A. Hagiwara

发表

Long-term toxicity and carcinogenicity test of ammonia-process caramel colouring given to B6C3F1 mice in the drinking-water.

S. Fukushima, A. Hagiwara, M. Shibata, 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways.

S. Fukushima, H. Wanibuchi, M. Wei, 2013, Toxicology and applied pharmacology.

Promoting Effect of the Peroxisome Proliferator, Clofibrate, but Not Di(2‐ethylhexyl)phthalate, on Urinary Bladder Carcinogenesis in F344 Rats Initiated by N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine

S. Fukushima, A. Hagiwara, S. Tamano, 1990, Japanese journal of cancer research : Gann.

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.

K. Imaida, M. Hirose, T. Shirai, 1997, Mutation research.

Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay

T. Shirai, A. Hagiwara, Y. Toda, 2005 .

Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels.

S. Fukushima, A. Hagiwara, M. Shibata, 1991, Teratogenesis, carcinogenesis, and mutagenesis.

Spontaneous Tumors in Aging (C57BL/6N X C3H/HeN)F1 (B6C3F1) Mice

A. Hagiwara, Y. Kurata, S. Tamano, 1988, Toxicologic pathology.

Carcinogenicity of butylated hydroxyanisole in F344 rats.

S. Fukushima, A. Hagiwara, M. Shibata, 1983, Journal of the National Cancer Institute.

Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses.

T. Sugimura, M. Nagao, M. Futakuchi, 1994, Carcinogenesis.

Lack of carcinogenicity of silicone resin (KS66) in F344 rats.

T. Shirai, A. Hagiwara, M. Sano, 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay.

S. Fukushima, K. Imaida, A. Hagiwara, 1993, Teratogenesis, carcinogenesis, and mutagenesis.

Chronic toxicity of butylated hydroxytoluene in Wistar rats.

K. Imaida, M. Hirose, A. Hagiwara, 1981, Food and cosmetics toxicology.

Chronic effects of norharman in rats treated with aniline.

M. Hirose, A. Hagiwara, H. Tsuda, 1980, Toxicology letters.

Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice.

A. Hagiwara, M. Shibata, H. Tsuda, 1982, Journal of the National Cancer Institute.

The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with carcinogenesis or tumor promotion.

J. Ward, L. Anderson, B. Diwan, 1988, Toxicology and applied pharmacology.

Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats.

M. Hirose, T. Shirai, A. Hagiwara, 1997, Cancer letters.

S. Imaoka, Y. Funae, T. Shirai, 1996, Cancer letters.

Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters.

J. Ward, L. Anderson, B. Diwan, 1986, Toxicology and applied pharmacology.

Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.

K. Imaida, T. Shirai, A. Hagiwara, 2001, Cancer letters.

Site‐specific Effects of Testosterone Propionate on the Prostate of Rat Pretreated with 3,2′‐Dimethyl‐4‐aminobiphenyl:Dose‐dependent Induction of Invasive Carcinomas

K. Imaida, M. Hirose, Satoru Takahashi, 1995, Japanese journal of cancer research : Gann.

Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.

K. Imaida, T. Shirai, A. Hagiwara, 1999, Journal of Toxicological Sciences.

Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.

K. Imaida, M. Hirose, T. Shirai, 1995, Cancer research.

Lack of Carcinogenicity of Quercetin in F344/DuCrj Rats

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Japanese journal of cancer research : Gann.

Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.

S. Fukushima, K. Imaida, T. Shirai, 1984, IARC scientific publications.

Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats.

M. Hirose, A. Hagiwara, N. Ito, 1986, Cancer letters.

Lack of tumor promoting effects of KCB-1, a recombinant human basic fibroblast growth factor, on two-stage skin carcinogenesis in female CD-1 (ICR) mice.

T. Nakamura, H. Sugimoto, A. Hagiwara, 1996, Cancer letters.

Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats

S. Fukushima, F. Furukawa, K. Nagano, 2015, Journal of Toxicologic Pathology.

Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.

S. Fukushima, F. Furukawa, K. Nagano, 2015, Journal of toxicologic pathology.

Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis.

K. Imaida, T. Shirai, A. Hagiwara, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of enhancing effect of two Kampo medicines, Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on rat urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

T. Shirai, A. Hagiwara, N. Ito, 2002, Teratogenesis, carcinogenesis, and mutagenesis.

Modifying Effects of Various Chemicals on Preneoplastic and Neoplastic Lesion Development in a Wide‐spectrum Organ Carcinogenesis Model Using F344 Rats

S. Fukushima, M. Hirose, A. Hagiwara, 1991, Japanese journal of cancer research : Gann.

Arachidonate-enriched triglyceride oil does not promote tumor development in a rat medium-term multi-organ carcinogenesis model.

