C. Vergelli

发表

Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

V. D. Piaz, M. C. Castellana, C. Vergelli, 2002, Journal of enzyme inhibition and medicinal chemistry.

Further modifications of 1H‐pyrrolo[2,3‐b]pyridine derivatives as inhibitors of human neutrophil elastase

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2019, Drug development research.

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.

E. Teodori, A. Khlebnikov, C. Vergelli, 2018, Bioorganic & medicinal chemistry.

Cinnoline derivatives as human neutrophil elastase inhibitors

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Five‐ and Six‐Membered N‐Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists

R. Ye, C. Vergelli, M. Giovannoni, 2017, Drug development research.

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

R. Ye, A. Khlebnikov, C. Vergelli, 2016, Bioorganic & medicinal chemistry.

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

M. Trincavelli, C. Martini, C. Ghelardini, 2015, European journal of medicinal chemistry.

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment.

C. Ghelardini, L. Micheli, L. di Cesare Mannelli, 2016, Mini reviews in medicinal chemistry.

α2‐Agonists as analgesic agents

C. Ghelardini, C. Vergelli, M. Giovannoni, 2009, Medicinal research reviews.

Synthesis and inverse virtual screening of new bi-cyclic structures towards cancer-relevant cellular targets

G. Floresta, C. Vergelli, M. Giovannoni, 2022, Structural Chemistry.

Synthesis and Evaluation as Antitubercular Agents of 5‐Arylethenyl and 5‐(Hetero)aryl‐3‐Isoxazolecarboxylate

S. Franzblau, B. Wan, C. Vergelli, 2013 .

Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.

M. Loza, M. Cadavid, J. Díaz, 2010, Bioorganic & medicinal chemistry.

Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents.

C. Ghelardini, L. di Cesare Mannelli, C. Vergelli, 2015, Bioorganic & medicinal chemistry.

1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.

G. Bartolucci, E. Teodori, C. Vergelli, 2021, Bioorganic & medicinal chemistry letters.

Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis

C. Ghelardini, E. Lucarini, L. di Cesare Mannelli, 2021, Molecules.

Novel formyl peptide receptors (FPRs) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis.

C. Ghelardini, C. Parisio, L. di Cesare Mannelli, 2020, Bioorganic chemistry.

Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists.

G. Bartolucci, C. Vergelli, M. Giovannoni, 2013, Chirality.

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.

G. Bartolucci, C. Vergelli, M. Giovannoni, 2012, Bioorganic & medicinal chemistry.

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.

J. Holderness, R. Ye, C. Vergelli, 2009, Journal of medicinal chemistry.

Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.

C. Vergelli, M. Giovannoni, A. Cilibrizzi, 2009, Journal of medicinal chemistry.

New 3,6‐Disubstituted Pyrazolo[1,5‐ a ]quinazolines as Ligands to GABA A Receptor Subtype

C. Martini, C. Vergelli, M. Giovannoni, 2019, Journal of Heterocyclic Chemistry.

Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABAA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity.

C. Martini, C. Ghelardini, L. di Cesare Mannelli, 2017, Journal of medicinal chemistry.

Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect

C. Martini, C. Ghelardini, L. Mannelli, 2017 .

Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.

C. Ghelardini, A. Pacini, L. Micheli, 2016, Rheumatology.

Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition

C. Zagni, G. Floresta, C. Vergelli, 2022, Pharmaceuticals.

GABAA Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays

M. P. Mascia, C. Vergelli, M. Giovannoni, 2022, International journal of molecular sciences.

Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors

V. D. Piaz, C. Vergelli, M. Giovannoni, 2007, Journal of enzyme inhibition and medicinal chemistry.

New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.

C. Vergelli, M. Giovannoni, V. Dal Piaz, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacological Evaluation of New Pyridazin‐Based Thioderivatives as Formyl Peptide Receptor (FPR) Agonists

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2013 .

[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents.

C. Ghelardini, N. Galeotti, C. Vergelli, 2003, Journal of medicinal chemistry.

4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity.

M. Scheideler, V. D. Piaz, C. Vergelli, 2003, Farmaco.

Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.

C. Ghelardini, N. Galeotti, C. Vergelli, 2006, Journal of medicinal chemistry.

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2013, European journal of medicinal chemistry.

