borea, 2007, Bioorganic & Medicinal Chemistry.

Stereospecific nitromethane conjugate addition to 4-oxygenated-2-substituted-cyclo pent-2-enones: a simple approach to prostaglandins

P. Baraldi, S. Benetti, G. Pollini, 1987 .

A new simple synthesis of α-substituted acrylonitriles

P. Baraldi, S. Benetti, G. Pollini, 1985 .

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.

Cristina Tintori, Tiziano Tuccinardi, Pier Andrea Borea, 2013, Journal of medicinal chemistry.

History and Perspectives of A2A Adenosine Receptor Antagonists as Potential Therapeutic Agents

K. Varani, P. Borea, P. Baraldi, 2015, Medicinal research reviews.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

C. Ghelardini, J. Gertsch, L. De Stefano, 2018, Journal of medicinal chemistry.

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists.

K. Varani, T. Tuccinardi, F. Vincenzi, 2016, European journal of medicinal chemistry.

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.

K. Varani, S. Merighi, S. Gessi, 2010, Biochemical pharmacology.

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

K. Varani, P. Mirandola, C. Simioni, 2007, Molecular Pharmacology.

Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells

D. Ferrari, G. Spalluto, K. Varani, 2001, British journal of pharmacology.

The P2X7 receptor as a therapeutic target

O. Cruz-López, S. Gessi, P. Borea, 2008, Expert opinion on therapeutic targets.

Structure-activity relationship of novel tallimustine derivatives: synthesis and antitumor activity

G. Spalluto, B. Cacciari, P. Baraldi, 1996 .

Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety.

Roberto Gambari, Paolo Cozzi, Nicoletta Bianchi, 2003, Bioorganic & medicinal chemistry.

Binding thermodynamics at the human A(3) adenosine receptor.

K. Klotz, K. Varani, S. Merighi, 2002, Biochemical pharmacology.

[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

K. Klotz, G. Spalluto, B. Cacciari, 2000, Molecular pharmacology.

The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia

F. Pedata, M. Giovannini, S. Cipriani, 2006, Brain Research.

A3 Adenosine Receptors in Human Neutrophils and Promyelocytic HL60 Cells: A Pharmacological and Biochemical Study

K. Varani, S. Merighi, S. Gessi, 2002 .

Cigarette smoke – induced neurogenic inflammation is mediated by α , β-unsaturated aldehydes and the TRPA 1 receptor in rodents

D. Massi, C. Créminon, N. Bunnett, 2008 .

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.

A. Brancale, G. Basso, G. Viola, 2018, European journal of medicinal chemistry.

Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives.

Jan Balzarini, Roberto Gambari, Ernest Hamel, 2010, Medicinal chemistry (Shariqah (United Arab Emirates)).

Elaboration of the .omega.-chain of 11-deoxyprostanoid derivatives through isoxazole intermediates

P. Baraldi, S. Benetti, G. Pollini, 1981 .

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.

S. Moro, G. Spalluto, G. Pastorin, 2003, Journal of medicinal chemistry.

DNA minor-groove binders. Design, synthesis and biological evaluation of ligands structurally related to CC-1065, distamycin, and anthramycin

P. Baraldi, R. Romagnoli, D. Preti, 2003 .

Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazo-pyrazole-5-carboxamides. 2.

M. Recanatini, B. Cacciari, S. Manfredini, 1991, Il Farmaco.

Pyrazolotriazolopyrimidine derivatives sensitize melanoma cells to the chemotherapic drugs: taxol and vindesine.

S. Capitani, K. Varani, P. Mirandola, 2003, Biochemical pharmacology.

Nitrile Oxide [3 + 2] Cycloaddition: Application to the Synthesis of 6-Substituted 3(2H)-Pyridazinones and 6-Substituted 4,5-Dihydro-4-hydroxy-3(2H)-pyridazinones

G. Spalluto, B. Cacciari, S. Manfredini, 1994 .

7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.

G. Spalluto, B. Cacciari, E. Ongini, 2002, Journal of medicinal chemistry.

PNU 157977: a new potent antitumour agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells.

G. Spalluto, R. Gambari, N. Bianchi, 1999, Anti-cancer drug design.

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).