F. Furukawa, H. Kawashima, A. Hagiwara, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat

T. Shirai, A. Hagiwara, M. Sano, 2006 .

Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.

S. Fukushima, A. Hagiwara, M. Shibata, 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

No enhancing effects of diacylglycerol oil on tumor development in a medium-term multi-organ carcinogenesis bioassay using male F344 rats.

O. Morita, A. Hagiwara, Y. Doi, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of significant alteration in the prostate or testis of F344 rat offspring after transplacental and lactational exposure to bisphenol A.

T. Shirai, A. Hagiwara, T. Ichihara, 2002, The Journal of toxicological sciences.

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat. (II): Metabolism in forestomach and covalent binding to tissue macromolecules.

A. Yoshitake, M. Hirose, J. Miyamoto, 1987, Toxicology.

Marriage of a medium-term liver model to surrogate markers--a practical approach for risk and benefit assessment.

K. Imaida, T. Shirai, A. Hagiwara, 1999, Toxicologic pathology.

13-Week Oral Toxicity and 4-week Recovery Study of Enzymatically Modified Isoquercitrin in F344/DuCrj Rats

K. Imaida, A. Hagiwara, M. Sano, 2002 .

HISTOPATHOLOGICAL EVALUATION OF SPONTANEOUS HEPATOCELLULAR TUMORS IN B6C3F1 HYBRID MICE

Satoru Takahashi, T. Shirai, A. Hagiwara, 1996 .

Carcinogenicity of Captafol in F344/DuCrj Rats

A. Hagiwara, Y. Kurata, N. Ito, 1990, Japanese journal of cancer research : Gann.

Carcinogenicity study of methyl hesperidin in B6C3F1 mice.

S. Fukushima, A. Hagiwara, Y. Kurata, 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Medium-term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats.

S. Fukushima, F. Furukawa, K. Nagano, 2011, Toxicology.

Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.

T. Shirai, Shugo Suzuki, A. Hagiwara, 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.

C. Masuda, Y. Funae, T. Shirai, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

SPONTANEOUS THYROID, PARATHYROID, AND PANCREATIC ISLET TUMORS IN F344 RATS AND B6C3F1 MICE

A. Hagiwara, M. Shibata, Y. Kurata, 1989 .

Responses of rat urine and urothelium to bladder tumor promoters: possible roles of prostaglandin E2 and ascorbic acid synthesis in bladder carcinogenesis.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Carcinogenesis.

Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine.

S. Fukushima, A. Hagiwara, M. Shibata, 1984, Gan.

Induction of squamous cell carcinoma in the forestomach of F344 rats treated with butylated hydroxyanisole.

S. Fukushima, A. Hagiwara, M. Shibata, 1982, Gan.

Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.

Y. Tsushima, T. Shirai, H. Aoki, 2003, Cancer letters.

Transplacental Initiation of Liver, Lung, Neurogenic, and Connective Tissue Tumors by N-Nitroso Compounds in Mice

L. Anderson, J. Rice, S. Rehm, 1989 .

Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice.

S. Fukushima, M. Hirose, A. Hagiwara, 1984, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats.

T. Shirai, A. Hagiwara, Y. Doi, 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of carcinogenicity of tragacanth gum in B6C3F1 mice.

T. Shirai, A. Hagiwara, N. Ito, 1992, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Oral toxicity study of tragacanth gum in B6C3F1 mice: development of squamous-cell hyperplasia in the forestomach and its reversibility.

T. Shirai, A. Hagiwara, N. Ito, 1991, Journal of toxicology and environmental health.

Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.

T. Shirai, A. Hagiwara, Y. Doi, 2006, The Journal of toxicological sciences.

Two Different Constituents of Madder Colors Lack Tumor Promoting or Carcinogenic Potential in a Medium-term Multi-organ Carcinogenesis Bioassay in Rats

K. Imaida, A. Hagiwara, M. Sano, 1997 .

Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, K. Imaida, A. Hagiwara, 1994, The Journal of toxicological sciences.