4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action.

C. Vergelli, M. Giovannoni, V. Dal Piaz, 2007, Bioorganic & medicinal chemistry.

4‐Amino‐3(2H)‐pyridazinones Bearing Arylpiperazinylalkyl Groups and Related Compounds: Synthesis and Antinociceptive Activity.

M. Scheideler, V. D. Piaz, C. Vergelli, 2004 .

Isoxazolo[3,4-d]pyridazinones and analogues as Leishmania mexicana PDE inhibitors.

M. C. Castellana, C. Vergelli, M. Giovannoni, 2002, Farmaco.

PDE5 inhibitors and their applications.

C. Vergelli, M. Giovannoni, V. Dal Piaz, 2010, Current medicinal chemistry.

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.

P. Puccini, C. Vergelli, M. Giovannoni, 2010, Bioorganic & medicinal chemistry.

Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors.

G. Bartolucci, G. Floresta, A. Khlebnikov, 2020, Bioorganic & medicinal chemistry.

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2013, Journal of medicinal chemistry.

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.

A. Khlebnikov, V. D. Piaz, C. Vergelli, 2011, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N‐formyl peptide receptors agonists

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2021, Chemical biology & drug design.

Synthesis and evaluation as PDE4 inhibitors of pyrimidine‐2,4‐dione derivatives

R. Matucci, C. Vergelli, M. Giovannoni, 2011 .

Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site

S. Uhlig, C. Vergelli, M. Giovannoni, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2017, Journal of enzyme inhibition and medicinal chemistry.

Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2020, Frontiers in Chemistry.

New 3‐unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation

E. Teodori, C. Vergelli, M. Giovannoni, 2019, Drug development research.

Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study

C. Martini, C. Vergelli, M. Giovannoni, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors

G. Bartolucci, Marta Menicatti, C. Vergelli, 2018, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

G. Bartolucci, Marta Menicatti, A. Khlebnikov, 2017, Chemistry Central Journal.

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors

A. Khlebnikov, C. Vergelli, M. Giovannoni, 2016, Drug development research.

α2‐Agonists as analgesic agents

C. Ghelardini, V. D. Piaz, C. Vergelli, 2009, Medicinal research reviews.

Novel 3‐Arylamino‐ and 3‐Cycloalkylamino‐5, 6‐diphenyl‐pyridazines Active as ACAT Inhibitors

A. Gelain, B. Kwon, L. Toma, 2002, Archiv der Pharmazie.

New Synthesis of Differently Fused Pyridazinoquinolines

V. D. Piaz, C. Vergelli, M. Giovannoni, 1999 .

4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABAA Receptor Subtype

C. Vergelli, M. Giovannoni, F. Melani, 2023, Molecules.

Selective ACAT inhibitors as promising antihyperlipidemic, antiathero-sclerotic and anti-Alzheimer drugs.

V. D. Piaz, C. Vergelli, M. Giovannoni, 2003, Mini reviews in medicinal chemistry.

Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold

C. Martini, M. P. Mascia, C. Vergelli, 2019, International journal of molecular sciences.

New Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as Potent and Selective PDE5 Inhibitors.

V. D. Piaz, C. Vergelli, M. Giovannoni, 2005 .

Protective and Pain-Killer Effects of AMC3, a Novel N-Formyl Peptide Receptors (FPRs) Modulator, in Experimental Models of Rheumatoid Arthritis

C. Ghelardini, E. Lucarini, C. Parisio, 2023, Antioxidants.

New quinoline-based PDE4 inhibitors through GSK-256066 fragment-based elaboration

C. Vergelli, M. Giovannoni, A. Cilibrizzi, 2023, Journal of Molecular Structure.

Optimization of 4‐amino‐pyridazin‐3(2H)‐one as a valid core scaffold for FABP4 inhibitors

Yu Chee Sonia Chen, G. Floresta, C. Vergelli, 2023, Archiv der Pharmazie.

4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action.

C. Ghelardini, C. Vergelli, M. Giovannoni, 2007, Journal of medicinal chemistry.

Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.

C. Vergelli, M. Giovannoni, A. Graziano, 2006, Journal of medicinal chemistry.

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

R. Ye, A. Khlebnikov, C. Vergelli, 2016, Bioorganic & medicinal chemistry.