T. Tuccinardi, A. Martinelli, P. Baraldi, 2015, European journal of medicinal chemistry.

Blockade of A2A receptors plus l-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from l-DOPA alone in the rat globus pallidus and substantia nigra reticulata

M. Morelli, A. Carta, P. Baraldi, 2003, Experimental Neurology.

Comparative molecular field analysis (CoMFA) of a series of selective adenosine receptor A2A antagonists

Maurizio Recanatini, Giampiero Spalluto, Pier Andrea Borea, 1999 .

Pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine Derivatives: Potent and Selective A2A Adenosine Antagonists.

G. Spalluto, B. Cacciari, E. Ongini, 1996 .

Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.

G. Spalluto, B. Cacciari, E. Ongini, 1998, Journal of medicinal chemistry.

1,2,3-Triazolo[5,4-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: a new class of A2A adenosine receptor antagonists.

G. Spalluto, B. Cacciari, S. Dionisotti, 1996, Farmaco.

Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Template: Organic and Medicinal Chemistry Approach

P. Borea, P. Baraldi, R. Romagnoli, 2006 .

Pyrazolo[4,3‐e][1,2,4]triazolo[1,5‐c]pyrimidine Template: Organic and Medicinal Chemistry Approach

P. Borea, P. Baraldi, R. Romagnoli, 2007 .

Current Developments of A2a Adenosine Receptor Antagonists

Barbara Cacciari, Giampiero Spalluto, Anna Borioni, 1995, Current Medicinal Chemistry.

Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.

M. Botta, K. Varani, T. Tuccinardi, 2008, Bioorganic & medicinal chemistry.

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.

S. Moro, K. Klotz, G. Spalluto, 2002, Journal of medicinal chemistry.

Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.

S. Moro, G. Spalluto, K. Jacobson, 2001, Journal of medicinal chemistry.

New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.

E. Novellino, K. Varani, A. Zaid, 2011, Journal of medicinal chemistry.

Expression, Pharmacological Profile, and Functional Coupling of A2B Receptors in a Recombinant System and in Peripheral Blood Cells Using a Novel Selective Antagonist Radioligand, [3H]MRE 2029-F20

K. Klotz, R. Rizzuto, K. Varani, 2005, Molecular Pharmacology.

Design, Synthesis and in vitro Cytotoxicity of a cis-Dichloroplatinum (II) Complex Linked to the Minor Groove Binder Stallimycin

R. Gambari, P. Baraldi, M. Pavani, 2003, Arzneimittelforschung.

Application of (3 + 2)Nitrile Oxide Cycloaddition Chemistry to the Construction of Retinoid Skeleton and to a New Formal Synthesis of (.+‐ .)‐Ascofuranone and Geiparvarin.

S. Manfredini, P. Baraldi, G. Pollini, 1994 .

An Efficient Synthesis of 4-Oxo-2,5-hexadienoates via Δ2-Isoxazoline Intermediates

G. Spalluto, S. Manfredini, P. Baraldi, 1993 .

An Efficient Synthesis of 4-Oxo-2,5-hexadienoates via δ2- Isoxazoline Intermediates.

G. Spalluto, S. Manfredini, P. Baraldi, 1994 .

Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development.

S. Merighi, S. Gessi, P. Borea, 2010, Current medicinal chemistry.

Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.

S. Moro, G. Spalluto, G. Pastorin, 2002, Journal of medicinal chemistry.

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.

G. Spalluto, K. Jacobson, B. Cacciari, 1998, Journal of medicinal chemistry.

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines.

K. Varani, S. Merighi, S. Gessi, 2005, Current medicinal chemistry.

From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.

O. Cruz-López, S. Gessi, P. Borea, 2007, Journal of medicinal chemistry.

Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.

F. Di Virgilio, A. Morelli, P. Baraldi, 2003, Journal of medicinal chemistry.

Synthesis of Conformationally Constrained Analogues of KN62, a Potent Antagonist of the P2X7‐Receptor.

F. Virgilio, P. Baraldi, R. Romagnoli, 2000 .

Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.

F. Di Virgilio, F. Virgilio, P. Baraldi, 2000, Bioorganic & medicinal chemistry letters.

The P2X7 receptor as a therapeutic target.

O. Cruz-López, S. Gessi, P. Borea, 2008, Expert opinion on therapeutic targets.

New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.

K. Varani, P. Borea, P. Baraldi, 2005, Journal of medicinal chemistry.

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.

