M. Suto

发表

Design of a gene family screening library targeting G-protein coupled receptors.

E. Bradley, P. Grootenhuis, M. Lamb, 2004, Journal of molecular graphics & modelling.

The wnt/β‐catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

Yonghe Li, T. D. King, M. Suto, 2012, Journal of cellular biochemistry.

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.

D. Bedwell, K. Keeling, S. Rowe, 2016, American journal of respiratory and critical care medicine.

Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer

Han-Xun Wei, P. Oliver, D. Buchsbaum, 2018, International journal of molecular sciences.

Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity.

M. Cohen, J. Domagala, M. Suto, 1992, Journal of medicinal chemistry.

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

M. Suto, J. Murphy-Ullrich, 2017, Matrix biology : journal of the International Society for Matrix Biology.

Ion-exchange resins for solution phase parallel synthesis of chemical libraries

M. Suto, L. Gayo, 1997 .

Solution-phase parallel synthesis using ion-exchange resins

M. Suto, M. Palanki, L. M. Gayo-Fung, 1998 .

Chapter 13. Antibacterial Agents, Targets and Approaches

J. Domagala, P. Miller, M. Suto, 1992 .

3D Cell Cultures: Mimicking In Vivo Tissues for Improved Predictability in Drug Discovery

I. Padmalayam, M. Suto, 2012 .

Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket*

L. DeLucas, A. West, E. White, 2014, The Journal of Biological Chemistry.

Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma.

M. Suto, Yang Yang, M. Pallero, 2016, The American journal of pathology.

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.

P. Sethupathy, A. Shalev, Jason K. Kim, 2020, Cell metabolism.

Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

J. Sebolt-Leopold, M. Suto, W. Turner, 1991, Anti-cancer drug design.

Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

M. Everts, G. Painter, M. Suto, 2016, Future virology.

HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007)

R. Ptak, M. Suto, Zhaohui Cai, 2020, Advances in virology.

Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals.

L. Zhai, M. Athar, J. R. Bostwick, 2022, Bioorganic & medicinal chemistry letters.

Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain

Wei Zhang, Yonghe Li, Wenyan Lu, 2017, Oncotarget.

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.

S. Hagen, J. Domagala, M. Schroeder, 1993, Journal of medicinal chemistry.

Development of novel small molecules for the treatment of ALS.

M. Suto, Bini Mathew, V. Pathak, 2020, Bioorganic & medicinal chemistry letters.

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

L. J. Cook, R. Bostwick, L. Zhai, 2020, PloS one.

A novel inhibitor of nuclear factor-kappa B and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivo.

R. Morris, M. Suto, M. Morikawa, 1997, Transplantation proceedings.

Peptide inhibitors of IKB protease: Modification of the C-termini of Z-LLF-CHO

M. Suto, R. Sullivan, L. Ransone, 1996 .

Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1

N. M. Nebane, L. Zhai, A. Zmijewska, 2022, Antioxidants.

Role of adiponectin in the metabolic syndrome: current perspectives on its modulation as a treatment strategy.

I. Padmalayam, M. Suto, 2013, Current pharmaceutical design.

Developments in solution-phase combinatorial chemistry.

M. Suto, 1999, Current opinion in drug discovery & development.

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.

Mark J. Suto, G. Rigdon, M. Suto, 2011, ACS medicinal chemistry letters.

Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate.

A. Manning, M. Suto, A M Manning, 2000, Bioorganic & medicinal chemistry letters.

Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].

A. Manning, B. Bennett, M. Suto, 2000, Journal of medicinal chemistry.

Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.

Nichole A. Tower, M. Heise, B. Tekwani, 2021, Journal of medicinal chemistry.

An efficient method for the synthesis of (R)-3-(1-amino-1-methylethyl)pyrrolidines for the antiinfective agent, PD 138312

M. Suto, J. Zeller, J. Wemple, 1994 .

An Efficient Method for the Synthesis of (R)-3-(1-Amino-1-methylethyl) pyrrolidines for the Antiinfective Agent, PD 138312.

M. Suto, J. Zeller, J. Wemple, 1994 .

Process Development and Optimization for Production of a Potassium Ion Channel Blocker, ICA-17043

M. Suto, G. McNaughton-Smith, B. Marron, 2012 .

1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach.

A M Triggle, D J Triggle, A J Solo, 1988, Journal of medicinal chemistry.

SYNTHESIS OF ANTIFUNGAL ISOCOUMARINS (I)

M. Suto, S. Nakajima, S. Sugiyama, 1979 .

Synthesis and Antibacterial Activity of New Quinolones Containing a 7‐( 3‐(1‐Amino‐1‐methylethyl)‐1‐pyrrolidinyl) Moiety. Gram‐Positive Agents with Excellent Oral Activity and Low Side‐Effect Potential.

S. Hagen, J. Domagala, S. Gracheck, 1994 .

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

A. Manning, B. Bennett, M. Suto, 2003 .

A new class of analogues of the bifunctional radiosensitizer alpha-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines.

W. Leopold, J. Sebolt-Leopold, M. Suto, 1991, Journal of medicinal chemistry.

Traceless linker: Oxidative activation and displacement of a sulfur-based linker

M. Suto, L. Gayo, 1997 .

Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.

S. Hagen, J. Domagala, S. Gracheck, 1994, Journal of medicinal chemistry.

Use of Pentafluorophenyl Esters for One-Pot Protection/Activation of Amino and Thiol Carboxylic Acids.

