H. Ryder

发表

Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

V. D. Piaz, M. C. Castellana, C. Vergelli, 2002, Journal of enzyme inhibition and medicinal chemistry.

Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative.

P. Charlton, I. Dale, R. Callaghan, 1998, British Journal of Cancer.

Identifying small-molecule lead compounds: the screening approach to drug discovery.

P Bevan, H. Ryder, P. Bevan, 1995, Trends in biotechnology.

XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase.

R. C. Coombes, H. Ryder, M. Donaldson, 1999, European journal of cancer.

Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.

J. Beleta, H. Ryder, Dolors Vilella, 2005, Bioorganic & medicinal chemistry letters.

The In Vitro Pharmacological Profile Of LAS100977 - A Potent, Selective And Long-acting Beta-2 Receptor Agonist

J. Cortijo, A. Gavaldá, J. Beleta, 2010, ATS 2010.

Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.

T. Hancox, P. Charlton, I. Dale, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483.

L. Santamaria, V. Segarra, H. Ryder, 1999, Bioorganic & medicinal chemistry.

Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.

J. Montero, A. Gavaldá, J. Beleta, 2011, European journal of medicinal chemistry.

Combinatorial approaches towards the discovery of new tryptase inhibitors.

F. Albericio, V. Segarra, H. Ryder, 2005, Bioorganic & medicinal chemistry letters.

(3R)-N-(1-(tert-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)- 1H-1,4-benzodiazepin-3-yl)-N′-(3(methylamino)phenyl)urea (YF476): A Potent and Orally Active Gastrin/CCK-B Antagonist.

A. Nishida, H. Ryder, S. Akuzawa, 1997 .

(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.

A. Nishida, H. Ryder, S. Akuzawa, 1997, Journal of medicinal chemistry.

Discovery of potent inhibitors of the lysophospholipase autotaxin.

H. Ovaa, A. Turnbull, W. Moolenaar, 2016, Bioorganic & medicinal chemistry letters.

New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.

M. Loza, M. Cadavid, J. Díaz, 2006, Bioorganic & medicinal chemistry letters.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[

S. Sentellas, S. Espinosa, V. Segarra, 2009, Journal of medicinal chemistry.

Efficacy And Safety Of Aclidinium Bromide 400 μg BID Compared With Placebo And Tiotropium In Patients With Moderate To Severe COPD

J. Cortijo, H. Ryder, J. Beleta, 2022 .

Pharmacological Characterization of Abediterol, a Novel Inhaled β2-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models

J. Cortijo, J. Beleta, H. Ryder, 2012, Journal of Pharmacology and Experimental Therapeutics.

Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors.

J. Casacuberta, V. Segarra, H. Ryder, 2000, Journal of medicinal chemistry.

Rolipram inhibits staphylococcal enterotoxin B-mediated induction of the human skin-homing receptor on T lymphocytes.

A. Giménez-Arnau, H. Ryder, J. Palacios, 1999, The Journal of investigative dermatology.

Computer-Assisted Comparison of the Structural and Electronic Dispositions of Ebastine and Terfenadine

V. Segarra, H. Ryder, J. Palacios, 1999, Drug safety.

Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.

V. Segarra, H. Ryder, J. Palacios, 2000, Journal of medicinal chemistry.

Thrombin inhibitors based on ketone derivatives of arginine and lysine.

H. Ryder, M. Szelke, D. M. Jones, 1995, Journal of enzyme inhibition.

Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.

F. Caturla, H. Ryder, J. Beleta, 2004, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.

J. Beleta, H. Ryder, J. Gras, 2004, Journal of medicinal chemistry.

Identification and biological activity of novel peptidomimetic gastrin/CCK-B receptor agonists

A. Nishida, H. Ryder, K. Miyata, 1996 .

Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.

V. Segarra, H. Ryder, J. Palacios, 1998, Journal of medicinal chemistry.

Efficient three-step sequence for the deamination of α-aminoesters. Application to the synthesis of CysLT1 antagonists

H. Ryder, J. Sanahuja, L. Sole, 2009 .

Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: an investigation of Alloc removal from secondary amines

F. Albericio, H. Ryder, E. Navarro, 2001 .

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.

S. Espinosa, V. Segarra, J. Beleta, 2011, Bioorganic & medicinal chemistry letters.

Efficient method for the preparation of (S)-5-hydroxynorvaline

V. Segarra, H. Ryder, J. Palacios, 2000 .

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-ALKYLCARBONYLMETHYL ANALOGUES OF YM022

A. Nishida, H. Ryder, S. Akuzawa, 1996 .

Synthesis and biological activity of 5-heteroaryl benzodiazepines: analogues of YM022

A. Nishida, H. Ryder, S. Akuzawa, 1996 .

In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance

P. Charlton, S. Eccles, I. Dale, 1999, British Journal of Cancer.

Stabilisation of the thromboxane ring system by electron-withdrawing substituents. Mechanism and reactivity in the hydrolysis of alkyl and aryl oxetane acetals

V. Matassa, H. Ryder, A. J. Kirby, 1990 .

Stabilisation of the thromboxane ring system by electron-withdrawing substituents: synthesis and attempted cyclisation of substituted tetrahydropyran-2,4-diols

V. Matassa, H. Ryder, A. J. Kirby, 1990 .

Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.

P. Charlton, H. Ryder, A. Folkes, 1999, Bioorganic & medicinal chemistry letters.

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.

S. Knapp, O. Fedorov, S. Müller, 2017, Journal of medicinal chemistry.

From Molecular Science to the Treatment of Allergy

M. Manns, Jane Wilkinson, P. Hufnagl, 1999, International Archives of Allergy and Immunology.

Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

V. Segarra, H. Ryder, J. Palacios, 2000 .

Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

J. Cortijo, J. Beleta, H. Ryder, 2009, Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-71696817-file00

J. Cortijo, J. Beleta, H. Ryder, 2009 .

A FACILE LARGE SCALE SYNTHESIS OF OPTICALLY ACTIVE 3-AMINO-5-(2-PYRIDYL)-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES

H. Ryder, M. Ohta, G. Semple, 1996 .

A Facile Large Scale Synthesis of Optically Active 3‐Amino‐5‐(2‐ pyridyl)‐1,4‐benzodiazepin‐2‐one Derivatives.

H. Ryder, M. Ohta, G. Semple, 1996 .

Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.

M. Loza, M. Cadavid, M. Calbet, 2007, Journal of medicinal chemistry.

Bond length and reactivity. Structure of 2-(4-nitrophenoxy)tetrahydrofuran

H. Ryder, P. Jones, A. Kirby, 1989 .

LAS100977, A Novel Beta-2 Receptor Agonist, With A Longer Duration Of Action And More Favourable Safety Margin Than Salmeterol In Anesthetised Dogs

J. Beleta, H. Ryder, J. Gras, 2010, ATS 2010.

Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

J. Cortijo, J. Beleta, H. Ryder, 2009, Journal of Pharmacology and Experimental Therapeutics.