G. Spalluto, B. Cacciari, K. Varani, 1999, Journal of medicinal chemistry.

A formal total synthesis of (±)-forskolin through [3 + 2] nitrile oxide cycloaddition chemistry

G. Spalluto, P. Baraldi, S. Benetti, 1991 .

Heterocyclic analogs of DNA minor groove alkylating agents.

G. Spalluto, B. Cacciari, A. Zaid, 1970, Current pharmaceutical design.

alpha-halogenoacrylic derivatives of antitumor agents.

O. Cruz-López, P. Baraldi, R. Romagnoli, 2009, Mini reviews in medicinal chemistry.

Blockade of globus pallidus adenosine A2A receptors displays antiparkinsonian activity in 6‐hydroxydopamine‐lesioned rats treated with D1 or D2 dopamine receptor agonists

M. Morelli, S. Fenu, N. Simola, 2008, Synapse.

Allosteric modulation of A1-adenosine receptor: a review.

P. Baraldi, R. Romagnoli, María Kimatrai-Salvador, 2013, Drug discovery today. Technologies.

Recent improvements in the field of A3 adenosine receptor ligands

P. Borea, P. Baraldi, R. Romagnoli, 2005 .

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.

K. Varani, O. Cruz-López, J. Shryock, 2008, Journal of medicinal chemistry.

The Use of Phase-Transfer Catalysis for the N-Alkylation of Indole

P. Baraldi, S. Benetti, G. Pollini, 1976 .

Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease

M. Morelli, S. Fenu, N. Simola, 2006, Journal of the Neurological Sciences.

Selective adenosine A2A receptor antagonists.

B. Cacciari, E. Ongini, A. Monopoli, 2001, Farmaco.

New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.

R. Gambari, C. Nastruzzi, S. Manfredini, 1992, Drug Design and Discovery.

Adenosine Receptor Antagonists: Translating Medicinal Chemistry and Pharmacology into Clinical Utility

Pier Andrea Borea, S. Gessi, P. Borea, 2008 .

Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists.

A. Ivanov, N. Zefirov, I. Baskin, 2005, Journal of Medicinal Chemistry.

Synthesis and Biological Activity of a New Series of N6-Arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-Carboxamido Derivatives of Adenosine-5′-N-ethyluronamide as A1 and A3 Adenosine Receptor Agonists.

P. Baraldi, 1998 .

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

S. Merighi, S. Gessi, P. Borea, 2017, Medicinal research reviews.

The A3 Adenosine Receptor: History and Perspectives

K. Varani, F. Vincenzi, S. Merighi, 2015, Pharmacological Reviews.

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.

D. Boger, A. Zaid, P. Baraldi, 2007, Journal of the American Chemical Society.

3,5-Disubstituted isoxazoles as a latent aldol moiety: application to the synthesis of (±)-[6]-gingerol

P. Baraldi, S. Benetti, G. Pollini, 1981 .

Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models

K. Varani, C. Corciulo, F. Vincenzi, 2013, PAIN®.

Ligands for A2B adenosine receptor subtype.

P. Baraldi, R. Romagnoli, D. Preti, 2006, Current medicinal chemistry.

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.

K. Varani, S. Merighi, S. Gessi, 2010, Biochemical pharmacology.

3,5-Disubstituted isoxazoles as synthons for (.+-.)-pyrenophorin and (.+-.)-vermiculine synthesis

P. Baraldi, S. Benetti, G. Pollini, 1983 .

Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.

María Kimatrai Salvador, A. Brancale, G. Viola, 2015, Journal of medicinal chemistry.

Asymmetrical nitrido tc-99m heterocomplexes as potential imaging agents for benzodiazepine receptors.

A. Duatti, K. Varani, P. Borea, 2003, Bioconjugate chemistry.

3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization.

A. Brancale, G. Viola, Roberta Bortolozzi, 2018, Bioorganic chemistry.

Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents

P. Baraldi, D. Preti, R. Patacchini, 2009, British journal of pharmacology.

Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.

J. Balzarini, P. Baraldi, R. Romagnoli, 2008, Medicinal chemistry (Shariqah (United Arab Emirates)).

Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.

E. Novellino, K. Varani, S. Cosconati, 2015, Journal of medicinal chemistry.