MODULATION OF N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE-INDUCED RAT URINARY BLADDER CARCINOGENESIS BY POST-TREATMENT WITH COMBINATIONS OF THREE PHENOLIC ANTIOXIDANTS

S. Fukushima, M. Hirose, A. Hagiwara, 1989 .

Long-term feeding study of N,N'-diphenyl-p-phenylenediamine in F344 rats.

S. Fukushima, A. Hagiwara, N. Ito, 1989, Toxicology.

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.

A. Yoshitake, M. Hirose, J. Miyamoto, 1988, Toxicology.

Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, A. Hagiwara, Y. Kurata, 1986, Cancer letters.

[Modifying effects of beraprost sodium (TRK-100) on N-methyl-N-nitrosourea (MNU) carcinogenesis in F344 rats].

S. Fukushima, A. Hagiwara, M. Shibata, 1989, The Journal of toxicological sciences.

Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats.

T. Shirai, A. Hagiwara, M. Shibata, 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Ectopic Intestinal Glands in the Forestomach of a F344 Rat

A. Hagiwara, Y. Kurata, S. Tamano, 1990, Veterinary pathology.

Rat strain differences in catechol carcinogenicity to the stomach.

K. Imaida, M. Hirose, T. Shirai, 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Four-week Feeding Study of Kusagi Color, a Natural Blue Food Colorant, in F344 Rats

K. Imaida, T. Shirai, A. Hagiwara, 2002 .

Medium-term bioassays as alternative carcinogenicity test.

N Ito, K. Imaida, T. Shirai, 1998, The Journal of toxicological sciences.

Enhancing Effects of Harman and Norharman on Induction of Preneoplastic and Neoplastic Kidney Lesions in Rats Initiated with N‐Ethyl‐N‐hydroxyethylnitrosamine

A. Hagiwara, N. Ito, R. Hasegawa, 1992, Japanese journal of cancer research : Gann.

Dose-Dependent Renal Tubular Toxicity of Harman and Norharman in Male F344 Rats

M. Hirose, A. Hagiwara, Y. Kurata, 1992, Toxicologic pathology.

A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats.

F. Furukawa, A. Hagiwara, Y. Toda, 2010, Food and Chemical Toxicology.

Tissue levels and biological effects of N-nitrosodimethylamine in mice during chronic low or high dose exposure with or without ethanol.

P. Magee, L. Anderson, H. Pylypiw, 1986, Drug metabolism and disposition: the biological fate of chemicals.

Hepatocarcinogenic activity of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats is not modified by sodium L-ascorbate.

S. Fukushima, T. Shirai, A. Hagiwara, 1999, Teratogenesis, carcinogenesis, and mutagenesis.

H‐ras p21 AND PEANUT LECTIN IMMUNOREACTIVITY OF HYPERPLASTIC, PRENEOPLASTIC AND NEOPLASTIC URINARY BLADDER LESIONS IN RATS

J. Ward, M. Tatematsu, A. Hagiwara, 1988, Japanese journal of cancer research : Gann.

Medium-term Rat Liver Bioassay for Rapid Detection of Hepatocarcinogenic Substances

K. Imaida, M. Hirose, T. Shirai, 1997 .

A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats.

Y. Tsushima, T. Shirai, K. Uchida, 2008, Food and Chemical Toxicology.

Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats.

A. Hagiwara, T. Numano, S. Tamano, 2010, The Journal of toxicological sciences.

Dose-dependent Induction of Glandular Stomach Preneoplastic and Neoplastic Lesions in Male F344 Rats Treated with Catechol Chronically

M. Hirose, T. Shirai, A. Hagiwara, 2001, Toxicologic pathology.

Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.

S. Fukushima, A. Hagiwara, N. Ito, 1982, Journal of the National Cancer Institute.

Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.

H. Wanibuchi, S. Imaoka, Y. Funae, 1998, Carcinogenesis.

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs.

A. Yoshitake, M. Hirose, J. Miyamoto, 1987, Toxicology.

Identity and pathogenesis of stomach tumors in Sprague-Dawley rats associated with the dietary administration of butachlor.

M. Tatematsu, G. Williams, A. Wilson, 1995, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.

K. Imaida, T. Shirai, H. Aoki, 2002, The Journal of toxicological sciences.

Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice.

T. Shirai, A. Hagiwara, N. Ito, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Dose‐dependent Induction of Mammary Carcinomas in Female Sprague‐Dawley Rats with 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

Ryohei Hasegawa, Tomoyuki Shirai, T. Sugimura, 1996, Japanese journal of cancer research : Gann.