M. Suto, L. Gayo, 1996 .

Use of pentafluorophenyl esters for one-pot protection/activation of amino and thiol carboxylic acids

M. Suto, L. Gayo, 1996 .

A General and Regiospecific Synthesis of 5,8-Disubstituted α-Tetralones

M. Rosen, M. Suto, M. Doubleday, 1998 .

Solution‐Phase Parallel Synthesis Using Ion‐Exchange Resins.

M. Suto, M. Palanki, L. M. Gayo-Fung, 1998 .

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins.

G. Adams, I. Stratford, M. Threadgill, 1990, Journal of medicinal chemistry.

Stereoselective Michael additions of nitromethane yielding 3R(1S N-substituted aminoethyl)pyrrolidines

M. Suto, M. Stier, J. S. Plummer, 1993 .

3-Ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2,4,5-trifluorobenzoic acids: Useful intermediate in the synthesis of quinolone antibacterials

M. Suto, W. Turner, 1993 .

Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus (VEEV).

Nichole A. Tower, M. Heise, R. Bostwick, 2019, ACS infectious diseases.

Chapter 16. Radiosensitizers

M. Suto, 1991 .

Effects of PD 128763, a New Potent Inhibitor of Poly(ADP-Ribose) Polymerase, on X-Ray-Induced Cellular Recovery Processes in Chinese Hamster V79 Cells'

J. Sebolt-Leopold, M. Suto, W. Turner, 1991 .

Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus

M. Heise, R. Bostwick, Nathaniel J. Moorman, 2021, Antimicrobial agents and chemotherapy.

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

R. Green, E. Mendenhall, R. Bostwick, 2021, Nature Communications.

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

Wei Zhang, M. Suto, C. Langford, 2017, Oncotarget.

Frizzled7 as an emerging target for cancer therapy.

Wei Zhang, Yonghe Li, M. Suto, 2012, Cellular signalling.

SRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells.

Yonghe Li, Wenyan Lu, P. Oliver, 2017, Cancer letters.

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

R. L. Juliano, W. Janzen, R. Juliano, 2015, Nucleic acids research.

Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides

Ling Wang, Xin Ming, Ling Wang, 2018, Nucleic acids research.

GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer

Bo Xu, R. Boohaker, M. Suto, 2020, Frontiers in Oncology.

Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1–Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow

A. Javed, M. Suto, T. Trotter, 2021, Molecular Cancer Therapeutics.

Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells.

J. Sebolt-Leopold, M. Suto, W. Turner, 1991, Radiation research.

Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction.

Bo Xu, R. Boohaker, M. Suto, 2018, Cancer letters.

2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3′,5′-bis (trifluoromethyl)phenyl)carboxamide: A Potent Inhibitor of NF-ϰB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry.

D. W. Anderson, C. Bigam, M. Suto, 1998 .

2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry.

D. W. Anderson, C. Bigam, M. Suto, 1998, Journal of medicinal chemistry.

Retraction of "Design and Synthesis of Novel Cyclic Amine Benzimidazoles for the Treatment of Pancreatic Cancer".

Yonghe Li, Wenyan Lu, Han-Xun Wei, 2017, Journal of medicinal chemistry.

Discovery of a novel inhibitor of kinesin-like protein KIFC1.

Wei Zhang, R. Bostwick, Yonghe Li, 2016, The Biochemical journal.

AlphaScreen HTS and Live-Cell Bioluminescence Resonance Energy Transfer (BRET) Assays for Identification of Tau–Fyn SH3 Interaction Inhibitors for Alzheimer Disease

R. Bostwick, E. Roberson, N. M. Nebane, 2014, Journal of biomolecular screening.

Runx2 deficiency in osteoblasts promotes myeloma resistance to bortezomib by increasing thrombospondin 1-mediated TGF-ß1 activation and suppression immunity in the bone marrow

A. Javed, M. Suto, T. Trotter, 2020 .

Dual-function radiosensitizers. Alpha-[[(2-bromoethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanol and related compounds: preparation via an aziridine equivalent.

M. Suto, M. Stier, L. M. Werbel, 1991, Journal of Medicinal Chemistry.

Role of Kv7 and Cav3 Ion Channels in Pain

M. Suto, J. Krajewski, D. Krafte, 2008 .

Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature

N. Yi, Bojun Xu, Zaixiang Tang, 2017, Oncology reports.

Development of a radiosensitivity gene signature for patients with soft tissue sarcoma

N. Yi, Bojun Xu, Zaixiang Tang, 2017, Oncotarget.

Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells*

Wei Zhang, M. Everts, E. White, 2016, The Journal of Biological Chemistry.

Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS.

Shilpa Dutta, M. Suto, R. Cowell, 2020, European journal of medicinal chemistry.

Identification of Cosalane as an Inhibitor of Human and Murine CC–Chemokine Receptor 7 Signaling via a High-Throughput Screen

M. F. Sassano, W. Janzen, K. Pearce, 2018, SLAS discovery : advancing life sciences R & D.

Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β.

Wei Zhang, M. Suto, M. Pallero, 2020, ACS medicinal chemistry letters.

SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo.

D. W. Anderson, R. Morris, M. Suto, 1996, Transplantation proceedings.

Abstract 5668: The rational design and evaluation of a peptide inhibitor of the PD-1/PD-L1 interaction

Bo Xu, R. Boohaker, M. Suto, 2018, Immunology.

Inhibition of NF-кB

Anthony M. Manning, Mark J. Suto, A. Manning, 2000 .

Retraction of "Design and Synthesis of Novel Cyclic Amine Benzimidazoles for the Treatment of Pancreatic Cancer".

Yonghe Li, Wenyan Lu, Han-Xun Wei, 2017, Journal of medicinal chemistry.