Organ‐dependent Modifying Effects of Caffeine, and Two Naturally Occurring Antioxidants α‐Tocopherol and n‐Tritriacontane‐16,18‐dione, on 2‐Amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine (PhIP)‐induced Mammary and Colonic Carcinogenesis in Female F344 Rats

M. Hirose, T. Shirai, A. Hagiwara, 1999, Japanese journal of cancer research : Gann.

A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats.

T. Shirai, A. Hagiwara, Y. Toda, 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioassay.

J. Ward, M. Tatematsu, A. Hagiwara, 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Spontaneous Pleomorphic Adenoma in the Submandibular Salivary Gland of an Aged Male (C57BL/6N × C3H/HeN)F1 (B6C3F1) Mouse

T. Shirai, A. Hagiwara, T. Ogiso, 1993, Veterinary pathology.

Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.

K. Imaida, T. Shirai, A. Hagiwara, 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of Tumor Promoting Effects of Carrageenan on 1,2-Dimethylhydrazine-induced Colorectal Carcinogenesis in Male F344 Rats

K. Imaida, T. Shirai, A. Hagiwara, 2001 .

Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats: Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil

S. Fukushima, A. Hagiwara, Y. Doi, 2005 .

F 344 / DuCri Rats

T. Shirai, A. Hagiwara, M. Sano, 2014 .

13-Week Oral Toxicity of Guarana Extract in F344/DuCrj Rats

T. Shirai, A. Hagiwara, M. Sano, 2005 .

Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats.

S. Fukushima, M. Hirose, A. Hagiwara, 1986, Journal of the National Cancer Institute.

Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats.

T. Shirai, H. Aoki, A. Hagiwara, 2003, The Journal of toxicological sciences.

Differences in susceptibility to N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine‐induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis

S. Fukushima, H. Wanibuchi, K. Tatematsu, 2005, Cancer science.

Time‐ and Dose‐dependent Induction of Invasive Urinary Bladder Cancers by N‐Ethyl‐N‐(4‐hydroxybutyl)nitrosamine in B6C3F1 Mice

S. Fukushima, T. Shirai, A. Hagiwara, 1991, Japanese journal of cancer research : Gann.

[A six-month chronic dietary toxicity study of pyriproxyfen in rats].

T. Watanabe, J. Kimura, A. Hagiwara, 1989, The Journal of toxicological sciences.

Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats

F. Furukawa, T. Shirai, Masanori Otsuka, 2011, Journal of toxicologic pathology.

WEAK SYNERGISTIC EFFECT OF URACIL AND N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE ON URINE COMPOSITION, EPITHELIAL MORPHOLOGY, AND DNA SYNTHESIS IN THE URINARY BLADDER OF SYRIAN GOLDEN HAMSTER

S. Fukushima, T. Shirai, A. Hagiwara, 1995 .

Correlation between Medium‐term Multi‐organ Carcinogenesis Bioassay Data and Long‐term Observation Results in Rats

S. Fukushima, K. Imaida, A. Hagiwara, 1993, Japanese journal of cancer research : Gann.

N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice.

L. Anderson, J. Rice, S. Rehm, 1988, Cancer letters.

Lack of carcinogenicity of butylated hydroxytoluene on long-term administration to B6C3F1 mice.

S. Fukushima, T. Shirai, A. Hagiwara, 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Subchronic toxicity study of sodium o-phenylphenate in mice.

S. Fukushima, A. Hagiwara, M. Shibata, 1985, Toxicology letters.

A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats.

T. Shirai, H. Aoki, A. Hagiwara, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.

M. Tatematsu, T. Shirai, A. Hagiwara, 1982, Gan.

Induction of hyperplastic liver nodules by phenobarbital in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine.

S. Fukushima, A. Hagiwara, M. Shibata, 1980, Gan.

Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N x C3H/HeN F1 mice.

M. Hirose, T. Shirai, A. Hagiwara, 1991, Cancer research.

Transplacental initiation of liver, lung, neurogenic, and connective tissue tumors by N-nitroso compounds in mice.

L. Anderson, J. Rice, S. Rehm, 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Epoprostenol sodium, a prostaglandin I2, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats.

H. Tokado, A. Hagiwara, M. Sano, 2001, Cancer letters.

Immunohistochemically Detected O6-and N7-Methyldeoxyguanosine in Organs of Rats Administrated N-Methyl-N-Nitrosourea

S. Fukushima, A. Hagiwara, S. Tamano, 1997 .

Sub-acute oral toxicity study with fullerene C60 in rats.

A. Ono, M. Hirata-Koizumi, A. Hirose, 2012, The Journal of toxicological sciences.

Carcinogenicity of 4‐methoxyphenol and 4‐methylcatechol in F344 rats

M. Hirose, Satoru Takahashi, A. Hagiwara, 2007, International journal of cancer.

Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C), in male F344 rats.

T. Sugimura, M. Nagao, A. Hagiwara, 1994, Carcinogenesis.

SACCHARIN-INDUCED HYPERPLASIA OF THE RAT URINARY BLADDER :

A. Hagiwara, M. Shibata, 2019 .

No Promoting Effect of Ethyl Tertiary-butyl Ether (ETBE) on Rat Urinary Bladder Carcinogenesis Initiated with N-Butyl-N-(4-hydroxybutyl)nitrosamine

S. Fukushima, F. Furukawa, K. Nagano, 2013, Journal of toxicologic pathology.

Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two-stage urinary bladder carcinogenesis.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Journal of toxicology and environmental health.

Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats.

A. Hagiwara, Y. Doi, T. Omoto, 2010, The Journal of toxicological sciences.

Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

M. Tatematsu, K. Imaida, A. Hagiwara, 1980, Journal of the National Cancer Institute.

Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)-nitrosamine

A. Hagiwara, N. Ito, M. Arai, 1980 .

Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.

K. Imaida, T. Shirai, M. Futakuchi, 2000, Cancer letters.

Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.

K. Imaida, M. Hirose, T. Shirai, 1995, Toxicology letters.

Carcinogenicity of captafol in B6C3F1 mice.

S. Fukushima, A. Hagiwara, M. Shibata, 1984, Gan.

Carcinogenicity and modification of carcinogenic response by antioxidants.

M. Hirose, A. Hagiwara, N. Ito, 1990, Basic life sciences.

Susceptibility of Four F1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis

S. Fukushima, R. Puatanachokchai, H. Wanibuchi, 2006 .

No promotion of urinary bladder carcinogenesis by sodium L-ascorbate in male ODS/Shi-od/od rats lacking L-ascorbic acid-synthesizing ability.

A. Hagiwara, M. Shibata, Y. Kurata, 1991, Carcinogenesis.

Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.

M. Hirose, M. Nagao, T. Shirai, 1995, Carcinogenesis.

Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.

S. Fukushima, A. Hagiwara, N. Ito, 1990, Cancer letters.

Subchronic toxicity study of L-isoleucine in F344 rats.

T. Shirai, A. Hagiwara, N. Ito, 1996, Journal of toxicology and environmental health.

Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice.

M. Futakuchi, A. Hagiwara, Y. Kurata, 1994, Toxicology letters.

DOSE-RESPONSE STUDY ON EARLY LESIONS AND CARCINOGENESIS OF RAT URINARY BLADDER INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL)-NITROSAMINE

S. Fukushima, K. Imaida, A. Hagiwara, 1988 .

A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats.

A. Hagiwara, T. Omoto, I. Asai, 2010, The Journal of toxicological sciences.

Effects of sodium salts of phenobarbital and barbital on development of bladder tumors in male F344/NCr rats pretreated with either N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-nitrosobutyl-4-hydroxybutylamine.

J. Ward, B. Diwan, J. Rice, 1989, Toxicology and applied pharmacology.

Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances

K. Imaida, T. Shirai, A. Hagiwara, 2003 .

13-Week Oral Toxicity Study of Pigments Extracted from the Purple Sweet Potato in F344/DuCrj Rats

K. Imaida, M. Hirose, A. Hagiwara, 1997 .

Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.

A. Hagiwara, Y. Kurata, H. Tsuda, 1990, Journal of toxicology and environmental health.

Saccharin-induced hyperplasia of the rat urinary bladder.

S. Cohen, A. Hagiwara, T. Ogiso, 1980, Cancer research.

Modification by Analgesics of Lesion Development in the Urinary Tract and Various Other Organs of Rats Pretreated with Dihydroxy‐di‐N‐propylnitrosamine and Uracil

T. Shirai, A. Hagiwara, M. Shibata, 1995, Japanese journal of cancer research : Gann.

K. Imaida, T. Shirai, H. Aoki, 2002, The Journal of toxicological sciences.

DNA synthesis and scanning electron microscopic lesions in renal pelvic epithelium of rats treated with bladder cancer promoters.

S. Fukushima, A. Hagiwara, M. Shibata, 1991, Toxicology letters.